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5,031 results for “mirnas”
Fig. 19a-f in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 19a-f: Metasoma of the females: (a) Andrena cyanomicans (Photo: ZOBODAT, 2021/25/03); (b) A. fratella (Photo: ZOBODAT, 2021/25/03); (c) A. maderensis (Photo: L. Haitzinger, OLML); (d) A. mirna (Photo: ZOBODAT, 2021/25/03); (e) A. notata (Photo: ZOBODAT, 2021/25/03); (f) A. portosanctana (Photo: V. Smith, CAS).
Fig. 18a-f in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 18a-f: Scopa: (a) Andrena cyanomicans (Photo: ZOBODAT, 2021/25/03); (b) A. fratella (Photo: ZOBODAT, 2021/25/03); (c) A. maderensis (Photo: A. Kratochwil); (d) A. mirna (Photo: ZOBODAT, 2021/25/03); (e) A. notata (Photo: ZOBODAT, 2021/25/03); (f) A. portosanctana (Photo: A. Kratochwil).
Fig. 33 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 33: PCA of 16 morphometric parameters (females) and 14 parameters (males). Cyan dot = A. portosanctana; green dot: A. maderensis, orange dot: A. notata. Abbreviations of biplot parameters see Table 1.
Fig. 29 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 29: Morphometric analyses (males) of body length (BL), clypeus length (CL), length of flagellomeres 1–3 (FL1–Fl3), and Fl1/Fl2 index.
Fig. 14a-d in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 14a-d: Details in head morphology of the females: (a) rugulae of Andrena mirna (Photo: ZOBODAT, 2021/25/03); (b) clypeus of A. mirna (Photo: ZOBODAT, 2021/25/03), (c) clypeus of A. maderensis (Photo: L. Haitzinger, OLML); (d) clypeus and labrum of A. notata (Photo: ZOBODAT, 2021/25/03).
Fig. 21a-d in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 21a-d: Details of the head of the males: (a) clypeus of Andrena notata with unpunctured medium line (Photo: ZOBODAT, 2021/25/03); (b) labrum of A. maderensis (Photo: A. Kratochwil); (c) labrum of A. mirna (Photo: M. Schwarz, OLML); (d) labrum of A. portosanctana (Photo: A. Kratochwil). Yellow arrow: central hollow of the labrum with hairs.
Fig. 12a-b in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 12a-b: Habitus of the males: (a) Andrena maderensis (Photo: A. Kratochwil); (b) A. mirna (Photo: M. Schwarz, OLML); (c) A. portosanctana (Photo: A. Kratochwil).
Fig. 10a-b in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 10a-b: Lectotype of Andrena portosanctana (female) deposited in the CAS (CAS TYPE15373); (a) dorsal view; (b) lateral view; labels (written by Cockerell, first label with pencil, second label with ink). Photos: V. Smith, CAS.
Fig. 13a-f in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 13a-f: Head of the females: (a) Andrena cyanomicans (Photo: ZOBODAT, 2021/25/03); (b) A. fratella (Photo: ZOBODAT, 2021/25/03); (c) A. maderensis (Photo: L. Haitzinger, OLML); (d) A. mirna (Photo: ZOBODAT, 2021/25/03); (e) A. notata (Photo: ZOBODAT, 2021/25/03); (f) A. portosanctana (Photo: V. Smith, CAS).
Fig. 6a-b in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 6a-b: Lectotype of the female of Andrena maderensis COCKERELL, 1922 (NHMUK). (a) dorsal view, (b) lateral view, labels. Photos: J. Monks, copyright NHMUK.
Fig. 5a-b in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 5a-b: Dorsal view of the type specimen of Andrena fratella with labels. (a) female (OLML Nr. 6952474); (b) male (OLML Nr. 6952473). Photos: ZOBODAT, 2021/25/03.
Fig. 7a-b in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 7a-b: Paralectotype of the male of Andrena maderensis COCKERELL, 1922 (NHMUK). (a) dorsal view, (b) lateral view, labels. Photos: J. Monks, copyright NHMUK.
