Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
235
datasets available to search
ShareScore release 0.9.0
Dataset results
235 results for “age-dependence”
Data from: Age-dependent changes in infidelity in Seychelles warblers
Open the record for dataset details and reuse information.
PI3K block restores age-dependent neurovascular coupling defects associated with cerebral small vessel disease
Open the record for dataset details and reuse information.
An age-dependent ovulatory strategy explains the evolution of dizygotic twinning in humans
Open the record for dataset details and reuse information.
Time spares no male: The age-dependent decline of olfactory attractiveness in red flour beetles <em>Tribolium castaneum</em>
Open the record for dataset details and reuse information.
Age-dependent genetic variation in aggression
Open the record for dataset details and reuse information.
Data and code from: Cholecystokinin modulates age-dependent thalamocortical neuroplasticity
Open the record for dataset details and reuse information.
Data from: Age-dependent hypopharyngeal gland size and protein content of stingless bee workers, Tetragonula pagdeni.
Open the record for dataset details and reuse information.
Inter-annual repeatability and age-dependent changes in plasma testosterone levels in a longitudinally monitored free-living passerine bird
Open the record for dataset details and reuse information.
Age-dependent modulation of bone metabolism in zebrafish scales as new model of male osteoporosis in lower vertebrates
<p>After middle age, in human bone, the resorption usually exceeds formation resulting in bone loss and increased risk of fractures in the aged population. Only few in vivo models in higher vertebrates are available for pathogenic and therapeutic studies about bone aging. Among these, male Danio rerio (zebrafish) can be successfully used as low vertebrate model to study degenerative alterations that affect the skeleton during aging, reducing the role of sex hormones.In this paper, we investigated the early bone aging mechanisms in male zebrafish (3, 6, 9 months old) scales evaluating the physiological changes and the effects of prednisolone, a pro-osteoporotic drug.The results evidentiated an age-dependent reduction of the mineralization rate in the fish scales, as highlighted by growing circle measurements. Indeed, the osteoblastic ALP activity at the matrix deposition site was found progressively downregulated.The higher TRAP activity was found in 63% of 9-month-old fish scales associated with resorption lacunae along the scale border. Gene expression analysis evidentiated that an increase of the tnfrsf1b (homolog of human rank) in aging scales may be responsible for resorption stimulation.Interestingly, prednisolone inhibited the physiological growth of the scale and induced in aged scales a more significant bone resorption compared with untreated fish (3.8% vs 1.02%). Bone markers analysis shown a significant reduction of ALP/TRAP ratio due to a prednisolone-dependent stimulation of tnfsf11 (homolog of human rankl) in scales of older fish.The results evidentiated for the first time the presence of a senile male osteoporosis in lower vertebrate. This new model could be helpful to identify the early mechanisms of bone aging and new therapeutic strategies to prevent age-related bone alterations in humans.</p>
The Age-dependent Changes of the Human Adrenal Cortical Zones Are Not Congruent SUPPLEMENTAL DATA
<p>Supplemental tables 1 and 2.</p>
Data from: Demographic drivers of age-dependent sexual selection
Sexual selection has a critical role in evolution, and it is fundamental to identify what ecological factors drive its variation. Disentangling the ecological correlates of sexual selection over the long term, however, is challenging and has rarely been done in nature. We sought to assess how demographic changes influenced the intensity, direction and form of sexual selection and whether selective pressures varied with age. We tested whether breeder sex ratio, number of competitors and age structure influenced selection differentials on horn length of wild bighorn rams (Ovis canadensis) of different age classes on Ram Mountain, Alberta. We used 21 years of data including a detailed pedigree, demographic parameters and repeated morphological measurements. Sexual selection on horn length of males of all ages was directional and positive. Selection intensity increased with the number of competitors, reflecting male–male encounter rate during the rut, but was independent of breeder sex ratio or age structure. This result can also be linked to changes in population size because the number of competitors was highly correlated to total number of sheep. This demographic effect likely arises from age-dependent mating tactics. Males aged 2–4 years are weakly competitive and experienced stronger sexual selection as they accounted for a greater proportion of all males. Selection experienced by mature males appeared independent of demography. Our study provides a rare description of the demographic determinants of sexual selection in nature.
