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3,430 results for “PD”
MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas
ClinicalTrials.gov study NCT03962543. IPD Sharing: YES. Countries: 1. Publications: 1.
Genomic, clinical data, and scripts for PD-1 blockade resistance in metastatic melanoma
Open the record for dataset details and reuse information.
DFT Calculated xyz and log Files in Support of "Reaction Mechanism of Pd-catalyzed "CO-free" Carbonylation Reaction Uncovered by In situ Spectroscopy: The Formyl Mechanism"
<p>Theoretically calculated xyz and log files for hydrogen, carbon monoxide, carbon dioxide, methane, methanol, methyl formate, butene, methyl pentanoate and multiple Pd-dtbpx complexes (dtbpx = 1,2-Bis(di-<em>tert</em>-butylphosphino)xylene) which catalyze the addition of HCOOMe/CO onto butene to form methyl pentanoate.</p> <p>All quantum chemical simulations were performed using the Gaussian16 software. The ground state equilibrium structures and electronic properties were obtained at the density functional (DFT) level of theory utilizing the B3LYP XC functional.The def2-SVP basis set as well as the respective core potentials were applied for all atoms. A subsequent vibrational analysis was carried out for each optimized ground state structure to verify that a minimum on the potential energy (hyper‑)surface (PES) was obtained. All calculations were performed including D3 dispersion correction with Becke-Johnson damping.</p> <p>An analogous computational setup was applied for the optimization of transition states (TSs), while an initial guess in the vicinity of the saddle point was at first obtained via the Nudged Elastic Band (NEB) method as implemented in pysisyphus with xtb.<sup> </sup>Thereafter, the TSs were obtained in Gaussian16 via the Berny algorithm, followed by a vibrational analysis to verify that a first-order saddle point on the PES was obtained.</p>
Response Rates to Anti–PD-1 Immunotherapy in Microsatellite-Stable Solid Tumors With 10 or More Mutations per Megabase
<p>This dataset has been used to analyze the association between tumor mutational burden and response to treatment in immunotherapy-treated patients with microsatellite-stable solid tumors. The dataset contains clinical and genomic data for 1,678 patients with 16 cancer types.</p> <p> </p>
6 Pd Cannon
Simple 6 pound cannon from the 18th century. Small piece from a big Project. Source: Objaverse 1.0 / Sketchfab
Data From: PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
<p>Source data files for Wang et al 'PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation'</p>
Structures of FDA-approved drugs and their active metabolites and data sets of experimental PD and PK properties
<p>Data sets are extracted from the 2024 release of the e-Drug3D Database (2118 FDA-approved drug structures)</p> <ol> <li><strong>e-Drug3D_2118.zip </strong>(contains e-Drug3D_2118.sdf)<strong> -</strong> <strong>Chemical Structures</strong> - The e-Drug3D collection in SDF format file - one 3D conformer; ionization of carboxylic acid, phosphate, phosphonate, phosphonoamide, amidinium and guanidinium groups. The datablock contains the ID, name (INN), CAS number and Status.</li> <li><strong>e-Drug3D_2118_PK.csv - </strong><strong>Pharmacokinetics</strong> - Column/field value is separated by a semicolon. It contains the e-Drug3D ID, INN (drug name), CAS number, year of approval, Status, is_or_has a metabolite, routes of administration, Volume of distribution (VD), Clearance (Cl), Plasma Protein Binding (PPB), Half-life (t1/2), Bioavailability (F), Cmax/Tmax, comment on solubility.</li> <li><strong>e-Drug3D_2118_PD.csv -</strong> <strong>Pharmacodynamics</strong> - Column/field value is separated by a semicolon. It contains the e-Drug3D ID, INN (drug name), CAS number, year of approval, Status, Primary target, ATC code(s), PDB codes and main list of drug targets.</li> <li><strong>e-Drug3D_2118_RD.csv -</strong> <strong>FDA Registration Data</strong> - Column/field value is separated by a semicolon. It contains the ID, name (INN), CAS number, First year of approval, Status, <a href="http://www.knapsackfamily.com/knapsack_core/top.php">KNApSAcK</a> or <a href="https://www.npatlas.org">NPAtlas</a> Id if natural product, all associated NDA numbers [FDA approval number, name of the label file in PDF format, company name, year of approval and commercial name of the drug] and the Indication/Therapeutic class information.</li> <li><strong>labels.tar.gz</strong> - The drug label files in PDF format (compressed directory). A label file is named with the NDA number. The NDA number is the approval number assigned by the FDA. A drug may possess several NDA numbers (see the above e-Drug3D-RD data set).</li> </ol>
