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360 results for “meningitis”
Data from: Meningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2
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Meningeal regulatory T cells inhibit nociception in female mice
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Genotype stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative Adults: the LAST ACT trial
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Using cerebrospinal fluid nanopore sequencing assay to diagnose tuberculous meningitis: a retrospective cohort study in China
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The effect of sertraline on depression and associations with persistent depression in survivors of HIV-related cryptococcal meningitis
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Data from: Single-dose oral ciprofloxacin prophylaxis as a response to a meningococcal meningitis epidemic in the African meningitis belt: a three-arm, open-label, cluster-randomized trial
Background: Antibiotic prophylaxis for contacts of meningitis cases is not recommended during outbreaks in the African meningitis belt. We assessed the effectiveness of single-dose oral ciprofloxacin administered to household contacts and in village-wide distributions on the overall attack rate (AR) in an outbreak of meningococcal meningitis. Methods and findings: In this 3-arm, open-label, cluster-randomized trial during a meningococcal meningitis outbreak in Madarounfa District, Niger, villages notifying a suspected case were randomly assigned (1:1:1) to standard care (the control arm), single-dose oral ciprofloxacin for household contacts within 24 hours of case notification, or village-wide distribution of ciprofloxacin within 72 hours of first case notification. The primary outcome was the overall AR of suspected meningitis after inclusion. A random sample of 20 participating villages was enrolled to document any changes in fecal carriage prevalence of ciprofloxacin-resistant and extended-spectrum beta-lactamase (ESBL)–producing Enterobacteriaceae before and after the intervention. Between April 22 and May 18, 2017, 49 villages were included: 17 to the control arm, 17 to household prophylaxis, and 15 to village-wide prophylaxis. A total of 248 cases were notified in the study after the index cases. The AR was 451 per 100,000 persons in the control arm, 386 per 100,000 persons in the household prophylaxis arm (t test versus control p = 0.68), and 190 per 100,000 persons in the village-wide prophylaxis arm (t test versus control p = 0.032). The adjusted AR ratio between the household prophylaxis arm and the control arm was 0.94 (95% CI 0.52–1.73, p = 0.85), and the adjusted AR ratio between the village-wide prophylaxis arm and the control arm was 0.40 (95% CI 0.19‒0.87, p = 0.022). No adverse events were notified. Baseline carriage prevalence of ciprofloxacin-resistant Enterobacteriaceae was 95% and of ESBL-producing Enterobacteriaceae was >90%, and did not change post-intervention. One limitation of the study was the small number of cerebrospinal fluid samples sent for confirmatory testing. Conclusions: Village-wide distribution of single-dose oral ciprofloxacin within 72 hours of case notification reduced overall meningitis AR. Distributions of ciprofloxacin could be an effective tool in future meningitis outbreak responses, but further studies investigating length of protection, effectiveness in urban settings, and potential impact on antimicrobial resistance patterns should be carried out.
Single Cell Profiling of Human Dura and Meningioma Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response
<p>This repository contains the single-cell RNA-seq data described in the publication “Single Cell Profiling of Human Dura and Meningioma Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response.” Data is provided as count matrices and Seurat objects.</p>
7 day clodronate depletion: brain and meninges
<p>These files contain data from mice given either clodronate or saline liposomes i.c.v. Brains and meninges were collected at 7 days post liposome administration and processed for flow cytometry. A workspace file is included to clarify gating and quantification.</p>
CX3CR1 CreERT2 TdTomato Fatemap Recombination for brain, meninges, and blood
<p>These files contain quantification of recombination efficiency in tamoxifen-injected CX3CR1 CreERT2 TdTomato mice. The blood data was acquired longitudinally over six weeks, whereas the brain and meninges data were acquired at the end of the six weeks. Workspace files are included to demonstrate gating and quantification.</p>
Intrathecal Gemcitabine to Treat Neoplastic Meningitis, IT Gemcitabine
ClinicalTrials.gov study NCT00074607. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Middle Meningeal Artery (MMA) Embolization Compared to Traditional Surgical Strategies to Treat Chronic Subdural Hematomas (cSDH)
ClinicalTrials.gov study NCT04095819. IPD Sharing: NO. Countries: 1. Publications: 1.
Zorifertinib With Osimertinib for NSCLC With Meningeal Progression
ClinicalTrials.gov study NCT07361705. IPD Sharing: NO. Countries: 1. Publications: 19.
Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer
ClinicalTrials.gov study NCT06431685. IPD Sharing: NO. Countries: 1. Publications: 10.
Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
ClinicalTrials.gov study NCT00000708. IPD Sharing: Not stated. Countries: 1. Publications: 3.
High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study
ClinicalTrials.gov study NCT02169882. IPD Sharing: NO. Countries: 1. Publications: 2.
Liposomal Amphotericin B for the Treatment of Cryptococcal Meningitis
ClinicalTrials.gov study NCT02136030. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis
ClinicalTrials.gov study NCT00976040. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment With Tamoxifen in Cryptococcal Meningitis
ClinicalTrials.gov study NCT03112031. IPD Sharing: UNDECIDED. Countries: 1. Publications: 57.
Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis
ClinicalTrials.gov study NCT04145258. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study
ClinicalTrials.gov study NCT01158755. IPD Sharing: Not stated. Countries: 1. Publications: 2.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.