Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
399
datasets available to search
ShareScore release 0.9.0
Dataset results
399 results for “MN”
Single-cell profiling reveals immune-based mechanisms underlying tumor radiosensitization by a novel Mn porphyrin clinical candidate, MnTnBuOE-2-PyP5+ (BMX-001)
<p>Manganese porphyrins reportedly exhibit synergic effects when combined with irradiation. However, an in-depth understanding of intratumoral heterogeneity and immune pathways, as affected by Mn porphyrins, remains limited. Here, we explored the mechanisms underlying immunomodulation of a clinical candidate, MnTnBuOE-2-PyP<sup>5+</sup> (BMX-001, MnBuOE), using single-cell analysis in murine carcinoma<em> </em>model. Mice bearing 4T1 tumors were divided into 4 groups: control, MnBuOE, radiotherapy (RT), combined MnBuOE, and radiotherapy (MnBuOE/RT). In epithelial cells, epithelial-mesenchymal transition, TNF-α signaling via NF-кB, angiogenesis, and hypoxia-related genes were significantly downregulated in the MnBuOE/RT compared to the RT. All subtypes of cancer-associated fibroblasts (CAFs) were reduced in MnBuOE and MnBuOE/RT. Inhibitory receptor-ligand interactions, in which epithelial cells and CAFs interacted with CD8+ T cells, were significantly lower in the MnBuOE/RT than in the RT. Trajectory analysis showed that DC maturation-associated markers were increased in MnBuOE/RT. M1 macrophages were significantly increased in the MnBuOE/RT compared to the RT, whereas myeloid-derived suppressor cells were decreased. CellChat analysis showed that the number of cell-cell communications was the lowest in the MnBuOE/RT. Our study is the first to provide evidence for the combined radiotherapy with a novel Mn porphyrin clinical candidate, BMX-001 from the perspective of each cell type within the tumor microenvironment.</p>
Dataset for the manuscript: "Elevated-Mn ChemCam Targets Illuminating Mn Redox Cycling and Diagenesis in the Bradbury Rise, Gale Crater, Mars"
<p><span>The dataset for the manuscript titled, “Elevated-Mn ChemCam Targets Illuminating Mn Redox Cycling and Diagenesis in the Bradbury Rise, Gale Crater, Mars” consists of a single CSV file. This CSV contains 1,539 rows, with one ChemCam observation point per row. The observation points in this file are from the ChemCam rock targets between martian solar days (sols) 1 and 600 of the MSL <em>Curiosity</em> rover mission that have at least one observation point with > 0.2 wt% MnO. Metadata and compositional data are provided for each row. The metadata includes the LIBS spectrum filename; the name of the target to which the observation point belongs; the class into which we grouped the target; the spacecraft clock value (timestamp) for the observation point; the sol on which the observation was taken; and the ChemCam sequence identifier; the observation point number within the sequence; the ChemCam-to-target distance (in meters); the laser power used for the LIBS measurements; the spectrum totals; and a binary column indicating whether the observation point has > 0.2 wt% MnO. The compositional data includes the oxide chemistry (oxide wt.%), RMSEP accuracy, and shot-to-shot standard deviation, for the major oxides SiO2, TiO2, Al2O3, FeOT, MgO, CaO, Na2O, K2O, as well as for MnO; the sum of oxides for each observation point is also provided.</span></p>
Distinct association of HRAS and KRAS with Mn(II) ion illustrated by paramagnetic NMR
<p><a name="OLE_LINK4"></a><span>RAS proteins are among crucial oncogenic proteins and are involved in several essential intracellular processes. The RAS protein has an intrinsic metal binding site for Mg<sup>2+</sup>, which is important for the conformational stability of the active site. Recently, it was reported that a second metal ion binding site, located further from the active site in HRAS, binds Ca<sup>2+</sup> with millimolar affinity.</span><span> As one of the most abundant metal ions in cells, Mn<sup>2+</sup> is a potential candidate for the second metal ion binding site in RAS proteins. Here, we examined the interaction of Mn<sup>2+</sup> with HRAS and KRAS using high resolution NMR spectroscopy. The NMR data showed that both the second metal ion binding site and the switch I and II regions bind Mn<sup>2+</sup> in the RAS proteins. Furthermore, our paramagnetic NMR results disclosed the conformational differences in helix </span><span>a</span><span>3 and the following loop between HRAS and KRAS, accompanied by the association with metal ion binding. These results provide new insights into the interaction of RAS proteins and Mn<sup>2+</sup> in the respective biological processes in cells.</span></p>
