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322 results for “chronic stress”
Risperidone Treatment for Military Service Related Chronic Post Traumatic Stress Disorder
ClinicalTrials.gov study NCT00099983. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress
ClinicalTrials.gov study NCT02058251. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Behavioral effects of chronic stress in Carioca High- and Low-conditioned Freezing rats
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Data from: Shift in distribution of division of labour in chronically stressed honeybee colonies after perturbation
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Data for: Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS
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Dataset Chronic water restriction triggers sex-specific oxidative stress and telomere shortening in lizards
<p>This dataset is related to "Chronic water restriction triggers sex-specific oxidative stress and telomere shortening in lizards" (Dupoué A., Angelier F., Ribout C., Meylan S., Rozen-Rechels D., Decencière B., Agostini S., Le Galliard J.-F.) </p> <p>The file reports the information on the responses of 100 yearling lizards identified with their code (lizard_ID), depending on their sex and hydric treatment. Abrevations: </p> <p>SVL: Snout-vent length</p> <p>ROM: Reactive Oxygen Metabolites (an index of oxidative damages)</p> <p>OXY: Non-enzymatic antioxydant activities (an index of defences)</p> <p>TL: Telomere length</p>
Data from: Gene expression under chronic heat stress in populations of the mustard hill coral (Porites astreoides) from different thermal environments
Recent evidence suggests that corals can acclimatize or adapt to local stress factors through differential regulation of their gene expression. Profiling gene expression in corals from diverse environments can elucidate the physiological processes that may be responsible for maximizing coral fitness in their natural habitat and lead to a better understanding of the coral's capacity to survive the effects of global climate change. In an accompanying paper, we show that Porites astreoides from thermally different reef habitats exhibit distinct physiological responses when exposed to 6 weeks of chronic temperature stress in a common garden experiment. Here, we describe expression profiles obtained from the same corals for a panel of 9 previously reported and 10 novel candidate stress response genes identified in a pilot RNA-Seq experiment. The strongest expression change was observed in a novel candidate gene potentially involved in calcification, SLC26, a member of the solute carrier family 26 anion exchangers, which was down-regulated by 92-fold in bleached corals relative to controls. The most notable signature of divergence between coral populations was constitutive up-regulation of metabolic genes in corals from the warmer inshore location, including the gluconeogenesis enzymes pyruvate carboxylase and phosphoenolpyruvate carboxykinase and the lipid beta-oxidation enzyme acyl-CoA dehydrogenase. Our observations highlight several molecular pathways that were not previously implicated in the coral stress response and suggest that host management of energy budgets might play an adaptive role in holobiont thermotolerance.
Data from: The insensitive dormouse: reproduction skipping is not caused by chronic stress in Glis glis
Entire populations of edible dormice (Glis glis) can skip reproduction in years without mast seeding of deciduous trees (particularly beech or oak seed), because juveniles require high caloric seeds for growth and fattening prior to hibernation. We hypothesized that, in mast failure years, female dormice may be forced to spend larger amounts of time foraging for low-quality food, which should increase their exposure to predators, mainly owls. This may lead to chronic stress, i.e., long-term increased secretion of Glucocorticoids (GC), which can have inhibitory effects on reproductive function in both female and male mammals. We monitored reproduction in free-living female dormice over three years with varying levels of food availability, and performed a supplemental feeding experiment. To measure stress hormone levels, we determined fecal GC metabolite (GCM) concentrations collected during the day, which reflect hormone secretion rates in the previous nocturnal activity phase. We found that year-to-year differences in beech mast significantly affected fecal GCM levels and reproduction. However, contrary to our hypothesis, GCM levels were lowest in a non-mast year without reproduction, and significantly elevated in full-mast and intermediate years, as well as under supplemental feeding. Variation in owl density in our study area had no influence on GCM levels. Consequently, we conclude that down-regulation of gonads and reproduction skipping in mast-failure years in this species is not caused by chronic stress. Thus, in edible dormice, delayed reproduction apparently is profitable in response to the absence of energy-rich food in non-mast years, but not in response to chronic stress.
Data from: Food restriction and chronic stress alter energy use and affect immunity in an infrequent feeder
Glucocorticoids are important mediators of energy utilization for key physiological processes, including immune function. Much work has focused on the effects of energy limitation and stress for key physiological processes such as reproduction and immunity. However, it is unclear how stress alters energy use across different energy states, and the physiological ramifications of such effects are even less clear. In this study, we altered energy and stress states of an infrequent feeder, the Terrestrial Gartersnake (Thamnophis elegans), using fasting and repeated restraint stress (Chronic Stressors) to test how these challenges interacted to affect immune function, energy metabolites, and glucocorticoid reactivity (a traditional indicator of stress state) to restraint stress, a standardized, acute stressor. After this acute stressor, the snakes which had received chronic stress had increased glucocorticoid reactivity, and both treatments altered energy metabolite use and storage. Evidence of interaction of food restriction and chronic stress treatments on innate immune function and energy metabolites (triglycerides and glycerol) suggests that stress alters energy use in a manner dependent on the energy state of the animal. Snakes have a remarkable ability to maintain functionality of key physiological processes under stressful conditions but are still susceptible to multiple simultaneous stressors, a situation increasingly prevalent in our ever-changing environment.