Data from: Age-dependent trajectories differ between within-pair and extra-pair paternity success
Reproductive success is associated with age in many taxa, increasing in early life followed by reproductive senescence. In socially monogamous, but genetically polygamous species, this generates the interesting possibility of differential trajectories of within-pair and extra-pair siring success with age in males. We investigate these relationships simultaneously using within-individual analyses with 13 years of data from an insular house sparrow (Passer domesticus) population. As expected, we found that both within- and extra-pair paternity success increased with age, followed by a senescence-like decline. However, the age trajectories of within- and extra-pair paternity successes differed significantly, with the extra-pair paternity success increasing faster, albeit non-significantly so, in early life, and showing a delayed decline by 1.5 years on average later in life compared to within-pair paternity success. These different trajectories indicate that the two alternative mating tactics should have age-dependent payoffs. Males may partition their reproductive effort between within- and extra-pair matings depending on their current age in order to reap the maximal combined benefit from both strategies. The interplay between these mating strategies and age-specific mortality may explain the variation in rates of extra-pair paternity observed within and between-species.
Individual variation in age-dependent reproduction: fast explorers live fast but senesce young?
<p>1. Adaptive integration of life history and behaviour is expected to result in variation in the pace-of-life. Previous work focused on whether "risky" phenotypes live-fast-but-die-young, but reported conflicting support. We posit that individuals exhibiting risky phenotypes may alternatively invest heavily in early-life reproduction but consequently suffer greater reproductive senescence.<br> 2. We used a 7-year longitudinal dataset with >1200 breeding records of >800 female great tits assayed annually for exploratory behaviour to test whether within-individual age-dependency of reproduction varied with exploratory behaviour. We controlled for biasing effects of selective (dis)appearance and within-individual behavioural plasticity.<br> 3. Slower and faster explorers produced moderate-sized clutches when young; faster explorers subsequently showed an increase in clutch size that diminished with age (with moderate support for declines when old), whereas slower explorers produced moderate-sized clutches throughout their lives. There was some evidence that the same pattern characterized annual fledgling success, if so, unpredictable environmental effects diluted personality-related differences in this down-stream reproductive trait.<br> 4. Support for age-related selective appearance was apparent, but only when failing to appreciate within-individual plasticity in reproduction and behaviour.<br> 5. Our study identifies within-individual age-dependent reproduction, and reproductive senescence, as key components of life history strategies that vary between individuals differing in risky behaviour. Future research should thus incorporate age-dependent reproduction in pace-of-life studies.</p>
In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease
<p>Supplementary datasets (Supplementary tables 1 to 10)</p>
Pathogenic LRRK2 causes age-dependent and region-specific deficits in ciliation, innervation and viability of cholinergic neurons_1
Open the record for dataset details and reuse information.
Age-Dependent Pulmonary Reactivity to House Dust Mite Allergen: A Model of Adult-Onset Asthma?
<p>3mo and 9mo mice treated with HDM or PBS. Right lung lavages and fixed in 4% PFA. Table represents average IHC scores for 6 different antibodies: IFN-gamma, IL-4, IL-13, IL-17A, Eotaxin-1, CD-4</p>
Modelling and simulating age-dependent pedestrian behaviour with an autonomous vehicle
<p>Video "1_SimulationWithoutAgel" shows the simulation before the modifications of the model and the implementation.</p> <p>Video "2_SimulationWithAge" shows the simulation after the modifications of the model and the implementation depending on the age data.</p> <p> </p> <p>Videos of the article: "Modelling and simulating age-dependent pedestrian behaviour with an autonomous vehicle"</p> <p>Abstract: In shared spaces, autonomous vehicles (AVs) will have to move efficiently and safely, without normal road signage, and with other users such as pedestrians, cyclists and drivers. To achieve this, AVs need to anticipate the behaviours of other road users in order to adapt their navigation accordingly. This paper focuses on age-related pedestrian behaviours with an autonomous vehicle. Looking at age as one of the main factors determining behaviour, a literature review is conducted. The results are used to integrate age-dependent pedestrian behaviours into a model for simulating more realistic pedestrian behaviours in shared spaces with an AV.</p>
Age-dependency of Cornea Biomechanics Using OCT Vibrography
ClinicalTrials.gov study NCT03230981. IPD Sharing: NO. Countries: 1. Publications: 3.
Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men
ClinicalTrials.gov study NCT03315325. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Age-dependent Effects of Flavanols on Vascular Status
ClinicalTrials.gov study NCT01639781. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.