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420 results for “novel associations”
Association mapping identified novel candidate loci affecting wood formation in Norway spruce
<p>Genotypic data set for the association mapping in Norway spruce for wood formation and tracheid traits.</p>
Genome-wide association study identifies 18 novel loci associated with left atrial volume and function
<p><strong>README</strong></p> <p>Publication: Genome-wide association study identifies 18 novel loci associated with left atrial volume and function</p> <p>Ahlberg and Andreasen et al.</p> <p>Published: 29 July 2021, doi: <a href="https://doi.org/10.1093/eurheartj/ehab466">https://doi.org/10.1093/eurheartj/ehab466</a></p> <p>summary statistics for LAmax: rntrn_ilamax.bgen.stats.betastd.tsv.gz <br> summary statistics for LAmin: rntrn_ilamin.bgen.stats.betastd.tsv.gz <br> summary statistics for LAAEF: rntrn_laaef.bgen.stats.betastd.tsv.gz <br> summary statistics for LAPEF: rntrn_lapef.bgen.stats.betastd.tsv.gz <br> summary statistics for LATEF: rntrn_latef.bgen.stats.betastd.tsv.gz </p> <p> </p> <p>Description:</p> <p>SNP: rs number or ID string<br> CHR: chromosome<br> BP: physical (base pair) position<br> GENPOS: genetic position either from bim file or interpolated from genetic map<br> ALLELE1: first allele in bim file (usually the minor allele), used as the effect allele<br> ALLELE0: second allele in bim file, used as the reference allele<br> A1FREQ: frequency of first allele<br> F_MISS: fraction of individuals with missing genotype at this SNP<br> BETA: effect size from BOLT-LMM approximation to infinitesimal mixed model<br> SE: standard error of effect size<br> P_BOLT_LMM_INF: infinitesimal mixed model association test p-value<br> P_BOLT_LMM: non-infinitesimal mixed model association test p-value<br> N: sample size <br> bstd: standardized effect size from BOLT-LMM <br> sestd: standardized standard error of effect size</p>
Trait-habitat associations explain novel bird assemblages mixing native and alien species across New-Zealand landscapes
<p><strong>Aim</strong>: Species introductions have reshaped island faunas for the last 200 years, often threatening native biodiversity. Approximately equal numbers of native and alien species currently co-occur in the New Zealand avifauna, but they show distinct habitat use. Antagonistic interactions, habitat affinities and legacies of introduction history may concur to explain their segregation along habitat gradients. To investigate these processes, we explored how habitat, ecological traits and introduction history relate with the current composition of bird assemblages.</p> <p><strong>Location</strong>: New Zealand</p> <p><strong>Taxon</strong>: Birds</p> <p><strong>Methods</strong>: We analysed 917 bird point counts spread along habitat and elevation gradients in the Canterbury region, South Island, and related 10 ecological traits to landscape composition using a three-table ordination method known as 'RLQ analysis', accounting for spatial autocorrelation and phylogeny. We tested whether alien species' positions in the RLQ were related to proxies of introduction history.</p> <p><strong>Results</strong>: Eighteen endemic, 11 native and 19 alien species were distributed along a gradient from forest to open-habitat assemblages, in relation to foraging mode, nesting site and body size. A second gradient segregated species between native and exotic forests according to territoriality, sedentarity and diet. Traits accounted for the separation of native and alien bird species in forests, but not in open habitats. Phylogenetic signals emerged from the separation of native and alien species by forest type, and spatial structures suggested a landscape-level, rather than regional or local determinism. These correlations were independent of introduction history, although open-habitat assemblages tended to host alien species introduced later in time. </p> <p><strong>Main conclusions: </strong>Habitat type and resource availability explain the spatial partitioning of New Zealand bird assemblages between native and alien species more consistently than competitive exclusion. We conclude that trait-mediated ecological differences among species have likely played a predominant role in species' segregation among landscapes, while maintaining endemic bird assemblages in native forests. </p>
A novel preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs - Supplementary Material
<p>All Supplementary materials and source data for the manuscript.</p> <p>The reported analyses and results can be reproduced via the described IPython notebooks which can be found under www.github.com/Novartis/SPD</p>
Nicotinic Cholinergic Modulation as a Novel Treatment Strategy for Aggression Associated With Autism
ClinicalTrials.gov study NCT02552147. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: BioID2-based tau interactome reveals novel and known protein interactions associated with multiple cellular pathways
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A novel autism-associated KCNB1 mutation dramatically slows Kv2.1 potassium channel gating activation, deactivation and inactivation
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Data from: novel associations among insect herbivores and trees: drivers of occurrence and damage on pines and eucalypts
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Data from: Convergent mosaic brain evolution is associated with the evolution of novel electrosensory systems in teleost fishes
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Phenotypic variability in chorea-acanthocytosis associated with novel VPS13A mutations
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Genetic insight into a polygenic trait using a novel Genome Wide Association approach in a wild amphibian population
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Experimental infection of bumble bees with honey bee associated viruses: no direct fitness costs but potential future threats to novel wild bee hosts
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Trait-habitat associations explain novel bird assemblages mixing native and alien species across New-Zealand landscapes