Fig. 17a-f in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 17a-f: Structure of the propodeum: (a) Andrena notata, female: roughly rugose without dorsoventral laminae (Photo: ZOBODAT, 2021/25/03); (b) A. notata, male: pattern similar to female (Photo: ZOBODAT, 2021/25/03); (c) A. mirna, male: roughly rugose without dorsoventral laminae (Photo: ZOBODAT, 2021/25/03); (d) A. fratella female: roughly rugose with dorsoventral laminae, red arrows (Photo: ZOBODAT, 2021/25/03); (e) A. cyanomicans female: roughly rugose with dorsoventral laminae, red arrow (Photo: ZOBODAT, 2021/25/03); (f) A. maderensis male: rugose only in the centre (Photo: A. Kratochwil).
Fig. 24a-f in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 24a-f: Genitals of the males: (a) Andrena cyanomicans (Photo: L. Haitzinger, OLML); (b) A. fratella (Photo: ZOBODAT, 2021/25/03); (c) A. maderensis (Photo: L. Haitzinger, OLML); (d) A. mirna (Photo: ZOBODAT, 2021/25/03); (e) A. notata (Photo: ZOBODAT, 2021/25/03); (f) A. portosanctana (Photo: L. Haitzinger, OLML).
Fig. 35 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 35: PCA of seven morphometric parameters (females) and 8 parameters (males). Red dot = A. mirna; blue dot: A cyanomicans. Abbreviations of biplot parameters see Table 1.
Fig. 8 in Taxonomic re-evaluation of Andrena cyanomicans PÉREZ, 1895, A. fratella WARNCKE, 1968, A. maderensis WARNCKE, 1969, A. mirna WARNCKE, 1969, A. notata WARNCKE, 1968, and A. portosanctana WARNCKE, 1969 (Hymenoptera, Anthophila)
Fig. 8: Dorsal view of the holotype specimen (female) of Andrena mirna with labels; female (OLML Nr. 6952277). Photos: ZOBODAT, 2021/25/03.
Integrated analysis of miRNA landscape and cellular networking pathways in stage-specific prostate cancer
<p><strong>Figure S1.</strong> Heat map of miRNA-microarray. Expression of miRNAs differentially expressed and assessed in microarray analysis of RNA isolated from four different cell lines of prostate cancer (LNCaP, PC3, DU145, 22Rv1) compared with control cell line of prostate cancer (PrEc). The red color depicts high and green color showed a lower level of expression at p value <0.01.</p> <p><strong>Figure S2A.</strong> Drug resistance by drug efflux. The internetworking relationship with miRNAs and plasma membrane protein P-glycoprotein (Pgp-plasma membrane protein). The miRNA-130a and miR-181a are downregulated in this pathway (green color) and linked with Pg and BCRP (breast cancer resistant protein). miR-133a and miR379 are involved in regulating the expression of MRP2. While miR-298, miR27a, miR331-5p and miR-130a are involved in regulating the expression of poly-glycoprotein (P-gp).</p> <p><strong>Figure S2B.</strong> Epithelial mesenchymal transition pathway. The miR-200b was downregulated during early-stage prostate cancer and was involved in inhibiting Jagged-2 (JAG2), one of the NOTCH ligands.</p> <p><strong>Figure S2C.</strong> Adipogenesis pathway. The expression of miR-326 was upregulated during the metastatic stage of prostate cancer, (red color) and involved in regulating the expression of CCAT/enhancer binding protein β (C/EBPβ), directly linked with the nuclear hormone receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ).</p> <p><strong>Figure S2D.</strong> Bone metamorphosis signaling pathway. The expression of miR-140, miR-145, and miR-155 was upregulated, along with miR-140 and miR-145 were associated with modulation of gene SOX9, and miR-155 was involved in regulating the gene FOXO3A.</p> <p><strong>Figure S2E.</strong> Th1 pathway. In this pathway, the expression of miR-146a showed a higher level of expression (red color) and modulated the expression of NF-κB signaling.</p> <p><strong>Figure S2F.</strong> Th1 and Th2 pathway. In this pathway, the expression of miR-146a showed a lower level of expression (green color) and may modulate the expression of NF-κB signaling.</p> <p><strong>Table S1.</strong> List of differentially expressed miRNAs derived from LNCaP cells lines statistically significant as P < 0.001.</p> <p><strong>Table S2.</strong> List of differentially expressed miRNAs derived from PC3 cells lines statistically significant as P < 0.001.</p> <p><strong>Table S3.</strong> List of differentially expressed miRNAs derived from DU145 cells lines statistically significant as P < 0.001.</p> <p><strong>Table S4.</strong> List of differentially expressed miRNAs derived from 22Rv1 cells lines statistically significant as P < 0.001.</p>
