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10,089 results for “Stimulant”

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zenodo44/100

Transcriptome analysis of the effect of over-expressing H2A.J mutants in proliferating WI38 fibroblasts for the paper entitled: The H2A.J histone variant contributes to Interferon-Stimulated Gene expression in senescence by its weak interaction with H1 and the derepression of repeated DNA sequences

<p>Abstract for overall study:</p> <p>The histone variant H2A.J was previously shown to accumulate in senescent human fibroblasts with persistent DNA damage to promote inflammatory gene expression, but its mechanism of action was unknown. We show that H2A.J accumulation contributes to weakening the association of histone H1 to chromatin and increasing its turnover. Decreased H1 in senescence is correlated with increased expression of some repeated DNA sequences, increased expression of STAT/IRF transcription factors, and transcriptional activation of Interferon-Stimulated Genes (ISGs). The H2A.J-specific Val-11 moderates the transcriptional activity of H2A.J, and H2A.J-specific Ser-123 can be phosphorylated in response to DNA damage with potentiation of its transcriptional activity by the phospho-mimetic S123E mutation. Our work demonstrates the functional importance of H2A.J-specific residues and potential mechanisms for its function in promoting inflammatory gene expression in senescence.</p> <p>Specific description for this dataset:</p> <p>H2A.J differs from canonical H2A only by a valine at position 11 instead of alanine, and the 7 C-terminal amino acids containing a potential minimal phosphorylation site SQ for DNA-damage response kinases. To test the functional importance of these H2A.J-specific sequences, we mutated Val-11 to Ala as is found in all canonical H2A sequences, and we mutated Ser-123 to either Glu to mimic a phospho-serine residue or to Ala to prevent phosphorylation. We also substituted the C-terminus of H2A.J with the C-terminus of H2A. These mutants, WT-H2A.J and canonical H2A-type1 were ectopically expressed in proliferating fibroblasts, and their microarray transcriptomes were compared to that of proliferating and senescent fibroblasts without ectopic histone expression. Genome-wide transcriptome analysis indicated that senescent fibroblasts clustered distinctly from proliferating fibroblasts, and proliferating fibroblasts expressing the H2A.J-V11A and H2A.J-S123E mutants clustered distinctly from fibroblasts expressing the other H2A.J mutants, WT-H2A.J, and H2A. Hallmark gene set enrichment analysis of the transcriptomes of fibroblasts expressing H2A.J-V11A or H2A.J-S123E versus control proliferating fibroblasts indicated that they showed the same highly significant enrichment for the Epithelial-Mesenchyme Transition, TNF-Alpha Signaling Via NF-kB, and Inflammatory Response gene sets. Notable inflammatory genes including IL1A, IL1B, IL6, CXCL8, and CCL2 are contained in these gene sets and are often induced in senescence as part of the senescence-associated secretory phenotype. Heat maps showed that the H2A.J-V11A and H2A.J-S123E mutants were particularly apt at activating the expression of these inflammatory genes in proliferating fibroblasts</p>

opencc-by-4.0Nov 2020View details →
zenodo44/100

Data set for "Optogenetic stimulation of cortex to map evoked whisker movements in awake head-restrained mice"

<p>Data set for: Auffret M, Ravano VL, Rossi GMC, Hankov N, Petersen MFA, Petersen CCH (2017) Optogenetic stimulation of cortex to map evoked whisker movements in awake head-restrained mice. Neuroscience, http://dx.doi.org/10.1016/j.neuroscience.2017.04.004</p> <p>There are 9 files in this data upload:</p> <ol> <li>'2017_Auffret_Neuroscience.pdf' - this is a pdf version of the online publication.</li> <li>'Auffret_data.mat' - this is a Matlab data structure, which contains all the data for the publication.</li> <li>'Auffret_data.npy' - this is a Python data structure, which contains all the data for the publication. The Python data was generated from 'Auffret_data.mat' by 'DataViewer.py'.</li> <li>'Auffret_data.xlsx' - this is an Excel file, which contains all the data for the publication. This Excel file was generated from 'Auffret_data.mat'.</li> <li>'DataViewer.fig' - this is a Matlab Figure file, which is the GUI layout for 'DataViewer.m'.</li> <li>'DataViewer.m' - this is a Matlab Code, which displays the data contained in 'Auffret_data.mat'.</li> <li>'DataViewer.py' - this is a Python Code, which generates 'Auffret_data.npy' from 'Auffret_data.mat', and displays an example trial.</li> <li>'FigureViewer.fig' - this is a Matlab Figure file, which is the GUI layout for 'FigureViewer.m'.</li> <li>'FigureViewer.m' - this is a Matlab Code, which analyses the data in 'Auffret_data.mat', and displays the results in the same way as the published figures (Auffret et al., 2017).</li> </ol>

