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3,626 results for “Vitamin”
Figure 3 in All aspects of the toxic effects of lipopolysaccharide on rat liver and the protective effect of vitamin E and sodium selenite
Figure 3. Liver section of the control rats, CV: central vein at 200×. Histological structures (A, B) of the control, VE, SS, and VE + SStreated rats were similar to the control group.
Figure 2 in All aspects of the toxic effects of lipopolysaccharide on rat liver and the protective effect of vitamin E and sodium selenite
Figure 2. TEAC values (μmol of Trolox equiv/gram tissue) in the liver of rats treated with LPS (10 mg/kg bw), VE (200 mg/kg bw), and SS (0.35 mg/kg bw). Significance was accepted as P <0.05.
Figure 1 in All aspects of the toxic effects of lipopolysaccharide on rat liver and the protective effect of vitamin E and sodium selenite
Figure 1. FRAP values (μmol of FeII equiv/gram tissue) in the liver of rats treated with LPS (10 mg/kg bw), VE (200 mg/kg bw), and SS (0.35 mg/kg bw). Significance was accepted as P <0.05.
Vitamin B12 deficiency anaemia and gestational diabetes mellitus: a two-sample Mendelian randomization study
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Vitamin D Study Datasets
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The effect of Vitamin D levels on the course of COVID-19 in hospitalized patients – a 1-year prospective cohort study
<p>Background: The aim of the current study was to assess the patients with COVID-19 and the impact of vitamin D supplementation on the course of COVID-19.<br> Methods: This prospective cohort study included patients hospitalized due to COVID-19 between December 2020 and December 2021. Patients' demographic, clinical, and laboratory parameters were analysed. <br> Results: 301 participants were enrolled in the study. 46 (15,3%) had moderate, and 162 (53,8%) had severe COVID-19. 14 (4,7%) patients died, and 30 (10,0%) were admitted to the ICU due to disease worsening. The majority needed oxygen therapy (n=224; 74,4%). Average vitamin 25(OH)D3 levels were below optimal at the admittance, and vitamin D deficiency was detected in 205 individuals. More male patients were suffering from vitamin D deficiency. Patients with the more severe disease showed lower levels of vitamin 25(OH)D3 in their blood. The most severe group of patients had more symptoms that lasted significantly longer with progressing disease severity. This group of patients also suffered from more deaths, ICU admissions, and treatments with dexamethasone, remdesivir, and oxygen.<br> Conclusion: Patients with the severe course of COVID-19 were shown to have increased inflammatory parameters, increased mortality, and higher incidence of vitamin D deficiency. The results suggest that the vitamin D deficiency might represent a significant risk factor for a severe course of COVID-19.</p> <p> </p>
Data platform (genotyping data set) related to ERDF postdoctoral project No. 1.1.1.2/VIAA/4/20/718 "The role of vitamin D gene polymorphisms and its receptors in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis".
<p><strong>Data platform </strong><strong>(genotyping dataset)</strong> <strong>related to the ERDF postdoctoral project No. </strong><strong>1.1.1.2/VIAA/4/20/718</strong><strong> “</strong><strong>The role of vitamin D and its receptor gene polymorphisms in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis</strong><strong>”.</strong></p> <p><strong>About the project and gathered data:</strong></p> <p>The dataset contains genotyping data on 289 sex-balanced samples (approximately 60% women / 40% men)) were created at the the multiple sclerosis (MS) Clinic of the Latvian Maritime Medical Center (LMMC) in 2011 (disease duration of 1-51 years); the collection was updated within the framework of the ERDF MS project (2017-2020) and replenished during the ERDF postdoctoral project No. 1.1.1.2/VIAA/4/20/718 “The role of vitamin D and its receptor gene polymorphisms in the modulation of intestinal inflammation in patients with relapsing and progressive forms of multiple sclerosis” (2021-2023).</p> <p>For the <strong>Genotyping dataset </strong>relevant information for each patient from the MS disease cohort, referring to proteasomal gene genetic variations (microsatellites and SNPs): (HSMS006 <em>(PSMA6),</em> HSMS602 <em>(FAM177A1),</em> HSMS701 <em>(KIAA0391)</em>, HSMS702 <em>(KIAA0391)</em> HSMS801 <em>(KIAA0391)</em>, rs11543947<em>(PSMB5), </em>rs2277460 (mi110), rs1048990 (mi8)<em> (PSMA6),</em> rs1048990 (mi8)<em> (PSMA6),</em> rs2295826/rs2295827<em>(PSMC6),</em> rs2348071 <em>(PSMA3),</em> rs2071543, rs9357155 <em>(PSMB8),</em> rs17587<em>(PSMB9),</em> rs74421874 <em>(PSMD9); </em>rs9275596 from HLA region; vitamin D-related genes (VDR and GC) polymorphisms: rs2228570, rs1544410, rs7975232, rs731236 (<em>VDR</em>) and rs7041, rs4588 <em>(GC).</em></p>
Flow cytometry data for "Vitamin B12 conveys a protective advantage to phycosphere-associated bacteria at high temperatures"
<p>More details—including the analysis pipeline—are available in the GitHub repository: <a href="http://github.com/maggimars/bactB12">https://github.com/maggimars/bactB12</a>. </p> <p>Direct link to analysis pipeline interactive document: <a href="https://maggimars.github.io/bactB12/Flow_Cytometry_Analysis.html">https://maggimars.github.io/bactB12/Flow_Cytometry_Analysis.html</a></p> <p> </p> <p> </p>
Vitamin C Supplementation Intervention
ClinicalTrials.gov study NCT04036110. IPD Sharing: YES. Countries: 1. Publications: 2.
