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287 results for “adverse effects”
Adverse Effects of RBC Transfusions: A Unifying Hypothesis
ClinicalTrials.gov study NCT00838331. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Paclitaxel, Bevacizumab and Pemetrexed in Patients With Untreated, Advanced Non-Small Cell Lung Cancer Using Web-Based Data Collection, Patient Self-Reporting of Adverse Effects and Automated Response
ClinicalTrials.gov study NCT00807573. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effects of Online Mindfulness Therapy on Pain and Stress in Adults With Chronic Migraine and Adverse Childhood Experiences
ClinicalTrials.gov study NCT07033520. IPD Sharing: NO. Countries: 1. Publications: 5.
Efficacy of Orally Disintegrating Selegiline in Parkinson's Patients Experiencing Adverse Effects With Dopamine Agonists
ClinicalTrials.gov study NCT00443872. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Adverse effects of remdesivir, hydroxychloroquine, and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomized trials
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Data from: Differential effects of early life adversity on male and female rhesus macaque lifespan
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3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects
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Data from: Single cell RNA-seq analysis reveals that prenatal arsenic exposure results in long-term, adverse effects on immune gene expression in response to Influenza A infection
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Meerkat helpers buffer the detrimental effects of adverse environmental conditions on fecundity, growth and survival
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Untargeted LC–MS metabolomics reveals an adverse effect of high-fat diet on hepatic metabolism of Oreochromis niloticus
<p>Hepatic steatosis commonly occurs in intensively farmed tilapia. This disease is harmful to fish growth and health, but knowledge of the metabolic changes in tilapia with fatty liver is limited. In the present study, we compared genetically improved farmed tilapia (GIFT, <em>Oreochromis niloticus</em>) fed a high-fat diet (HFD) with those fed a normal-fat diet (NFD) for 8 weeks using LC-MS-based hepatic metabolomic assays and traditional nutritional assessments. Juvenile GIFT fed a HFD displayed higher fat disposition in the liver than did those fed a NFD. The metabolomic analyses revealed 61 differentially accumulated metabolites between the groups, and these metabolites were involved in 37 signaling pathways. Our results illustrate the development of metabolic disorders related to various hepatic biological processes, including protein metabolism, lipid metabolism, carbohydrate metabolism, and nucleotide metabolism in HFD-fed GIFT. These physiological changes may be related to the lower growth rate of GIFT. Overall, our study reveals the metabolic disorders in GIFT fed HFD, and enhance our knowledge of the mechanism of fatty liver formation in GIFT.</p>
Data from: Intergenerational effects of early adversity on survival in wild baboons
Early life adversity can affect an individual's health, survival, and fertility for many years after the adverse experience. Whether early life adversity also imposes intergenerational effects on the exposed individual's offspring is not well understood. We fill this gap by leveraging prospective, longitudinal data on a wild, long-lived primate. We find that juveniles whose mothers experienced early life adversity exhibit high mortality before age 4, independent of the juvenile's own experience of early adversity. These juveniles often preceded their mothers in death by 1 to 2 years, indicating that high adversity females decline in their ability to raise offspring near the end of life. While we cannot exclude direct effects of a parent's environment on offspring quality (e.g., inherited epigenetic changes), our results are completely consistent with a classic parental effect, in which the environment experienced by a parent affects its future phenotype and therefor e its offspring's phenotype.