Depression, anxiety and stress in chronic otitis media
<p><strong>Purpose</strong>: Persistent symptoms of chronic otitis media cause limitations in daily routine and social interactions, significantly influencing patients' quality of life and mental health. The purpose of the study was to assess the intensity of depression, anxiety, and stress symptoms in patients with chronic otitis media and to examine if patient demographic data, characteristics, and reported symptoms of otitis influence reported depression, anxiety, and stress symptoms.</p> <p><strong>Material and Methods</strong>: The study included 316 adult patients diagnosed with unilateral or bilateral chronic otitis media with or without cholesteatoma. Patients underwent a complete otological, audiological and radiological assessment. Chronic otitis media questionnaire 12 (COMQ-12) was used to assess the impact of COM and Depression Anxiety Stress Scale 21 (DASS-21) was used for depression, anxiety, and stress assessment.</p> <p><strong>Results</strong>: Some levels of anxiety and stress were detected in 70.57% and 49.37% of the patients, respectively. 13.29% of the patients had scores indicating depression disorder. The mean value of the COMQ-12 questionnaire for this group of patients was 26.24 (SD±11.47) More intense symptoms of COM were significantly associated (p<0.05) with higher scores on DASS-21 subscales. Multivariate logistic regression analysis indicated that significant positive predictors of higher anxiety scores were pure tone average (PTA) on the better and worse hearing ear (p<0.05). Drainage from the ear, hearing problems at home, and tinnitus were significant positive predictors of a higher DASS-depression score. (p<0.05).</p> <p><strong>Conclusion</strong>: The study confirmed a positive correlation between reported levels of anxiety, depression, and stress, the severity of COM symptoms, and quality of life. Levels of hearing in the better and worse hearing ear were significant positive predictors of anxiety and stress in patients with COM.</p>
Predictors of depression, anxiety and stress indicators in a cohort of women with chronic pelvic pain data set
<p>Data set for submission of paper 'Predictors of depression, anxiety and stress indicators in a cohort of women with chronic pelvic pain'</p>
Predictors of depression, anxiety and stress indicators in a cohort of women with chronic pelvic pain - data set 2
<p>Data set for PPSA study - 2. A second data set was created for the PPSA study publication to isolate variables of interest to make the statistics manageable, due to the sheer number of variables in the initial data set </p>
FIG. 7 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 7. Hellbender neutrophil: lymphocyte ratio across 2017 and 2018 at Little River (LR; n ¼ 8), Tumbling Creek (TC; n ¼ 12), Hiwassee River (HR; n ¼ 11), Elk River (ER; n ¼ 3), North Fork Triplett Creek (NFTC; n ¼ 4), Little Buffalo River (LBR; n ¼ 4), Doe River (DR; n ¼ 1), and South Fork New River (SFNR; n ¼ 5). Letters indicate among-site differences, where sites that are significantly different have different letters, and error bars represent two standard deviations from the mean.
FIG. 5 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 5. Scatterplot showing regression between Hellbender neutrophil: lymphocyte ratio and water pH observed in 2018.
FIG. 4 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 4. Scatterplots showing multiple linear regression comparing Hellbender neutrophil: lymphocyte ratio and water characteristics for 2018. The first row of graphs depicts neutrophil: lymphocyte ratio on the y-axis and corresponding environmental variables on the x-axis; all other rows depict the relationship among water quality parameters assessed. R2 values are provided for each graph, the red line represents the overall trend line, and significant variables are indicated with an asterisk.
FIG. 3 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 3. Scatterplots showing regressions between Hellbender neutrophil: lymphocyte ratios and conductivity (A), pH (B), and dissolved oxygen (C), in 2017.
FIG. 1 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 1. Map of eight sites surveyed between 2017 and 2018 for Hellbenders, including North Fork Triplett Creek (NFTC) in Kentucky, Little Buffalo River (LBR), Hiwassee River (HR), Little River (LR), Doe River (DR), Tumbling Creek (TC), and Elk River (ER) in Tennessee, and South Fork New River (SFNR) in North Carolina.
Stress Intervention for Chronic Urticaria
ClinicalTrials.gov study NCT01111136. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Furosemide Stress Test as a Predictor of Tubular Function in Chronic Kidney Disease
ClinicalTrials.gov study NCT02417883. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Low-dose Cortisol in Chronic Posttraumatic Stress Disorder
ClinicalTrials.gov study NCT00362661. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.