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140
datasets available to search
ShareScore release 0.9.0
Dataset results
140 results for “articular cartilage”
Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage Defects
ClinicalTrials.gov study NCT01694823. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Knee Articular Cartilage Debridement in Conjunction With Partial Meniscectomy
ClinicalTrials.gov study NCT00613535. IPD Sharing: Not stated. Countries: 1. Publications: 15.
The Anabolic and Catabolic Effect of Loaded and Unloaded Exercise on Articular Cartilage Health
ClinicalTrials.gov study NCT05925244. IPD Sharing: NO. Countries: 1. Publications: 1.
The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects
ClinicalTrials.gov study NCT00891501. IPD Sharing: Not stated. Countries: 1. Publications: 3.
HyaloFAST Trial for Repair of Articular Cartilage in the Knee
ClinicalTrials.gov study NCT02659215. IPD Sharing: NO. Countries: 9. Publications: 1.
Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women
ClinicalTrials.gov study NCT05889598. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Safety, Tolerability, Preliminary Efficacy of Intra-articular LNA043 Injections in Patients With Articular Cartilage Lesions and Knee Osteoarthritis.
ClinicalTrials.gov study NCT03275064. IPD Sharing: YES. Countries: 3. Publications: 0.
The Effect of High Impact Exercise on Bone and Articular Cartilage in Post-menopausal Women
ClinicalTrials.gov study NCT03225703. IPD Sharing: YES. Countries: 1. Publications: 1.
Hyaluronic acid-binding, anionic, nanoparticles inhibit ECM degradation and restore compressive strength in aggrecan-depleted articular cartilage explants
Open the record for dataset details and reuse information.
Distal interphalangeal joint capsule enthesopathy of the middle phalanx and articular cartilage loss
Open the record for dataset details and reuse information.
The effect of intra-articular injection of secretome of umbilical cord mesenchymal stem cells in articular cartilage repair in sheep model
<p><b>Introduction: </b>Articular cartilage is an avascular, aneural, and alymphatic tissue that has limited capacity to regenerate. Numerous techniques have been employed to repair or regenerate; however, the success rate varies. In fact, most of them result in the formation of fibrocartilage, not hyaline cartilage. The future of treating cartilage defects lies in providing biologic solutions through cartilage regeneration. Mesenchymal stem cells (MSCs) represent a promising therapy for cartilage regeneration. These cells secrete factors that enhance cartilage repair. In this study, the effects of intra-articular injection of human umbilical cord MSC (hUC-MSC) secretome on cartilage damage was studied in a sheep model.</p> <p><b>Methods: </b>Standardized rectangular (5x5 mm) full-thickness chondral defects were created in the lateral femoral condyle of 15 adult sheep and debrided down to the subchondral bone plate. Three treatment groups were tested: 4 microfracture perforations using 1.0mm diameter awls (group 1), intra-articular injection of hUC-MSC secretome (group 2), and combination of microfracture and intra-articular injection of hUC-MSC secretome (group 3). Osteochondral repair was assessed at 6 months in vivo using established macroscopic and histological analyses.</p> <p><b>Results: </b><b></b> Macroscopically, application of combined therapy shows significant improvement of cartilage repair compared to microfracture alone (p=0.004). Microscopically, the application of combined therapy shows significant improvement of cartilage repair compared to secretome injection alone (p=0.031)</p> <p><b>Conclusion:</b> Microfracture combined with injection of hUCB-MSCs secretome could be an effective alternative for repairing articular cartilage defects in vivo.</p>
Contrast solution properties and scan parameters influence the apparent diffusivity of computed tomography contrast agents in articular cartilage
<p>The inability to detect early degenerative changes to the articular cartilage surface that commonly precede bulk osteoarthritic degradation is an obstacle to early disease detection for research or clinical diagnosis. Leveraging a known artifact that blurs tissue boundaries in clinical arthrograms, contrast agent diffusivity can be derived from computed tomography arthrography (CTa) scans. We combined experimental and computational approaches to study protocol variations that may alter the CTa-derived apparent diffusivity. In experimental studies on bovine cartilage explants, we examined how contrast agent dilution and transport direction (absorption vs. desorption) influence the apparent diffusivity of untreated and enzymatically digested cartilage. Using multiphysics simulations, we examined mechanisms underlying experimental observations and the effects of image resolution, scan interval and early scan termination. The apparent diffusivity during absorption decreased with increasing contrast agent concentration by an amount similar to the increase induced by tissue digestion. Models indicated that osmotically induced fluid efflux strongly contributed to the concentration effect. Simulated changes to spatial resolution, scan spacing and total scan time all influenced the apparent diffusivity, indicating the importance of consistent protocols. With careful control of imaging protocols and interpretations guided by transport models, CTa-derived diffusivity offers promise as a biomarker for early degenerative changes.</p>
T2 orientation anisotropy mapping of articular cartilage using qMRI
<p>Data and codes for publication entitled "T2 orientation anisotropy mapping of articular cartilage using qMRI"</p>
Study to Evaluate the Safety and Performance of Treatment of Articular Cartilage Lesions Located on the Femoral Condyle With gelrinC
ClinicalTrials.gov study NCT00989794. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors
ClinicalTrials.gov study NCT00111241. IPD Sharing: NO. Countries: 1. Publications: 0.
Autologous Cell-derived Tissue Engineered Cartilage for Repairing Articular Cartilage Lesions
ClinicalTrials.gov study NCT02770209. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial
ClinicalTrials.gov study NCT04210986. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of Safety and Exploratory Efficacy of CARTISTEM®, a Cell Therapy Product for Articular Cartilage Defects
ClinicalTrials.gov study NCT01733186. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Study to Assess the Safety of Treatment of Articular Cartilage Lesions With CartiLife®
ClinicalTrials.gov study NCT03517046. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Study to Assess the Efficacy and Safety of Treatment of Articular Cartilage Lesions With CartiLife®
ClinicalTrials.gov study NCT03545269. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.