Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
267
datasets available to search
ShareScore release 0.9.0
Dataset results
267 results for “target of selection”
(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis
ClinicalTrials.gov study NCT03580655. IPD Sharing: Not stated. Countries: 12. Publications: 3.
Population genomics of big mice from the Faroe islands: Hybridization, colonization, and a new challenge to identifying genomic targets of selection
Open the record for dataset details and reuse information.
Combining GWAS and FST-based approaches to identify targets of Borrelia-mediated selection in natural rodent hosts
Open the record for dataset details and reuse information.
Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure
Open the record for dataset details and reuse information.
Data from: Targeted checkpoint control of B cells undergoing positive selection in germinal centers by follicular regulatory T cells
Open the record for dataset details and reuse information.
Data from: Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule
Open the record for dataset details and reuse information.
Data from: Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteins
Open the record for dataset details and reuse information.
Data from: Individual inversions or their combinations: which is the main selective target in a natural population of Drosophila subobscura?
It is generally accepted that chromosomal inversions have been key elements in adaptation and speciation processes. In this context, D. subobscura has been, and still is, an excellent model species due to its rich chromosomal polymorphism. In this species, many analyses from natural populations have demonstrated the adaptive potential of individual inversions (and their overlapped combinations, the so called arrangements). However, little information is available on the evolutionary role of combinations generated by inversions located in homologous and non-homologous chromosomes. The aim of this research is to ascertain whether these combinations are also a target for natural selection. For this objective, we have studied the inversion composition of homologous and non-homologous chromosomes from a D. subobscura sample collected in a well-studied population, Mount Avala (Serbia). No significant deviation from H-W expectations was detected, and when comparing particular karyotypic combinations, likelihood ratios close to 1 were obtained. Thus, it seems that for each pair of homologous chromosomes inversions no deviation from randomness was detected. Finally, no linkage disequilibrium was observed between inversions located in different chromosomes of the karyotype. For all these reasons it can be assumed that, at the cytological level, the individual inversions rather than their combinations in different chromosomes are the main target of selection.
Data from: Sexual selection targets cetacean pelvic bones
Male genitalia evolve rapidly, probably as a result of sexual selection. Whether this pattern extends to the internal infrastructure that influences genital movements remains unknown. Cetaceans (whales and dolphins) offer a unique opportunity to test this hypothesis: since evolving from land-dwelling ancestors, they lost external hind limbs and evolved a highly reduced pelvis which seems to serve no other function except to anchor muscles that maneuver the penis. Here we create a novel morphometric pipeline to analyze the size and shape evolution of pelvic bones from 130 individuals (29 species) in the context of inferred mating system. We present two main findings: 1) males from species with relatively intense sexual selection (inferred by relative testes size) have evolved relatively large penises and pelvic bones compared to their body size, and 2) pelvic bone shape diverges more quickly in species pairs that have diverged in inferred mating system. Neither pattern was observed in the anterior-most pair of vertebral ribs, which served as a negative control. This study provides evidence that sexual selection can affect internal anatomy that controls male genitalia. These important functions may explain why cetacean pelvic bones have not been lost through evolutionary time.
Data from: Energy expenditure and body size are targets of natural selection across a wide geographic range, in a terrestrial invertebrate
One of the central questions in evolutionary ecology is how different functional capacities impact fitness, and how it varies across populations. For instance, do phenotypic attributes influence fitness similarly across geographic gradients? Which traits (physiological, morphological, life history) are most likely to be targets of natural selection? Do particular combinations of traits maximize fitness? In a semi-natural experiment, we analyzed introduced populations of an invasive species, the garden snail (Cornu aspersum) in Chile, which show low levels of genetic differentiation in spite of the distance. Specifically, we addressed whether the magnitude, sign and form of selection in snail populations could explain the differentiation (or its absence) among populations. A common garden/reciprocal transplant experiment was performed in three populations (La Serena, Constitución and Valdivia) that span a 1300 km latitudinal gradient and differ markedly in climate (semiarid North to humid South). We then released ca. 450 individuals per population (two generations after field-captured snails) in replicated enclosures at the range extremes (La Serena and Valdivia). Morphological (size and shell darkness), physiological (standard metabolic rate and digestive efficiency) and life history (growth rate) traits were measured in all snails before the release. Survival was recorded monthly during one year. However, we only detected significant selection on body size (MB), residual standard metabolic rate (SMRR) and growth rate. Survival was significantly higher in snails from La Serena than in snails from Constitución and Valdivia, when raised at La Serena. However, at Valdivia survival was not different among source populations. Interestingly, we found negative correlational selection in MB and SMRR at La Serena whereas at Valdivia, we only found directional selection on growth rate and MB, and stabilizing selection on SMRR. These results suggest that selection on physiological traits related with energy allocation is pervasive, irrespective of climate and distance.
