Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
70
datasets available to search
ShareScore release 0.9.0
Dataset results
70 results for “gene rearrangement”
HTGTS-TCR-seq for profiling of mouse and human T-cell receptor α and β gene rearrangements and diversity [RACE]
GEO Series GSE307969. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Immunoproteasome function maintains oncogenic gene expression in KMT2a-rearranged leukemia [RNA-seq I]
GEO Series GSE225315. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
TALEN-Engineered AR Gene Rearrangements Reveal Endocrine Uncoupling of Androgen Receptor in Prostate Cancer
GEO Series GSE49196. Homo sapiens. 12 samples. Type: Expression profiling by array.
Genes expression in case of PEV caused by chromosomal rearrangement
GEO Series GSE71842. Drosophila melanogaster. 8 samples. Type: Expression profiling by high throughput sequencing.
Deep sequencing of the murine Igh repertoire reveals complex regulation of non-random V gene rearrangement frequencies
GEO Series GSE47766. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide survey of adjacent gene rearrangements in breast cancer identifies triple-negative specific BCL2L14-ETV6 fusions
GEO Series GSE120919. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
HTGTS-TCR-seq for profiling of mouse and human T-cell receptor α and β gene rearrangements and diversity
GEO Series GSE308002. Mus musculus; Homo sapiens. 109 samples. Type: Other; Expression profiling by high throughput sequencing.
The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement
GEO Series GSE173597. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
Epigenetic enhancer marks and transcription factor binding influence Vk gene rearrangement frequencies in pre-B cells and pro-B cells
GEO Series GSE113306. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
UVB induces a major genome-wide rearrangement of RNA polymerase II at transcribed human genes
GEO Series GSE52789. Homo sapiens. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The retinoblastoma gene is targeted for rearrangements in BRCA1-deficient basal-like breast cancer.
GEO Series GSE25307. Homo sapiens. 577 samples. Type: Expression profiling by array.
Immunoproteasome function maintains oncogenic gene expression in KMT2a-rearranged leukemia [ATAC-seq]
GEO Series GSE225374. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Immunoproteasome function maintains oncogenic gene expression in KMT2a-rearranged leukemia [Cut & Tag]
GEO Series GSE227474. Homo sapiens. 18 samples. Type: Other.
Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma
GEO Series GSE76354. Homo sapiens; Rattus norvegicus. 5 samples. Type: Expression profiling by high throughput sequencing.
Immunoproteasome function maintains oncogenic gene expression in KMT2a-rearranged leukemia [RNA-seq II]
GEO Series GSE225356. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Redistribution of the Lamin B1 genomic binding profile affects spatial rearrangement of heterochromatic domains and gene expression during senescence
GEO Series GSE49341. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Data from: Annotation of pseudogenic gene segments by massively parallel sequencing of rearranged lymphocyte receptor loci
Background: The adaptive immune system generates a remarkable range of antigen-specific T-cell receptors (TCRs), allowing the recognition of a diverse set of antigens. Most of this diversity is encoded in the complementarity determining region 3 (CDR3) of the β chain of the αβ TCR, which is generated by somatic recombination of noncontiguous variable (V), diversity (D), and joining (J) gene segments. Deletion and non-templated insertion of nucleotides at the D-J and V-DJ junctions further increases diversity. Many of these gene segments are annotated as non-functional owing to defects in their primary sequence, the absence of motifs necessary for rearrangement, or chromosomal locations outside the TCR locus. Methods: We sought to utilize a novel method, based on high-throughput sequencing of rearranged TCR genes in a large cohort of individuals, to evaluate the use of functional and non-functional alleles. We amplified and sequenced genomic DNA from the peripheral blood of 587 healthy volunteers using a multiplexed polymerase chain reaction assay that targets the variable region of the rearranged TCRβ locus, and we determined the presence and the proportion of productive rearrangements for each TCRβ V gene segment in each individual. We then used this information to annotate the functional status of TCRβ V gene segments in this cohort. Results: For most TCRβ V gene segments, our method agrees with previously reported functional annotations. However, we identified novel non-functional alleles for several gene segments, some of which were used exclusively in our cohort to the detriment of reported functional alleles. We also saw that some gene segments reported to have both functional and non-functional alleles consistently behaved in our cohort as either functional or non-functional, suggesting that some reported alleles were not present in the population studied. Conclusions: In this proof-of-principle study, we used high-throughput sequencing of the TCRβ locus of a large cohort of healthy volunteers to evaluate the use of functional and non-functional alleles of individual TCRβ V gene segments. With some modifications, our method has the potential to be extended to gene segments in the α, γ, and δ TCR loci, as well as the genes encoding for B-cell receptor chains.
Safety, Efficacy, and Tolerability of BOS172738 in Patients With Advanced Rearranged During Transfection (RET) Gene-Altered Tumors
ClinicalTrials.gov study NCT03780517. IPD Sharing: Not stated. Countries: 7. Publications: 0.
A Phase 1 Dose Escalation and Expanded Cohort Study of EPZ-5676 in the Treatment of Pediatric Patients With Relapsed/Refractory Leukemias Bearing a Rearrangement of the MLL Gene
ClinicalTrials.gov study NCT02141828. IPD Sharing: Not stated. Countries: 2. Publications: 0.
X-396 Capsule in Advanced NSCLC Patients With ROS1 Gene Rearrangement
ClinicalTrials.gov study NCT03608007. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.