Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
522
datasets available to search
ShareScore release 0.9.0
Dataset results
522 results for “cell expansion”
Data from: An increase in immature β-cells lacking Glut2 precedes the expansion of β-cell mass in the pregnant mouse
A compensatory increase in β-cell mass occurs during pregnancy to counter the associated insulin resistance, and a failure in adaptation is thought to contribute to gestational diabetes. Insulin-expressing but glucose-transporter-2-low (Ins+Glut2LO) progenitor cells are present in mouse and human pancreas, being predominantly located in extra-islet β-cell clusters, and contribute to the regeneration of the endocrine pancreas following induced ablation. We therefore sought to investigate the contribution of Ins+Glut2LO cells to β-cell mass expansion during pregnancy. Female C57Bl/6 mice were time mated and pancreata were collected at gestational days (GD) 6, 9, 12, 15, and 18, and postpartum D7 (n = 4/time-point) and compared to control (non-pregnant) animals. Beta cell mass, location, proliferation (Ki67+), and proportion of Ins+Glut2LO cells were measured using immunohistochemistry and bright field or confocal microscopy. Beta cell mass tripled by GD18 and β-cell proliferation peaked at GD12 in islets (≥6 β-cells) and small β-cell clusters (1–5 β-cells). The proportion and fraction of Ins+Glut2LO cells undergoing proliferation increased significantly at GD9 in both islets and clusters, preceding the increase in β-cell mass and proliferation, and their proliferation within clusters persisted until GD15. The overall number of clusters increased significantly at GD9. Quantitative PCR showed a significant increase in Pdx1 presence at GD9 vs. GD18 or control pancreas, and Pdx1 was visualized by immunohistochemistry within both Ins+Glut2LO and Ins+Glut2HI cells within clusters. These results indicate that Ins+Glut2LO cells are likely to contribute to β-cell mass expansion during pregnancy.
A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies
ClinicalTrials.gov study NCT05006716. IPD Sharing: YES. Countries: 16. Publications: 0.
Phase I/II Study of Lenalidomide Plus Pembrolizumab in Patients With Solid Tumors With Expansion in Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT02963610. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dose Escalation, Expansion Study of Vofatamab (B-701) in Treatment of Locally Advanced or Metastatic Urothelial Cell Carcinoma
ClinicalTrials.gov study NCT02401542. IPD Sharing: NO. Countries: 9. Publications: 0.
Data from: An increase in immature β-cells lacking Glut2 precedes the expansion of β-cell mass in the pregnant mouse
Open the record for dataset details and reuse information.
Data from: Auxin steers root cell expansion via apoplastic pH regulation in Arabidopsis thaliana
Open the record for dataset details and reuse information.
Genetic code expansion in stable cell lines enables encoded chromatin modification
GEO Series GSE73823. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Antigen-driven CD8+ T cell clonal expansion is a prominent feature of MASH in humans and mice [human]
GEO Series GSE270488. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Other.
The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8 T cells in chronic viral infection (RNA-Seq I)
GEO Series GSE210537. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Longitudinal single-cell immunoprofiling links durable CAR T response to sustained activation and clonotypic expansion of the native cytotoxic T cell repertoire
GEO Series GSE290722. Homo sapiens. 184 samples. Type: Other; Expression profiling by high throughput sequencing.
Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability [BGI-RNA-Seq]
GEO Series GSE190226. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Injury prevents Ras mutant cell expansion in mosaic skin
GEO Series GSE195892. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Single-cell analysis reveals clonal expansions of pro-inflammatory tissue-resident memory Th17 cells in Crohn's disease
GEO Series GSE247264. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Ex-vivo Human Hematopoietic Stem Cell Expansion Requires Coordination of Cellular Reprogramming with Mitochondrial Remodeling and P53 Activation [bulk]
GEO Series GSE110968. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI.
GEO Series GSE161508. Homo sapiens. 94 samples. Type: Other.
Argonaute2 mediates compensatory expansion of the pancreatic ß-cell
GEO Series GSE46623. Mus musculus. 12 samples. Type: Expression profiling by array.
Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets [scRNA-Seq]
GEO Series GSE275239. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses (Experiment 1: RNA-seq)
GEO Series GSE119749. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Neonatal bone marrow interstitial fluid supports expansion and osteogenic ability of human bone marrow mesenchymal stromal cells
GEO Series GSE290284. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
HuR-dependent NK cell expansion is required for control of solid tumors and long-term virus infection
GEO Series GSE217392. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.