opencc-by-4.0Apr 2017View details →
zenodo44/100

MOSID (Microcontroller On-chip Sensor IDentification): A dataset of readings from the internal monitoring sensors of STM32L152RTXX microcontrollers during the stimulation of their electronic activity

<p>The MOSID (Microcontroller On-chip Sensor IDentification) dataset consists of 5 acquired data subsets (6,72 GB total, compressed into 560 MB), each collected during different experiments and periods using various equipment (HMP4040, DF1731SB &amp; HM305) and acquisition strategies. These subsets contain readings from the temperature and voltage sensors embedded in 20 STM32L-DISCOVERY devices. The data was captured during the execution of 5 different workloads as stimuli, repeated over 20 iterations. The stimuli employed are as follows:</p><ol><li>20x20 Long-type matrix product.</li><li>20x20 Float-type matrix product.</li><li>Algorithm for ascending sorting, Bubble Sort.</li><li>Algorithm for 2D-point clustering, Convex Hull.</li><li>Encryption algorithm AES 128-bit.</li></ol><p>The subsets are structured according to the folder format "X_Y," where X is the manually assigned number to the board, and Y is the corresponding number for the executed algorithm. Within each of these folders, files are present in the format "data_Z.txt," where Z represents the iteration number to which the file belongs. In total, the dataset comprises 9600 files with a final size of approximately 7 GB. The different presented subsets are as follows:</p><ul><li>ACQ1: Derived from the experiment named "Automatic Acquisition 1 (HMP4040)" conducted using a daisy-chain topology (20 out of 20 boards, 2000 files).</li><li>ACQ2: Derived from the experiment named "Automatic Acquisition 2 (HMP4040)" conducted using a daisy-chain topology (20 out of 20 boards, 2000 files).</li><li>ACQ3: Derived from the experiment named "Individual Acquisitions (HMP4040)", performed board by board from idle conditions (20 out of 20 boards, 2000 files).</li><li>ACQ4: Derived from the experiment named "GOLD SOURCE DF1731SB Acquisitions" conducted using a partial daisy-chain setup (2 devices at a time, 18 out of 20 boards excluding boards , 1800 files).</li><li>ACQ5: Derived from the experiment named "HANMATEK HM305 Acquisitions" conducted using a partial daisy-chain setup (2 devices at a time, 18 out of 20 boards, 1800 files).</li></ul><p>In each "data_Z.txt" file, starting from the 5th line, temperature and voltage raw ADC conversions from the sensors are provided, captured during the execution of the stimulus in successive lines. Additionally, a table (Table_UIDS.csv) with metadata for each of the boards used in the experiments is included, which is needed in order to normalize the data in terms of ºC and Volts.</p><ul><li>BOARD_NUM, which contains the manually assigned board number.</li><li>UID, which contains the Unique Identifier of the board assigned by the manufacturer.</li><li>T_CAL_1, which holds the calibration value of the board's temperature sensor at 30ºC.</li><li>T_CAL_2, which holds the calibration value of the board's temperature sensor at 100ºC.</li><li>VREFINT_CAL, which contains the calibration value of the board's voltage sensor.</li></ul>

opencc-by-4.0Oct 2023View details →
zenodo44/100

Improving causality perception judgments in schizophrenia spectrum disorder via transcranial direct current stimulation - Dataset

