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datasets available to search
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Dataset results
162 results for “Rotavirus”
Phase I/II Descending Age Study of P2VP8 Subunit Parenteral Rotavirus Vaccine in Healthy Toddlers and Infants
ClinicalTrials.gov study NCT02109484. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Vaccine Efficacy Against Rotavirus Diarrhea; Vaccine Given With Routine Childhood Vaccinations in Healthy African Infants
ClinicalTrials.gov study NCT00241644. IPD Sharing: YES. Countries: 2. Publications: 7.
Safety and Immunogenicity of Rotavirus Vaccine (RotaTeq(R)) in Infants With Short Bowel Syndrome
ClinicalTrials.gov study NCT00767364. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Safety and Immune Response of a Rotavirus Vaccine in HIV-infected and Uninfected Children Born to HIV-infected Mothers
ClinicalTrials.gov study NCT00880698. IPD Sharing: Not stated. Countries: 4. Publications: 4.
Evaluation of Reactogenicity and Safety of GSK Biologicals' Rotarix™ (Human Rotavirus Vaccine) in Infants
ClinicalTrials.gov study NCT00779779. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Reactogenicity and Safety of GSK Biologicals' Rotarix (Human Rotavirus Vaccine) in Infants
ClinicalTrials.gov study NCT00750893. IPD Sharing: NO. Countries: 1. Publications: 1.
Data and code from: Impact of dosing schedules on performance of rotavirus vaccines in Ghana
Open the record for dataset details and reuse information.
Data from: Rotavirus NSP1 subverts the antiviral oligoadenylate synthetase-RNase L pathway by inducing RNase L degradation
Open the record for dataset details and reuse information.
Crosstalk between imbalanced gut microbiota caused by antibiotics and rotavirus replication in the intestine
<p>In this manuscript, we discover that 10% of young adults are asymptomatic rotavirus infected. Imbalanced gut microbiota caused by veterinary antibiotics and preferred as veterinary antibiotics play an important role in this situation. High level of lipopolysaccharide produced by gram-negative bacteria promote rotavirus replication. Our results demonstrated that patients have a disrupted gut microbiota following rotavirus infection, and therefore may be at risk for long-term health complications. We believe that our findings widen the knowledge about the infection of rotavirus.</p>
m6A modifications regulate intestinal immunity and rotavirus infection
<p>N6-methyladenosine (m6A) is an abundant mRNA modification and affects many biological processes. However, how m6A levels are regulated during physiological or pathological processes such as virus infections, and the <em>in vivo</em> function of m6A in the intestinal immune defense against virus infections are largely unknown. Here, we uncover a novel antiviral function of m6A modification during rotavirus (RV) infection in small bowel intestinal epithelial cells (IECs). We found that rotavirus infection induced global m6A modifications on mRNA transcripts by down-regulating the m6a eraser ALKBH5. Mice lacking the m6A writer enzymes METTL3 in IECs (<em>Mettl3</em><sup>ΔIEC</sup>) were resistant to RV infection and showed increased expression of interferons (IFNs) and IFN-stimulated genes (ISGs). Using RNA-sequencing and m6A RNA immuno-precipitation (RIP)-sequencing, we identified IRF7, a master regulator of IFN responses, as one of the primary m6A targets during virus infection. In the absence of METTL3, IECs showed increased <em>Irf7</em> mRNA stability and enhanced type I and III IFN expression. Deficiency in IRF7 attenuated the elevated expression of IFNs and ISGs and restored susceptibility to RV infection in <em>Mettl3</em><sup>ΔIEC</sup> mice. Moreover, the global m6A modification on mRNA transcripts declined with age in mice, with a significant drop from 2 weeks to 3 weeks post birth, which likely has broad implications for the development of intestinal immune system against enteric viruses early in life. Collectively, we demonstrated a novel host m6A-IRF7-IFN antiviral signaling cascade that restricts rotavirus infection <em>in vivo</em>.</p>
Llama Antibody, Rotavirus Diarrhoea, Children
ClinicalTrials.gov study NCT01259765. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Immunogenicity Study of Live Attenuated Indian Rotavirus Vaccine Candidate Strains 116E and I321 in Infants
ClinicalTrials.gov study NCT00280111. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fractional Inactivated Poliovirus Vaccine Booster and Rotavirus Study
ClinicalTrials.gov study NCT02847026. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study to Estimate the Occurrence of Rotavirus Gastroenteritis in Children < 5 Years of Age, in Bulgaria and Latvia
ClinicalTrials.gov study NCT01733849. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Estimation of the Burden of Rotavirus Gastroenteritis (RV GE) in Children Less Than 5 Years in Greece
ClinicalTrials.gov study NCT00751686. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Immunogenicity & Safety of 2 Different Formulations of Human Rotavirus (HRV) Vaccine for the Prophylaxis of Rotavirus Gastroenteritis
ClinicalTrials.gov study NCT00137930. IPD Sharing: YES. Countries: 1. Publications: 1.
Study to Assess the Impact of Vaccination on Hospitalizations and Outpatient Visits Due to Rotavirus Gastroenteritis
ClinicalTrials.gov study NCT01733862. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Randomized, Controlled Single-blind Clinical Study to Assess Vaccine Interchangeability Between RV5 and RV1 Using Seven Combined Anti-rotavirus Prevention Programs
ClinicalTrials.gov study NCT02193061. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Predictors of Poor Immune Response to Rotavirus Vaccine in Infants
ClinicalTrials.gov study NCT01700127. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Evaluation of Universal Rotavirus Vaccination Program
ClinicalTrials.gov study NCT01273077. IPD Sharing: Not stated. Countries: 1. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.