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1,543 results for “Malaria”
Figure 1 in Challenges of drug-resistant malaria
Figure 1. Different proteins present inside the parasitic organelle that contribute to drug resistance in malaria under selective drug pressure and new drugs in development, targeting the same pathway to rescue resistance. PRBC: parasitized red blood cell, ER: endoplasmic reticulum, MT: mitochondria, DHPS: dihydropterate synthetase, DHFR: dihydrofolate reductase, ATPase6: sacro/endoplasmic reticulum calcium dependent ATPase orthologue, CRT: chloroquine resistance transporter, MDR1: multidrug resistance.
Рис. 2. 1 — китайский маΛярийный комар Anopheles sinensis; 2 — рисунок крыΛа китайского маΛярийного комара Anopheles sinensis Fig. 2. 1 — Chinese malaria mosquito Anopheles sinensis; 2 — the wing pattern of the Chinese malaria mosquito Anopheles sinensis in Mosquitoes (Diptera, Culicidae) Of The Nature Reserve "Udyl" (Khabarovsk Krai, Russia)
Рис. 2. 1 — китайский маΛярийный комар Anopheles sinensis; 2 — рисунок крыΛа китайского маΛярийного комара Anopheles sinensis Fig. 2. 1 — Chinese malaria mosquito Anopheles sinensis; 2 — the wing pattern of the Chinese malaria mosquito Anopheles sinensis
Fig. 2 in Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Fig. 2 Effect of probenecid (PBN) on the activity of PM, MTX, and TMX. Y axis represents the percentage decrease in IC50 in the presence of PBN. One hundred percent (100%) represents the IC50 in the absence of PBN. In the absence of PBN, the MTX, TMX, and PM IC50 values were 30, 7, and 1,200 nM, respectively
Fig. 3 in Persistent low avian malaria in a tropical species despite high community prevalence
Fig. 3. Maximum likelihood phylogenetic inference of (A) Haemoproteus and (B) Plasmodium from the Australasian region. Sequences were included if they were at least 479 nucleotides in length and were found to be unique from a pairwise distance analysis (see methods). Bootstrap support values are shown if greater than 50. Dots indicate the 14 lineages that were detected in this study and their colour denotes the bird species they occurred within [Purple = PCFW (M. c. coronatus), Red = RBFW (M. melanocephalus), Yellow = BSR (P. cerviniventris), Grey = WGH (L. unicolor)]. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2 in Persistent low avian malaria in a tropical species despite high community prevalence
Fig. 2. (A) Malarial parasite prevalence across years in four bird species, buff-sided robin (BSR, n = 66), purple-crowned fairy-wren (PCFW, n = 731), red-backed fairy-wren (RBFW, n = 78), white-gaped honeyeater (WGH, n = 25). Fisher's exact P-values test for annual differences in infection within each bird species. (B) Longitudinal sampling of infected PCFW adults (individuals presented were sampled more than twice and were identified as infected with Haemoproteus or Plasmodium). Dotted lines indicate uncertainty in years when no sample was available. Each individual was infected with a single lineage. (C) Percentage of individual PCFW infected within each age category. (D) Local phylogenetic relationship between parasite lineages, colours refer to host species as for (A). Maximum likelihood tree was inferred using GTR + G + I with 1000 bootstrap replicates; novel lineages are indicated by *. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 1 in Persistent low avian malaria in a tropical species despite high community prevalence
Fig. 1. Map of Australia and the Kimberly region. Sampling was conducted at the Australian Wildlife Conservancy's Mornington Wildlife Sanctuary (17̊31′S, 126̊6'E). Star indicates the location of the field site where samples were collected.
Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis
<p>Source Data of "Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis".</p> <p>The raw data underlying each figure is represented in single data sheets.</p>
A pooled analysis of the duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine: data & analysis output
<p>Data files and analysis output associated with the medRxiv preprint article: Bretscher et al. 2019 A pooled analysis of the duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine. </p>
SPSS data of malaria patient in East Nile locality, Khartoum, Sudan
<p>Column 1= Age</p> <p>Column 2= Sex (male=1, female=2)</p> <p>Column 3= Residence (E.N= East Nile Locality)</p> <p>Column 4= Occupation (Government=1, Private=2, home worker=3, Student=4, Child=5)</p> <p>Column 5= Chronic disease (Diabetes mellitus =1, Blood pressure=2, Heart disease=3, Asthma=4, </p> <p> Healthy=5, Renal disease=6)</p> <p>Column 6 = Recurrent infection (yes=1, No = 2)</p> <p>Column 7 = Test sensitivity (yes=1, No=2)</p> <p>Column 8 = Treatment (Quinine=1, Quartum=2, Artemether=3, Not take any treatment= 4)</p> <p>Column 9= Changing stored water (yes=1, No=2)</p> <p>Column 10: Do you use bed nets? (yes=1, No=2)</p> <p>Column 11= Spraying insecticides (yes=1, No=2)</p> <p>Column 12= Blood film (Positive=1, Negative =2)</p> <p>Column 13= Plasmodium species (P.falciparum= 1, P. vivax= 2, Mixed infection=3)</p> <p>Column 14= Plasmodium stage (Ring stage=1, Late trophozoite =2, Schizont=3)</p> <p>Column 15= Density of parasite (+=1, ++=2,+++=3,++++=4)</p> <p>Column 16= Interferon</p> <p>Column 17= Interleukin 10</p> <p>Column 18= Tumer necrosis factor</p> <p>Column 19= Control sample Interferon</p>
Fig. 5 in A longitudinal molecular study of the ecology of malaria infections in freeranging mandrills
Fig. 5. Influence of P. gonderi prevalence on N/L ratio in female (F) and male (M) mandrills aged 4–16yrs (a) and of P. mandrilli parasitaemia in young animals (b). (a) Means and standard errors of the mean calculated from raw values are represented. Sample sizes are provided for each category. (b) For clarity sake, we distinguished two categories of individuals: animals that were younger than the average (< 9.1 yrs) observed in the data set analyzed and those that were older (≥9.1 yrs). Preliminary observations indicated no relationship between N/L ratio and P. mandrilli parasitaemia in old individuals (not represented), we therefore chose to present visible effects in young animals only.
Fig. 4 in A longitudinal molecular study of the ecology of malaria infections in freeranging mandrills
Fig. 4. Influence of P. gonderi parasitaemia on female's (a) and male's (b) skin temperatures. Raw values are represented.
Fig. 2 in A longitudinal molecular study of the ecology of malaria infections in freeranging mandrills
Fig. 2. Kernel density estimates for the distribution of ages across all studied individuals (dashed green line) and those infected by P. mandrilli (solid blue line) and P. gonderi (dashed red line). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 1 in A longitudinal molecular study of the ecology of malaria infections in freeranging mandrills
Fig. 1. Annual patterns of prevalences (a) and parasitaemia (number of copies/ μl of blood; b) for the two studied Plasmodium species. Means and standard errors of the mean calculated from raw values are represented. For parasitaemia, outliers were excluded from mean calculations to allow visible interannual comparisons. We excluded four values for P. mandrilli (30,929, 134,387, 273,424, 1,267,280 copies) and four values for P. gonderi (78,322, 100,182, 767,718, 2,551,395 copies), all these elevated parasitaemia were measured in 2015, except one value measured in 2014 for P. mandrilli.
Fig. 3 in Fatal avian malaria in captive Atlantic puffins (Fratercula arctica) in Switzerland
Fig. 3. Modified Wright-stained peripheral blood smear of a captive Atlantic puffin (case 5). Intra-erythrocytic stages of Plasmodium relictum: trophozoites (short arrows); mature meront (long arrow) with marked displacement of the erythrocyte's nucleus; pigment granules (arrowheads). Picture: Veterinary Laboratory, Vetsuisse Faculty, University of Zurich.