<p>Raw data related to the publication:</p> <p>Sch&uuml;lke, R., Schmitter, C. V., &amp; Straube, B. (2023). Improving causality perception judgments in schizophrenia spectrum disorder via transcranial direct current stimulation. <em>Journal of Psychiatry and Neuroscience</em>, <em>48</em>(4), E245&ndash;E254. <a href="https://doi.org/10.1503/jpn.220184">https://doi.org/10.1503/jpn.220184</a></p> <p>Variables:</p> <ul> <li>Subject</li> <li>Condition &ndash; Stimulation condition; parietal (left parietal cathodal, right parietal anodal [LPC-RPA]), frontoparietal (left frontal cathodal, right parietal anodal [LFC-&shy;RPA]), frontal (left frontal cathodal, right frontal anodal [LFC&shy;-RFA])</li> <li>Timepoint &ndash; Before/After (stimulation)</li> <li>Angle &ndash; in degrees</li> <li>Angle_scaled &ndash; mean-centered and scaled Angle</li> <li>Delay_ms &ndash; in milliseconds</li> <li>Delay_ms_scaled &ndash; mean-centered and scaled Delayed_ms</li> <li>Causality &ndash; causal/non-causal (judgment)</li> <li>RT &ndash; reaction time in milliseconds</li> </ul> <p>In the original version of the data, the data had been incorrectly labelled: The data actually corresponding to the LFC-RPA condition had been incorrectly labelled as LPC-RPA, and the data actually corresponding to the LPC-RPA condition had been incorrectly labelled as LFC-RPA. This has been corrected with the 04/2024 version of the dataset.</p>

opencc-by-4.0Sep 2023View details →
zenodo44/100

Dataset of ipsilateral motor-evoked potentials induced by transcranial magnetic stimulation

<p>The dataset includes 4244 trials of EMG recordings after ipsilateral TMS under muscle contraction. This data was used for the evaluation of the DiMEP toolbox https://pypi.org/project/dimep/</p> <p>All subjects provided written, informed consent before participation and following approval by the local ethics committee. Subjects had no contraindications to TMS. TMS was delivered with a MagVenture MagPro-R30 with MagOption and a MCF-B70 figure 8-coil at an orientation of 45&deg; to the midsagittal plane (see figure 1A). First, the motor hotspot of the contralateral, i.e., right, extensor digitorum communis (EDC) was determined by applying 40 stimuli to the left hemisphere. 40% MSO was used as the starting intensity and increased in steps of 5% MSO in case no MEPs could be elicited. Next, at the locations of the three stimuli that resulted in the greatest MEP, i.e., the largest MEP peak-to-peak amplitude, additional three stimuli were applied. The stimulation location that consistently elicited the largest MEPs in the contralateral EDC was then selected as the hotspot. A neuro-navigation system (TMS Navigator, Localite GmbH, Germany) supported coil positioning throughout the measurements. In order to measure ipsilateral MEPs, TMS pulses were applied to the motor hotspot with 5s &plusmn; 1.25 s between pulses (at an intensity of 90% MSO). To increase the likelihood of exhibiting ipsilateral MEPs, subjects were requested to isometrically contract their left biceps brachii (BB) to 30% of its maximum voluntary contraction while receiving visual feedback of the BB activity relative to the required target level of contraction on a computer display. The electromyographical response (EMG) to TMS was recorded with a BrainProducts ExG bipolar amplifier from the ipsilateral EDC. All trials were divided into 1s segments, i.e., 500 ms before and after each TMS pulse, and sampled at 1000 Hz.</p>

opencc-by-4.0Aug 2021View details →
zenodo44/100

Stimulation of medial amygdala GABA neurons with kinetically different channelrhodopsins yields opposite behavioral outcomes

<p>This dataset continues the dataset accessible by doi 10.5281/zenodo.4311847. The latter also contains all the relevant metadata description.</p>

opencc-by-4.0Dec 2021View details →
zenodo44/100

Experimental study dataset: "Enhancing Touch Sensibility with Sensory Electrical Stimulation and Sensory Retraining"

<p>Experimental study dataset: &quot;Enhancing Touch Sensibility with Sensory Electrical Stimulation and Sensory Retraining&quot;.</p> <p>This research was supported by the Swiss National Science Foundation through the grant PP00P2 163800. This work was also supported by SENACYT and IFARHU, the Panamanian Government.</p> <p>Files and data to upload:</p> <ol> <li>Description of variables&nbsp;</li> <li>Continue robot data (pickles)</li> <li>Discontinue robot data (task performance)</li> <li>EEG data</li> </ol>

opencc-by-4.0Jun 2023View details →
zenodo44/100

Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus: optogenetical stimulation data

