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125 results for “glycogen”
Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics
ClinicalTrials.gov study NCT00481598. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy
ClinicalTrials.gov study NCT06174220. IPD Sharing: NO. Countries: 1. Publications: 5.
rhGAA in Patients With Infantile-onset Glycogen Storage Disease-II (Pompe Disease)
ClinicalTrials.gov study NCT00053573. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Glycogen synthase kinase 3 inhibition controls Mycobacterium tuberculosis Infection
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Data from: A splice mutation in the PHKG1 gene causes high glycogen content and low meat quality in pig skeletal muscle
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GLAM: Glycogen-derived Lactate Absorption Map for visual analysis of dense and sparse surface reconstructions of rodent brain structures on desktop systems and virtual environments
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Conservation of the glycogen metabolism pathway underlines a pivotal function of storage polysaccharides in Chlamydiae
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Data from: Phylogenomic analysis of glycogen branching and debranching enzymatic duo
Branched polymers of glucose are universally used for energy storage in cells, taking the form of glycogen in animals, fungi, Bacteria, and Archaea, and of amylopectin in plants. Some enzymes involved in glycogen and amylopectin metabolism are similarly conserved in all forms of life, but some, interestingly, are not. In this paper we focus on phylogeny of glycogen branching and debranching enzymes, respectively involved in introducing and removing of the alpha(1->6) bonds in glucose polymers, bonds that provide the unique branching structure to glucose polymers. Results: We performed a large scale phylogenomic analysis of branching and debranching enzymes in over 400 completely sequenced genomes, including more than 200 from eukaryotes. We show that branching and debranching enzymes can be found in all kingdoms of life, including all major groups of eukaryotes, and thus were likely to have been present in the last universal common ancestor (LUCA) but have been lost in seemingly random fashion in numerous single celled eukaryotes. We also show how animal branching and debranching enzymes evolved from their LUCA ancestors by acquiring additional domains. Furthermore, we show that enzymes commonly perceived as orthologous, such as human branching enzyme GBE1 and E. coli branching enzyme glgB, are in fact related by a gene duplication and consequently paralogous. Conclusions: Despite its well known association with animal liver cells and plant starch, energy storage in the form of branched glucose polymers is clearly an ancient process and has been present in the earliest cells. The evolution of enzymes enabling this form of energy storage is more complex than previously thought and illustrates the need for explicit phylogenomic analysis in the study of even seemingly "simple" metabolic enzymes. Patterns of conservation and divergence in the evolution of the glycogen/starch branching and debranching enzymes have interesting biomedical connotations, as mutations in these enzymes lead to a variety of inheritable diseases in humans and other mammals.
Study of the Relationship Between Glycogen Storage Disease Type Ia and Inflammatory Bowel Disease
ClinicalTrials.gov study NCT01854242. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Lithium as a Glycogen-Synthase-Kinase-3 (GSK-3) Inhibitor in Mild Cognitive Impairment
ClinicalTrials.gov study NCT02601859. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Study of Glycogen Storage Disease and Associated Disorders
ClinicalTrials.gov study NCT00001342. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Dietary Treatment Strategies and Metabolic Control in Glycogen Storage Disease Type I
ClinicalTrials.gov study NCT06852612. IPD Sharing: YES. Countries: 1. Publications: 0.
Safety, Tolerability, and Pharmacokinetics of UX053 in Patients With Glycogen Storage Disease Type III (GSD III)
ClinicalTrials.gov study NCT04990388. IPD Sharing: NO. Countries: 3. Publications: 0.
Data from: Phylogenomic analysis of glycogen branching and debranching enzymatic duo
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Data from: Phylogeny and evolutionary history of glycogen synthase kinase 3/SHAGGY-like kinase genes in land plants
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Glycogen Synthase Kinase-3 Inhibition and Insulin Synergistically Enhance Proliferation and Inhibit Maturation of Human iPSC-derived Cardiomyocytes via TCF and FOXO Signaling
GEO Series GSE278598. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
CREB-Regulated Transcription During Glycogen Synthesis in Astrocytes
GEO Series GSE243500. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc)
GEO Series GSE165033. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Diurnal glycogen metabolism drives rhythmic liver protein secretion [in vivo]
GEO Series GSE283707. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of gene expression in mouse embryonic stem cells when individual glycogen synthase kinase 3 (GSK3) paralog is inhibited via chemical genetic approach
GEO Series GSE98080. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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