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129 results for “Skeletal muscle function”
Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance
ClinicalTrials.gov study NCT04783207. IPD Sharing: NO. Countries: 1. Publications: 0.
Up-regulation of sarcoplasmic reticulum function protects skeletal muscle against cytoplasmic calcium overload during hibernation in ground squirrels
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Data from: Hindlimb muscle function in turtles: is novel skeletal design correlated with novel muscle function?
Variations in musculoskeletal lever systems have formed an important foundation for predictions about the diversity of muscle function and organismal performance. Changes in the structure of lever systems may be coupled with changes in muscle use and give rise to novel muscle functions. The two extant turtle lineages, cryptodires and pleurodires, exhibit differences in hindlimb structure. Cryptodires possess the ancestral musculoskeletal morphology, with most hip muscles originating on the pelvic girdle, which is not fused to the shell. In contrast, pleurodires exhibit a derived morphology, in which fusion of the pelvic girdle to the shell has resulted in shifts in the origin of most hip muscles onto the interior of the shell. To test how variation in muscle arrangement might influence muscle function during different locomotor behaviors, we combined measurements of muscle leverage in five major hindlimb muscles with data on muscle use and hindlimb kinematics during swimming and walking in representative semiaquatic cryptodires and pleurodires. We found substantial differences in muscle leverage between the two species. Additionally, we found that there were extensive differences in muscle use in both species, especially while walking, with some pleurodire muscles exhibiting novel functions associated with their derived musculoskeletal lever system. However, the two species shared similar overall kinematic profiles within each environment. Our results suggest that changes in limb lever systems may relate to changes in limb muscle motor patterns and kinematics, but that other factors must also contribute to differences in muscle activity and limb kinematics between these taxa.
Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice
<p>The loss of skeletal muscle function with age, known as sarcopenia, significantly reduces independence and quality of life and can have significant metabolic consequences. Although exercise is effective in treating sarcopenia it is not always a viable option clinically, and currently there are no pharmacological therapeutic interventions for sarcopenia. Here we show that chronic treatment with pan-adiponectin receptor agonist AdipoRon improved muscle function in male mice by a mechanism linked to skeletal muscle metabolism and tissue remodeling. In aged mice, 6 weeks of AdipoRon treatment improved skeletal muscle functional measures in vivo and ex vivo. Improvements were linked to changes in fiber type, including an enrichment of oxidative fibers, and an increase in mitochondrial activity. In young mice, 6 weeks of AdipoRon treatment improved contractile force and activated the energy sensing kinase AMPK and the mitochondrial regulator PGC-1a (peroxisome proliferator activated receptor gamma coactivator 1 alpha). In cultured cells, the AdipoRon induced stimulation of AMPK and PGC-1a was associated with increased mitochondrial membrane potential, reorganization of mitochondrial architecture, increased respiration, and increased ATP production. Furthermore, the ability of AdipoRon to stimulate AMPK and PGC1a was conserved in nonhuman primate cultured cells. These data show that AdipoRon is an effective agent for the prevention of sarcopenia in mice and indicate that its effects translate to primates, suggesting it may also be a suitable therapeutic for sarcopenia in clinical application.</p>
Ferric Carboxymaltose to Improve Skeletal Muscle Metabolism in Heart Failure Patients With Functional Iron Deficiency
ClinicalTrials.gov study NCT03218384. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Supplemental Vitamin D on Skeletal Muscle Function in Chronic Obstructive Pulmonary Disease (COPD) Patients
ClinicalTrials.gov study NCT00914810. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Carnitine Supplementation and Skeletal Muscle Function
ClinicalTrials.gov study NCT02692235. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects
ClinicalTrials.gov study NCT03565328. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Alternative Exercise Program to Improve Skeletal Muscle Function and Fatigue in Cancer Survivors
ClinicalTrials.gov study NCT02739620. IPD Sharing: YES. Countries: 1. Publications: 0.
A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in Elderly
ClinicalTrials.gov study NCT02245620. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Hindlimb muscle function in turtles: is novel skeletal design correlated with novel muscle function?
Open the record for dataset details and reuse information.
Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice
Open the record for dataset details and reuse information.
Total RNA sequencing in multiple Sus Scrofa tissues reveals novel long non-coding RNAs functioning in skeletal muscle development
GEO Series GSE73763. Sus scrofa. 13 samples. Type: Expression profiling by high throughput sequencing.
Enhanced skeletal muscle regeneration upon Bmi1 gain of function is driven by Mt1-mediated protection from oxidative stress.
GEO Series GSE41878. Mus musculus. 6 samples. Type: Expression profiling by array.
Spatially resolved transcriptomics reveals innervation-responsive functional cluster in skeletal muscle.
GEO Series GSE198596. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age [RNA-seq]
GEO Series GSE280699. Mus musculus. 78 samples. Type: Expression profiling by high throughput sequencing.
Functional dissection of metabolic trait-associated variants in steady state and stimulated human skeletal muscle cells [II]
GEO Series GSE282190. Homo sapiens. 8 samples. Type: Other.
Perfusable adipose decellularized extracellular matrix biological scaffoldco-recellularizedwith adipose-derived stem cellsand L6 promotes functional skeletal muscle regeneration following volumetric m
GEO Series GSE247751. Rattus norvegicus. 2 samples. Type: Expression profiling by high throughput sequencing.
Functional TDP-43 amyloids bind sarcomeric mRNA to direct skeletal muscle formation
GEO Series GSE104796. Mus musculus. 8 samples. Type: Other.
A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation (RNA-seq)
GEO Series GSE62659. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.