Female preference and adverse developmental effects of glyphosate-based herbicides on ecologically relevant traits in Japanese quail
<p>Controversial glyphosate-based herbicides (GBHs) are the most frequently used herbicides globally. An increasing number of studies have identified GBH residues in soil, water and even human food that may expose non-target organism including wildlife, livestock, and humans to health risks. After a heated debate, European Union allowed the use of GBHs to continue until 2022, after which their risks will be re-evaluated. Thus, decision makers urgently need scientific evidence on GBH residues and their possible effects on ecosystems. An important, yet neglected, aspect is to assess whether animals show preference or avoidance for GBH contaminated food, as it can influence the likelihood of adverse health effects in wildlife. Here, using Japanese quails (<i>Coturnix japonica</i>) as our model, we show that females preferred GBH-contaminated food compared to control food. In females, exposure to GBHs caused delayed plumage development, and GBH residues were present in eggs, muscles and liver. These results indicate that female preference is not adaptive, potentially exposing non-target animals to greater risk of adverse effects of GBHs in natural and agricultural environments. Our results on tissue residues suggest that further studies are needed to understand the risks of such residues in the food chain.</p>
Lipidomics and metabolomics datasets for "Adverse effects of arsenic uptake in rice metabolome and lipidome revealed by untargeted liquid chromatography coupled to mass spectrometry (LC-MS) and regions of interest multivariate curve resolution"
<p><strong>Files description</strong></p> <p>Raw files for lipidomics and metabolics studies on the impact of arsenic exposure on rice growth.</p> <p>File details on the worksheets lipids_files.xlsx and metabolomics_files.xlsx</p> <p>Files have been organized as follows:</p> <p><strong>Lipidomics</strong></p> <blockquote> <p>1) Control samples: lip_controls.rar<br> 2) Watering low As exposure: lip_water_1.rar<br> 3) Watering high As exposure: lip_water_1000.rar<br> 4) Soil low As exposure: lip_soil_5.rar<br> 5) Soil high As exposure: lip_soil_50.rar<br> 6) QC samples: lip_qcs.rar</p> </blockquote> <p><strong>Metabolomics (positive ionization mode)</strong></p> <blockquote> <p>1) Control samples: met_pos_controls.rar<br> 2) Watering low As exposure: met_pos_water_1.rar<br> 3) Watering high As exposure: met_pos_water_1000.rar<br> 4) Soil low As exposure: met_pos_soil_5.rar<br> 5) Soil high As exposure: met_pos_soil_50.rar<br> 6) QC samples: met_pos_qcs.rar</p> </blockquote> <p><strong>Metabolomics (negative ionization mode)</strong></p> <blockquote> <p>1) Control samples: met_neg_controls.rar<br> 2) Watering low As exposure: met_neg_water_1.rar<br> 3) Watering high As exposure: met_neg_water_1000.rar<br> 4) Soil low As exposure: met_neg_soil_5.rar<br> 5) Soil high As exposure: met_neg_soil_50.rar<br> 6) QC samples: met_neg_qcs.rar<br> </p> </blockquote> <p> </p> <p><strong>Experimental details</strong></p> <blockquote> <p><strong>Arsenic Exposure</strong></p> <p>Arsenic was supplied through two main routes: watering with contaminated water or soil containing arsenic. In addition, this new study includes metabolomic as well as lipidomic analysis, in order to have a more global overview of arsenic exposure.</p> <p>For the watering treatment, during the first 11 days, rice was irrigated with Milli-Q water. From that day until harvesting, plants were watered with 1 and 1000 μM of As (V) for the two concentration levels of exposure, and with Milli-Q water for control samples. The lowest concentration was established at 1 μM as it is the limit of the acceptable arsenic concentration in water by European legislation. The upper concentration was set at 1000 μM, a threshold established to ensure that the experiment was performed under sub-lethal arsenic concentration for the plant, based on previous studies.</p> <p>For the soil treatment, two containers were prepared with 1 kg of soil two days before planting. Soil from the container was exposed to two arsenic concentration levels (5 and 50 mg L<sup>-1</sup>). Once sowing, rice was irrigated the whole growth period with a solution containing 0.001 μM of As (V). The lowest arsenic limit in this treatment was set at 5 mg L<sup>-1</sup> as a maximum value of common arsenic leaches without toxic characteristics, although background soil content of arsenic varies between one and 40 ppm according to the US food and drug administration (FDA) report. The highest arsenic limit was established to 50 mg L<sup>-1</sup>, as a considerably high arsenic content in the soil, slightly above the maximum frequently encountered levels.</p> <p><strong>Lipidomic Analysis</strong></p> <p>The lipidomic analysis was performed using a Waters Acquity UPLC system (Waters Corporation, MA, USA), connected to a Waters LCT Premier orthogonal accelerated time of flight mass spectrometer (Waters), operated in both positive and negative electrospray (ESI) ionization modes. Full scan spectra were acquired from 50 to 1500 Da.