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454
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ShareScore release 0.9.0
Dataset results
454 results for “Preclinical”
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3)
ClinicalTrials.gov study NCT02058095. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Network-Level Mechanisms for Preclinical Alzheimer's Disease Development
ClinicalTrials.gov study NCT03461861. IPD Sharing: NO. Countries: 1. Publications: 15.
Natriuretic Peptide System as Therapy in Human Preclinical Left Ventricle Dysfunction
ClinicalTrials.gov study NCT00387621. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Behavioral data for: A preclinical model of THC edibles that produces high-dose cannabimimetic responses
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DNDI-6174, a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1 complex – Figures 3 and S2-8 raw data
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Identification of a small molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical models
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Burden of cardiometabolic risk factors and preclinical target organ damage among adults in Freetown, Sierra Leone: a community-based health-screening survey
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Targeted inhibition of kisspeptin neurons reverses hyperandrogenemia and abnormal hyperactive LH secretion in a preclinical mouse model of polycystic ovary syndrome
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Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma
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mRNA prime–boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models
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A multi-laboratory preclinical trial to assess treatment candidates for acute ischemic stroke
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Dataset for: Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis
<p>This upload contains the data extracted from studies included in our meta-analysis entitled "Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis". It also contains the code used to perform the meta-analysis and generate the figures in the publication in R. </p>
Dataset related to article "Intracerebral Injection of Extracellular Vesicles from Mesenchymal Stem Cells Exerts Reduced Aβ Plaque Burden in Early Stages of a Preclinical Model of Alzheimer's Disease."
<p>Bone marrow Mesenchymal Stem Cells (BM-MSCs), due to their strong protective and anti-inflammatory abilities, have been widely investigated in the context of several diseases for their possible therapeutic role, based on the release of a highly proactive secretome composed of soluble factors and Extracellular Vesicles (EVs). BM-MSC-EVs, in particular, convey many of the beneficial features of parental cells, including direct and indirect β-amyloid degrading-activities, immunoregulatory and neurotrophic abilities. Therefore, EVs represent an extremely attractive tool for therapeutic purposes in neurodegenerative diseases, including Alzheimer's disease (AD). We examined the therapeutic potential of BM-MSC-EVs injected intracerebrally into the neocortex of APPswe/PS1dE9 AD mice at 3 and 5 months of age, a time window in which the cognitive behavioral phenotype is not yet detectable or has just started to appear. We demonstrate that BM-MSC-EVs are effective at reducing the Aβ plaque burden and the amount of dystrophic neurites in both the cortex and hippocampus. The presence of Neprilysin on BM-MSC-EVs, opens the possibility of a direct β-amyloid degrading action. Our results indicate a potential role for BM-MSC-EVs already in the early stages of AD, suggesting the possibility of intervening before overt clinical manifestations.</p>
Association between exposure to ecotoxicants and clinical and laboratory indices at clinical and preclinical stages of rheumatoid arthritis
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Raw data for "Preclinical upper- limb neurorobotic platform to assess, rehabilitate and develop therapies"
<p>Source data for all figures. Tabulated data underlying the data points in all plots of each individual figure.</p>
Processed Seurat Object of scRNAseq data from wildtype and CaMKK2 KO immune infiltrate of CT2a preclinical murine glioma
<p>This repository contains the processed Seurat objects generated from the raw data deposited at the Gene Expression Omnibus (GEO) under GSE197879.</p> <p>Details about the experiment and sequencing are available under GSE197879.</p> <p>Information on how the Seurat objects were created can be found in this GitHub repository https://github.com/wht10/CT2A_scRNAseq_CaMKK2KOvWT .</p> <p>Notable metadata within each Seurat object:</p> <p>1. Processed_CD45_Live_Fig2b.rds</p> <ul> <li>Genotype - whether the cell is from a WT or CaMKK2 KO mouse</li> <li>HTO_maxID - The biological replicate that the cell came from (4 biological replicates per genotype)</li> <li>MouseID - A concatenation between the genotype and HTO_maxID, providing a unique identifier for each biological replicate</li> <li>Cell.Type - The cell type annotations for each cell. Can be assigned to "Idents()" to change the name of the cell identities.</li> <li>Geno.Ident - A concatenation between Genotype and Cell.Type. By re-assigning this to "Idents()" "FindMarkers()" can be used to investigate differentially expressed genes within a cell-type between genotypes. </li> </ul> <p>2. Reclustered_TILs_Fig3a.rds</p> <ul> <li>Genotype - whether the cell is from a WT or CaMKK2 KO mouse</li> <li>HTO_maxID - The biological replicate that the cell came from (4 biological replicates per genotype)</li> <li>MouseID - A concatenation between the genotype and HTO_maxID, providing a unique identifier for each biological replicate</li> <li>Celltype - The cell type annotations for each cell. Can be assigned to "Idents()" to change the name of the cell identities.</li> <li>Geno_Ident - A concatenation between Genotype and cell-type. By re-assigning this to "Idents()" "FindMarkers()" can be used to investigate differentially expressed genes within a cell-type between genotypes. </li> </ul>
Data of individuals who are in Preclinical RA
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Dataset supporting the paper "Characterization of a mouse-sized receive-only coil for a preclinical magnetic particle imaging scanner"
<p>We have recently submitted a paper on the characterization of a mouse-sized receive-only coil for the Bruker preclinical MPI scanner. This dataset contains the measurements for our comparison between the native transmit-receive (TxRx) coil of the scanner and the new mouse-sized receive-only (Rx) coil. </p> <p>Included are: </p> <ul> <li>Network analyzer (NA) measurements as csv, first column=frequency, second column=power transfer. There are measurements at the center of the coils and along x- and y-axis with a 2mm step size.</li> <li>System matrix (SM) measurements, including the background (BG) measurements and the calculated particle signal-to-noise ratio (SNR) (Bruker file format).</li> <li>MPI measurements of a dilution series (Bruker file format). In the dilution series folders there is a readme, which sample "#A" was measured at which position "_A"/"_B"/"_C", is saved in which folder "(E#)" and contains which iron amount (in ng). </li> </ul>
Effects of the Hypnotic Alkylphenol Derivative Propofol on Breast Cancer Progression. A Focus on Preclinical and Clinical Studies.
<p>Propofol is a hypnotic alkylphenol derivative with many biological activities. It is predominantly used in anesthesia and is the most used parenteral anesthetic agent in the United States. Accumulating preclinical studies have shown that this compound may inhibit cancer recurrence and metastasis. Nevertheless, other investigations provided evidence that this compound may promote breast cancer cell progression by modulating different molecular pathways. Clinical data on this topic are scarce and derive from retrospective analyses. For this reason, we reviewed and evaluated the available data to reveal insight into this controversial issue. More preclinical and clinical investigations are necessary to determine the potential role of propofol in the proliferation of breast cancer cells.</p>
Preclinical to Clinical Translation for Intervertebral Disc Repair: Effects of Species-Specific Scale, Metabolism and Matrix Synthesis Rates on Cell-Based Regeneration
<p>Supporting datasets for journal article funded by the ERC</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.