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915 results for “human development”
Data supporting the manuscript "Human adolescent brain network development is different for paralimbic versus neocortical zones"
<p>This data supports the manuscript "Human adolescent brain network development is different for paralimbic versus neocortical zones" by Dorfschmidt et al. All code used in the analysis can be found here: https://github.com/LenaDorfschmidt/morphometric-similarity-adolescence/</p>
Development of human pancreatic cancer avatars as a model for dynamic immune landscape profiling and personalised therapy
<div> <div> <div> <p>Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer, a disease with dismal overall survival. Advances in treatment are hindered by a lack of preclinical models. Here we show how a personalised organotypic 'avatar' created from resected tissue, allows spatial and temporal reporting on a complete in situ tumour microenvironment, and mirrors clinical responses. Our perfusion culture method extends tumour slice viability, maintaining stable tumour content, metabolism, stromal composition, and immune cell populations for 12 days. Using multiplexed immunofluorescence and spatial transcriptomics, we identify immune neighbourhoods and potential for immunotherapy. We employed avatars to assess the impact of a pre-clinically validated metabolic therapy and show recovery of stromal and immune phenotypes and tumour re-differentiation. To determine clinical relevance, we monitored avatar response to gemcitabine treatment and identified a patient avatar-predicable response from clinical follow-up. Thus, avatars provide valuable information for the syngeneic testing of novel therapeutics and a truly personalised therapeutic assessment platform for patients.</p> </div> </div> </div>
Modeling Data vs Modeling Processes: How Digital Humanities developed in Russia
<p>2nd lecture</p>
A transposase-derived gene responsible for human brain development
<p><span>Vertebrate brain development is associated with prominent neuronal cell death and DNA breaks, but their causes and functions are not well understood. DNA transposable elements and transposase-derived genes could contribute to DNA breaks and somatic genome rearrangements, however their contributions to brain development are largely unknown. PiggyBac Transposable Element Derived 5 (PGBD5) is an evolutionarily conserved vertebrate DNA transposase-derived gene with retained nuclease activity in human cells. Here, we show that PGBD5 contributes to normal brain development in mice and humans, and its deficiency causes disorder of intellectual disability, movement, and seizures. In mice, Pgbd5 is required for the developmental induction of post-mitotic DNA breaks and recurrent somatic brain<em> </em>genome rearrangements. In the cerebral cortex, loss of Pgbd5 leads to aberrant differentiation and gene expression of distinct neuronal populations, including specific types of glutamatergic neurons, which can explain the features of PGBD5 deficiency in humans. Thus, PGBD5 is a transposase-derived gene required for brain development in mammals. </span></p>
Experimental and computational approach to biomechanical human head modelling: advanced Head models for safety Enhancement And medical Development (aHEAD)
<p>Data regarding <strong>Experimental and computational approach to biomechanical human head modelling: advanced Head models for safety Enhancement And medical Development (aHEAD)</strong></p>
Impressive pan-genomic diversity of E. coli from a wild animal community near urban development reflects human impacts
<p>Data provided here support the findings of this study and code will allow the replication of analyses therein. To do so, first download and unzip the associated data files.</p> <p>For each analysis, the following files are required:</p> <p>PCAs: PCA.R, prokka_annotations.zip (and VirulenceFinder_results.csv for virulence factor PCA)</p> <p>Sankey diagram: Plasmid_AMR_Sankey.R, mlplasmids_results.zip, MOBsuite_results.zip, ResFinder_results.csv</p> <p>Pathotype assignment: VF_data_analysis.R, VirulenceFinder_results.csv</p> <p>TableS1_Ecoli_metadata.csv contains the isolate metadata (n=143) for all above analyses.</p>
The Development of a Human Model of Respiratory Syncytial Virus Infection
ClinicalTrials.gov study NCT01349543. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Development of Human Nasal Challenge Models With Microbial Constituents and Grass Pollen
ClinicalTrials.gov study NCT02090374. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Growth and Microbiome Development in Very Low Birth Weight Infants Fed Primarily Mother's Own Milk vs. Donor Human Milk
ClinicalTrials.gov study NCT02573779. IPD Sharing: Not stated. Countries: 1. Publications: 29.
Targeting Human Milk Fortification to Improve Preterm Infant Growth and Brain Development
ClinicalTrials.gov study NCT03977259. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Responses of sympatric canids to human development revealed through citizen science
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Data from: Molecular and cellular dynamics of the developing human neocortex
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Dataset: Inverse responses of species richness and niche specialization to human development
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Multimodal 3-D histology atlas volumes and plates for developing human brains
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Data from: Gridded global datasets for Gross Domestic Product and Human Development Index over 1990-2015
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Data for: Development of a method for the measurement of human scent samples using comprehensive two-dimensional gas chromatography with mass detection
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MERFISH+, a large-scale, multi-omics spatial technology resolves the transcriptomic holograms of the 3D human developing heart
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Development of human pancreatic cancer avatars as a model for dynamic immune landscape profiling and personalised therapy
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Human nasal epithelial organoids for therapeutic development in cystic fibrosis
<p>Table S1: Individual subject demographics and available clinical data for selected participants contributing functional data. Figure S1: Example measurement of µOCT ciliary beat frequencies, Figure S2: Organoid CFTR (green) co-localization with apical ZO-1 (red). (A) To illustrate the location of the ZO-1 staining within the organoid, an alpha-blended 3-D volume reconstruction was created with the fluorescence intensity increased to reveal the organoid’s shape and orient the reader to the location of the 2D co-localization image below. (B) Magnified view of the yellow frame in (A) to better visualize the CFTR and ZO-1 overlay, Video S1: Brightfield video of luminal movement of mucus, Video S2: µOCT video of luminal movement of mucus, Video S3: Brightfield video of luminal cilia beating, Video S4: µOCT video of cilia beating, Video S5: FIS assay of non-CF organoids, Video S6: FIS assay of F508del/P67L organoids. Video S7: FIS assay of F508del/F508del organoids.</p>
Data from: Development of an adrenocortical cancer humanized mouse model to characterize anti-PD1 effects on tumor microenvironment
Context: While the development of immune checkpoint inhibitors has transformed treatment strategies of several human malignancies, research models to study immunotherapy in ACC are lacking. Objective: To explore the effect of anti-PD1 immunotherapy on the alteration of the immune milieu in ACC in a newly generated preclinical model and correlate with the response of the matched patient. Design, Setting and Intervention: To characterize the CU-ACC2-M2B patient-derived xenograft in a humanized mouse model, evaluate the effect of a PD-1 inhibitor therapy and compare to the CU-ACC2 patient with metastatic disease. Results: Characterization of the CU-ACC2-hu-CB-BRGS model confirmed ACC origin and match with the original human tumor. Treatment of the mice with pembrolizumab demonstrated significant tumor growth inhibition (TGI = 60%) compared to controls, which correlated with increased tumor infiltrating lymphocyte activity, with an increase of human CD8+ T cells (p<0.05), HLA-DR+ T cells (p<0.05) as well as Granzyme B+ CD8+ T cells (<0.001). In parallel, treatment of the CU-ACC2 patient, who had progressive disease, demonstrated a partial response with 79%-100% reduction in the size of target lesions, and no new sites of metastasis. Pre-treatment analysis of the patient's metastatic liver lesion demonstrated abundant intra-tumoral CD8+ T cells by immunohistochemistry. Conclusions: Our study reports the first humanized ACC PDX mouse model which may be useful to define mechanisms and biomarkers of response and resistance to immune-based therapies, to ultimately provide more personalized care for patients with ACC.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.