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3,430 results for “PD”
Evaluation of PD-L1 expression in vulvar cancer
<p><strong>background & Aims: </strong>Vulvar cancer accounts for about 4% of all female genital malignancies. Squamous cell carcinoma is the most common histological type.PD-L1 is a membranous protein of nucleated cells. By binding to its PD-1 receptor, PD-L1 inactivates T lymphocytes. It plays a key role in the treatment of some cancers. Our aims were to study the expression profile of PD-L1 in vulvar cancer by immunohistochemistry and to correlate its expression with survival rates. <strong>Methods:</strong> A retrospective study was conducted in the Pathology Department of Saleh Azaiez Institute, involving 55 patients followed for vulvar cancer over a period of 13 years from January 2008 to December 2021. Clinicopathologic data were collected from medical records and pathology reports. Immunohistochemical analysis was performed using an automaton (Leica Biosystems™). <strong>Results:</strong> PD-L1 expression in vulvar squamous cell carcinoma was observed in 44% of cases. This expression was noted in 11% of cases at the level of lymphocytes whose dissection was negative in all cases with a maximum tumor size of 40 mm. PDL1 was expressed in tumor cells in 33% of cases where there was a positive inguinal dissection in 22% of cases and a maximum tumor size of 90 mm. <strong>Conclusions:</strong> The immune checkpoint inhibitor PD-1/PD-L1 seems to have an important prognostic effect on the development of some cancers (breast cancer, lymphoma). Indeed, the expression of PD-L1 in tumors is often considered a factor of poor prognosis due to its immunosuppressive activity in tumor tissues. Many studies have attempted to determine the prognostic factors of vulvar cancer in order to optimize therapeutic management. PD-L1 expression in vulvar squamous cell carcinoma has not been studied before, hence the interest of our study which suggested, as in the literature, a prognostic role for this protein.</p>
Single-cell RNA-seq profiles of tumor-bearing mice treated with PAGln with or without anti-PD-1
<p>single-cell RNA sequencing (scRNA-seq) profiles of tumor-bearing mice treated using Phenylacetylglutamine (PAGln) with or without anti-PD-1 were performed to compare the alterations of immune microenvironment affected by PAGln under the condition of anti-PD-1 treatment.</p>
Identification and Functional Characterization of an Alternative Cancer-derived PD-L1 Isoform (supplemental data)
<p>The enclosed files contain all of the supplemental data from: Identification and Functional Characterization of an Alternative Cancer-derived PD-L1 Isoform. The files include the complete tables in CSV-formatted files.</p>
XRD data for Pd EnCat™ 30 recycling
<p>X-ray powder diffraction data for Pd EnCat™ 30. recycling The results refer to the pure catalyst, and its structural changes after each reuse after Suzuki reaction. The data were collected after 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 reaction cycles, showing depletion of palladium acetate and formation of metallic palladium with plane (1 1 1) and (2 0 0) at 40 and 45 degree 2theta angle.</p>
QC and WGS data on compound heterozygous PRKN-mutant (R275W/dEx8) PD patient
<p>Primary/raw data for QC on the characterisation of an iPSC line from a PD patient (Stem Cell Research)</p>
X-ray diffraction images of endothiapepsin complexed with the phosphostatine inhibitor PD-130,328.
<p>X-ray diffraction images collected at the ESRF (Grenoble) beamline ID14-2 using an ADSC Quantum 4R CCD detector on 9 Apr 2000. </p>
Composition and electrical resistance results of a Ir-Pd-Pt-Rh-Ru composition spread thin film materials library
<p>The dataset contains the results of electrical resistance measurement and composition analysis of a thin film composition spread materials library. </p> <p>342 measurement areas were evaluated for chemical composition using energy dispersive X-ray spectroscopy and electrical resistance using a 4-point probe.</p> <p>CSV columns:</p> <p>x: x-coordinate of materials library in µm</p> <p>y: y-coordinate of materials library in µm</p> <p>Ir: relative chemical composition in at.%</p> <p>Pd: relative chemical composition in at.%</p> <p>Pt: relative chemical composition in at.%</p> <p>Rh: relative chemical composition in at.%</p> <p>Ru: relative chemical composition in at.%</p> <p>Resistance: electrical resistance in Ohm</p> <p> </p> <p>This dataset is supplementary information for an associated publication. A link to the publication will be provided after publishing.</p>
Optimized atomic structures of thin Ag films on Pt(111) and Pd(111) surfaces
<p>VASP coordinate files of thin Ag films on Pt(111) and Pd(111) surfaces and the summary spreadsheet of corresponding energies. </p>
EXPLANATION OF PLATE I Left lateral aspect of skull of Stephanosaurus marginatus; one- fifth the natural size. Abbreviations.-D, lateral temporal fossa; DN, dentary; J, jugal; L, lachrymal; MX, maxilla; N, nasal; NO, nasal opening; OR, orbit; PD, predentary; PF, prefrontal; PM, premaxilla; Q, quadrate; QJ, quadrato-jugal; S, squamosal; SA, surangular. in On a new genus and species of carnivorous dinosaur from the Belly River Formation of Alberta, with a description of the skull of Stephanosaurus marginatus from the same horizon
EXPLANATION OF PLATE I Left lateral aspect of skull of Stephanosaurus marginatus; one- fifth the natural size. Abbreviations.-D, lateral temporal fossa; DN, dentary; J, jugal; L, lachrymal; MX, maxilla; N, nasal; NO, nasal opening; OR, orbit; PD, predentary; PF, prefrontal; PM, premaxilla; Q, quadrate; QJ, quadrato-jugal; S, squamosal; SA, surangular.