Data from: Direct propylene epoxidation via water activation over Pd-Pt electrocatalysts
<p>Direct electrochemical propylene epoxidation using water oxidation intermediates presents a sustainable alternative to existing routes that involve hazardous chlorine or peroxide reagents. Here we report an oxidized palladium-platinum alloy catalyst (PdPtO<sub>x</sub>/C), which reaches a Faradaic efficiency of 66±5% toward propylene epoxidation at 50 mA/cm<sup>2</sup> at ambient temperature and pressure. Embedding platinum into the palladium oxide crystal structure stabilized oxidized platinum species, resulting in improved catalyst performance. The reaction kinetics suggest that epoxidation on PdPtO<sub>x</sub>/C proceeds through electrophilic attack by metal-bound peroxo (OO*) intermediates. This work demonstrates an effective strategy for selective electrochemical oxygen-atom transfer from water, without mediators, for diverse oxygenation reactions.</p>
ALAMEDA PD Dyskinesia
<p><span>The ALAMEDA_PD_dyskinesia_dataset.csv contains 92 features extracted from raw accelerometer data after pre-processing, 2 dyskinesia-related labels and some other metadata. In total, it includes 97 columns:</span></p> <ol> <li> <p><span>The first two columns correspond to the start_timestamp and the end_timestamp of the time window from which the respective features have been extracted.</span></p> </li> <li> <p><span>The third column corresponds to the subject_id, which is used to uniquely identify PD patients enrolled in the current study.</span></p> </li> <li> <p><span>The next 92 columns correspond to features extracted from raw triaxial accelerometer data collected with the GENEActiv smart bracelets throughout 30-min MDS-UPDRS assessment during in-clinic visits, after applying some preprocessing steps. First, the accelerometer signals were band-pass filtered [0.25 Hz, 3.5 Hz] to enable dyskinesia detection. Then, the magnitude and the first principal component of the filtered signals were computed to attenuate the dependency on sensor placement and orientation. Finally, the transformed signals were segmented into time windows of 2048 samples (or 20.48 sec) with 50% overlap. Then, 92 features were extracted in both time and frequency domains. Spectral features were extracted after applying Fast Fourier Transform. The full list of the extracted features is demonstrated in the table below. These features can feed Machine Learning models to predict the presence/absence of PD dyskinesia.</span></p> </li> </ol>
Dataset for publication: Test Bench and Frequency Response of a Magnetic Antenna used in GIS PD Measurements
<p>Data set belonging to the <a href="https://ieeexplore.ieee.org/xpl/conhome/9611374/proceeding">2021 IEEE Electrical Insulation Conference (EIC)</a> paper with DOI: <a href="https://doi.org/10.1109/EIC49891.2021.9612372">10.1109/EIC49891.2021.9612372</a></p> <p>The authors preprint is available from Zendodo with DOI: <a href="https://doi.org/10.5281/zenodo.5815710">10.5281/zenodo.5815710</a>. </p> <p>Mier Escurra, Christian; Mor, Armando Rodrigo</p> <p><em>Test Bench and Frequency Response of a Magnetic Antenna used in GIS PD Measurements</em></p>
A comparative study on the stability of the furfural molecule on the low index Ni, Pd and Pt surfaces