Text-fig. 10. The chronostratigraphic position of the sites of Erkertshofen 1, Erkertshofen 2 and Petersbuch 2 and the biochronology of some European Neogene bats in Central Europe (species distribution after Revilliod 1920, Zapfe 1950, Rachl 1983, Ziegler 1993, 1994, 1998, 2000, 2003, Horáček 2001, Mörs 2002, Ginsburg and Mein 2012, Rosina and Rummel 2012, 2017, Rasser et al. 2013, Rosina et al. 2019). Miocene time scale after Steininger 1999, MN zones modified after Jones 1999, Rögl 1999. in The Early Miocene Bats (Chiroptera, Mammalia) From The Karstic Sites Of Erkertshofen And Petersbuch 2 (Southern Germany)
Text-fig. 10. The chronostratigraphic position of the sites of Erkertshofen 1, Erkertshofen 2 and Petersbuch 2 and the biochronology of some European Neogene bats in Central Europe (species distribution after Revilliod 1920, Zapfe 1950, Rachl 1983, Ziegler 1993, 1994, 1998, 2000, 2003, Horáček 2001, Mörs 2002, Ginsburg and Mein 2012, Rosina and Rummel 2012, 2017, Rasser et al. 2013, Rosina et al. 2019). Miocene time scale after Steininger 1999, MN zones modified after Jones 1999, Rögl 1999.
Text-fig. 2. Scatter diagram of the length/width ratio of the upper fourth premolar (P4) of Chalicomys jaegeri from Grytsiv as compared to those of C. jaegeri only (a) and additionally of Euroxenomys minutus rhenanus (E. min rhen), Euroxenomys minutus (Eurex min) (b) from other localities. Abbreviations for localities: Cana – Çanakkale (probably MN 8/9 after Sen 2016; data from Ünay 1974), DornD – Dorn-Dürkheim 1 (MN 11; data from Franzen and Storch (1975) for both C. jaegeri and E. minutus rhenanus), Epp – Eppelsheim (MN 9; Stefen 2009), Kücük – Küçükçekmece (probably MN 8/9; Sen 2016), and Sansan (MN 6 after Sen 1997; data from Hugueney and Duranthon 2012). A single specimen from Grytsiv (G) – NMNHU-P 22/218 is tentatively assigned to Euroxenomys minutus based on its size. in Beavers (Castoridae, Rodentia) From The Late Miocene (Mn 9) Locality Grytsiv In Ukraine
Text-fig. 2. Scatter diagram of the length/width ratio of the upper fourth premolar (P4) of Chalicomys jaegeri from Grytsiv as compared to those of C. jaegeri only (a) and additionally of Euroxenomys minutus rhenanus (E. min rhen), Euroxenomys minutus (Eurex min) (b) from other localities. Abbreviations for localities: Cana – Çanakkale (probably MN 8/9 after Sen 2016; data from Ünay 1974), DornD – Dorn-Dürkheim 1 (MN 11; data from Franzen and Storch (1975) for both C. jaegeri and E. minutus rhenanus), Epp – Eppelsheim (MN 9; Stefen 2009), Kücük – Küçükçekmece (probably MN 8/9; Sen 2016), and Sansan (MN 6 after Sen 1997; data from Hugueney and Duranthon 2012). A single specimen from Grytsiv (G) – NMNHU-P 22/218 is tentatively assigned to Euroxenomys minutus based on its size.
Text-fig. 2. The relation between number of genera and localities in MN 5 of central Europe (CE) and the Iberian Peninsula (IB). a. Localities ordered from highest to lowest number of taxa; the distribution is more equitable in the Iberian Peninsula. b. Genera ordered from most common to rarest; the distribution of genera is more equitable in central Europe. The low number of common genera is an artefact of incomplete faunal lists (see text). in Generically Speaking, A Survey On Neogene Rodent Diversity At The Genus Level In The Now Database
Text-fig. 2. The relation between number of genera and localities in MN 5 of central Europe (CE) and the Iberian Peninsula (IB). a. Localities ordered from highest to lowest number of taxa; the distribution is more equitable in the Iberian Peninsula. b. Genera ordered from most common to rarest; the distribution of genera is more equitable in central Europe. The low number of common genera is an artefact of incomplete faunal lists (see text).
