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5,016 results for “THERAPEUTICS”
The c-Abl inhibitor IkT-148009 therapeutically suppresses neurodegeneration in models of heritable and sporadic Parkinson’s Disease
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Opportunities for targeted therapies: trametinib as a therapeutic approach to canine oral squamous cell carcinomas
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Inactivating conditions of therapeutic mycobacteriophages
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Dataset for: Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis
<p>This upload contains the data extracted from studies included in our meta-analysis entitled "Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis". It also contains the code used to perform the meta-analysis and generate the figures in the publication in R. </p>
Human nasal epithelial organoids for therapeutic development in cystic fibrosis
<p>Table S1: Individual subject demographics and available clinical data for selected participants contributing functional data. Figure S1: Example measurement of µOCT ciliary beat frequencies, Figure S2: Organoid CFTR (green) co-localization with apical ZO-1 (red). (A) To illustrate the location of the ZO-1 staining within the organoid, an alpha-blended 3-D volume reconstruction was created with the fluorescence intensity increased to reveal the organoid’s shape and orient the reader to the location of the 2D co-localization image below. (B) Magnified view of the yellow frame in (A) to better visualize the CFTR and ZO-1 overlay, Video S1: Brightfield video of luminal movement of mucus, Video S2: µOCT video of luminal movement of mucus, Video S3: Brightfield video of luminal cilia beating, Video S4: µOCT video of cilia beating, Video S5: FIS assay of non-CF organoids, Video S6: FIS assay of F508del/P67L organoids. Video S7: FIS assay of F508del/F508del organoids.</p>
Consolidated criteria for reporting qualitative studies (COREQ): 32-item checklist for "The experience of adherence among hemodialysis patients undergoing therapeutic regimen: a qualitative study"
<p>Reporting guidelines Consolidated criteria for reporting qualitative studies (COREQ): 32-item checklist for "The experience of adherence among hemodialysis patients undergoing therapeutic regimen: a qualitative study"</p>
Data from: Randomized study of the impact of a therapeutic education program on patients suffering from chronic low-back pain who are treated with transcutaneous electrical nerve stimulation
Background: Transcutaneous electrical nerve stimulation (TENS) is often used for the treatment of low-back pain (LBP). However, its effectiveness is controversial. Objective: To determine the efficacy of TENS in the treatment LBP when associated to a therapeutic education program (TEP). Design: Open randomized monocentric study. Setting: University hospital between 2010 and 2014. Patients: A total of 97 patients suffering from LBP. Interventions: Routine care (TENS group) or routine care plus a therapeutic education program (TENS-TEP group) based on consultation support by a pain resource nurse Main outcome measures: EIFEL and Dallas Pain Questionnaire scores. Results: Twenty-two patients (44%) were still assessable at the end-of-study visit, whereas 33 (70%) were assessable at the same time point in the TENS-TEP group (P = 0.013). The EIFEL score and the Dallas score had a similar evolution over time between groups (p = 0.18 and p = 0.50 respectively). Similarly, there were no significant differences between the groups with respect to resting pain scores (p = 0.94 for back pain and p = 0.16 for leg pain) and movement pain scores (p = 0.52 for back pain and p = 0.56 for leg pain). At Month 6, there was no significant difference between the groups (p = 0.85) with regard to analgesics and social impact. Two patients presented a serious adverse event during the study (one in each group) but non-attributable to the treatment studied. Conclusion: This study does not support the use of TENS in the treatment of patients with chronic LBP even though patients benefited from a therapeutic education program by a pain resource nurse. However, the higher number of premature withdrawals in the TENS group may be due to early withdrawal of patients who did not experience improvement of their symptoms.