</p> <p>The chromatographic column employed was a Kinetex C8 (100 x 2.1 mm, 1.7 μm) (Phenomenex) under the following conditions (already used in [47]): temperature at 30˚C, injection volume at 10 μL, and flow rate at 0.3 mL min<sup>-1</sup>. Mobile phases selected were (A) MeOH 1mM ammonium formate, and (B) H<sub>2</sub>O 2mM ammonium formate, both at 0.2% formic acid. The gradient started at 80% A, increased to 90% A in 3 min, from 3 to 6 min remained at 90% A, changed to 99 % A until minute 15, remained constant 1 min, and returned to initial conditions until minute 20.</p> <p><strong>Metabolomic analysis</strong></p> <p>The metabolomic analysis was performed using a Waters Acquity UPLC system connected to a Q-Exactive (Thermo Fisher Scientific, Hemel Hempstead, UK) equipped with a quadrupole-Orbitrap mass analyzer. Electrospray (ESI) was used as an ionization source in both positive and negative ion modes. Full scan mass range was set from <em>m/z</em> 90 to 1000, and all ion fragmentation (AIF) was performed with normalized collision energy (NCE) of 35 eV.</p> <p>The column employed was an HILIC TSK gel amide-80 column (250 x 2.0 mm i.d., 5 μm) provided by Tosoh Bioscience (Tokyo, Japan), under the following experimental conditions (already employed in [45]): flow rate at 0.15 mL min<sup>-1</sup>, at room temperature, and 5 μL injection volume. Mobile phases were (A) AcN, and (B) 5 mM ammonium acetate, adjusted at pH 5.5 with acetic acid. The gradient employed was: starting conditions at 25% B, then increased until 30% B in 8 min; a 60% B was reached at 10 min, held for 2 min more and then back to 25% B until minute 14 min; lastly, a re-equilibration step was added and from 14 to 20 min at 25% B.</p> </blockquote> <p> </p> <p><strong>Funding:</strong> This research was funded by the Spanish Ministry of Science and Innovation (MCI, Grant CTQ2017-82598-P) and Severo Ochoa Project CEX2018-000794-S (funded by MCIN/AEI/ 10.13039/501100011033), and supported from the Catalan Agency for Management of University and Research Grants (AGAUR, Grant 2017SGR753). MPC was funded by a predoctoral FPU 16/02640 scholarship from the Spanish Ministry of Education and Vocational Training (MEFP). </p> <p> </p>
Mediating effects of Trait Emotional Intelligence on the association between Adverse Childhood Experiences (ACEs) and Self-reported Health
<p>Data for two studies which investigate the role of trait emotional intelligence in resilience following adverse childhood experiences. </p>
Elevated CO2 alleviates adverse effects of drought on plant water relations and photosynthesis: a global meta-analysis
<p><span>1. </span><span>The elevated CO2 concentration (eCO2) is expected to improve plant water relations and carbon (C) uptakes, with a potential to mitigate drought stress. However, the interactive effects of eCO2 and drought on plant physiology and growth are not clear. </span></p> <p><span>2. </span><span>We performed a meta-analysis on the interactive effects of eCO2 and drought on plant water relations, photosynthesis, biomass production and allocation. </span></p> <p><span>3. </span><span>We found that eCO2 did not lead to conservation of soil water, but improved leaf water status under drought conditions as evidenced by a higher leaf relative water content and a less negative midday leaf water potential, resulting from reduced stomatal conductance (gs) and increased root to shoot ratio. Elevated CO2 retarded gs response to drought, which may be mediated by decreases in leaf abscisic acid concentration under eCO2 and drought. Drought imposed stomatal limitations on photosynthesis (A), which was alleviated by eCO2 via increasing intercellular CO2 concentration (Ci). This led to a stronger A response to eCO2 under drought, supporting the "low Ci effect". However, no interaction of eCO2 and drought was detected on plant biomass production. Intrinsic water use efficiency (iWUE) increased proportionally with eCO2, while plant-scale WUE was less responsive to eCO2 regardless of water availability. The advantages of eCO2 on C3 plants over C4 plants under well-watered conditions diminished under drought conditions. Within C3 plants, drought caused a greater reduction in biomass for woody plants than for herbs. Biomass declined progressively as drought prolonged for plants growing in both ambient CO2 and eCO2. The physiology and biomass of plants growing in pots showed more negative responses to drought than those growing in field. Biomass increase in free-air carbon dioxide enrichment experiments was significantly less than those in growth chamber and open top chamber experiments. </span></p> <p><span>4. </span><span>Synthesis</span><span>. These findings suggest that eCO2 can alleviate the adverse impacts of drought on plant water relations and C sequestration, and are of significance in the prediction of plant growth and ecosystem productivity under global changes.</span></p>
Blasting Quarry Operations: Adverse And Cumulative Effects, Lawsuits And Complaints, And Suggested Remedies
