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83 results for “gentamicin”
Gentamicin for Junctional Epidermolysis Bullosa
ClinicalTrials.gov study NCT03526159. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Six Month Study of Gentamicin in Duchenne Muscular Dystrophy With Stop Codons
ClinicalTrials.gov study NCT00451074. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Collagen-Gentamicin Implant in the Treatment of Contaminated Surgical Abdominal Wounds
ClinicalTrials.gov study NCT00977405. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis
ClinicalTrials.gov study NCT02898961. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function
ClinicalTrials.gov study NCT02379754. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Local Collagen-Gentamicin and Extra Fixation of the Sternum for Prevention of Sternal Wound Infection in Cardiac Surgery
ClinicalTrials.gov study NCT00484055. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Gentamicin Treatment of Muscular Dystrophy
ClinicalTrials.gov study NCT00005574. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Vestibular Rehabilitation for Unsteadiness After Intratympanic Gentamicin in Patients With Meniere's Disease
ClinicalTrials.gov study NCT06143462. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Gentamicin-loaded silk/nanosilver composite scaffolds for MRSA-induced chronic osteomyelitis
Methicillin-resistant staphylococcus aureus (MRSA) often induces chronic osteomyelitis and then bone defects. Here, gentamicin-loaded silk/nanosilver composite scaffolds were developed to treat MRSA-induced chronic osteomyelitis. AgNO3 was reduced with silk as a reducing agent in formic acid, forming silver nanoparticles in situ that were distributed uniformly in the composite scaffolds. Superior antibacterial properties against MRSA were achieved for the composite scaffolds, without the compromise of osteogenesis capacity. Then gentamicin was loaded on the scaffolds for better treatment of osteomyelitis. In vivo results showed effective inhibition of the growth of MRSA bacteria, confirming the promising future in the treatment of chronic osteomyelitis.
Figure 1 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 1 Results of thymol (TML) on: A. Serum creatinine and neutrophil gelatinase-associated lipocalin (NGAL); B. Renal malondialdehyde (MDA), nitric oxide (NO), and total antioxidant capacity (TAC); C. Renal tumor necrosis factor-α (TNF-α) and interleukin-18 (IL-18); D. Renal Bax; E. Renal caspase-3, and caspase-9 in gentamicin (GN)-challenged rats. Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs GN.
Figure 2 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 2 H&E (200×) of rat kidneys of: A. Control showing normal renal architecture; B. Gentamicin (GN) group demonstrating marked distortion of kidney architecture, renal tubular necrosis and dilatation, desquamation of lining epithelium (white arrow), cytoplasmic vacuolization (black arrow), interstitial edema, coagulative necrosis (black head), and inflammatory cell infiltration (white head); C. Thymol (TML) + GN showing preservation of the normal kidney histological picture; D. Score of tubular injury. Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs. GN.
Figure 4 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 4 Immunohistochemistry (200×) of kidney injury molecule-1 (KIM-1) of rat kidneys of: A. Control showing no staining (NS); B. Gentamicin (GN) group demonstrating a significant increment of KIM-1 immunopositivity in brown color; C. Thymol (TML) + GN showing a significant decrement of KIM-1 immunoreactivity; D. Immunoreactive area (µm2). Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs. GN.
Figure 3 from: Fouad AA, Moussa NA, Kareem MMA, Akl UI, Abdelghany MI, Abdel-Aziz AM (2022) Thymol exerts antioxidant, anti-inflammatory, and anti-apoptotic protective effects against gentamicin nephrotoxicity in rats. Pharmacia 69(1): 181-186. https://doi.org/10.3897/pharmacia.69.e77338
Figure 3 Immunohistochemistry (200×) of nuclear factor-κB p65 (NF-κB p65) of rat kidneys of: A. Control showing no staining (NS); B. Gentamicin (GN) group demonstrating a significant increment of NF-κB p65 immunopositivity in brown color; C. Thymol (TML) + GN showing a significant decrement of NF-κB p65 immunoreactivity; D. Immunoreactive area (µm2). Results are mean ± S.E.M., *p < 0.05 vs. control, ≠p < 0.05 vs. GN.
Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury
ClinicalTrials.gov study NCT03503513. IPD Sharing: NO. Countries: 1. Publications: 0.
Topical Antibiotic Irrigation (Gentamicin) in Prophylaxis of Midfacial Fracture Surgical Wounds
ClinicalTrials.gov study NCT03483363. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Peritoneal Lavage With Clindamycin-gentamicin Solution on Postoperative Colorectal Cancer Infection in Elective Surgery
ClinicalTrials.gov study NCT01378832. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Gentamicin for RDEB
ClinicalTrials.gov study NCT03012191. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of a Topical Gentamicin-Collagen Sponge Along With Systemic Antibiotic in Infected Diabetic Foot Ulcers
ClinicalTrials.gov study NCT02447172. IPD Sharing: Not stated. Countries: 16. Publications: 0.
Topical Gentamicin and Vancomycin for Vascular Surgical Site Infection Prophylaxis
ClinicalTrials.gov study NCT04238923. IPD Sharing: NO. Countries: 0. Publications: 30.
Gentamicin Bladder Instillation in Individuals With Spinal Cord Injury Having Chronic Urinary Tract Infections
ClinicalTrials.gov study NCT03931408. IPD Sharing: NO. Countries: 1. Publications: 0.
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OpenNeuro
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