Text-fig. 3. MN 12 localities in the NOW database (The NOW Community 2019). Note that the unit is not represented in major parts of Europe. in Generically Speaking, A Survey On Neogene Rodent Diversity At The Genus Level In The Now Database
Text-fig. 3. MN 12 localities in the NOW database (The NOW Community 2019). Note that the unit is not represented in major parts of Europe.
Text-fig. 1. Result of cumulative random counting of MN 5 localities in central Europe and the Iberian Peninsula. Ten simulations were run for each area. a. Results of the count including the average in bold, showing the clearly lower diversity in IB. b. The average lines standardized, showing similar patterns in the two areas. Note that in the simulation around thirty localities were needed to capture 80 % of the regional diversity. in Generically Speaking, A Survey On Neogene Rodent Diversity At The Genus Level In The Now Database
Text-fig. 1. Result of cumulative random counting of MN 5 localities in central Europe and the Iberian Peninsula. Ten simulations were run for each area. a. Results of the count including the average in bold, showing the clearly lower diversity in IB. b. The average lines standardized, showing similar patterns in the two areas. Note that in the simulation around thirty localities were needed to capture 80 % of the regional diversity.
FIG. 5 in Amphibians and squamate reptiles from the late early Miocene (MN 4) of Béon 1 (Montréal-du-Gers, southwestern France)
FIG. 5. — Varanus sp., trunk vertebra (Béon 2004 LT 54), in anterior (a), dorsal (d), left lateral (l), posterior (p), and ventral (v) views. Scale bar: 5 mm.
FIG. 4. — A, B in Amphibians and squamate reptiles from the late early Miocene (MN 4) of Béon 1 (Montréal-du-Gers, southwestern France)
FIG. 4. — A, B, Pseudopus laurillardi (Lartet, 1851); A, right dentary (Béon 2004 LT 39); B, posterior part of a braincase (Béon 2004 LT 38); C, Ophisaurus sp., left dentary (Béon 2004 LT 49). Dorsal (d), left lateral (l), medial (m), and right lateral (r) views. Abbreviations: dr, dorsal ridge; pms, posteromedial surface of paroccipital process; vb, ventral border of trigeminal notch. Scale bars: A, B, 5 mm; C, 2 mm.
FIG. 2 in Amphibians and squamate reptiles from the late early Miocene (MN 4) of Béon 1 (Montréal-du-Gers, southwestern France)
FIG. 2. — Latonia cf. L. ragei Hossini, 1993; A, left premaxilla (Béon 2004 LT 11); B, right maxilla (Béon 2004 LT 12); C, right oticoccipital (Béon 2004 LT 14); D, sacral vertebra (Béon 2004 LT 16); E, left humerus of a male (Béon 2004 LT 18); F, right ilium (Béon 2004 LT 20). Anterior (a), dorsal (d), medial (m), posterior (p), right lateral (r), and ventral (v) views. Scale bars: 2 mm.
FIG. 1 in Amphibians and squamate reptiles from the late early Miocene (MN 4) of Béon 1 (Montréal-du-Gers, southwestern France)
FIG. 1. — Caudata; A, cf. Chelotriton sp., trunk vertebra (Béon 2004 LT 1); B, Triturus aff. T. helveticus (Razoumowsky, 1789), trunk vertebra (Béon 2004 LT 2); C, Triturus cf. T. marmoratus (Latreille, 1800), trunk vertebra (Béon 2004 LT 5). Dorsal (d), left lateral (l), right lateral (r), and ventral (v) views. Scale bars: 2 mm.
FIG. 3. — A-C in Amphibians and squamate reptiles from the late early Miocene (MN 4) of Béon 1 (Montréal-du-Gers, southwestern France)
FIG. 3. — A-C, Rana sp. synkl. R. esculenta Linnaeus, 1758; A, left humerus of a female (Béon 2004 LT 24); B, right humerus of a female (Béon 2004 LT 25); C, right ilium (Béon 2004 LT 27); D, gekkonid lizard, right dentary (Béon 2004 LT 28); E, lacertid lizard, unidentified genus and species 1, left dentary (Béon 2004 LT 30); F, lacertid lizard, unidentified genus and species 2, right dentary (Béon 2004 LT 32). Medial (m), posterior (p), right lateral (r), and ventral (v) views. Scale bars: 2 mm.
