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ShareScore release 0.9.0
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56 results for “Neurotransmitter”
Neurotransmitter release is triggered by a calcium-induced rearrangement in the Synaptotagmin-1/SNARE complex primary interface
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Gene expression of neurotransmitter receptors over reproductive cycle of Nicrophorus vespilloides
<p>Understanding genetic influences of traits in non-model organisms is crucial to understanding how novel traits arise. Do new traits require new genes, or are old genes repurposed? How predictable is this process? Here we examine this question for gene expression influencing parenting behavior in a beetle, <i>Nicrophorus</i> <i>vespilloides</i>. Parental care, produced from many individual behaviors, should be influenced by changes of expression of multiple genes and one suggestion is that the genes can be predicted based on knowledge of behavior expected to be precursors to parental care, such as, aggression, resource defense, and mating on a resource. Thus, testing gene expression during parental care allows us to test expectations of this "precursor hypothesis" for multiple genes and traits. We tested for changes of the expression of serotonin, octopamine/tyramine, and dopamine receptors, as well as, one glutamate receptor, predicting that these gene families would be differentially expressed during social interactions with offspring and associated resource defense. We found that serotonin receptors were strongly associated with social and aggression behavioral transitions. Octopamine receptors produced a complex picture of gene expression over a reproductive cycle. Dopamine was not associated with the behavioral transitions sampled here, while the glutamate receptor was most consistent with a behavioral change of resource defense/aggression. Our results generate new hypotheses, refine candidate lists for further studies, and inform the genetic mechanisms that are co-opted during the evolution of parent-offspring interactions, a likely evolutionary path for many lineages that become fully social. The precursor hypothesis, while not perfect, does provide a starting point for identifying candidate genes.</p>
Effects of Vortioxetine (Lu AA21004) on the Concentrations of Selected Neurotransmitters in Healthy Male Adults
ClinicalTrials.gov study NCT01299805. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Neurotransmitter Analysis, Stress, and Energy Availability in Athletes
ClinicalTrials.gov study NCT06683625. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
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Gene expression of neurotransmitter receptors over reproductive cycle of Nicrophorus vespilloides
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The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells
GEO Series GSE157352. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons
GEO Series GSE168762. Homo sapiens; Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Cell specific profiling of neurons expressing differnet neurotransmitters during Drosophila development
GEO Series GSE139888. Drosophila melanogaster. 31 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mice Exposed to Bisphenol A Exhibit Depressive-like Behavior with Neurotransmitter and Neuroactive Steroid Dysfunction
GEO Series GSE102849. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Molecular phenotyping of a test compound (small-molecule neurotransmitter receptor antagonist) in primary human hepatocytes
GEO Series GSE64588. Homo sapiens. 41 samples. Type: Expression profiling by high throughput sequencing.
PGC-1a Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from ParvalbuminPositive Interneurons
GEO Series GSE100341. Homo sapiens. 6 samples. Type: Expression profiling by array.
Single-nucleus transcriptional profiling of Gad2-positive neurons from the mouse lateral habenula with distinct expression of neurotransmitter-related genes
GEO Series GSE179198. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
The Effectiveness of a Caralluma Fimbriata Extract on Stress, Sleep and Neurotransmitters
ClinicalTrials.gov study NCT05232266. IPD Sharing: NO. Countries: 1. Publications: 0.
Neurotransmitters in Treatment Resistant Schizophrenia Patients With add-on Sodium Benzoate
ClinicalTrials.gov study NCT06340789. IPD Sharing: NO. Countries: 0. Publications: 0.
Evaluation of Behavior, Executive Function, Neurotransmitter Function and Genomic Expression Kuvan Nonresponders
ClinicalTrials.gov study NCT01274026. IPD Sharing: NO. Countries: 1. Publications: 0.
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
ClinicalTrials.gov study NCT03849963. IPD Sharing: NO. Countries: 1. Publications: 0.
Motivation and Neurotransmitters in Rowers
ClinicalTrials.gov study NCT07235124. IPD Sharing: NO. Countries: 1. Publications: 0.
Relationship Between Neurotransmitter Receptor Polymorphisms, Plasma Concentrations and Clinical Response to Clozapine
ClinicalTrials.gov study NCT00581932. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MR(Magnetic Resonance) Imaging of Neurotransmitters in Chronic Pain
ClinicalTrials.gov study NCT01620775. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.