Edoxaban Treatment Versus Vitamin K Antagonist in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
ClinicalTrials.gov study NCT02866175. IPD Sharing: YES. Countries: 18. Publications: 3.
SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)
ClinicalTrials.gov study NCT04344184. IPD Sharing: NO. Countries: 1. Publications: 10.
Study To Understand Fall Reduction and Vitamin D in You
ClinicalTrials.gov study NCT02166333. IPD Sharing: YES. Countries: 1. Publications: 11.
Vitamin B12, Neurodevelopment and Growth in Nepal
ClinicalTrials.gov study NCT02272842. IPD Sharing: YES. Countries: 1. Publications: 9.
Edoxaban Treatment Versus Vitamin K Antagonist (VKA) in Patients With Atrial Fibrillation (AF) Undergoing Catheter Ablation
ClinicalTrials.gov study NCT02942576. IPD Sharing: YES. Countries: 11. Publications: 10.
Vitamin D status is heritable and under environment-dependent selection in the wild
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Vitamin D and Calcium in Children 0-36 months: A Scoping Review of Health Outcomes
<p>We conducted a scoping review to describe the extent (size), range (variety), and nature (characteristics) of the evidence on published primary research and systematic reviews since 2008 relating to vitamin D or calcium intake (or biomarkers of intake) in relation to any health outcome in generally healthy infants and children less than 3 years old. The list of these set-aside studies with extracted data is available in Supplemental Data File 1. Data extracted from interventional studies are included in Supplemental Data File 2. Data extracted from observational studies are included in Supplemental Data File 3. </p>
Food composition database for nutrient intake: selected vitamins and minerals in selected European countries
<p>Following a request from the European Commission for a review of European dietary reference values (DRVs), the EFSA’s Panel on Dietetic Products, Nutrition and Allergies (NDA) has prepared a number of Scientific Opinions on DRVs for micronutrients. The DATA Unit supported this activity by estimating the nutrient intake of a number of micronutrients in nine selected European countries and different age groups. In addition, the DATA Unit also provided information on average content of food sources of the respective nutrients per country based on the composition database, as well as main food group contributors to nutrient intakes and assessed the comparability of the provided data with pertinent published intake data.</p> <p>Intake estimates have been assessed using food consumption data from the EFSA Comprehensive Food Consumption Database (EFSA, 2011a) and the EFSA Nutrient composition database. Food composition data used to populate the Nutrient composition database were provided to EFSA through the EFSA procurement project ‘<em>Updated food composition database for nutrient intake’</em> (Roe at al., 2013). Data were provided following the EFSA specification for standard sample description for food and feed and were classified according to the FoodEx2 classification system of EFSA (EFSA, 2011b).</p> <p>The food composition data used in these assessments and here published cover the following vitamins and minerals: calcium (Ca); copper (Cu); cobalamin (vitamin B12); magnesium (Mg); niacin; phosphorus (P); potassium (K); riboflavin; thiamin; iron (Fe); selenium (Se); vitamin B6; vitamin K, zinc (Zn), and vitamin E<sup>1</sup>. The food composition dataset contains data from seven<sup>2</sup> countries: Finland, France, Germany, Italy, Netherlands, Sweden, and United Kingdom. This dataset version has been checked for outliers but is prior to data completion for missing foods and nutrient values.</p> <p><sup>1</sup> Vitamin E is defined as alpha-tocopherol (AT) only, however as most food composition databases in the EU contain values as alpha-tocopherol equivalents (TE), data on TE are also provided</p> <p><sup>2</sup> For the nutrient intake estimates of Ireland and Latvia present in the opinions of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), food composition data from UK and Germany were respectively used</p>
Data from: An insight into vitamin E and lipid nutrition of the plains-wanderer Pedionomus torquatus
<p>Vitamin E, as α-tocopherol, is an essential antioxidant protecting the body from free radicals. The vitamin E requirement of managed wildlife species is known to be greater than their wild counterparts, predominantly due to higher dietary lipid content and potentially stressful environments. The plains-wanderer (<em>Pedionomus torquatus</em>, Family Pedionomidae [monotypical]) is a critically endangered, superficially quail-like bird that is the focus of an ongoing captive breeding program in Australia. It is estimated that plains-wanderers have a high vitamin E requirement (compared to domestic poultry species) to offset a high lipid diet and their naturally flighty temperament. This study therefore aims to gain a greater understanding of the nutritional status and vitamin E