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119 results for “disease susceptibility”
Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali
ClinicalTrials.gov study NCT01168271. IPD Sharing: NO. Countries: 1. Publications: 7.
Susceptibility to Infections, Tumor Risk and Liver Disease in Patients With Ataxia Telangiectasia
ClinicalTrials.gov study NCT03357978. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Susceptibility to Infectious Diseases in obEsity: an endocRine trAnslational socioLogic Evaluation, "SIDERALE"
ClinicalTrials.gov study NCT06236932. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Data from: Landscape-level variation in disease susceptibility related to shallow-water hypoxia
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Data from: Degree of host susceptibility in the initial disease outbreak influences subsequent epidemic spread
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Data from: Increased susceptibility to fungal disease accompanies adaptation to drought in Brassica rapa
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Noise pollution: acute noise exposure increases susceptibility to disease and chronic exposure reduces host survival
<p>Anthropogenic noise is a pervasive global pollutant that has been detected in every major habitat on the planet. Detrimental impacts of noise pollution on physiology, immunology and behaviour have been shown in terrestrial vertebrates and invertebrates. Equivalent research on aquatic organisms has until recently been stunted by the misnomer of a silent underwater world. In fish, however, noise pollution can lead to stress, hearing loss, behavioural changes and impacted immmunity. But, the functional effects of impacted immunity on disease resistance due to noise exposure have remained neglected. Parasites that cause transmissible disease are key drivers of ecosystem biodiversity and a significant factor limiting the sustainable expansion of the animal trade. Therefore, understanding how a pervasive stressor is impacting host-parasite interactions will have far reaching implications for global animal health. </p> <p><span><span><span><span><span><span><span><span><span><span><span>Here, we investigated the impact of acute and chronic noise on vertebrate susceptibility to parasitic infections, using a model host-parasite system (guppy-<i>Gyrodactylus turnbulli</i>). Hosts experiencing acute noise suffered significantly increased parasite burden compared to those in no noise treatments. In contrast, fish experiencing chronic noise had the lowest parasite burden. However, these hosts died significantly earlier compared to those exposed to acute and no noise treatments, demonstrating a potential functional trade-off between improved parasite-resistance and shorter life span. By revealing the detrimental impacts of acute and chronic noise on host-parasite interactions, we add to the growing body of evidence demonstrating a link between noise pollution and reduced animal health. </span></span></span></span></span></span></span></span></span></span></span></p>
Data from: Queen presence mediates the relationship between collective behavior and disease susceptibility in ant colonies
The success of social living can be explained, in part, by a group's ability to execute collective behaviors unachievable by solitary individuals. However, groups vary in their ability to execute these complex behaviors, often because they vary in their phenotypic composition. Group membership changes over time due to mortality or emigration, potentially leaving groups vulnerable to ecological challenges in times of flux. In some societies, the loss of important individuals (e.g., leaders, elites, queens) may have an especially detrimental effect on groups' ability to deal with these challenges. Here, we test whether the removal of queens in colonies of the acorn ant Temnothorax curvispinosus alters their ability to execute important collective behaviors and survive outbreaks of a generalist entomopathogen. We employed a split-colony design where one half of a colony was maintained with its queen, while the other half was separated from the queen. We then tested these subcolonies' performance in a series of collective behavior assays and finally exposed colonies to the entomopathogenic fungus Metarhizium robertsii by exposing two individuals from the colony and then sealing them back into the nest. We found that queenright subcolonies outperformed their queenless counterparts in nearly all collective behaviors. Queenless subcolonies were also more vulnerable to mortality from disease. However, queenless groups that displayed more interactions with brood experienced greater survivorship, a trend not present in queenright subcolonies. Queenless subcolonies that engage in more brood interactions may have had more resources available to cope with two physiological challenges (ovarian development after queen loss and immune activation after pathogen exposure). Our results indicate that queen presence can play an integral role in colony behavior, survivorship, and their relationship. They also suggest that interactions between workers and brood are integral to colonies survival. Overall, a social group's history of social reorganization may have strong consequences on their collective behaviors and their vulnerability to disease outbreaks.
Data from: Keeping pace with the Red Queen: identifying the genetic basis of susceptibility to infectious disease
Genome-wide association studies are widely used to identify "disease genes" conferring resistance/susceptibility to infectious diseases. Using a combination of mathematical models and simulations we demonstrate that genetic interactions between hosts and parasites (GxG interactions) can drastically affect the results of these association scans and hamper our ability to detect genetic variation in susceptibility. When hosts and parasites coevolve, these GxG interactions often make Genome-wide association studies unrepeatable over time or across host populations. Reanalyzing previously published data on Daphnia magna susceptibility to infection by Pastueria ramosa, we identify genomic regions consistent with GxG interactions. We conclude by outlining possible avenues for designing more powerful and more repeatable association studies.
Data from: Genetic susceptibility to infectious disease in East African Shorthorn Zebu: a genome-wide analysis of the effect of heterozygosity and exotic introgression
[No abstract entered]
Susceptibility to a sexually transmitted disease in a wild koala population shows heritable genetic variance but no inbreeding depression
<p><span>The koala, one of the most iconic Australian wildlife species, is facing several concomitant threats that are driving population declines. Some threats are well known and have clear methods of prevention (e.g., habitat loss can be reduced with stronger land-clearing control), whereas others are less easily addressed. One of the major current threats to koalas is chlamydial disease, which can have major impacts on individual survival and reproduction rates and can translate into population declines. Effective management strategies for the disease in the wild are currently lacking, and to date we know little about the determinants of individual susceptibility to disease. Here we investigated the genetic basis of variation in susceptibility to chlamydia using one of the most intensively studied wild koala populations. We combined data from veterinary examinations, chlamydia testing, genetic sampling and movement monitoring. Out of our sample of </span><span>342 wild koalas, 60 were found to have chlamydia.</span><span> Using genotype information on 5007 SNPs to investigate the role of genetic variation in determining disease status, we found no evidence of inbreeding depression, but a heritability of 0.11 (95%CI = 0.05 – 0.23) for the probability that koalas had chlamydia. Heritability of susceptibility to chlamydia could be relevant for future disease management, as it suggests adaptive potential for the population.</span></p>
Data from: Queen presence mediates the relationship between collective behavior and disease susceptibility in ant colonies
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Data from: Genetic susceptibility to infectious disease in East African Shorthorn Zebu: a genome-wide analysis of the effect of heterozygosity and exotic introgression
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Susceptibility to a sexually transmitted disease in a wild koala population shows heritable genetic variance but no inbreeding depression
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Data from: Behavioural phenotypes predict disease susceptibility and infectiousness
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Data from: Keeping pace with the Red Queen: identifying the genetic basis of susceptibility to infectious disease
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Noise pollution: acute noise exposure increases susceptibility to disease and chronic exposure reduces host survival
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Identification of self- and pathogen-targeted miRNAs from resistant and susceptible Theobroma cacao variety to black pod disease
GEO Series GSE244955. Theobroma cacao. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Next-generation interaction screening to discover luciferase (construct #2) related protein-protein interactions regulating barley powdery mildew disease immunity and susceptibility
GEO Series GSE164762. Hordeum vulgare; Blumeria hordei. 4 samples. Type: Other.
Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility [mono-colonized_RNA-seq]
GEO Series GSE289591. Mus musculus. 29 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.