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68 results for “cause of death”
Data from: Downregulation of endometrial mesenchymal marker SUSD2 causes cell senescence and cell death in endometrial carcinoma cells
The cause of death among the majority of endometrial cancer patients involves migration of cancer cells within the peritoneal cavity and subsequent implantation of cancer spheroids into neighbouring organs. It is, thereby, important to identify factors that mediate metastasis. Cell adhesion and migration are modified by the mesenchymal stem cell (MSC) marker Sushi domain containing 2 (SUSD2), a type I transmembrane protein that participates in the orchestration of cell adhesion and migration through interaction with its partner Galactosidase-binding soluble-1 (LGALS1). MSCs have emerged as attractive targets in cancer therapy. Human endometrial adenocarcinoma (Ishikawa) cells were treated with TGFβ (10ng/ml) for 72h. SUSD2, LGALS1 and MKI67 transcript levels were quantified using qRT-PCR. The proportion of SUSD2 positive (SUSD2+) cells and SMAD2/3 abundance were quantified by FACS and Western blotting, respectively. Senescent cells were identified with β-galactosidase staining; cell cycle and cell death were quantified using Propidium Iodide staining. Treatment of endometrial cancer cells (Ishikawa cells) with TGFβ (10ng/ml) significantly decreased SUSD2 transcript levels and the proportion of SUSD2 positive cells. Silencing of SUSD2 using siRNA resulted in senescence and cell death of Ishikawa cells via activation of SMAD2/3. These findings suggest that SUSD2 counteracts senescence and cell death and is thus a potential chemotherapeutic target in human endometrial cancer.
Data from: Oxygen limitation is not the cause of death during lethal heat exposure in an insect
Oxygen- and capacity-limited thermal tolerance (OCLTT) is a controversial hypothesis claiming to explain variation in, and mechanistically determine, animal thermal limits. The lack of support from Insecta is typically argued to be a consequence of their high-performance respiratory systems. However, no studies have reported internal body oxygen levels during thermal ramping so it is unclear if changes in ambient gas are partially or fully offset by a compensatory respiratory system. Here we provide such an assessment by simultaneously recording haemolymph oxygen (pO2) levels – as an approximation of tissue oxygenation - while experimentally manipulating ambient oxygen and subjecting organisms to thermal extremes in a series of thermolimit respirometry experiments using pupae of the butterfly Pieris napi. The main results are that while P. napi undergo large changes in haemolymph pO2 that are positively correlated with experimental oxygen levels, haemolymph pO2 is similar pre- and post-death during thermal assays. OCLTT predicts that reduction in body oxygen level should lead to a reduction in CTmax. Despite finding the former, there was no change in CTmax across a wide range of body oxygen levels. Thus, we argue that oxygen availability is not a functional determinant of the upper thermal limits in pupae of P. napi.
Reflex Bleeding in Tonically Immobilized Larvae Causes Debris-Based Camouflage in the Blue Death-Feigning Beetle, Asbolus verrucosus LeConte (Coleoptera: Tenebrionidae) - Supplementary videos 1 to 4
<p>Supplementary videos demonstrating methods for inducing death feigning in <em>Asbolus verrucosus</em>, LeConte (1851), as well as wriggling behavior, death-feigning behavior and reflex bleeding in immature stages.</p> <p><strong>Supplementary video 1</strong>. The hand transfer method is demonstrated. A moment after the investigator releases the larva, a fine mist of blood is quickly squirted and then then the larva oozes blood (indicated with arrow). A portion of the video is then shown enlarged and slowed to 10% original speed to better show the reflex bleeding.</p> <p><strong>Supplementary video 2</strong>. The rotisserie method is demonstrated with the three species investigated (labeled as they pass by for the first time). The <em>Asbolus verrucosus</em> larva displays death feigning behavior and maintains a rigid but slightly curved posture (tonic immobility), while the other two species continue twisting and wandering about their enclosures.</p> <p><strong>Supplementary Video 3</strong>. Wriggling behavior is induced in larvae, then in a pupa of <em>Asbolus verrucosus</em>.</p> <p><strong>Supplementary Video 4</strong>. This video shows typical death feigning behavior in a blue death feigning beetle larva. Imperceptibly slow movements are more readily observed if the video is viewed at high speed.</p>
Figure 6 from: Sampaio FDF, Silva-de-Assis HC, Bettim FL, Fávaro LF, Freire CA (2019) Water acidification causes death of marine ornamental fish (Perciformes: Pomacentridae) during transport: contributing to the conservation of wild populations. Zoologia 36: 1-10. https://doi.org/10.3897/zoologia.36.e25083
Figure 6 Transport water volume (ml) per gram of fish weight versus total body length (cm). Black circles, fish that were alive at the end of the experiment; white circles, fish that died during the experiment. Vertical and horizontal dashed lines respectively indicate maximum suggested length for the transport of A.saxatilis (6 cm) to ensure survival, and maximum water volume/fish weight relationship (125 ml/g fish) to minimize transport costs.