Dataset related to article "Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations"
<p>This record contains raw data related to article "Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations"</p> <p>Recent evidence indicates synaptic dysfunction as an early mechanism affected in neuroinflammatory diseases, such as multiple sclerosis, which are characterized by chronic microglia activation. However, the mode(s) of action of reactive microglia in causing synaptic defects are not fully understood. In this study, we show that inflammatory microglia produce extracellular vesicles (EVs) which are enriched in a set of miRNAs that regulate the expression of key synaptic proteins. Among them, miR-146a-5p, a microglia-specific miRNA not present in hippocampal neurons, controls the expression of presynaptic synaptotagmin1 (Syt1) and postsynaptic neuroligin1 (Nlg1), an adhesion protein which play a crucial role in dendritic spine formation and synaptic stability. Using a Renilla-based sensor, we provide formal proof that inflammatory EVs transfer their miR-146a-5p cargo to neuron. By western blot and immunofluorescence analysis we show that vesicular miR-146a-5p suppresses Syt1 and Nlg1 expression in receiving neurons. Microglia-to-neuron miR-146a-5p transfer and Syt1 and Nlg1 downregulation do not occur when EV-neuron contact is inhibited by cloaking vesicular phosphatidylserine residues and when neurons are exposed to EVs either depleted of miR-146a-5p, produced by pro-regenerative microglia, or storing inactive miR-146a-5p, produced by cells transfected with an anti-miR-146a-5p. Morphological analysis reveals that prolonged exposure to inflammatory EVs leads to significant decrease in dendritic spine density in hippocampal neurons in vivo and in primary culture, which is rescued in vitro by transfection of a miR-insensitive Nlg1 form. Dendritic spine loss is accompanied by a decrease in the density and strength of excitatory synapses, as indicated by reduced mEPSC frequency and amplitude. These findings link inflammatory microglia and enhanced EV production to loss of excitatory synapses, uncovering a previously unrecognized role for microglia-enriched miRNAs, released in association to EVs, in silencing of key synaptic genes.</p>
Figs. 1–2 in First high-altitude record of Bucculatrix mirnae Vargas and Moreira (Lepidoptera, Bucculatricidae) on a newly documented host plant: the importance of host plant distribution for conservation on the western slopes of the Andes mountains of northern Chile
Figs. 1–2. The habitats of Bucculatrix mirnae in the arid northern Chile. (1) The lowland Azapa Valley (type locality) located in the coastal Atacama Desert close sea level. (2) The highland neighborhood of Putre village at about 3500 m elevation on the western slopes of the Andes.
Spatiotemporal dysregulation of neuron-glia related genes and pro-/anti-inflammatory miRNAs in the 5xFAD mouse model of Alzheimer's disease - Supplementary data
<p><strong>Supplementary Table 1. </strong> Gene expression profile by RT-qPCR analysis revealed no significant differences when simultaneously considering the genotype (WT/5xFAD), age (6/9 months) and brain region (HPC, hippocampus/PFC, prefrontal cortex). </p> <p><strong>Supplementary Table 2.</strong> miRNA-target table for the Analyzed microRNAs and targets selected for this study. Obtained in the online platform https://www.mirnet.ca/</p> <p><strong>Supplementary Table 3. </strong> Node table for the analyzed microRNAs and targets selected for this study. We only considered miRNAs and/or targets with a node degree of at least 2. Obtained in the online platform https://www.mirnet.ca/</p> <p><strong>Supplementary Table 4.</strong> Bivariate Pearson’s correlation coefficients and respective p-values obtained between all miRNAs and genes.</p> <p><strong>Supplementary Table 5.</strong> List of microRNAs analyzed by RT-qPCR and their primer sequences.</p> <p><strong>Supplementary Table 6.</strong> List of genes and respective primer sequences used for mRNA analysis by RT-qPCR.</p> <p><strong>Supplementary Table 7.</strong> Raw data used for correlational analysis in hippocampus (HPC) and prefrontal cortex (PFC) using the cor function in RStudio software.</p>
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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