<p>This dataset contains 2-photon calcium imaging data from the paper 'Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus'. This is the calcium imaging data from CA1 pyramidal cells and interneurons, including both spontaneous activity and activity in response to optogenetic stimulation.</p> <p><strong>Data organization</strong></p> <p>This dataset contains all the data related to the all-optical part of the paper and was analyzed using the code from the <a href="https://gitlab.com/cossartlab/bocchio-vorobyev-et-al-2023/-/tree/main/Optogenetical%20stimulation?ref_type=heads">lab repository</a>. The original calcium imaging movies are excluded due to size limitations.</p> <p><strong>Further information</strong></p> <p>Please email vorobev[a t]phystech.edu if you need further information on the data or if you wish to access the raw calcium imaging movies (not uploaded here due to storage limitations).</p>

opencc-by-4.0Jun 2024View details →
zenodo44/100

Dataset for the stimulator of interferon genes protein (STING1) antibody screening study

<p><strong>This antibody characterization dataset is related to the F1000 research article openly available at F1000Research.</strong></p> <p><em>This dataset contains the following underlying raw data for a study which characterized sixteen antibodies for the stimulator of interferon genes protein (STING1) in western blot, immunoprecipitation and immunofluorescence. The corresponding study is accessible on the YCharOS community on Zenodo (<a href="https://doi.org/10.5281/zenodo.11582350">https://doi.org/10.5281/zenodo.11582350</a>).</em></p> <p><em>The Dataset is in the format of a zip file. Once downloaded, please expand the zip file to access the folders containing the underlying data for Western blot (Wb), immunoprecipitation (IP) and immunofluorescence (IF).</em></p>

opencc-by-4.0Jul 2024View details →
zenodo44/100

Phantom measurement data for 'Fast bias-corrected conductivity mapping using stimulated echoes', Iyyakkunnel et al. (2024)

<p>This dataset contains the phantom measurement data used in the article by Iyyakkunnel et al., titled "Fast Bias-Corrected Conductivity Mapping Using Stimulated Echoes," published in MAGMA, 2024 (doi: 10.1007/s10334-024-01194-3). In this study, the feasibility of using a stimulated echo sequence for electrical properties tomography (EPT) is demonstrated. The data were acquired with a 3T MRI system (Magnetom Prisma; Siemens Healthcare, Erlangen, Germany) using a dual-tuned 1H/23Na quadrature head coil for transmission and reception (Rapid Biomedical, Rimpar, Germany).<br>The dataset includes magnitude and phase measurements for the proposed Double-Angle Stimulated Echo (DA-STE) sequence, as well as reference measurements, including Double Angle measurements using a Gradient Echo sequence (GRE-DAM) for the B1+ magnitude, and a Single Echo Spin Echo sequence (SE) for the transceive phase.<br>For both the DA-STE and SE sequences, each measurement was repeated with inverted readout gradient polarities, denoted as LR (left-right) and RL (right-left) in the respective measurement folders. For each measurement, magnitude and phase data are provided in separate folders (in dicom (.dcm) format). Please note that for DA-STE, the two echo acquisitions are sequentially stored in the same measurement folder.<br>For further measurement details, please refer to the mentioned original article.</p>

opencc-by-4.0Aug 2024View details →
zenodo44/100

Closed-loop auditory stimulation targeting alpha and theta oscillations during REM sleep induces phase-dependent power and frequency changes

<p>This repository contains raw data, sleep scoring, and data to create the figures for the paper:</p> <p><strong>"Closed-loop auditory stimulation targeting alpha and theta oscillations during REM sleep induces phase-dependent power and frequency changes"</strong></p> <p>by Valeria Jaramillo, Henry Hebron, Sara Wong, Giuseppe Atzori, Ullrich Bartsch, Derk-Jan Dijk*, Ines R. Violante* (* contributed equally).</p> <p>Journal article has been published in SLEEP and can be found here: <a href="https://doi.org/10.1093/sleep/zsae193">https://doi.org/10.1093/sleep/zsae193</a></p> <p>Code can be found here: <a href="https://gitlab.surrey.ac.uk/nemo/RSN">https://gitlab.surrey.ac.uk/nemo/RSN</a></p> <p>Please cite as indicated under 'Citation' on this page.</p> <p>More information on the datafiles can be found in the README.</p>

