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Dataset results
83 results for “Thalamus”
Optogenetic activation of visual thalamus generates artificial visual percepts
<p>The lateral geniculate nucleus (LGN), a retinotopic relay center where visual inputs from the retina are processed and relayed to the visual cortex, has been proposed as a potential target for artificial vision. At present, it is unknown whether optogenetic LGN stimulation is sufficient to elicit behaviorally relevant percepts, and the properties of LGN neural responses relevant for artificial vision have not been thoroughly characterized. Here, we demonstrate that tree shrews pre-trained on a visual detection task can detect optogenetic LGN activation using an AAV2-CamKIIα-ChR2 construct and readily generalize from visual to optogenetic detection. Simultaneous recordings of LGN spiking activity and primary visual cortex (V1) local field potentials (LFP) during optogenetic LGN stimulation show that LGN neurons reliably follow optogenetic stimulation at frequencies up to 60 Hz, and uncovered a striking phase locking between the V1 local field potential (LFP) and the evoked spiking activity in LGN. These phase relationships were maintained over a broad range of LGN stimulation frequencies, up to 80 Hz, with spike field coherence values favoring higher frequencies, indicating the ability to relay temporally precise information to V1 using light activation of the LGN. Finally, V1 LFP responses showed sensitivity values to LGN optogenetic activation that were similar to the animal's behavioral performance. Taken together, our findings confirm the LGN as a potential target for visual prosthetics in a highly visual mammal closely related to primates.</p>
SANTE - Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy
ClinicalTrials.gov study NCT00101933. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Cognitive Control Functions of the Human Thalamus
ClinicalTrials.gov study NCT06920992. IPD Sharing: NO. Countries: 1. Publications: 5.
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
ClinicalTrials.gov study NCT07217652. IPD Sharing: NO. Countries: 1. Publications: 3.
Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy
ClinicalTrials.gov study NCT04897776. IPD Sharing: NO. Countries: 1. Publications: 5.
Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes
ClinicalTrials.gov study NCT03867149. IPD Sharing: NO. Countries: 1. Publications: 4.
Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy
ClinicalTrials.gov study NCT02076698. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Optogenetic activation of visual thalamus generates artificial visual percepts
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Electron microscopy images of thalamus from acutely hydrogen sulfide poisoned mice
<p class="MsoNormal"><span>To date, the mitochondrial morphological changes that take place after an acute H<sub>2</sub>S exposure are not well described. In the present study, we analyzed images of transmission electron microscopy of thalami from mice subjected to a single acute (1000 ppm) H<sub>2</sub>S exposure and euthanized at various time points to assess the mitochondrial structure and morphometric parameters over time. From our observations, changes induced by H<sub>2</sub>S up to 48 h were mostly limited to increased cristae and matrix compartments' disorganization in mainly accumulated round-shaped mitochondria. At 72 h, H<sub>2</sub>S induced a spectrum of morphological cellular changes. Impaired H<sub>2</sub>S-mediated energy-producing capacity of mitochondria relative to their normal-sized counterparts was inferred from our observations of disorganization and paucity of the inner mitochondrial membrane, the infoldings of which—into cristae—are well-documented to increase the surface area for ATP production, the evaluation of a disorganized network, and likely a disrupted mitophagy because of changes in mitochondrial shape. </span></p>
High Frequency Stimulation of the GPi or Thalamus in Tourette's Syndrome
ClinicalTrials.gov study NCT00139308. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Nucleus reuniens of the thalamus contains head direction cells
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Electron microscopy images of thalamus from acutely hydrogen sulfide poisoned mice
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Impact of c-JUN deficiency on thalamus development in mice and human neural models [ATACseq, RNAseq, CUT&Tag]
GEO Series GSE260732. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Single-cell RNA sequencing of E12.5 mouse thalamus
GEO Series GSE122012. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Tracheal occlusion conditioning in conscious rats modulates gene expression profile of medial thalamus
GEO Series GSE25152. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
Impact of c-JUN deficiency on thalamus development in mice and human neural models
GEO Series GSE243735. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene Expression Analysis in the Thalamus and Cerebrum of Horses Experimentally Infected with West Nile Virus
GEO Series GSE30347. Equus caballus. 36 samples. Type: Expression profiling by array.
mRNA sequencing of perilesional cortex and ipsilateral thalamus at 3-months after lateral fluid-percussion injury or sham-operation
GEO Series GSE192979. Rattus norvegicus. 24 samples. Type: Expression profiling by high throughput sequencing.
Microarray analysis in the thalamus of mouse exposed to pain-stimulated ultrasound vocalizations
GEO Series GSE272934. Mus musculus. 1 samples. Type: Expression profiling by array.
Neurons and astrocytes elicit brain region specific transcriptional responses to prion disease in the murine CA1 and thalamus
GEO Series GSE201249. Mus musculus. 50 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.