Data from: Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation
A third of the global population relies heavily upon traditional or folk medicines, such as the African shrub Mallotus oppositifolius. Here, we used pharmacological screening and electrophysiological analysis in combination with in silico docking and site-directed mutagenesis to elucidate the effects of M. oppositifolius constituents on KCNQ1, a ubiquitous and influential cardiac and epithelial voltage-gated potassium (Kv) channel. Two components of the M. oppositifolius leaf extract, mallotoxin (MTX) and 3-ethyl-2-hydroxy-2-cyclopenten-1-one (CPT1), augmented KCNQ1 current by negative shifting its voltage dependence of activation. MTX was also highly effective at augmenting currents generated by KCNQ1 in complexes with native partners KCNE1 or SMIT1; conversely, MTX inhibited KCNQ1-KCNE3 channels. MTX and CPT1 activated KCNQ1 by hydrogen bonding to the foot of the voltage sensor, a previously unidentified drug site which we also find to be essential for MTX activation of the related KCNQ2/3 channel. The findings elucidate the molecular mechanistic basis for modulation by a widely used folk medicine of an important human Kv channel and uncover novel molecular approaches for therapeutic modulation of potassium channel activity.
Supplemental data for Structural dynamics of therapeutic nucleic acids with phosphorothioate backbone modification, Carlesso et al.
<p>Description of the parameterization strategy for phosphorothioate-modified therapeutic nucleic acids, and files related to the system preparation, MD trajectories and analysis.</p>
Therapeutic Evaluation of Bifidobacterium animalis subsp. lac-tis MH-02, as an Adjunctive Treatment in Patients with Reflux Esophagitis: A Randomized, Double-Blind, Placebo-Controlled Trial
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Data for multi-dimensional characterization of cellular states in ovarian cancer reveals clinically relevant immunological subtypes and therapeutic vulnerabilities
<p>The data for figures</p>
Proteomics data for "Gut Microbial Beta-Glucuronidases Influence Endobiotic Homeostasis and Are Modulated by Diverse Therapeutics"
<p>Proteomics data used to generate results in "Gut Microbial Beta-Glucuronidases Influence Endobiotic Homeostasis and Are Modulated by Diverse Therapeutics" as published in <em>Cell Host and Microbe</em>. <a href="https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00138-0">Manuscript Link</a></p>
Identification and prioritization of novel therapeutic candidates against Glutamate racemase from Klebsiella pneumoniae
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Therapeutic Potential of Nigella sativa Extract against Inflammatory Markers Interleukin-1ß (IL-1ß) and Tumor Necrosis Factor-α (TNF-α) in Rat Models with High Fat Diet
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SAUUHUPP-Based Explorations and Therapeutic Approaches for Cognitive, Emotional, and Behavioral Health
<p>Dear Visitor,</p> <p> </p> <p>Welcome to this Zenodo repository, a resource dedicated to SAUUHUPP-based explorations and potential therapeutics for the brain, mind, and cognitive, emotional, and behavioral health. Here, we bring together a collection of research and suggested approaches that utilize the principles of SAUUHUPP to provide fresh insights into these critical areas of human well-being.</p> <p> </p> <p>The Self-Aware Universe in Universal Harmony over Universal Pixel Processing (SAUUHUPP) model offers a unique lens through which we can explore mental and physical health. Rather than focusing solely on symptom management, SAUUHUPP-based approaches encourage alignment between self-awareness and universal harmony, proposing that many health challenges arise when our mental and emotional states fall out of sync with adaptive patterns observed in nature and the universe.</p> <p> </p> <p>In this repository, you will find:</p> <p> </p> <p>1. Research and Explorations: Studies and papers explore how SAUUHUPP principles apply to mental, emotional, and behavioral health. These documents investigate the potential link between misaligned self-awareness and various health challenges, including PTSD, anxiety, ADHD, and addiction.