opencc-by-4.0Sep 2024View details →
zenodo44/100

Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors

<p>Summary statistics for chromatin accessibility and gene expression quantitative trait loci (ca/eQTLs) from Matoba, N., Le, B.D., Valone, J.M.&nbsp;<em>et al.</em>&nbsp;Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors.&nbsp;<em>Nat Neurosci</em> (2024). https://doi.org/10.1038/s41593-024-01773-6</p>

opencc-by-4.0Sep 2024View details →
zenodo44/100

Murine Bone Marrow Derived Macrophages (BMDM's) stimulated with LPS and treated with PBS, Epirubicin and Aclarubicin

<p>This dataset was used in the analysis which composes the GitHub repository:</p> <p><a href="https://github.com/andrebolerbarros/Chora_etal_2022">https://github.com/andrebolerbarros/Chora_etal_2022</a></p> <p>The files presented here&nbsp;correspond to:</p> <p><em>gene_counts.tab:</em>&nbsp;the table for the gene counts produced by the alignment of fastq files using STAR;</p> <p><em>sampleTable.csv:</em>&nbsp;the treatment information for each sample produced.</p>

opencc-by-4.0Dec 2022View details →
zenodo44/100

Altered nanoparticle uptake by lung carcinoma cells when stimulated with epidermal growth factor

<p>This dataset provides the raw data supporting the paper &quot;Altered nanoparticle uptake by lung carcinoma cells when stimulated with epidermal growth factor&quot;. The&nbsp;focus of the study was to investigate the uptake of two different sizes of silica NPs and gold NPs in lung epithelial cells A549 in the presence of epidermal growth factor (EGF).&nbsp;</p> <p>The data set includes:</p> <ul> <li>Screening for EGF receptor using western blot and confocal microscopy (Figure 1 and Figure S1)</li> <li>Investigating expression of RAC1/CDC42 proteins&nbsp;upon EGF stimulation using Western blot (Figure 2)</li> <li>Investigating expression of RAC1 gene upon EGF stimulation using RT-qPCR (Figure S2)</li> <li>Evaluating&nbsp;uptake of endocytic markers&nbsp;upon EGF stimulation&nbsp;using confocal laser scanning microscopy (Figure 3, Figure S4) and flow cytometry (Figure 3)</li> <li>Nanoparticle characterization using TEM (Figure 4, Figure S6) and UV-Vis (Figure S5, Figure S6)</li> <li>Evaluating silica nanoparticle uptake upon EGF stimulation using confocal laser scanning microscopy (Figure&nbsp;5, Figure S8) and&nbsp;flow cytometry (Figure&nbsp;5)</li> <li>Evaluating gold nanoparticle uptake upon EGF stimulation using dark-field microscopy and ICP-AES&nbsp;(Figure 6)</li> <li>Investigating expression of c-MYC gene upon EGF stimulation using RT-qPCR (Figure 6)</li> <li>Cell viability results, analysed via lactate dehydrogenase assay (Figure S3) and MTS assay (Figure S9)</li> <li>Raw integrated density data from dark-field images (Figure S9)</li> </ul>

opencc-by-4.0Feb 2023View details →
zenodo44/100

Summary statistics of stimulated fibroblast eQTLs

<p>This dataset comprises summary statistics from an eQTL mapping study of stimulated fibroblast eQTLs demonstrated in the manuscript entitled &quot;Mapping interindividual dynamics of innate immune response at single-cell resolution&quot; by Kumasaka et al.</p>

opencc-by-4.0Feb 2023View details →
zenodo44/100

Data part of the manuscript Anaerobic methanotrophy is stimulated by graphene oxide in a brackish urban canal sediment

<p>We surveyed three canals in the city of Amsterdam (Netherlands) for it methane emissions and potential to filter methane through anaerobic oxidation of methane in the canal sediment. To unravel the mechanisms involved we characterised the sediment geochemically. All data present in the manuscript is available in the Excel file.</p>

opencc-by-4.0Dec 2022View details →
zenodo44/100

Reconstructing dust provenance from quartz optically stimulated luminescence (OSL) and electron spin resonance (ESR) signals: Preliminary results on loess from around the world

