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117 results for “cochlea”
Figure 5 in The shape of water: adaptations of cochlea morphology in seals and oưers
Figure 5. Differences of morphological traits between Lutrinae, Pinnipedia, and terrestrial Caniformia are highlighted by side-to-side comparison. A, the ratio of tympanic membrane area to oval window area is drastically altered in aquatic specimens when compared to their terrestrial relatives. The ratio of seals is significantly smaller, but the same effect is visible in oưers albeit to a smaller degree. B, the distance between the tympanic sulcus and the oval window is drastically altered in aquatic species. There is however liưle difference between oưers (Lutrinae) and seals (Pinnipedia). C, comparison of the area size of the opening of the ECF/canaliculus cochleae, normed for body-length of all specimens with sufficient scan resolution (N = 35). Direct comparison shows clear differentiation between pinnipeds and the other groups, displaying an increase in area size of the opening. * = P ≤ 0.05, ** = P ≤ 0.01, ***= P ≤ 0.001, **** = P ≤ 0.0001.
Figure 4 in The shape of water: adaptations of cochlea morphology in seals and oưers
Figure 4. Comparison of tympanic membrane, oval window, and round window areas of terrestrial and aquatic Caniformia. A, the areas of the tympanum, oval window, and round window (N = 33) correlate with body length in terrestrial (green dots, N = 19) and aquatic (blue dots, N = 14) taxa. B, when the membrane areas are size-corrected, only the oval window areas correlate (not strongly) negatively with head-bodylength. C, we also tested for the median difference plots are themselves a visual testing method as described in Ho et al.. When the unpaired median differences between aquatic and terrestrial Caniformia differ from zero, this points to a clear effect size between the two groups (Ho et al., 2019). This is found for the tympanal membrane area that is smaller in aquatic Caniformia and the round window area that is larger in aquatic Caniformia. The unpaired median differences for the round window area were not exactly 0, but they were very close, indicating that if there is an effect it is minimal.
Figure 3. Aquatic Caniformia have disc-shaped cochleae. A in The shape of water: adaptations of cochlea morphology in seals and oưers
Figure 3. Aquatic Caniformia have disc-shaped cochleae. A, exemplary wireframes made based on landmark coordinates along the cochleae of six taxa belonging to different subgroups (Mustelinae, Canidae, Lutrinae, Ursidae, Otariidae, and Phocidae). The arrangement in the graph corresponds to the PC1 vs. PC2 position in Figure 2. Aquatic Caniformia (blue cochleae) with negative PC1 and positive PC2 values have a compressed disc-shaped cochlea with a small number of turns. An increase in the number of turns correlates with the increase of PC1 values, from negative PC1 values with a small number of turns to positive PC1 values with a high number of turns (green shaded area). Further, the shape of the cochlea changes with negative PC2 values, a pyramid cochlea shape is found for Ursus maritimus and Enhydra lutris (semi-aquatic). With positive PC1 and PC2 values, cochleae are tower shaped (terrestrial, Mustela nivalis and Vulpes vulpes as representatives for mustelids and canids). B, Boxplot of the body size corrected centroid size for three different phylogenetic groups: Lutrinae (light blue, N = 7 species), terrestrial Musteloidea/Canidae/Ursidae (green, N = 21 species), and Pinnipedia (dark blue, N = 10 species). C, correlation analysis between PC1 values and the number of cochlear turns shows a clear positive relationship between an increasing PC1 value and the number of turns. The colour code is the same as in Figure 1. * = P ≤ 0.05, ** = P ≤ 0.01, **** = P ≤ 0.0001).
Figure 7. Bridging cochlea shape with audiogram data. A in The shape of water: adaptations of cochlea morphology in seals and oưers
Figure 7. Bridging cochlea shape with audiogram data. A, examples of audiograms of the same taxa as in Figure 3 (see Supporting Information, Table S1 for audiogram sources). B, linear regression of the relative cross-section area of the first turn and CF, with a significant result for terrestrial species and the combined data of all animals. C, CF and cochlea base width are negatively correlated in terrestrial species and Caniformia in general. D, linear regression for relative cochlea centroid size and CF exhibits significant correlation for terrestrial animals and the combined dataset. E, correlation for the relative distance between the tympanic sulcus and the oval window and CF results in a clustering by habitat with very liưle overlap and clear negative correlation significant for both groups. Legend: ** = P ≤ 0.01, *** = P ≤ 0.001, **** = P ≤ 0.0001.
Auditory Brainstem Implant (ABI) in Children With No Cochleae or Auditory Nerves
ClinicalTrials.gov study NCT02310399. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Correlation Between NRT and Radiological Measurements in Detection of Position of the Electrode Inside the Cochlea.
ClinicalTrials.gov study NCT03306108. IPD Sharing: Not stated. Countries: 1. Publications: 3.
SCUBA belt transects for abundance data H. cochlea and H. aequicostatus
Open the record for dataset details and reuse information.
Multi-center Study to Examine Changes to the Environment Surrounding the Electrodes in the Cochlea and to Capture the Most Challenging Listening Environments Experienced by Persons With a Cochlear Imp
ClinicalTrials.gov study NCT06173687. IPD Sharing: NO. Countries: 3. Publications: 0.
Single-cell RNA sequencing analysis reveals Greater Epithelial Ridge cells degeneration during postnatal development of cochlea in Rats
GEO Series GSE170810. Rattus norvegicus. 2 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration
GEO Series GSE224563. Mus musculus. 52 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
A single-cell level comparison of human inner ear organoids with the human cochlea and vestibular organs
GEO Series GSE214099. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Identification of glucocorticoid-dependent circadian genes in the cochlea
GEO Series GSE88954. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Shared and organ-specific gene-expression programs during the development of the cochlea and the superior olivary complex [miRNA-seq]
GEO Series GSE221546. Mus musculus. 21 samples. Type: Non-coding RNA profiling by high throughput sequencing.
MicroRNA expression in the newborn mouse cochlea and vestibule
GEO Series GSE15496. Mus musculus; Homo sapiens. 6 samples. Type: Non-coding RNA profiling by array.
Dual Mechanisms of Supporting Cell Regeneration in the Neonatal Mouse Cochlea
GEO Series GSE291228. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
scRNA-seq of P20 mouse cochlea
GEO Series GSE181454. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Dusp1 deletion unveils its central role in the regulation of redox homeostasis and inflammation in the mouse cochlea
GEO Series GSE176114. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Cochlea Neomycin Timecourse
GEO Series GSE6050. Gallus gallus; Mus musculus; Homo sapiens. 51 samples. Type: Expression profiling by array.
Transcriptomic analysis of cochleae after hair cell damage
GEO Series GSE129718. Gallus gallus; Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Expression data from proximal, middle, and distal segments of E6.5 chicken cochlea
GEO Series GSE56888. Gallus gallus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.