FIG. 15. — Acteocemas beatrix n in Les Vertébrés des sables continentaux d'âge orléanien inférieur (MN 3) de Mauvières à Marcilly-sur-Maulne (Indre-et-Loire), La Brosse à Meigné-le-Vicomte (Maine-et-Loire) et Chitenay (Loir-et-Cher)
FIG. 15. — Acteocemas beatrix n. sp., appendice frontal droit, type (MB); A, face antérieure; B, face postérieure. Échelle: 1 cm.
FIG. 11 in Les Vertébrés des sables continentaux d'âge orléanien inférieur (MN 3) de Mauvières à Marcilly-sur-Maulne (Indre-et-Loire), La Brosse à Meigné-le-Vicomte (Maine-et-Loire) et Chitenay (Loir-et-Cher)
FIG. 11. — Diagrammes (largeur × Longueur) des dents de Cainotherium de Espira-du-Conflent (Cainotherium lintillae lintillae), Estrepouy (Cainotherium lintillae lintillae/ligericum), Chitenay, Les Beilleaux, La Brosse, Mauvières (Cainotherium lintillae ligericum).
FIG. 7. — A in Les Vertébrés des sables continentaux d'âge orléanien inférieur (MN 3) de Mauvières à Marcilly-sur-Maulne (Indre-et-Loire), La Brosse à Meigné-le-Vicomte (Maine-et-Loire) et Chitenay (Loir-et-Cher)
FIG. 7. — A, Phoberocyon dehmi, m3 g, La Brosse (Fs 2337), face occlusale; B-E, Pseudaelurus turnauensis, PM4 g, La Brosse (Fs 2284); B, face linguale; C, face occlusale; D, m1 d, La Brosse (Fs 2163), face labiale; E, MtIV d (Mauv 24), face médiale. Échelle: 10 mm.
FIG. 5 in Les Vertébrés des sables continentaux d'âge orléanien inférieur (MN 3) de Mauvières à Marcilly-sur-Maulne (Indre-et-Loire), La Brosse à Meigné-le-Vicomte (Maine-et-Loire) et Chitenay (Loir-et-Cher)
FIG. 5. — Eucricetodon infralactorensis; A, M1 d (retournée) (Mauv 52); B, m1 d (retournée) (Mauv 53); C, m2 g (Mauv 54); D, m2 d (retournée) (Mauv 1); E, m2 g (Fs 2374). × 15.
FIG. 10. — A in Les Vertébrés des sables continentaux d'âge orléanien inférieur (MN 3) de Mauvières à Marcilly-sur-Maulne (Indre-et-Loire), La Brosse à Meigné-le-Vicomte (Maine-et-Loire) et Chitenay (Loir-et-Cher)
FIG. 10. — A, Diaceratherium aurelianensis, calcanéum g, Chitenay (CHT 1), face proximale; B, Plesiaceratherium cf. platyodon, PM4 d, La Brosse (Fs 2169), face occlusale. Échelle: 10 mm.
FIG. 14 in Les Vertébrés des sables continentaux d'âge orléanien inférieur (MN 3) de Mauvières à Marcilly-sur-Maulne (Indre-et-Loire), La Brosse à Meigné-le-Vicomte (Maine-et-Loire) et Chitenay (Loir-et-Cher)
FIG. 14. — Ligeromeryx praestans, hémimandibule gauche de Chitenay avec pm3-m3 (SO 2060); A, face labiale; B, face occlusale; C, face linguale. Échelle: 1 cm.
FIG. 9 in Les Vertébrés des sables continentaux d'âge orléanien inférieur (MN 3) de Mauvières à Marcilly-sur-Maulne (Indre-et-Loire), La Brosse à Meigné-le-Vicomte (Maine-et-Loire) et Chitenay (Loir-et-Cher)
FIG. 9. — Protaceratherium minutum; A, PM(3) d, La Brosse, (Fs 2444), face occlusale; B, PM(3) g, La Brosse, (Fs 2226), face occlusale; C, M1 g, Chitenay, (SO 310), face occlusale. Échelle: 10 mm.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.