Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
45
datasets available to search
ShareScore release 0.9.0
Dataset results
45 results for “Neuromuscular Junction”
Cellular and molecular evidence that synaptic Schwann cells contribute to aging of mouse neuromuscular junctions
GEO Series GSE222631. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Data from: Mutational analysis of Rab3 function for controlling active zone protein composition at the Drosophila neuromuscular junction
At synapses, the release of neurotransmitter is regulated by molecular machinery that aggregates at specialized presynaptic release sites termed active zones. The complement of active zone proteins at each site is a determinant of release efficacy and can be remodeled to alter synapse function. The small GTPase Rab3 was previously identified as playing a novel role that controls the distribution of active zone proteins to individual release sites at the Drosophila neuromuscular junction. Rab3 has been extensively studied for its role in the synaptic vesicle cycle; however, the mechanism by which Rab3 controls active zone development remains unknown. To explore this mechanism, we conducted a mutational analysis to determine the molecular and structural requirements of Rab3 function at Drosophila synapses. We find that GTP-binding is required for Rab3 to traffick to synapses and distribute active zone components across release sites. Conversely, the hydrolytic activity of Rab3 is unnecessary for this function. Through a structure-function analysis we identify specific residues within the effector-binding switch regions that are required for Rab3 function and determine that membrane attachment is essential. Our findings suggest that Rab3 controls the distribution of active zone components via a vesicle docking mechanism that is consistent with standard Rab protein function.
Investigating Loss of Neuromuscular Junction Transmission Fidelity in Older Adults
ClinicalTrials.gov study NCT04904926. IPD Sharing: NO. Countries: 1. Publications: 0.
Presymptomatic Neuromuscular Junction Defects and Compensatory Mechanisms in ALS
ClinicalTrials.gov study NCT03573466. IPD Sharing: NO. Countries: 1. Publications: 0.
A Registry-Based Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to ALS
ClinicalTrials.gov study NCT02463825. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Evaluation of the Neuromuscular Junction in Neonates Using the TetraGraph
ClinicalTrials.gov study NCT07133412. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of Neuromuscular Junction Function in Motor Fatigue in Multiple Sclerosis
ClinicalTrials.gov study NCT02418897. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Mutational analysis of Rab3 function for controlling active zone protein composition at the Drosophila neuromuscular junction
Open the record for dataset details and reuse information.
The miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction (miRNA array)
GEO Series GSE43943. Drosophila melanogaster. 3 samples. Type: Non-coding RNA profiling by array.
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia [TSCmKO data set].
GEO Series GSE139213. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Muscle Stem Cell Response to Perturbations of the Neuromuscular Junction Are Attenuated With Aging
GEO Series GSE165978. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia
GEO Series GSE118825. Rattus norvegicus. 54 samples. Type: Expression profiling by array.
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance (bulk RNA-Seq)
GEO Series GSE267909. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Exon array data from neuromuscular junction (NMJ) in mouse skeletal muscle.
GEO Series GSE92400. Mus musculus. 6 samples. Type: Expression profiling by array.
Spinal motor neuron-enriched secreted protein R-spondin 2 induces Wnt-mediated neuromuscular junction formation
GEO Series GSE51122. Mus musculus. 12 samples. Type: Expression profiling by array.
Neuromuscular Junction
GEO Series GSE2394. Mus musculus. 4 samples. Type: Expression profiling by array.
Temporal transcriptomics of human 3D neuromuscular cultures reveal key signatures of neuromuscular junction development
GEO Series GSE297790. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling [scRNA-seq]
GEO Series GSE311353. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
GEO Series GSE299537. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Lack of desmin in mice causes structural and functional disorders of neuromuscular junctions
GEO Series GSE154573. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.