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47 results for “Subjective cognitive decline”
Minor neuropsychological deficits in patients with subjective cognitive decline
<p><b>Objective: </b>To determine the nature and extent of minor neuropsychological deficits in patients with subjective cognitive decline (SCD) and their association with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD).</p> <p><b>Method: </b>We analyzed data from n=449 cognitively normal participants (n=209 healthy controls, n=240 SCD patients) from an interim data release of the <i>German Center for Neurodegenerative Diseases<b> </b>Longitudinal Cognitive Impairment and Dementia Study</i> (DELCODE). An extensive neuropsychological test battery was applied at baseline for which we established a latent, five cognitive domain factor structure comprising learning & memory, executive functions, language abilities, working memory and visuospatial functions. We compared groups regarding global and domain-specific performance and correlated performance with different CSF markers of AD pathology.</p> <p><b>Results: </b>We observed worse performance (Cohen's d≈0.25-0.5, adjusted for age-, sex differences with ANCOVA) in global performance, memory, executive functions and language abilities for the SCD group compared to healthy controls. In addition, worse performance in these domains was moderately (r≈0.3) associated with lower CSF-Aβ42/40 and CSF-Aβ42/ptau181 in the whole sample and specifically in the SCD subgroup.</p> <p><b>Conclusions:</b> Within the spectrum of clinically unimpaired (i.e., "pre- mild cognitive impairment") cognitive performance, SCD is associated with minor deficits in memory, executive function and language abilities. The association of these subtle cognitive deficits with AD CSF biomarkers speaks to their validity and potential use for the early detection of underlying preclinical AD.</p>
Dysfunctions-of-Multiscale-Dynamic-Brain-Functional-Networks-in-Subjective-Cognitive-Decline
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DEMA-Pro Intervention for Seniors With Subjective Cognitive Decline and Living at Home
ClinicalTrials.gov study NCT04796415. IPD Sharing: NO. Countries: 1. Publications: 0.
Crossover Trial for Nicotinamide Riboside in Subjective Cognitive Decline and Mild Cognitive Impairment
ClinicalTrials.gov study NCT04078178. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Subjective cognitive decline and risk of MCI: the Mayo Clinic Study of Aging
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Minor neuropsychological deficits in patients with subjective cognitive decline
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Efficacy of Tinkering Activities in Individuals With Subjective Cognitive Decline
ClinicalTrials.gov study NCT06110858. IPD Sharing: NO. Countries: 1. Publications: 0.
Senior Driving Simulation Training for Subjective Cognitive Decline and Mild Cognitive Impairment
ClinicalTrials.gov study NCT05380284. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of Cognitive Strategy Training on Daily Function in People With Subjective Cognitive Decline
ClinicalTrials.gov study NCT04330404. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
ClinicalTrials.gov study NCT06335836. IPD Sharing: Not stated. Countries: 1. Publications: 0.
German Validation Study of the Subjective Cognitive Decline Questionnaire (SCD-Q)
ClinicalTrials.gov study NCT06711952. IPD Sharing: NO. Countries: 1. Publications: 0.
dTMS for Subjective Cognitive Decline
ClinicalTrials.gov study NCT06095063. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Olfactory Network of Electro-acupuncture for Subjective Cognitive Decline: A Multicenter Randomized Controlled Trial and fMRI Study
ClinicalTrials.gov study NCT06758154. IPD Sharing: YES. Countries: 1. Publications: 0.
Effects of Mediterranean Diet on Subjective Cognitive Decline
ClinicalTrials.gov study NCT06287489. IPD Sharing: NO. Countries: 1. Publications: 0.
β-AARC: Cohort Study for the Identification of Blood-based Biomarkers in a Population With Subjective Cognitive Decline
ClinicalTrials.gov study NCT04935372. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Efficacy of a Multicomponent Cognitive Intervention in Adults With Subjective Cognitive Decline and Mild Cognitive Impairments
ClinicalTrials.gov study NCT04023032. IPD Sharing: NO. Countries: 1. Publications: 0.
Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline
ClinicalTrials.gov study NCT04009382. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
ClinicalTrials.gov study NCT03851523. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effectiveness of Interventions Targeting Self-Perception of Aging in Older Adults with Subjective Cognitive Decline
ClinicalTrials.gov study NCT06622889. IPD Sharing: NO. Countries: 1. Publications: 0.
tDCS-enhanced Working Memory Training in Subjective Cognitive Decline
ClinicalTrials.gov study NCT03236454. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.