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ShareScore release 0.9.0
Dataset results
90 results for “cardiovascular system”
The Impact of Selected Factors on the Cardiovascular System in Chronic Kidney Disease
ClinicalTrials.gov study NCT05214872. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Association Analysis of Cardiovascular and Nervous System Diseases and Intestinal Microbiome Based on Multi-omics Big Data and Related Applications
ClinicalTrials.gov study NCT06099496. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Acute Intermittent Porphyria Related Abnormalities in Cardiovascular System
ClinicalTrials.gov study NCT05882136. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress
<p><span><span><span><span><span><span><span><span><span><span><span>Adrenomedullin (AM) is a peptide hormone with multiple physiological functions, which are regulated by its receptor activity-modifying proteins, RAMP2 and RAMP3. We previously reported that AM or RAMP2 knockout (AM-/-, RAMP2-/-) is embryonically lethal in mice, whereas RAMP3-/- mice are apparently normal. AM, RAMP2 and RAMP3 are all highly expressed in the heart; however, their functions there are not fully understood. Here, we analyzed the pathophysiological functions of the AM-RAMP2 and AM-RAMP3 systems in hearts subjected to cardiovascular stress.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>Cardiomyocyte-specific RAMP2-/- (C-RAMP2-/-) and RAMP3-/- showed no apparent heart failure at base line. After one week of transverse aortic constriction (TAC), however, C-RAMP2-/- exhibited significant cardiac hypertrophy, decreased ejection fraction and increased fibrosis as compared to wild-type mice. Both dP/dtmax and dP/dtmin were significantly reduced in C-RAMP2-/-, indicating reduced ventricular contractility and relaxation. Exposing C‑RAMP2‑/- cardiomyocytes to isoproterenol enhanced their hypertrophy and oxidative stress as compared to wild-type cells. C‑RAMP2‑/- cardiomyocytes also contained fewer viable mitochondria and showed reduced mitochondrial membrane potential and respiratory capacity. RAMP3-/- also showed reduced systolic function and enhanced fibrosis after TAC, but those only became apparent after 4 weeks. A reduction in cardiac lymphatic vessels was the characteristic feature in RAMP3-/-.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span>These observations indicate the AM-RAMP2 system is necessary for early adaptation to cardiovascular stress through regulation of cardiac mitochondria. AM-RAMP3 is necessary for later adaptation through regulation of lymphatic vessels. The AM-RAMP2 and AM-RAMP3 systems thus play separate critical roles in the maintenance of cardiovascular homeostasis against cardiovascular stress.</span></span></span></span></span></span></span></span></span></span></span></p>
Clinical Decision Support System for Remote Monitoring of Cardiovascular Disease Patients
ClinicalTrials.gov study NCT05196802. IPD Sharing: YES. Countries: 0. Publications: 11.
The Effect of Left Uterine Displacement on Parturient Cardiovascular System
ClinicalTrials.gov study NCT02828176. IPD Sharing: UNDECIDED. Countries: 0. Publications: 4.
Cardiovascular System in Obesity: Effect of Treatment
ClinicalTrials.gov study NCT00000506. IPD Sharing: Not stated. Countries: 0. Publications: 9.
Testosterone Patch's Effects on the Cardiovascular System and Libido
ClinicalTrials.gov study NCT01208038. IPD Sharing: NO. Countries: 1. Publications: 0.
Relation of Antibodies Against Oxidized Low Density Lipoproteins to Disease Activity and Cardiovascular Affection in Systemic Lupus.
ClinicalTrials.gov study NCT05479071. IPD Sharing: NO. Countries: 0. Publications: 5.
The Impact of Subclinical Hypothyroidism on Cardiovascular System
ClinicalTrials.gov study NCT04236232. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Data from: Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress
Open the record for dataset details and reuse information.
Long non-coding RNA TYKRIL controls pericyte function and survival in the cardiovascular and central nervous system through regulation of p53 activity and PDGFRß expression
GEO Series GSE84730. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Cholesin Receptor Signalling is Active in Cardiovascular System-Associated Adipose Tissue and Correlates with SGLT2i Treatment in Patients with Diabetes
GEO Series GSE263644. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profile of the rat cardiovascular system at single-cell resolution
GEO Series GSE280111. Rattus norvegicus. 78 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic Analysis of Nicotine on the Cardiovascular System Using a Diverse Population of Human Induced Pluripotent Stem Cell-derived Endothelial Cells
GEO Series GSE274506. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
S1_raw_images paper "Use of dual-flow bioreactor to develop a simplified model of nervous-cardiovascular systems crosstalk: a preliminary assessment
<p>Original uncropped and unadjusted images underlying all blot or gel results reported in a submission’s figures and Supporting Information files.</p>
"Effects of Different Neck Manual Lymphatic Drainage Maneuvers on the Nervous, Cardiovascular, Respiratory and Musculoskeletal Systems in Healthy Students"
Open the record for dataset details and reuse information.
Determination of the RANKL/Osteoprotegerin Ratio in Patients With Systemic Lupus Erythematosus. Role in Osteoporosis and Cardiovascular Calcification
ClinicalTrials.gov study NCT02799173. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effectiveness of a Intraoperative Blood Recovery System in Cardiovascular Surgery in Brazil
ClinicalTrials.gov study NCT06601582. IPD Sharing: NO. Countries: 1. Publications: 0.
The Incidence of Pulmonary, Cardiovascular and Renal System Non-communicable Complications Associated With the Post-acute Phase of the Infection by Covid-19
ClinicalTrials.gov study NCT06608849. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.