</p> <p>2. Suggested Therapeutics: SAUUHUPP-based therapeutics offer new possibilities in treatment by focusing on reprogramming self-awareness and reconnecting it with universal patterns. Techniques such as neurostimulation, recursive feedback, and structured educational sessions are designed to foster resilience, balance, and cognitive clarity.</p> <p>3. Novel AI Insights and Computational Approaches: Inspired by SAUUHUPP, we delve into how concepts like fractal-based patterns, quantum-inspired dynamics, and recursive processing might enhance our understanding of mental health. This repository includes practical applications of these principles, from diagnosis to therapy design.</p> <p> </p> <p>This repository is intended for researchers, mental health professionals, and anyone interested in pioneering approaches to health that align with both individual needs and broader, universal dynamics. We encourage you to explore these materials, adapt the insights, and consider how SAUUHUPP-based methods might complement existing practices in mental and emotional health.</p> <p> </p> <p>Thank you for visiting. We hope these resources inspire new perspectives on the path to integrated and sustainable wellness.</p> <p> </p> <p>Contact info: <a href="mailto:paradisepru@icloud.com">paradisepru@icloud.com</a> </p>
Spatial Transcriptomics in Breast Cancer Reveals Tumour Microenvironment-Driven Drug Responses and Clonal Therapeutic Heterogeneity
<p>We acquired 10x Visium spatial transcriptomics (ST) data from 9 patients with invasive adenocarcinomas [1–5] to explore the role of the tumour microenvironment (TME) on intratumor heterogeneity (ITH) and drug response in breast cancer. By leveraging a new version of Beyondcell [6] (<a href="https://github.com/cnio-bu/beyondcell" target="_blank" rel="noopener">cnio-bu/beyondcell</a>), a tool for identifying tumour cell subpopulations with distinct drug response patterns, we predicted sensitivity to over 1,200 drugs while accounting for the spatial context and interaction between the tumour and TME compartments. Moreover, we also used Beyondcell to compute spot-wise functional enrichment scores and identify niche-specific biological functions.</p> <p>Here, you can find:</p> <p>In signatures folder:</p> <ul> <li><strong>SSc breast:</strong> Collection of gene signatures used to predict sensitivity to > 1,200 drugs derived from breast cancer cell lines.</li> <li><strong>Functional signatures:</strong> Collection of gene signatures used to compute enrichment in different biological pathways.</li> </ul> <p>In visium folder:</p> <ul> <li><strong>Visium objects:</strong> Processed ST Seurat objects with deconvoluted spots, SCTransform-normalised counts, and clonal composition predicted with SCEVAN [7]. These objects, together with the signatures, were used to compute the Beyondcell objects.</li> </ul> <p>In single-cell folder:</p> <ul> <li><strong>Single-cell objects:</strong> Raw and filtered merged single-cell RNA-seq (scRNA-seq) Seurat objects with unnormalised counts used as a reference for spot deconvolution.</li> </ul> <p>In beyondcell folder:</p> <ul> <li><strong>Beyondcell </strong><strong>sensitivity </strong><strong>objects</strong> with prediction scores for all drug response signatures in SSc breast.</li> <li><strong>Beyondcell functional objects </strong>with enrichment scores for all functional signatures.</li> </ul>
Table A6 images from Computer-aided drug design (CADD) to de-orphanise marine molecules: Finding potential therapeutic agents for neurodegenerative and cardiovascular diseases
<p>High Reslution Images from Table A6</p>
Hemodynamic data from the Inspired Therapeutics NeoMate Mechanical Circulatory Support System for neonates and infants as tested in static mock circulatory loops, dynamic mock circulatory loops, and acute animal studies
