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Dataset results
71 results for “invasive aspergillosis”
Bronchoalveolar Lavage Lateral-Flow Device Test for Invasive Pulmonary Aspergillosis: a Multicenter Study
ClinicalTrials.gov study NCT02058316. IPD Sharing: Not stated. Countries: 2. Publications: 2.
PET/CT Guided Antifungal Stewardship in Invasive Pulmonary Aspergillosis
ClinicalTrials.gov study NCT02955966. IPD Sharing: NO. Countries: 1. Publications: 11.
Nebulized Liposomal Amphotericin B Ambisome for Prophylaxis of Invasive Pulmonary Aspergillosis
ClinicalTrials.gov study NCT00391014. IPD Sharing: Not stated. Countries: 1. Publications: 24.
A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients
ClinicalTrials.gov study NCT00163722. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Clinical and Prognostic Comparisons Between Invasive Pulmonary Aspergillosis With or Without Invasive Tracheobronchitis During Severe Influenza: a Retrospective Multicenter Cohort Study.
ClinicalTrials.gov study NCT04077697. IPD Sharing: NO. Countries: 1. Publications: 1.
Early Molecular Detection for the Improved Diagnosis of Invasive Pulmonary Aspergillosis and Invasive Pulmonary Zygomycosis
ClinicalTrials.gov study NCT00923832. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Impaired T Cell Responsiveness to Interleukin-6 in Hematological Patients with Invasive Aspergillosis
Invasive mold infections (IMI) are among the most devastating complications following chemotherapy and hematopoietic stem cell transplantation (HSCT), with high mortality rates. Yet, the molecular basis for human susceptibility to invasive aspergillosis (IA) and mucormycosis remain poorly understood. Herein, we aimed to characterize the immune profile of individuals with hematological malignancies (n = 18) who developed IMI during the course of chemotherapy or HSCT, and compared it to that of hematological patients who had no evidence of invasive fungal infection (n = 16). First, we measured the expression of the pattern recognition receptors pentraxin 3, dectin-1, and Toll-like receptors (TLR) 2 and 4 in peripheral blood of chemotherapy and HSCT recipients with IMI. Compared to hematological controls, individuals with IA and mucormycosis had defective expression of dectin-1; in addition, patients with mucormycosis had decreased TLR2 and increased TLR4 expression. Since fungal recognition via dectin-1 favors T helper 17 responses and the latter are highly dependent on activation of the signal transducer and activator of transcription (STAT) 3, we next used phospho-flow cytometry to measure the phosphorylation of the transcription factors STAT1 and STAT3 in response to interferon-gamma (IFN-γ) and interleukin (IL)-6, respectively. While IFN-γ/STAT1 signaling was similar between groups, naïve T cells from patients with IA, but not those with mucormycosis, exhibited reduced responsiveness to IL-6 as measured by STAT3 phosphorylation. Furthermore, IL-6 increased Aspergillus-induced IL-17 production in culture supernatants from healthy and hematological controls but not in patients with IA. Altogether, these observations suggest an important role for dectin-1 and the IL-6/STAT3 pathway in protective immunity against Aspergillus.
Radiologic Features of Invasive Pulmonary Aspergillosis
ClinicalTrials.gov study NCT01178177. IPD Sharing: Not stated. Countries: 0. Publications: 1.
MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037)
ClinicalTrials.gov study NCT00076869. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory Invasive Pulmonary Aspergillosis (OPERA-T Study)
ClinicalTrials.gov study NCT05238116. IPD Sharing: NO. Countries: 20. Publications: 0.
Diagnosis of Invasive Pulmonary Aspergillosis, Specific Testing in Bronchial Secretions Versus Bronchoalveolar Fluid
ClinicalTrials.gov study NCT04848831. IPD Sharing: NO. Countries: 0. Publications: 15.
Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene)
ClinicalTrials.gov study NCT00620074. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluate Safety and Efficacy of the Coadministration of Ibrexafungerp With Voriconazole in Patients With Invasive Pulmonary Aspergillosis
ClinicalTrials.gov study NCT03672292. IPD Sharing: NO. Countries: 5. Publications: 0.
Data from: Impaired T Cell Responsiveness to Interleukin-6 in Hematological Patients with Invasive Aspergillosis
Open the record for dataset details and reuse information.
Molecular profiling reveals human biomarker signatures in patients after allogeneic stem cell transplantation suffering from invasive aspergillosis
GEO Series GSE174825. Homo sapiens. 72 samples. Type: Expression profiling by high throughput sequencing.
Galactomannan Antigen in Bronchoalveolar Lavage in the Diagnosis of Invasive Aspergillosis in Neutropenic Patients
ClinicalTrials.gov study NCT01128907. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Pre-existing Invasive Aspergillosis on Allogeneic Stem Cell Transplantation
ClinicalTrials.gov study NCT03014934. IPD Sharing: NO. Countries: 6. Publications: 0.
Non-invasive Diagnosis of Invasive Pulmonary Aspergillosis by Use of Biomarkers in Exhaled Breath Condensate
ClinicalTrials.gov study NCT04358419. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nebulised Liposomal Amphotericin for Invasive Pulmonary Aspergillosis (NAIFI01 Study)
ClinicalTrials.gov study NCT04267497. IPD Sharing: YES. Countries: 1. Publications: 0.
Liver Cirrhosis Patients With Invasive Pulmonary Aspergillosis: in Depth Understanding Clinical Host Risk Factors
ClinicalTrials.gov study NCT07238114. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.