<p>Dataset for publication</p> <p><strong>Reconstructing dust provenance from quartz optically stimulated luminescence (OSL) and electron spin resonance (ESR) signals: </strong></p> <p><strong>Preliminary results on loess from around the world</strong></p> <p>&nbsp;</p> <p>Quantitative provenance analysis studies are instrumental in understanding the tectonic and climatic processes that shape the earth&rsquo;s landscape. Although the most abundant mineral in the sedimentary system is quartz, almost all studies in provenance analysis investigate accessory minerals. Quartz crystals contain a vast number of point defects, intrinsic or due to impurities. For a signal to be an accurate indicator of provenance one needs to show that it is either dose independent or reaches a quantifiable steady state characteristic of the source rock. For signals used by trapped charge dating methods (optically stimulated luminescence (OSL) and electron spin resonance (ESR)), the latter option is the feasible one. By using quartz samples collected from the Chinese Loess Plateau (Luochuan loess-paleosol section), we show that the laboratory and natural dose response curves of E`<sub>1</sub> and and peroxy electron spin resonance signals of quartz (as defined later) overlap and reach a steady state for doses over about 1000 Gy. For E&rsquo;<sub>1</sub> signals we attribute this steady state to reaching an equilibrium state between diamagnetic oxygen vacancies (the oxygen deficiency centre (ODC), Si=Si<em>)</em> and paramagnetic oxygen vacancies (E&rsquo;<sub>1</sub>). For sedimentary quartz irradiated naturally or artificially in this dose range we show a strong linear relationship with zero intercept between E&rsquo;<sub>1</sub> and peroxy signals for samples worldwide, supporting the hypothesis that these defects are Frenkel pairs. Further, we show significant correlations between the optically stimulated (OSL) sensitivity and the above two mentioned ESR signals. The very strong correlations (Pearson`s r ˃0.9) between E&rsquo;<sub>1</sub>, peroxy and OSL sensitivity remain valid after the samples have been heated for 15 min to 350 ˚C for E&rsquo;<sub>1</sub> to reach its maximum value, believed to be a result of the conversion of diamagnetic oxygen vacancies to E&rsquo;<sub>1</sub>, clearly suggesting a relationship between OSL sensitivity and oxygen vacancies in general. Samples collected from different loess sites around the world can be distinguished based on both these OSL and ESR properties. An empirical increase in OSL sensitivity as well as oxygen related defect concentrations is observed in areas where the source material has components with older detrital zircon U-Pb ages, inferring a positive correlation between OSL sensitivity, as well as the signal intensity for E<sub>1</sub>` and peroxy defects and the age of the source rocks.</p>

opencc-by-4.0May 2023View details →
zenodo44/100

Datasets for "Placebo effects of transcranial direct current stimulation on motor skill acquisition"

<p>The following two .csv files contain the participant level data for the primary analyses conducted within the research study:</p> <p>&quot;Placebo effects of transcranial direct current stimulation on motor skill acquisition&quot;</p> <p>Data are formatted in long format for ease of analysis</p> <p>Dataset used in first analysis - Estimation of TDCS effect and Placebo effect including a NO TDCS control group</p> <p>ALLGROUPS.csv</p> <p>subid = Participant specific identifier<br> Age = Participant age in years<br> Sex = Participant sex (M/F)<br> RASex = Sex of research assistant that conducted the study for the participant<br> TrialNum = Trial number for the reaching task<br> Performance = Total trial time of the trial in seconds<br> AssignGrp = Group participant was assigned: Active = Active TDCS, Sham = Sham TDCS, Ctrl = No TDCS</p> <p>Dataset used in second analysis - Estimation of expectancy effects on Performance among TDCS groups ONLY</p> <p>TDCSGroupsONLY.csv</p> <p>subid = Participant specific identifier<br> Age = Participant age in years<br> Sex = Participant sex (M/F)<br> RASex = Sex of research assistant that conducted the study for the participant<br> TrialNum = Trial number for the reaching task<br> Performance = Total trial time of the trial in seconds<br> AssignGrp = Group participant was assigned: Active = Active TDCS, Sham = Sham TDCS, Ctrl = No TDCS<br> PostExp = Expectancy score post practice<br> PreExp = Expectancy score pre practice<br> Suggestibility = Suggestibility score<br> Prior Know = Prior knowledge of TDCS (Yes/No)<br> Prior Study = Participation in a study using TDCS (Yes/No)</p>

opencc-by-4.0Jun 2023View details →
zenodo40/100

Dataset related to article "TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem Cells."