<p>We present a comparative density functional theory investigation of the furfural (Ff ) molecule on the low index Ni, Pd and Pt surfaces to understand its geometrical and electronic properties to gain mechanistic insights into the experimentally measured catalytic reactivities of these metal catalysts. We show that the number of metal d-states, which hybridize with the nearest C and O p-orbitals of the Ff molecule, can be used to explain the stability of the Ff molecule on these surfaces. We find that the hybridization between atoms with higher electronegativity and the metal d-states plays a crucial role in determining the stability of these systems. Furthermore, we also find electron transfer from metal to the Ff molecule on the Ni and Pd surfaces, with a reverse process occurring on the Pt surface.</p>
Impact of CD4 T cells on intratumoral CD8 T cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors
<p>scRNA-seq data (Cellranger filtered feature-barcode matrices) and scVDJ-seq data (Cellranger filtered_contig_annotations.csv files) for publication listed above.</p>
Raw data for the article " Pd(II)-Catalyzed Aminoacetoxylation of Alkenes via Tether Formation"
<p>Raw NMR and MS data for the article "Pd(II)-Catalyzed Aminoacetoxylation of Alkenes via Tether Formation" published in Organic Letters, DOI: </p> <p><a href="https://doi.org/10.1021/acs.orglett.2c01838">https://doi.org/10.1021/acs.orglett.2c01838</a></p> <p>The number of the folders correspond to compounds numbers in the article. All details concerning conditions and equipment for measurements can be found in the supporting information of the article.</p>
Flame-made ternary Pd-In2O3-ZrO2 catalyst with enhanced oxygen vacancy generation for CO2 hydrogenation to methanol
<p>Source data for figures displayed in the manuscript.</p>
Distinct mechanisms of mismatch repair deficiency delineate two modes of response to PD-1 immunotherapy in endometrial carcinoma
<p>Responses to immune checkpoint blockade (ICB) are variable even among mismatch repair deficient (MMRd) cancers. We completed a phase 2 clinical trial of the PD-1 inhibitor pembrolizumab in 24 patients with MMRd endometrial cancer (NCT02899793). Patients with mutational MMRd tumors (6 patients) had higher response rates and longer survival than those with epigenetic MMRd tumors (18 patients). Mutation burden was higher in tumors with mutational MMRd compared to epigenetic MMRd; however, within each category of MMRd, mutation burden was not associated with ICB response. Notably, JAK1 mutations did not confer resistance to pembrolizumab. Longitudinal single-cell RNA-seq of circulating immune cells revealed contrasting modes of anti-tumor immunity against mutational and epigenetic MMRd tumors. Whereas effector CD8+ T cell responses correlated with mutational MMRd, highly active CD16+ NK cells were associated with epigenetic MMRd tumors responsive to ICB. These data highlight factors beyond neoantigen burden that influence ICB response.</p>
Data for "Orientational self-sorting in cuboctahedral Pd cages"
<p>In the following subdirectories are the input and output of GFN2-xTB and Gaussian calculations for this publication:</p> <p>Published: 10.1039/d2sc03856k</p> <p>Previously uploaded in 10.5281/zenodo.8432296 and <a href="https://github.com/andrewtarzia/citable_data" rel="noopener noreferrer">https://github.com/andrewtarzia/citable_data</a></p> <p>xtb_m12_structures directory:</p> <ul> <li>contains the structures from xTB optimisation as "_opt.mol"</li> </ul> <p> <br>dft_m12_IO_structures directory:</p> <ul> <li>contains the structures input and output files of Gaussian calculations and optimisations performed by Victor Posligua</li> <li>HSE and PBE0 optimised structures are separated into directories.</li> </ul> <p><br>xtb_m24_structures directory:</p> <ul> <li>contains the input and output structures of XTB optimisations of Pd24L48 cages.</li> <li>cleaned.xyz : initial structures, cleaned from provided .pdb files</li> <li>opt.xyz : optimised structures</li> </ul> <p> </p>
Imaging mass cytometry analysis of brain tissues with CNS immune-related adverse events during anti-PD-1 cancer immunotherapy
<p><span>Dataset accompanying the manuscript "Anti-PD-1 cancer immunotherapy induces CNS immune-related adverse events by Spleen tyrosine kinase activation in microglia".</span></p> <p><span>The Metadata.xls file includes the metadata, the raw image data is saved as .txt file, the segmented cellular expression data is available as csv files. </span></p>
