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92 results for “REM sleep”
Fig 3 Swichr++ sustained inactivation, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recording data for Swichr++ mice, extended inhibition. Associated with Figure 3.</p>
Data for: Regularly occurring bouts of retinal movements suggest an REM sleep–like state in jumping spiders
<p>Sleep and sleep-like states are present across the animal kingdom, with recent studies convincingly demonstrating sleep-like states in arthropods, nematodes, and even cnidarians. However, the existence of different sleep phases across taxa is as yet unclear. In particular, the study of rapid eye movement (REM) sleep is still largely centered on terrestrial vertebrates, particularly mammals and birds. The most salient indicator of REM sleep is the movement of eyes during this phase. Movable eyes, however, have evolved only in a limited number of lineages—an adaptation notably absent in insects and most terrestrial arthropods—restricting cross-species comparisons. Jumping spiders, however, possess movable retinal tubes to redirect gaze, and in newly emerged spiderlings, these movements can be directly observed through their temporarily translucent exoskeleton. Here, we report evidence for an REM sleep–like state in a terrestrial invertebrate: periodic bouts of retinal movements coupled with limb twitching and stereotyped leg curling behaviors during nocturnal resting in a jumping spider. Observed retinal movement bouts were consistent, including regular durations and intervals, with both increasing over the course of the night. That these characteristic REM sleep–like behaviors exist in a highly visual, long-diverged lineage further challenges our understanding of this sleep state. Comparisons across such long-diverged lineages likely hold important questions and answers about the visual brain as well as the origin, evolution, and function of REM sleep.</p>
Transition from NREM to REM sleep
<p>This is the data and matlab code to accompany the paper entitled "Which region enters REM sleep first: Intracerebral properties of NREM to REM sleep transitions in human sleep," by L Peter-Derex, N von Ellenrieder, F van Rosmalen, J Hall, F Dubeau, J Gotman, and B Frauscher.</p> <p>The file NREM_to_REM_sleep_transitions.mat contains the data necessary for reproducing the results, the file NREM_to_REM_sleep_transitions_results.mat contains the results, and the file NREM_to_REM_transitions_script.m contains the code to produce the results, and also contains more information on the variables provided in the first two files.</p> <p> </p>
Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE)
ClinicalTrials.gov study NCT03072940. IPD Sharing: Not stated. Countries: 1. Publications: 1.
French Validation of a Severity Scale in REM Sleep Behavior Disorder (SEV-TCSP)
ClinicalTrials.gov study NCT04071899. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease
ClinicalTrials.gov study NCT02789592. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Neurobiological Correlates of Post Traumatic Stress Disorder (PTSD) During Rapid Eye Movement (REM) Sleep
ClinicalTrials.gov study NCT00871650. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Establishing Alpha-synuclein RT-QuIC Assay as a Diagnostic Technique in REM Sleep Behaviour Disorder
ClinicalTrials.gov study NCT04266457. IPD Sharing: UNDECIDED. Countries: 1. Publications: 24.
Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder
ClinicalTrials.gov study NCT01886131. IPD Sharing: Not stated. Countries: 1. Publications: 17.
Wearable Neural Interfacing System for REM Sleep Restoration and Enhancement
ClinicalTrials.gov study NCT07190287. IPD Sharing: NO. Countries: 1. Publications: 3.
Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism
ClinicalTrials.gov study NCT02312908. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
Neurovascular coupling and bilateral connectivity during NREM and REM sleep
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Data from: REM sleep stabilizes hypothalamic representation of feeding behavior
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Data from: Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption
Rapid eye movement (REM) sleep loss is associated with increased consumption of weight-promoting foods. The prefrontal cortex (PFC) is thought to mediate reward anticipation. However, the precise role of the PFC in mediating reward responses to highly palatable foods (HPF) after REM sleep deprivation is unclear. We selectively reduced REM sleep in mice over a 25–48 hr period and chemogenetically inhibited the medial PFC (mPFC) by using an altered glutamate-gated and ivermectin-gated chloride channel that facilitated neuronal inhibition through hyperpolarizing infected neurons. HPF consumption was measured while the mPFC was inactivated and REM sleep loss was induced. We found that REM sleep loss increased HPF consumption compared to control animals. However, mPFC inactivation reversed the effect of REM sleep loss on sucrose consumption without affecting fat consumption. Our findings provide, for the first time, a causal link between REM sleep, mPFC function and HPF consumption.
Data from: Risk factors for possible REM sleep behavior disorder: a CLSA population-based cohort study
Objective: Idiopathic REM sleep behavior disorder (RBD) is a powerful marker of prodromal neurodegenerative synucleinopathy, with 80% of patients ultimately phenoconverting to defined disease. Several environmental risk factors for RBD have been suggested, but associations vary between studies. We assessed sociodemographic, socioeconomic and clinical correlates of RBD in a 30,000-subject national cohort. Methods: Subjects aged 45-85 years in Canada were collected as part of the Canadian Longitudinal Study on Aging. Possible RBD (pRBD) was screened with the RBD-1Q, a questionnaire with 94% specificity and 87% sensitivity. To improve diagnostic reliability, subjects screening positive for apnea or non-REM parasomnia (young onset pRBD), and subjects self-reporting dementia or Parkinson's disease were excluded. A series of sociodemographic, life style and mental health variables were analysed cross-sectionally. Potential correlates were assessed via multivariable logistic regression. Results: Of 30,097 subjects, 958 (3.2%) had pRBD. Male sex (OR=2.14 ,95%CI=[1.84, 2.49]) and lower education (OR=0.95 [0.92, 0.98] were associated with pRBD. pRBD subjects had smoked more (total smoking years OR=1.006 [1.010, 1.011]) and were more likely to be moderate-heavy drinkers (OR=1.25 [1.03, 1.50]). There was a strong association between pRBD and self-reported antidepressant treatment for depression (OR=2.76 [2.22, 3.44]), psychological distress (OR=1.52 [1.37, 1.69]), mental illness (OR=2.08 [1.79, 2.41]), and post-traumatic stress disorder (OR=2.84 [2.55, 3.54]). Conclusions: Our study replicated previous reported associations between pRBD and smoking, low education and male sex, and found previously-unreported links with alcohol use and psychological distress. The risk factors for pRBD differ from those previously defined for neurodegenerative synucleinopathies.
Longitudinal Network Changes and Phenoconversion Risk in Isolated REM Sleep Behavior Disorder
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Fig 6 ChR2 50 s open loop, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recording data for ChR2 50 s open loop experiments. Associated with Figure 6.</p>
Fig S5 AAVrg-ChR2 closed loop, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recording data for AAVrg closed loop experiments. Associated with Figure S5.</p>
Fig 1 eYFP open loop, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recordings for eYFP open loop control data. Associated with Figure 1.</p>
Fig 2 Swichr++ closed loop, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recording data for swichr++ closed loop experiments. Associated with Figure 2D.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.