<p>Inspired Therapeutics (Merritt Island, FL) is developing a mechanical circulatory support (MCS) system designed as a single driver with interchangeable, extracorporeal, magnetically levitated pumps. The NeoMate system design features an integrated centrifugal rotary pump, motor, and controller that will be housed in a single compact unit. Conceptually, the primary innovation of this technology will be the combination of disposable, low-cost pumps for use with a single, multi-functional, universal controller to support multiple pediatric cardiopulmonary indications. In response to the paucity of clinically available pediatric devices, Inspired Therapeutics is specifically targeting the underserved neonate and infant heart failure (HF) patient population first. In this article, we present the development of the prototype Inspired Therapeutics NeoMate System for pediatric left ventricular assist device (LVAD) support, and feasibility testing in static mock flow loops (H-Q curves), dynamic mock flow loops (hemodynamics), and in an acute healthy ovine model (hemodynamics and clinical applicability). The resultant hydrodynamic and hemodynamic data demonstrated the ability of this prototype pediatric LVAD and universal controller to function over a range of rotary pump speeds (500-6000 RPM), to provide pump flow rates of up to 2.6 L/min, and to volume unload the left ventricle in acute animals. Key engineering challenges observed and proposed solutions for the next design iteration are also presented.</p>
Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/CTLA-4 Protein Complex
<p>Data underlying the figures in the publication: Liu, Z. <em>et al</em>. “Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/Ctla-4 Protein Complex” <em>Nano Lett</em>. <strong>2022</strong>, <em>22</em>, 179-87, <a href="https://doi.org/10.1021/acs.nanolett.1c03584">https://doi.org/10.1021/acs.nanolett.1c03584</a></p> <p>TOC</p> <ol> <li><strong>Figure 2-3.xlsx</strong> Source data for <em>Figures 2-3</em></li> <li><strong>Figure S2-S13.xlsx</strong> Source data for <em>Figures S2-S13</em></li> </ol>
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma
<p>Data related to the manuscript "Therapeutic targeting of ATR in alveolar rhabdomyosarcoma"</p> <p> </p> <p>It can be divided in three parts</p> <p><strong>Raw data from the phosphoproteomics screen (Raw data phosphoprot.7z)</strong></p> <p>Inside contains the following files:<br> Phosphopeptides in three replicates:</p> <ul> <li>Waldorf_20170621_KI_HS_314_phospho_1_L-ctrl_H-inh_NH4OH.raw</li> <li>Waldorf_20170621_KI_HS_314_phospho_1_L-ctrl_H-inh_pipe.raw</li> <li>Waldorf_20170621_KI_HS_314_phospho_2_L-ctrl_H-inh_NH4OH.raw</li> <li>Waldorf_20170621_KI_HS_314_phospho_2_L-ctrl_H-inh_pipe.raw</li> <li>Waldorf_20170621_KI_HS_314_phospho_3_L-inh_H-ctrl_NH4OH.raw</li> <li>Waldorf_20170621_KI_HS_314_phospho_3_L-inh_H-ctrl_pipe.raw</li> </ul> <p>Total proteome (three replicates):</p> <ul> <li>Waldorf_20170621_KI_HS_314_whole_1.raw</li> <li>Waldorf_20170621_KI_HS_314_whole_2.raw</li> <li>Waldorf_20170621_KI_HS_314_whole_3.raw</li> </ul> <p><strong>Raw data from the CRISPRa screen (CRISPR.7z)</strong></p> <p>Inside contains the following files:</p> <ul> <li>(control sample) flexbarOut_barcode_DMSO.fastq</li> <li>(treated sample) flexbarOut_barcode_AZD6738.fastq</li> </ul> <p><strong>Raw data from the RNAseq experiment (RNAseq.7z)</strong></p> <p>Inside contains the following files (NOTE: paired-end sequencing):</p> <ul> <li>(control sample) AH_HDG_1_S1_R1_001.fastq</li> <li>(control sample) AH_HDG_1_S1_R2_001.fastq</li> <li>(treated sample) AH_HDG_2_S2_R1_001.fastq</li> <li>(treated sample) AH_HDG_2_S2_R2_001.fastq</li> <li>(control sample) AH_HDG_3_S3_R1_001.fastq</li> <li>(control sample) AH_HDG_3_S3_R2_001.fastq</li> <li>(treated sample) AH_HDG_4_S4_R1_001.fastq</li> <li>(treated sample) AH_HDG_4_S4_R2_001.fastq</li> <li>(control sample) AH_YB_027_S7_R1_001.fastq</li> <li>(control sample) AH_YB_027_S7_R2_001.fastq</li> <li>AH_YB_028_S8_R1_001.fastq</li> <li>AH_YB_028_S8_R2_001.fastq</li> </ul>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.