<p>Breaking rock for road construction, installation of infrastructure or for extraction typically involves detonation of explosives. Any time explosives are detonated there are undesirable impacts on the environment and its inhabitants, which are always more severe in populated areas of significant human and non-human activity. The primary focus of this paper is on the impact that blasting quarry operations have on the environment and its inhabitants. A number of civil cases, investigations, published articles and press releases documenting the adverse and cumulative effects of blasting rock are presented, discussed and analyzed. The extensive number of documented cases and media reports of the adverse and cumulative effects of blasting quarry operations on the environment and its inhabitants shed light on the gas lighting strategy employed by the aggregate industry and their explosives engineers to alter the public’s perception of reality by consistently and repeatedly claiming that blasting within regulatory limits cannot cause structural damage and that the vibrations felt from blasting are no more than a minor inconvenience. Gas lighting is a form of psychological manipulation in which the abusers, in this case the aggregate industry and its explosives engineers, attempt to sow self-doubt and confusion in the minds of their victims, and to mislead approval authorities and cause them to question their own judgment and intuition from a practical non-theoretical perspective. The research conducted supports reducing Peak Particle Velocity (PPV) to a maximum of 2 mm per second measured along the entire perimeter of a blasting quarry operation, combined with a permanent onsite 500-metre setback and offsite minimum separation distance of 1,000 metres from incompatible land uses to minimize damage from structural response to ground vibrations and airblast (concussion), and to eliminate or reduce substantially lawsuits and complaints from residents exposed to the adverse impacts of blasting. None of the <span>adverse effects </span>prohibited under the <span>Ontario </span>Environmental Protection Act are permitted to impact public or private third-party properties beyond the boundary of an existing or proposed blasting or non-blasting quarry operation.</p>
Adverse effects of chemotherapy on the teeth and surrounding tissues of children with cancer: a systematic review with meta-analysis
<p>Datasets of the journal publication.</p>
Supplementary tables for the paper: "Comprehensive computational analysis via Adverse Outcome Pathways and Aggregate Exposure Pathways in exploring synergistic effects from radon and tobacco smoke on lung cancer."
<p><strong>Authors</strong>:<br>Thomas Jaylet, Vinita Chauhan, Laura Mezquita, <em>Nadia Boroumand</em><em>, </em>Olivier Laurent, <em>Karine Elihn</em><em>, Lovisa Lundholm</em><em>, </em>Olivier Armant, Karine Audouze</p>
Data from: Density-dependent dispersal strategy of pollinator moderates the adverse effect of habitat loss on plant reproduction
<p><span>1. </span><span>Major challenges for plant conservation are predicting the effect of habitat loss on pollination success and plant reproduction </span><span>potential</span><span>. Most studies report that pollinator movement is affected by quantitative and spatial characteristics of landscapes. However, little is known about the role of pollinator movement, impacted by floral volatiles and intraspecies interaction, on plant reproduction in fragmented landscapes.</span></p> <p><span>2. </span><span>To clarify the effect of pollinator movement on plant reproduction </span><span>relative to </span><span>habitat loss, we developed an integrated model incorporating pollinator's foraging response with its </span><span>dispersal</span> <span>process mediated by a density-dependent dispersal (DDD) strategy</span><span>.</span> <span>This model</span> <span>performed better in capturing behaviorals response of pollinators than do current methods. The integrated model was verified with field results of pollinator visitation and plant reproduction of saltcedar (<em>Tamarix</em> <em>chinensis</em>) inhabiting the Yellow River Delta, and then was compared against a dispersal strategy called density-independent dispersal (DID). The model was applied to landscapes with various non-habitat percentage (<em>NHP</em>) to explore the effect of habitat loss on plant reproduction.</span></p> <p><span>3. </span><span>Results suggested that saltcedar populations differ in their responses to habitat loss, which depended on the spatial scales considered. At landscape scale, increasing <em>NHP</em> significantly inhibited the dispersion extent of floral volatiles and therefore reduced pollinator visitation and subsequent seed production, especially when <em>NHP</em> exceeded the critical threshold of 0.6.</span> <span>However, at patch scale, comparing with DID strategy, the DDD strategy enabled pollinators to increase their utilization of flowers by 43.42% and 6.79% in low-density and distant plant patches, whereas their utilization was reduced by 7.75% and 2.24% in high-density and central patches, respectively. </span><span>Plant reproduction was improved correspondingly</span> <span>in low-density and distant patches under different <em>NHP</em>s.</span></p> <p><span>4. </span><span>Consequently, habitat loss inhibits the volatiles dispersion and interferes with the foraging success of pollinators, a major factor influencing plant reproduction at landscape scale. At patch scale, adaptive utilization of pollinators exhibiting DDD strategy alleviates the negative effect of habitat loss on plant production and maintains plant population persistence. Since pollinator behavioral response is critical to plant reproduction, we recommend the use of the here-presented integrated model to assess the impact of habitat loss on plant reproduction.</span></p>
Effect of Oxygen Therapy for Patients With Precapillary Pulmonary Hypertension Who Experience an Altitude Related Adverse Health Effect (ARAHE) During 30h Exposure to 2500m
ClinicalTrials.gov study NCT05112172. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.