FT-IR spectra in triplicate for Pd EnCat™ 30 recycling
<p>FT-IR spectra in triplicate for Pd EnCat™ 30. The spectra were obtained for the pure catalyst and after 1, 10, 20, and 30 Suzuki coupling reactions to monitor its structural changes during recycling.</p>
AMP-PD release 4: snRNA-seq and WGS dataset
<p>snRNA-seq dataset from 100 Parkinson’s disease cases and controls profiled in 5 postmortem brain regions. </p>
Electrochemical activity of several compositions in the system Ag-Pd-Pt-Ru for the oxygen reduction reaction in 0.05 M KOH solution pH 12.5
<p>The dataset comprises electrochemical screening data of several compositions from three different thin film materials libraries in the system Ag-Pd-Pt-Ru. Given are three csv files that contain the measurement coordinates, the chemical composition in atomic percent and the electrochemical current that was evaluated from linear sweep voltammograms at a potential of 0.85V vs. RHE. </p> <p><strong>Experimental description</strong></p> <p>Materials libraries were fabricated by co-sputtering thin films on 100 mm diameter sapphire wafers (c-plane) from 4 elemental tar-gets. The targets were confocally aligned to a 100 mm substrate (target-substrate distance approx. 12 cm). Target materials had a purity of 99.99,%. Ar (99.9999 %) was used as a sputter gas. The deposition pressure was 0.667 Pa. The film thickness was 100 - 150 nm. The chemical composition of the materials libraries was measured by energy dispersive X-ray spectroscopy (EDX) with an acceleration voltage of 20 kV. 81 measurements were done on a regular grid of 9x9 (8.5 mm spacing) on each library. Linear regression was used to interpolate the composition over the 342 measurement areas of a 4.5 mm grid that was used in the scanning droplet cell experiments. Electrochemical measurements were conducted with the use of a high-throughput scanning droplet cell (SDC). The SDC head incorporates counter (Pt wire) and reference (Ag|AgCl|3 M KCl) electrodes and a teflon tip with 1 mm diameter. The materials library is connected as working electrode, e.g. the surface of the investigated sample in every spot where the tip touches the sample. The electrolyte was replaced for every measurement area. Linear sweep voltammograms were measured in 0.05 M KOH, pH 12.5, with a scan rate of 10 mV/s. All potentials are reported versus the RHE according to the following equation: URHE (V) = U(Ag|AgCl|3 M KCl) + 0.210 + (0.059 * pH), where U(Ag|AgCl|3 M KCl) is the potential measured versus Ag|AgCl|3 M KCl reference electrode, 0.210 V is the standard potential of the Ag|AgCl|3 M KCl reference electrode at 25◦C. Note that 0.059 is the result of (RT )· (nF)−1, where R is the gas constant, T is the temperature (298 K), F is the Faraday constant, and n is the number of electrons transferred during the reaction.</p> <p> </p>
On the conversion of CO2 to value added products over composite PdZn and H-ZSM-5 catalysts: excess Zn over Pd, a compromise or a penalty? Supplementary information
<p>Supplementary Material: N2 adsorption, TEM, XAS, PXRD, test results</p>
A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of Alomfilimab (KY1044) as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advance
ClinicalTrials.gov study NCT03829501. IPD Sharing: YES. Countries: 6. Publications: 0.
Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease
ClinicalTrials.gov study NCT02925650. IPD Sharing: YES. Countries: 1. Publications: 2.
Platinum-Based Chemotherapy With/Without INCMGA00012, an Anti-PD-1 Antibody, in Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT04205812. IPD Sharing: YES. Countries: 17. Publications: 1.
Safety and Immunotherapeutic Activity of an Anti-PD-1 Antibody (Cemiplimab) in Participants With HIV-1 on Suppressive cART
ClinicalTrials.gov study NCT03787095. IPD Sharing: YES. Countries: 1. Publications: 2.
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of TAK-925 Study in Sleep-Deprived Healthy Adults
ClinicalTrials.gov study NCT03522506. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Evaluate the Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) for TAK-906 in Participants With Diabetes Mellitus and Gastroparesis (DG) or With Idiopathic Gastroparesis (IG)
ClinicalTrials.gov study NCT03268941. IPD Sharing: YES. Countries: 1. Publications: 1.
Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabraf
ClinicalTrials.gov study NCT02124772. IPD Sharing: YES. Countries: 5. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.