DATASET: Using a Bacterial Protein to Selectively Target Bacterial Biofilms: Treatment of S. epidermidis Biofilms with Targeted Photothermal Gold Nanoparticles
<p>Supporting data for the manuscript.</p>
Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes
<p>A single Dcp1-Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5' to 3' decay, but the molecular mechanisms controlling selective mRNA targeting by the enzyme remain elusive. Through extensive genetic analyses we uncover <i>cis</i>-regulatory elements in the Dcp2 C-terminal domain that control selective targeting of the decapping enzyme by forming distinct decapping complexes. Two Upf1-binding motifs target the decapping enzyme to NMD substrates, and a single Edc3-binding motif targets both Edc3 and Dhh1 substrates. Pat1-binding leucine-rich motifs target Edc3 and Dhh1 substrates under selective conditions. Although it functions as a unique targeting component of specific complexes, Edc3 is a common component of multiple complexes. Xrn1 also has a specific Dcp2 binding site, allowing it to be directly recruited to decapping complexes. Collectively, our results demonstrate that Upf1, Edc3, and Pat1 function as regulatory subunits of the holo-decapping enzyme, controlling both its targeting specificity and enzymatic activation</p>
Pre-fitted Bayesian models for "Gene panel selection for targeted spatial transcriptomics"
<p>simulation_parameters_DARTFISH_slim.rds: Bayesian model fitted on the Zhang dataset.</p> <p>simulation_parameters_MERFISH_slim.rds: Bayesian model fitted on the Moffit dataset.</p> <p>simulation_parameters_osmFISH_slim.rds: Bayesian model fitted on the Codeluppi dataset.</p> <p> </p>
Data underlying the article: "A patient-centric knowledge graph approach to prioritize mutants for selective anti-cancer targeting"
<p>This repository contains the data and code underlying the article: "A patient-centric knowledge graph approach to prioritize mutants for selective anti-cancer targeting" available on BioRxiv. </p>
Targets of sexual selection on the Drosophila wing
Open the record for dataset details and reuse information.
Demographic History and Genomic Targets of Positive Selection in Giant Gough Mice
<p>A key challenge in understanding how natural selection operates is to identify the mutations and genes that make it possible. Positive selection on beneficial mutations distorts linked variation by altering the site frequency spectrum, the configuration of haplotypes, and population differentiation. By comparing patterns of sequence variation to neutral predictions across genomes, the targets of positive selection can be located. We applied this logic to an unusual population of house mice that shows phenotypic and ecological hallmarks of selection. Mice from Gough Island are twice the body size of mainland mice, eat live seabirds, maintain a very high population density, and inhabit an environment without predators or humans. We used massively parallel short-read sequencing to survey the genomes of 14 Gough Island mice. We computed a set of summary statistics to capture diverse aspects of variation across these genome sequences, used approximate Bayesian computation to reconstruct a null demographic model, and then applied machine learning to estimate the posterior probability of positive selection in each region of the genome. We conducted parallel analyses on genome sequences from 8 mice from Germany, treating them as representatives of a mainland reference population. A few thousand 5kb windows show strong evidence for positive selection in Gough Island mice but not in German mice. Genic regions and the X chromosome contain disproportionate shares of these selection windows. Over-represented gene ontologies in selection windows emphasize neurological themes. Inspection of genomic regions harboring many selection windows with high posterior probabilities pointed to genes with known effects on exploratory behavior and body size as potential targets. Some genes in these regions have missense mutations and/or putative regulatory mutations with large differences between Gough Island mice and German/French mice in the frequency of the derived allele; these are candidates for adaptive variants. Our results provide a genomic portrait of adaptation to island conditions and position Gough Island mice as a powerful system for understanding the genetic component of natural selection.</p>
Supplementary Table S1 and Supplementary Table S2 - Part of "Next generation leishmanization: revisiting molecular targets for selecting genetically engineered live-attenuated Leishmania"
<p>Supplementary Table S1 and Supplementary Table S2 -</p> <p>Part of "Next generation leishmanization: revisiting molecular targets for selecting genetically engineered live-attenuated Leishmania"</p>
Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein
<p>Dataset pertaining to Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein</p>
ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours
ClinicalTrials.gov study NCT06597721. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Safety and Activity Study of PSCA-Targeted CAR-T Cells (BPX-601) in Subjects With Selected Advanced Solid Tumors
ClinicalTrials.gov study NCT02744287. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.