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102 results for “immune priming”
Evaluating the Safety and Immune Response of a Prime-Boost HIV Vaccine Regimen in Healthy, HIV-Uninfected, Vaccinia-Naive Adults
ClinicalTrials.gov study NCT01571960. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Senescence in immune priming and attractiveness in a beetle
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Data from: Trans-generational immune priming protects the eggs only against gram-positive bacteria in the mealworm beetle
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Data from: Immune priming specificity within and across generations reveals the range of pathogens affecting evolution of immunity in an insect
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Data from: Specificity of oral immune priming in the red flour beetle Tribolium castaneum
Immune specificity is the degree to which a host's immune system discriminates among various pathogens or antigenic variants. Vertebrate immune memory is highly specific due to antibody responses. On the other hand, some invertebrates show immune priming, i.e. improved survival after secondary exposure to a previously encountered pathogen. Until now, specificity of priming has only been demonstrated via the septic infection route or when live pathogens were used for priming. Therefore, we tested for specificity in the oral priming route in the red flour beetle, Tribolium castaneum. For priming, we used pathogen-free supernatants derived from three different strains of the entomopathogen, Bacillus thuringiensis, which express different Cry toxin variants known for their toxicity against this beetle. Subsequent exposure to the infective spores showed that oral priming was specific for two naturally occurring strains, while a third engineered strain did not induce any priming effect. Our data demonstrate that oral immune priming with a non-infectious bacterial agent can be specific, but the priming effect is not universal across all bacterial strains.
Data from: Different effects of paternal trans-generational immune priming on survival and immunity in step and genetic offspring
Paternal trans-generational immune priming, whereby fathers provide immune protection to offspring, has been demonstrated in the red flour beetle Tribolium castaneum exposed to the insect pathogen Bacillus thuringiensis. It is currently unclear how such protection is transferred, as in contrast to mothers, fathers do not directly provide offspring with a large amount of substances. In addition to sperm, male flour beetles transfer seminal fluids in a spermatophore to females during copulation. Depending on whether paternal trans-generational immune priming is mediated by sperm or seminal fluids, it is expected to either affect only the genetic offspring of a male, or also their step offspring that are sired by another male. We therefore conducted a double-mating experiment and found that only the genetic offspring of an immune primed male show enhanced survival upon bacterial challenge, while phenoloxidase activity, an important insect immune trait, and the expression of the immune receptor PGRP were increased in all offspring. This indicates that information leading to enhanced survival upon pathogen exposure is transferred via sperm, and thus potentially constitutes an epigenetic effect, whereas substances transferred with the seminal fluid could have an additional influence on offspring immune traits and immunological alertness.
Supplementary material 1 from: Prigot-Maurice C, Depeux C, Paulhac H, Braquart-Varnier C, Beltran-Bech S (2022) Immune priming in Armadillidium vulgare against Salmonella enterica: direct or indirect costs on life history traits? In: De Smedt P, Taiti S, Sfenthourakis S, Campos-Filho IS (Eds) Facets of terrestrial isopod biology. ZooKeys 1101: 131-158. https://doi.org/10.3897/zookeys.1101.77216
Tables S1–S4, Figures S1–S3
Immune Response & Safety of GSK Biologicals' Mencevax™ ACWY in Subjects Primed in the DTPW-HBV=HIB-MENAC-TT-011 Study
ClinicalTrials.gov study NCT00291343. IPD Sharing: YES. Countries: 1. Publications: 0.
Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small
ClinicalTrials.gov study NCT03233724. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Specificity of oral immune priming in the red flour beetle Tribolium castaneum
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Data from: Different effects of paternal trans-generational immune priming on survival and immunity in step and genetic offspring
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Data from: Male pregnancy and bi-parental immune priming
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Epigenetic priming enhances anti-tumor immunity in resistant ovarian cancer [RNA-Seq]
GEO Series GSE188249. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
A primed immune transcriptional programme is activated in oligodendroglia in multiple sclerosis [ATAC-Seq and RNA-Seq II]
GEO Series GSE193240. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Priming of Antiviral Innate Immune Responses in Specific Alveolar Macrophage Subsets by Cholesterol Deprivation
GEO Series GSE264004. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Stromal reprogramming by FAK inhibition overcomes radiation resistance to allow for immune priming and response to checkpoint blockade [in vitro]
GEO Series GSE207717. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
A primed immune transcriptional programme is activated in oligodendroglia in multiple sclerosisn [RNA-Seq]
GEO Series GSE193236. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade
GEO Series GSE234161. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Stromal reprogramming by FAK inhibition overcomes radiation resistance to allow for immune priming and response to checkpoint blockade.
GEO Series GSE207718. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
Intravenous BCG induces primed immune signaling that correlates with protection against tuberculosis
GEO Series GSE211191. Macaca mulatta. 32 samples. Type: Expression profiling by high throughput sequencing.
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Annotated Behaviour and Observability Dataset (ABODe)
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