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93 results for “soleus”
Transcriptional analysis of soleus from mice preserved with the Rapid Freeze hardware
Data from the NASA Rodent Research-1 (RR-1) mission showed that gene-expression levels in mouse livers are different depending on what tissue preservation protocol is used and that slow freezing is not an effective method for preserving signals in gene-expression data. In response to these and other observations the Rapid Freeze hardware was built for use on the International Space Station. The Rapid Freeze hardware freezes mouse tissues (Glovebox freezer) and whole carcasses (Cryochiller) at rates closely mimicking those attained with immersion in liquid nitrogen. Because this hardware will be used extensively on future rodent research missions it is crucial to understand whether or not it preserves signals in gene expression data in order to maximize the value of these rare and expensive spaceflight experiments. Therefore this study was designed with three goals: 1) To evaluate the temperature profile of the Cryochiller and Glovebox freezer cartridges (Rapid Freeze hardware) over time during mock on-orbit procedures; 2) To determine the freezing profiles of tissues and carcasses using Rapid Freeze hardware at both optimal and sub-optimal temperatures (to mimic on-orbit operations) compared with those frozen in liquid nitrogen (the laboratory gold standard) or frozen at -80 C (the current standard method); 3) To identify gene expression changes in a) tissues that were frozen via the Glovebox freezer and b) tissues dissected from whole or partial carcasses that were frozen via the Cryochiller versus tissues that were frozen via control methods (liquid nitrogen or -80C slow freeze) to assess how the Rapid Freeze hardware compares with laboratory gold standard practices and our current standard methods.
Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression
Gene expression changes induced by acute skeletal muscle unloading which leads to physiological changes including muscle atrophy fibre-type switching and loss of ability to transition between lipid and glucose as energy source (metabolic inflexibility) was investigated by hind-limb suspension (HLS) treatment of Male ICR mice (28 x9632 g body wt; Harlan Indianapolis IN). Agilent Whole Mouse Genome Oligo Microarrays were utilised to examine the effects of HLS on mRNA expression profiles of the soleus muscle and the gastrocnemius muscle in the hindlimbs of freely ambulating control and 24h HLS treated mice.
miRNA signature detection and countermeasures against HZE radiation exposure for tissue degeneration-Soleus muscle
Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach our previous NASA work has shown both TGF xce xb2 signaling pathways and miRNAs have a critical impact on defining health risks with and without space irradiation. We hypothesize that circulating microRNA (miRNA) signatures are driving microvascular disease and muscle degeneration associated with accelerating aging and will be enhanced by exposure to the space environment (radiation and microgravity). We investigated this hypothesis both in vivo and in vitro and test novel antagonist therapies to these miRNA signatures as countermeasures to reduce space radiation-induced health risks. A comprehensive Systems Biology approach was used to examine the influence by high atomic number by high (H) atomic number (Z) and energy (E) (HZE) irradiation. To simulate low-dose exposure due to galactic cosmic rays (GCR) we used the ions energy and doses determined by a NASA consensus formula of 7 different ions to represent GCR (referred to as GCR sim model). To simulate high-dose radiation exposure due to solar particle events (SPE) we used an acute dose of SPE simulated beam at 1Gy which has energies ranging from 50MeV to 150MeV. C57BL/6 wild-type mice were utilized for irradiation with our established simulated microgravity model (hindlimb suspension model) and an in vitro 3D microvasculature tissue model under simulated microgravity (clinostat) conditions will also be irradiated. To expand on the circulating miRNA signature determined from our preliminary data we determined a group of conserved miRNAs which are commonly being regulated in the majority of the organs and tissues throughout the host using our established techniques. MiRNA-sequencing on serum (before IR and at time of sacrifice) liver heart and muscle tissue for all radiation groups revealed the key circulating miRNA signature (consisting of multiple miRNAs) impacting disease risk. Collectively understanding of how whole body space radiation impacts microvascular and tissue degeneration through circulating miRNAs will greatly enhance health risk prognostication and provide possible new mechanisms for protection against space radiation.
RNA-Seq transcriptome profiling of soleus from adult and aged mice following disuse muscle atrophy and recovery
Rodent hind limb unloading was used as a model for reduced muscle activity and eventual atrophy. After a 10 day period of unloading mice in this study were xe2 x80 x9creloaded xe2 x80 x9d for 3 days and regained use of their hind limbs. We report the application of Next-generation sequencing (NGS) technology for high-throughput profiling of mRNA in soleus muscle of adult (6 mo) and aged (22-24 mo) mice. Our goal was to determine the effects of hind limb unloading and reloading on mRNA profiles in soleus muscle and compare between adult and aged mice. We find that there are distinct response in the profile of fatty acid oxidation TCA cycle ETC oxidative phosphorylation gene expression patterns in response to unloading and reloading. The repsonses are generally simialr between young and old mice.
Porphyromonas gingivalis affects gene expression in skeletal muscle, soleus muscle
GEO Series GSE146635. Mus musculus. 8 samples. Type: Expression profiling by array.
Transcriptional changes in soleus muscle for rats exposed to different activities after contusion injury to the spinal cord and transcriptional changes in soleus muscle with complete spinal cord trans
GEO Series GSE129694. Rattus norvegicus. 20 samples. Type: Expression profiling by high throughput sequencing.
Disrupted Macrophage Metabolic Reprogramming in Aged Soleus Muscle During Early Recovery following Disuse Atrophy
GEO Series GSE158987. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after three-day dry immersion
GEO Series GSE216845. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
PolyA RNA sequencing of soleus muscles of WT and LSD1-mKO mice after voluntary wheel running
GEO Series GSE198827. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional effects of KLF15 deletion in soleus muscle
GEO Series GSE160848. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Molecular insights into human soleus muscle atrophy development: long-term dry immersion effects on the transcriptomic profile and post-translational signaling
GEO Series GSE268033. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
High througuput sequencing of skeletal muscle-specific Site-1 Protease knockout mouse gastrocnemius and soleus
GEO Series GSE199014. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profiles of muscular dystrophy with myositis (mdm) in extensor digitorum longus, psoas, and soleus muscles from mice
GEO Series GSE210263. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression profiling of mouse soleus hindlimb muscle following gradual exposure to hypoxia
GEO Series GSE64076. Mus musculus. 16 samples. Type: Expression profiling by array.
Skeletal muscle of Eif6 heterozygous mice - soleus
GEO Series GSE116714. Mus musculus. 8 samples. Type: Expression profiling by array.
Effect of deletion of ERRalpha, ERRbeta and/or ERRgamma on gene expression in soleus and extensor digitorum longus (EDL) skeletal muscles
GEO Series GSE214876. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of the soleus muscle extracted from Dnm2 K562E point-mutant heterozygous mice
GEO Series GSE134488. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression
GEO Series GSE9802. Mus musculus. 20 samples. Type: Expression profiling by array.
Gene Expression Changes in Soleus Muscle in Mice after Pericytes-Deletion
GEO Series GSE229364. Mus musculus. 1 samples. Type: Expression profiling by array.
Effect of Soleus Pushup Exercise in Type 2 Diabetes Patients
ClinicalTrials.gov study NCT06020846. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.