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38 results for “cognitive reserve”
Data from: Cognitive reserve and clinical progression in Alzheimer's disease: a paradoxical relationship
Objective: To investigate the relationship between cognitive reserve (CR) and clinical progression across the Alzheimer's disease (AD) spectrum. Methods: We selected 839 Aβ-positive subjects with normal cognition (NC, n=175), mild cognitive impairment (MCI, n=437) or AD dementia (n=227) from the Alzheimer's Disease Neuroimaging Initiative. CR was quantified using standardized residuals (W-scores) from a (covariate-adjusted) linear regression with global cognition (ADAS-Cog 13) as an independent variable-of-interest, and either gray matter volumes or white matter hyperintensity volume as dependent variables. These W-scores, reflecting whether an individual's degree of cerebral damage is lower or higher than clinically expected, were tested as predictors of diagnostic conversion (i.e. NC to MCI/AD dementia, or MCI to AD dementia) and longitudinal changes in memory (ADNI-MEM) and executive functions (ADNI-EF). Results: The median follow-up period was 24 months (interquartile range: 6-42). Corrected for age, sex, APOE4-status and baseline cerebral damage, higher gray matter volume-based W-scores (i.e. greater CR) were associated with a lower diagnostic conversion risk (hazard ratio [HR]= .22, p<.001) and slower decline in memory (β=.48, p<.001) and executive functions (β=.67, p<.001). Stratified by disease stage, we found similar results for NC (diagnostic conversion: HR=.30, p=.038; ADNI-MEM: β=.52, p=.028; ADNI-EF: β=.42, p=.077) and MCI (diagnostic conversion: HR=.21, p<.001; ADNI-MEM: β=.43, p=.003; ADNI-EF: β=.59, p<.001), but opposite findings (i.e. more rapid decline) for AD dementia (ADNI-MEM: β=-.91, p=.002; ADNI-EF: β=-.77, p=.081). Conclusions: Among Aβ-positive individuals, greater CR related to attenuated clinical progression in pre-dementia stages of AD, but accelerated cognitive decline after the onset of dementia.
Factors related to cognitive reserve among caregivers of severe acquiredbrain injury
<p>Stroke is one of the severe cause of motor and cognitive disabilities. These type of disabilities occurred a strong impact on whole family system. Caregiver burden may determine in relatives of patients with brain injury a decreasement of mental and physical health. The present study aims to better clarify the mechanism through which chronic stress influence caregivers’ cognitive functioning and how the psychological and cognitive resources may represent as a predictive factor. Caregivers were submitted to neuropsychological tests that evaluated level of mental health ad level of burden. Our results showed a significant correlation between cognitive reserve and self-efficacy skills in health care of patients. Findings suggested that the caregiver burden and the level of general distress influenced the cognitive performance. An improvement of cognitive functions is associated with a reduction of self-efficacy skills, causing a caregiver burden improvement.</p>
Treating Early Stages With an Intervention Targeting Cognitive Reserve
ClinicalTrials.gov study NCT05288049. IPD Sharing: NO. Countries: 1. Publications: 0.
Cognitive Reserve on Pain Catastrophizing and Cognitive Function in Geriatric Patients With Chronic Pain
ClinicalTrials.gov study NCT05933564. IPD Sharing: NO. Countries: 1. Publications: 0.
Cognitive Reserve and Second Language Acquisition
ClinicalTrials.gov study NCT03638882. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cognitive Reserve-building Activities in Multiple Sclerosis
ClinicalTrials.gov study NCT05691192. IPD Sharing: NO. Countries: 1. Publications: 0.
Study Efficacy of Enhancing Cognitive Reserve in Patients With a First Bipolar Episode
ClinicalTrials.gov study NCT06081634. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Preoperative Cognitive Reserve in Older Surgical Patients: a Feasibility Study
ClinicalTrials.gov study NCT06245005. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Intellectual Enrichment to Build Cognitive Reserve in MS
ClinicalTrials.gov study NCT01978574. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Brain and Cognitive Reserve
ClinicalTrials.gov study NCT02819167. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Amyloïd Load in Elderly Population: Effect of Cognitive Reserve
ClinicalTrials.gov study NCT02196116. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients
ClinicalTrials.gov study NCT04493996. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Cognitive Reserve Disorder Affecting Depression in Aged Related Hearing Loss Via Rest State EEG
ClinicalTrials.gov study NCT05892731. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Cognitive reserve and clinical progression in Alzheimer’s disease: a paradoxical relationship
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Modifiable risk factors for dementia and cognitive reserve in early phases of cognitive decline: A data-driven cluster analysis.
<p>Dataset refers to a data-driven cluster analysis aimed at identifying sub-groups of patients at risk of cognitive decline based on their modifiable risk factors (MRFs) and cognitive reserve (CR). It was then explored how the identified clusters differ in determining the individual well-being of participants, by considering their sociodemographic characteristics, cognitive functioning, and mental health. Results suggested that people who adopt protective behaviours present a more positive individual wellbeing.</p>
Cognitive reserve in multiple sclerosis
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In person cognitive rehabilitation versus telerehabilitation in patients at risk of dementia: How can cognitive reserve, lifestyle habits, and other factors explain this choice?
<p>“In person cognitive rehabilitation versus telerehabilitation in patients at risk of dementia: How can cognitive reserve, lifestyle habits, and other factors explain this choice?” to be submitted to Frontiers in Psychology journal. Dataset evaluated how patients’ preference for in presence cognitive rehabilitation program (CoRe) or telerehabilitation one (HomeCore) could be associated to different factors: cognitive reserve and lifestyle habits, sociodemographic characteristics, cognitive functioning, and mental health. Considering those factors could facilitate the discrimination a priori between patients who will potentially prefer TR, by ensuring a high probability of treatment adherence and then success. To this end, we used explorative descriptive approach, logistic regression, and non-parametric models to explore the overall contribution of each variable.</p>
Cognitive reserve predicts episodic memory enhancement induced by transcranial direct current stimulation in healthy older adults
<p>In this dataset we provide data from the Cognitive Reserve Index questionnaire (CRI-q), from an Experimental Memory Task and from the questionnaire to assess the sensations induced by tDCS in a sample of healthy elderly participants.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.