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Genome-wide association results from: Transcriptomic stratification of late-onset Alzheimer’s cases reveals novel genetic modifiers of disease pathology
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Data from: Integrative genomic analysis in African American children with asthma finds 3 novel loci associated with lung function
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Post-association barrier to host switching maintained despite strong selection in a novel mutualism
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Mutations in a novel cadherin gene associated with Bt resistance in Helicoverpa zea
Transgenic corn and cotton produce crystalline (Cry) proteins derived from the soil bacterium Bacillus thuringiensis (Bt) that are toxic to lepidopteran larvae. Helicoverpa zea, a key pest of corn and cotton in the U.S., has evolved widespread resistance to these proteins produced in Bt corn and cotton. While the genomic targets of Cry selection and the mutations that produce resistant phenotypes are known in other lepidopteran species, little is known about how selection by Cry proteins shape the genome of H. zea. We scanned the genomes of Cry1Ac-selected and unselected H. zea lines, and identified twelve genes on five scaffolds that differed between lines, including cadherin-86C (cad-86C), a gene from a family that is involved in Cry1A resistance in other lepidopterans. Although this gene was expressed in the H. zea larval midgut, the protein it encodes has only 17 to 22% identity with cadherin proteins from other species previously reported to be involved in Bt resistance. An analysis of midgut-expressed cDNAs showed significant between-line differences in the frequencies of putative nonsynonymous substitutions (both SNPs and indels). Our results indicate that cad-86C is a likely target of Cry1Ac selection in H. zea. It remains unclear, however, whether genomic changes at this locus directly disrupt midgut binding of Cry1Ac and cause Bt resistance, or indirectly enhance fitness of H. zea in the presence of Cry1Ac by some other mechanism. Future work should investigate phenotypic effects of these nonsynonymous substitutions and their impact on fitness of H. zea larvae that ingest Cry1Ac.
Vicarious reward unblocks associative learning about novel cues in male rats
<p>Many species, including humans, are sensitive to social signals and their valuation is important in social learning. When social cues indicate that a conspecific is experiencing reward, they could convey vicarious reward value and prompt social learning. Here, we introduce a task that investigates if mutual reward delivery in male rats can drive social reinforcement learning in a formal associative learning experiment. Using the blocking/unblocking paradigm, we found that when actor rats have fully learned a stimulus-self reward association, adding a cue that predicted additional reward to a partner unblocked associative learning about this cue. In contrast, additional cues that did not predict partner reward remained blocked from acquiring positive associative value. Importantly, this social unblocking effect was still present when controlling for secondary reinforcement but absent when social information exchange was impeded, when mutual reward outcomes were disadvantageously unequal to the actor or when the added cue predicted reward delivery to an empty chamber. Taken together, these results suggest that mutual rewards can drive associative learning in rats and is dependent on vicariously experienced social and food related cues.</p>
Data from: Morphological convergence in a Mexican garter snake associated with the ingestion of a novel prey
Morphological convergence is expected when organisms which differ in phenotype experience similar functional demands, which lead to similar associations between resource utilization and performance. To consume prey with hard exoskeletons, snakes require either specialized head morphology, or to deal with them when they are vulnerable, e.g. during molting. Such attributes may in turn reduce the efficiency with which they prey on soft-bodied, slippery animals such as fish. Snakes which consume a range of prey may present intermediate morphology, such as that of Thamnophiine (Natricidae) which may be classified morphometrically across the soft-hard prey dietary boundary. In this study, we compared the dentition and head structure of populations of Thamnophis melanogaster that have entered the arthropod-crustacean (crayfish)-eating niche and those that have not, and tested for convergence between the former and two distantly related crayfish specialists of the genus Regina (R. septemvittata and R. grahamii). As a control, we included the congener T. eques. Multivariate analysis of jaw length, head length, head width, and number of maxillary teeth yielded three significant canonical variables that together explained 98.8 % of the variance in the size-corrected morphological data. The first canonical variable significantly discriminated between the three species. The results show that head dimensions and number of teeth of the two Regina species are more similar to those of crayfish-eating T. melanogaster than to non-crayfish-eating snakes or of T. eques. It is unclear how particular head proportions or teeth number facilitates capture of crayfish, but our results and the rarity of soft crayfish ingestion by T. melanogaster may reflect the novelty of this niche expansion, and are consistent with the hypothesis that some populations of T. melanogaster have converged in their head morphology with the two soft crayfish-eating Regina species, although we cannot rule out the possibility of a morphological preadaptation to ingest crayfish.
Fig. 2 in Stephanopachys conicolaFisher (Coleoptera: Bostrichidae) Feeding on Decaying Western Juniper (Juniperus occidentalisHooker) Berries: A Novel Association for Bostrichidae
Fig. 2. Juniperus occidentalis berries damaged (left) by Stephanopachys conicola and undamaged (right).
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.