Fig. 1. H&E in Fatal avian malaria in captive Atlantic puffins (Fratercula arctica) in Switzerland
Fig. 1. H&E-stained histological sections of the liver (A, B, C) and the spleen (D) of captive Atlantic puffins at 400x magnification. A: Case 1, multiple protozoan Plasmodium schizonts of up to 20 μm in diameter (arrows). B: Case 2, periportal infiltration with lymphocytes and presence of multiple intracytoplasmic Plasmodium schizonts, which contain numerous merozoites (arrows). C: Case 3, Plasmodium merozoites within the liver parenchyma (arrow). D: Case 5, multiple histiocytes with intracytoplasmic brown, finely granular pigment (accumulation of iron-based pigment). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2. H&E in Fatal avian malaria in captive Atlantic puffins (Fratercula arctica) in Switzerland
Fig. 2. H&E-stained histological sections of the liver (A, B, D) and the spleen (C) of captive Atlantic puffins at 1000x magnification, showing Plasmodium schizonts of up to 15 μm in diameter, containing multiple merozoites of 1–2 μm (arrows): A: Case 2, B: Case 4, C: Case 6, D: Case 7.
Fig. 6 in Plasmodium relictum MSP-1 capture antigen-based ELISA for detection of avian malaria antibodies in African penguins (Spheniscus demersus)
Fig. 6. Analysis of the sensitivity and specificity of the P. relictum MSP-1 capture antigen-based ELISA. Serial dilutions of normal chicken serum and three sera samples from P. relictum-infected penguins (8776, 8783 and 8784) were used for coating the assay wells. Each dilution was performed in triplicate, and the data shown represent means of three independent experiments with standard error bars and levels of statistical significance (****: P <0.0001).
Fig. 4 in Plasmodium relictum MSP-1 capture antigen-based ELISA for detection of avian malaria antibodies in African penguins (Spheniscus demersus)
Fig. 4. Validation of ELISA. The ELISA developed using P. relictum MSP-1 protein was tested with known P. relictum positive penguin serum collected from penguin # 8790 at week 26. Black column represents positive penguin serum. Hatched and white columns represent negative controls containing normal chicken serum and PBS, respectively. Grey column represents the positive reaction containing streptavidin alkaline-phosphatase and its substrate pnitrophenyl phosphate. Each reaction was performed in triplicate, and the data shown represent means of three independent experiments with standard error bars and levels of statistical significance (****: P <0.0001).
Fig. 2 in Plasmodium relictum MSP-1 capture antigen-based ELISA for detection of avian malaria antibodies in African penguins (Spheniscus demersus)
Fig. 2. Verification of the biotinylation of recombinant P. relictum MSP-1. Purified recombinant P. relictum MSP-1 protein was labeled with biotin. Biotinylation of MSP-1 was confirmed using an enzyme (streptavidin alkaline phosphatase)-linking assay and absorbance read at 405 nm indicated the presence of biotinylated MSP-1. Black column represents biotinylated MSP-1 protein. Hatched column and white column represent negative controls containing non-biotinylated MSP-1 and PBS, respectively. Grey column represents the positive control containing streptavidin alkaline-phosphatase (SAP) and its substrate p-nitrophenyl phosphate (PNPP). Each reaction was performed in triplicate, and the data shown represent means of three independent experiments with standard error bars and levels of statistical significance (****: P <0.0001).
Fig. 3 in Plasmodium relictum MSP-1 capture antigen-based ELISA for detection of avian malaria antibodies in African penguins (Spheniscus demersus)
Fig. 3. Biotin-labeled MSP-1 protein titration curve. Serially diluted (300 ng/ μL to 0.003 ng/μL) biotinylated MSP-1 was used for coating the surfaces of the reaction wells overnight at 4 ◦C. The amount of biotinylated MSP-1 immobilized on the surface of the well was proportional to the intensity of the colored product generated which in turn was proportional to the absorbance value measured at 405 nm wavelength. Reactions were performed in triplicate, and the data shown represent means of three independent experiments with standard error bars.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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