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35
datasets available to search
ShareScore release 0.9.0
Dataset results
35 results for “Single-Cell Pathology”
Synovial fibroblasts from obese hip osteoarthritis patients exhibit distinct single-cell subsets characterised by pathological inflammatory functions
GEO Series GSE152815. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology [scRNA-seq]
GEO Series GSE236902. Gallus gallus. 13 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptional profiling and gene regulatory network modeling in Tg2576 mice reveal gender-dependent molecular features preceding Alzheimer-like pathologies
GEO Series GSE285694. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
Single-Cell RNA Sequencing in Multiple Pathologic Types of Renal Cell Carcinoma Revealed Novel Potential Tumor-Specific Markers
GEO Series GSE152938. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2 [protein levels]
GEO Series GSE163529. Homo sapiens. 330 samples. Type: Other.
Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology [CUT&RUN]
GEO Series GSE236904. Gallus gallus. 20 samples. Type: Other.
Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology.
GEO Series GSE236905. Gallus gallus. 37 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2 [gene expression levels]
GEO Series GSE162911. Homo sapiens; blank sample. 784 samples. Type: Expression profiling by high throughput sequencing; Other.
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
GEO Series GSE163530. Homo sapiens; blank sample. 1194 samples. Type: Expression profiling by high throughput sequencing; Other.
Single-cell RNA-seq analysis of the lymphoproliferative disorders triggered by defective LAT signalosome. Modulation of the pathology in the context of two additional mutations, Stat6KO or Grap2KO
GEO Series GSE210453. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Macrophage Involvement in the Pathology of Chronic Thromboembolic Pulmonary Hypertension: Lessons from Single-Cell and Single-Nucleus RNA Sequencing
GEO Series GSE270483. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Cross-Species Single-Cell Analysis Reveals Sex Differences in Mitochondrial Dysfunction as a Conserved Feature of Tau Pathology
GEO Series GSE310345. Danio rerio. 8 samples. Type: Expression profiling by high throughput sequencing.
Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling
<p>SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune response to SARS-CoV-2 is critical to unravel the causative factors underlying differences in disease severity and to develop optimal vaccines against new SARS-CoV-2 variants. We combined single-cell RNA and T cell receptor sequencing with CITE-seq antibodies to characterize the CD8+ T cell response to SARS-CoV-2 infection at high resolution and compared responses between mild and severe COVID-19. We observed a population of exhausted CD8+ T cells in severe SARS-CoV-2 infection and identified a population of NK-like, terminally differentiated CD8+ effector T cells characterized by expression of FCGR3A (encoding CD16). Further characterization of NK-like CD8+ T cells revealed heterogeneity among CD16+ NK-like CD8+ T cells and profound differences in cytotoxicity, exhaustion, and NK-like differentiation between mild and severe disease conditions. We propose a model in which differences in the surrounding inflammatory milieu lead to crucial differences in NK-like differentiation of CD8+ effector T cells, ultimately resulting in the appearance of NK-like CD8+ T cell populations of different functionality and pathogenicity. Our in-depth characterization of the CD8+ T cell-mediated response to SARS-CoV-2 infection provides a basis for further investigation of the importance of NK-like CD8+ T cells in COVID-19 severity.</p>
Single-cell and spatial transcriptomic atlas of pathological scars uncovers neuro-fibroblast crosstalk mechanisms across scar types
GEO Series GSE307504. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Dataset related to article "Single-Cell and Single-Nucleus Multiomics Reveal Cardiac Endothelial Cell Heterogeneity and Novel Pathological Processes in Pressure Overload-Induced Hypertrophy"
<p>This record contains raw data related to article “<em><span>Single-Cell and Single-Nucleus Multiomics Reveal Cardiac Endothelial Cell Heterogeneity and Novel Pathological Processes in Pressure Overload-Induced Hypertrophy</span></em>"</p> <p>Endothelial cells, the most prevalent cellular population in the heart, line the internal walls of coronary and lymphatic vessels and form the endocardium and cardiac valves. The heterogeneity of cardiac endothelium poses a challenge in fully understanding endothelial states. However, to better grasp the plasticity of endothelial cell phenotypes, it's crucial to distinguish the varied responses of endothelial populations to physiological and pathological stimuli. Endothelial dysfunction plays a significant role in the development and progression of heart failure, a condition impacting millions globally. For the heart to sustain pressure-overload-induced remodelling, endothelial cells must proliferate and generate new blood vessels. When cardiomyocyte hypertrophy and angiogenesis become uncoupled, it leads to decompensated heart failure. Despite this, the molecular mechanisms governing cardiac vascularization during pathological hypertrophy remain unclear.</p> <p>Transcriptional phenotyping methods have been widely used to capture endothelial cell plasticity and heterogeneity. However, only single-cell profiling has effectively resolved distinct phenotypes. While single-cell RNA sequencing can create detailed cellular maps and cell-to-cell communication networks, it does not fully elucidate how gene regulatory programs are established or how cell states, functions, and responses are specified. To address these gaps, multimodal omics approaches have been developed, allowing for simultaneous profiling of chromatin accessibility and gene expression within the same cell.</p> <p>In our study, we aimed to characterize the transcriptional and epigenetic profiles of cardiac endothelial cells in a mouse model of pressure-overload-induced hypertrophy using multiomics bioinformatic approaches at single-cell resolution. This innovative technology enabled us to uncover the regulatory mechanisms that drive endothelial cell sub-population specifications following banding. Our resulting atlas is intended to serve as a valuable reference and resource for future studies and the development of therapeutic strategies targeting endothelial cells in cardiovascular diseases.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.