requirements of plains-wanderers in managed environments. Total lipid and α-tocopherol intake were quantified for 26 zoo-managed plains-wanderers over a series of diet intake trials in addition to measurement of plasma α-tocopherol and cholesterol concentrations. Plains-wanderers that consumed higher portions of dietary fat had significantly lower circulating α-tocopherol concentrations than birds that consumed lower total dietary fat (p < 0.001). Additionally, plasma cholesterol concentrations of managed plains-wanderers were found to be significantly greater than all other bird species reviewed, irrespective of Family or feeding type. We also present the first published data quantifying the nutritional makeup of stomach contents of a wild plains-wanderer for use as a potential guide for diet formulation. This study forms a vital foundational insight into the nutritional management of plains-wanderers, but further research is required to understand their dietary habits and cholesterol metabolism. </p>
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency
<p>Vitamin B12 is critical for hematopoiesis and myelination. Deficiency can cause neurologic deficits including loss of coordination and cognitive decline. However, diagnosis relies on vitamin B12 measurement in the blood which may not accurately reflect levels in the brain. Using programmable phage display, we identified an autoantibody targeting the transcobalamin receptor (CD320) in a patient with progressive tremor, ataxia, and scanning speech. Anti-CD320 impaired cellular uptake of cobalamin (B12) <em>in vitro</em>. Despite normal serum levels, B12 was nearly undetectable in her cerebrospinal fluid (CSF). Immunosuppressive treatment and high-dose systemic B12 supplementation were associated with increased CSF B12 levels and clinical improvement. Optofluidic screening enabled rapid isolation of a patient-derived monoclonal antibody that impaired B12 transport across an <em>in vitro</em> model of the blood-brain barrier. Autoantibodies targeting the same epitope of CD320 were identified in 7 other patients with neurologic deficits of unknown etiology, in 6% of healthy controls, and in 21.4% of a neuropsychiatric lupus cohort. In 132 paired serum and CSF samples, detection of anti-CD320 in the blood predicted B12 deficiency in the brain. However, these individuals did not display any hematologic signs of B12 deficiency despite systemic CD320 impairment. Using a genome-wide CRISPR screen, we discovered that the LDL receptor serves as an alternative B12 uptake pathway in hematopoietic cells. These findings dissect the tissue-specificity of B12 transport and elucidate an autoimmune neurologic condition that may be amenable to immunomodulatory treatment and nutritional supplementation.</p>
The role of rehabilitation and vitamin D supplementation on motor and psychological outcomes in poststroke patients.
<p>Post-Stroke depression affects between 12% and 72% of patients who have suffered a stroke. The association between low serum levels of 25-hydroxyvitamin D (25(OH) D) and increased risk of depression is reported in both stroke and non-stroke patients. Similarly, high 25(OH) D levels might be associated with greater functional improvement during rehabilitation program.</p> <p>We wanted to investigate the effects of an intensive rehabilitation on poststroke outcomes. We wondered if the daily rehabilitation of motor and cognitive functions could also have an effect on mood and functional abilities in addition to or as an alternative to vitamin D supplementation.</p> <p>We conducted a 12-week, randomized trial, double blind, parallel, monocentric clinical trial of 40 patients undergoing intensive neuro-rehabilitation treatment at a specialized care facility for ischemic or hemorrhagic brain stroke. Participants were randomly assigned, in a 1:1 ratio, to 1 of 2 parallel groups: in the experimental group, 2000 IU/day of oral cholecalciferol was administered; in the control group patients were not taking vitamin D supplementation. Patients underwent a text evaluation to investigate psychological and motor outcomes.</p> <p>Significant intra-group difference in outcomes measures was found but not between control group and experimental group. In the vitamin D group, we highlighted significant differences between T0 and T1 in calcium (<em>P</em> < .001), vitamin D (<em>P</em> < .001), in Montgomery Aasberg Depression Rating Scale (<em>P</em> = .001), and in Functional Independent Measures (<em>P</em> < .001). In the health control group, we found a significant difference in calcium (<em>P</em> = .003), vitamin D (<em>P</em> < .001), Montgomery Aasberg Depression Rating Scale (<em>P</em> = 0.006), in general self-efficacy (<em>P</em> = .009), and in Functional Independent Measures (<em>P</em> < .001).</p> <p>Our results show that the beneficial effect on mood and functional recovery is mainly due to neurorehabilitation rather than vitamin D supplementation.</p>
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