<p>Mesenchymal stem cells (MSCs) are well established to have promising therapeutic properties. TNF-stimulated gene-6 (TSG-6), a potent tissue-protective and anti-inflammatory factor, has been demonstrated to be responsible for a significant part of the tissue-protecting properties mediated by MSCs. Nevertheless, current knowledge about the biological function of TSG-6 in MSCs is limited. Here, we demonstrated that TSG-6 is a crucial factor that influences many functional properties of MSCs. The transcriptomic sequencing analysis of wild-type (WT) and TSG-6<sup>-/-</sup> -MSCs shows that the loss of TSG-6 expression leads to the perturbation of several transcription factors, cytokines, and other key biological pathways. TSG-6<sup>-/-</sup> -MSCs appeared morphologically different with dissimilar cytoskeleton organization, significantly reduced size of extracellular vesicles, decreased cell proliferative rate, and loss of differentiation abilities compared with the WT cells. These cellular effects may be due to TSG-6-mediated changes in the extracellular matrix (ECM) environment. The supplementation of ECM with exogenous TSG-6, in fact, rescued cell proliferation and changes in morphology. Importantly, TSG-6-deficient MSCs displayed an increased capacity to release interleukin-6 conferring pro-inflammatory and pro-tumorigenic properties to the MSCs. Overall, our data provide strong evidence that TSG-6 is crucial for the maintenance of stemness and other biological properties of murine MSCs.</p> <p>&nbsp;</p> <p>Some dataset of this research are in prism format, to ensure open access we attach a pdf instruction about this format and a link where downoladed it</p>

opencc-by-4.0Mar 2020View details →
zenodo40/100

Raw data for "Examining the effects of transcranial direct current stimulation on human episodic memory with machine learning"

<p>This is the raw dataset for &quot;Examining the effects of transcranial direct current stimulation on human episodic memory with machine learning&quot;. Each .xlsx file represents an experimental results of a single participant.</p> <p>Directory description:</p> <p>Eng_sham - the results from experiments without stimulation on English sample from Medvedeva, 2019.</p> <p>Eng_vlPFC - the results from experiments with vLPFC stimulation on English sample from Medvedeva, 2019.</p> <p>enc_off_new - the results from experiments with dLPFC offline encoding stimulation on Russian sample.</p> <p>enc_on_new - the results from experiments with dLPFC online encoding stimulation on Russian sample.</p> <p>sham_no stimulation - the results from experiments without stimulation offline encoding stimulation on Russian sample.</p> <p>vlPFC_stimulation - the results from experiments with vLPFC stimulation on Russian sample.</p> <p>Age.xlsx - the ages of the participants</p> <p>&nbsp;</p>

opencc-by-4.0Jun 2020View details →

ScienceDex guides

Understand access before you commit

These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.

Compare curated datasets

Allen Brain Atlas

Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.

allen-brain-atlas
neuroscienceopenDocumentation, web resources, and API references are available online.
Last verified 2026-04-30Open record

Annotated Behaviour and Observability Dataset (ABODe)

ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.

abode-home-cage
behavioral-neuroscienceopenThe DataShare record exposes download links for annotations, documentation, license text, and the zipped per-snippet data directory.
Last verified 2026-04-30Open record

DANDI Archive for NWB datasets

DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.

dandi-nwb
electrophysiologyopenPublished Dandiset metadata and archive endpoints are available through the production DANDI API.
Last verified 2026-04-30Open record

International Brain Laboratory public data

The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.

ibl
behavioral-neuroscienceopenPublic sessions can be searched and loaded from the IBL public data server through ONE.
Last verified 2026-04-29Open record

OpenNeuro

OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.

openneuro
neuroscienceopenPublished datasets are available on demand over the internet.
Last verified 2026-04-29Open record