Figures 4-5 from: Sampaio FDF, Silva-de-Assis HC, Bettim FL, Fávaro LF, Freire CA (2019) Water acidification causes death of marine ornamental fish (Perciformes: Pomacentridae) during transport: contributing to the conservation of wild populations. Zoologia 36: 1-10. https://doi.org/10.3897/zoologia.36.e25083
Figures 4-5 Relationship between weight (g) and total length (cm) of A.saxatilis: (4) weight (g) as a function of the total length (cm) of the fish. Black circles, fish that were alive at the end of the experiment (n = 53); white circles, fish that died during the experiment (n = 14). (5) Weight/length ratio versus fish length, with separate linear regressions for living (solid line) and dead (dashed line) fish, and respective r2 values.
Figures 7-8 from: Sampaio FDF, Silva-de-Assis HC, Bettim FL, Fávaro LF, Freire CA (2019) Water acidification causes death of marine ornamental fish (Perciformes: Pomacentridae) during transport: contributing to the conservation of wild populations. Zoologia 36: 1-10. https://doi.org/10.3897/zoologia.36.e25083
Figures 7-8 3-D mesh plots showing the relationship among the 3 water parameters, whole set of data. NH3-N (mg/L) versus DO(mg/L) versus pH, for live (7) and dead (8) fish. Legend illustrates color codes for pH interpolation.
Figures 1-3 from: Sampaio FDF, Silva-de-Assis HC, Bettim FL, Fávaro LF, Freire CA (2019) Water acidification causes death of marine ornamental fish (Perciformes: Pomacentridae) during transport: contributing to the conservation of wild populations. Zoologia 36: 1-10. https://doi.org/10.3897/zoologia.36.e25083
Figures 1-3 Time course of variation of water parameters for living and dead A.saxatilis: (1) water dissolved oxygen (DO, mg/L), (2) total ammonia-N (NH3-N, mg/L) and (3) pH versus time (h). Values shown are means ± SEMs. When not apparent, SEM is smaller than the symbol. This happened for the water of the reference fish, ammonia and pH. Black circles: fish that were alive at the end of the experiment; white circles: fish that died during the experiment. *: water parameter for dead fish is different from that of live fish.
Fig. 3 in Air sac trematodes: Morishitium polonicum as a newly identified cause of death in the common blackbird (Turdus merula)
Fig. 3. Morishitium polonicum from the air sacs of Turdus merula. A. Tongue-shaped specimen of M. polonicum. In the posterior part of the body are clearly visible the two large testes and the ovary lying between them. (scale bar = 200 μm). B. Anterior end of M. polonicum showing the eggs inside the uterus. (scale bar = 100 μm). C. Posterior end of M. polonicum showing two globular testes situated obliquely to each other, an intertesticular oval ovary placed in a longitudinal straight line with the testes, two caeca joined posteriorly and two symmetrical vitelline glands not confluent posteriorly. (scale bar = 300 μm). D. The oral sucker, the pharynx, the genital pore of M. polonicum in the anterior end (scale bar = 50 μm).
Fig. 2 in Air sac trematodes: Morishitium polonicum as a newly identified cause of death in the common blackbird (Turdus merula)
Fig. 2. Turdus merula female, histology of different coelomic organs. A. Lower power magnification of an area where flukes are adherent to the liver. The presence of inflammatory infiltrate is observed on the Glissonian capsule (arrow) in the contact area with the parasite. At this magnification a general overview of the parasite is also clear: the cephalic portion (arrow-head), different internal organs and the uterus filled by the ova (asterisk) are appreciated (H&E, scale bar = 0.2 cm). B. Detail of the contact area between the fluke tegument and liver serosa, involved in the inflammatory reaction (arrow). Note the pyogranulomatous exudate represented by large amounts of mononuclear cells with interspersed heterophils in the area of close contact with the parasite (asterisk). Trematode eggs and an internal gland (arrow-head) are also visible (H&E, scale bar = 200 μm). C. Fluke localization on the kidney capsule: note the same inflammatory reaction (arrow) described in the liver, in the areas of more close contact (H&E, scale bar = 2 mm). D. Air sacs inflammation and modification in the site of parasite attachment (arrow). Note the previously described inflammatory infiltrate and the altered lung parenchyma (asterisk) in the area of the affected air sac. The pulmonary parenchyma is congested and collapsed, as observed also at gross examination (H&E, scale bar = 200 μm).
Data from: Oxygen limitation is not the cause of death during lethal heat exposure in an insect
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Data from: Downregulation of endometrial mesenchymal marker SUSD2 causes cell senescence and cell death in endometrial carcinoma cells
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Data from: Evolution of male age-specific reproduction under differential risks and causes of death: males pay the cost of high female fitness
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Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death [tRNA seq]
GEO Series GSE185827. Homo sapiens. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Minor spliceosome inactivation in the developing mouse cortex causes self-amplifying radial glial cell death and microcephaly.
GEO Series GSE96616. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death [Ribo-Seq]
GEO Series GSE185826. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice
GEO Series GSE129006. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Targeted degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal stem cells
GEO Series GSE206223. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress
GEO Series GSE157467. Homo sapiens. 130 samples. Type: Expression profiling by high throughput sequencing; Other.
Deregulation of growth-phase-dependent expression of SdsR causes cell death in Escherichia coli
GEO Series GSE116435. Escherichia coli str. K-12 substr. MG1655. 3 samples. Type: Expression profiling by high throughput sequencing.
Overexpression of the receptor-like kinase BIR1 gene causes SOBIR1- and EDS1-dependent cell death phenotypes in Arabidopsis
GEO Series GSE234036. Arabidopsis thaliana. 24 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.