Metabolomic analysis of cultured TRAMP-C2 cells in the presence or absence of PD-L1 expression
<p>The interaction between the immune inhibitory receptor PD-1 and its ligand PD-L1 is a critical mechanism for altering immune responses, especially during chronic antigen exposures such as cancer. While much research has focused on the PD-1 receptor, recent evidence suggests that PD-L1 can have cell-intrinsic effects in cancer and immune cells. These functions are distinct from its ability to bind and trigger PD-1 activity and are notable given that PD-L1 is widely expressed in mammals. One such cell-intrinsic function is the modulation of cellular metabolism, including regulation of mTOR activity and glycolysis. As part of our investigation into PD-L1 function, we analyzed the metabolome of cultured mouse prostate cancer cells (TRAMP-C2) expressing PD-L1 or with PD-L1 deleted via CRISPR/Cas9. We quantified 186 water-soluble metabolites from TRAMP-C2 cells expressing PD-L1 or not to better understand what metabolic pathways and processes are regulated by PD-L1 expression/activity. We found a broad range of differentially abundant metabolites, most notably a decreased abundance of glycolytic metabolites when PD-L1 expression is knocked out. In our manuscript, we show that this has a functional outcome on viral infection and cytokine signaling.</p>
Spatial dynamics of CD39⁺CD8⁺ exhausted T cells reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer
<p><strong>Data related to the paper</strong>: <em>"Spatial dynamics of CD39+CD8+ exhausted T cells reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer,”</em> <em>Nature Communications</em> (2024)</p> <p>The repository data consists of two main folders: <strong>IMC_dataset</strong> and <strong>MC_normalized_dataset</strong>.</p> <p><strong>IMC_dataset</strong> includes:</p> <ol> <li> <p><strong>IMC_denoised_dataset</strong>: This folder contains cell mask images and noise-reduced images for each sample.</p> </li> <li> <p><strong>IMC_raw_dataset</strong>: This folder contains raw, unprocessed data.</p> </li> <li> <p><strong>IMC_processed_data</strong>: This folder contains standardized single-cell information and spillover-corrected FCS files, along with the compensation matrix.</p> </li> </ol> <p>The <strong>MC_normalized dataset</strong> includes FCS files that have been sorted by barcode.</p> <p><strong>Please note</strong> that in the IMC dataset, the following mass channels are blank:</p> <ul> <li><strong>Tumor-ROI</strong>: 80Ar, 127I, 131Xe, 145Nd, 146Nd, 149Sm, 160Gd, 171Yb, 174Yb, 176Yb, 190Os</li> <li><strong>SLO-ROI</strong>: 80Ar, 127I, 131Xe, 145Nd, 146Nd, 149Sm, 160Gd, 176Yb, 190Os</li> </ul> <p>The names attached to the file names are IDs.</p>
Reaction-Induced Metal-Metal Oxide Interactions in Pd In2O3/ZrO2 Catalysts Drive Selective and Stable CO2 Hydrogenation to Methanol
<p>Ternary Pd-In<sub>2</sub>O<sub>3</sub>/ZrO<sub>2</sub> systems hold promise as industrial catalysts for CO<sub>2</sub>-based methanol synthesis, but maximization of their productivity requires appropriate structuring of the active phase, promoter, and carrier. Here, we report that Pd-In<sub>2</sub>O<sub>3</sub>/ZrO<sub>2</sub> systems prepared by impregnation evolve into a unique catalyst architecture under CO<sub>2</sub> hydrogenation conditions, leading to selective and stable behavior. Detailed space and time-resolved <em>operando</em> characterization and simulations reveal that the restructuring process, completed within the first 30 min under reaction conditions, is governed by the energetics of metal-metal oxide interactions. The resulting architecture comprises InPd<em><sub>x</sub></em> alloy particles decorated by InO<em><sub>x</sub></em> layers, whose proximity is crucial to avoiding performance losses typically observed when palladium agglomerates. The findings highlight the potential beneficial role of reaction-induced restructuring in advancing catalyst design.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.