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29,897 results for “activism”
Fig. 17 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 17. Chemical structures of prenylated flavonoids with anti-diabetes activity (445–465) and estrogenic activity (466–467).
Fig. 15 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 15. Synthesis of icaritin derivatives (403–412). Reagents and conditions: (f) α,ω-dibromoalkanes (15 equiv), K2CO3 (5 equiv), acetone, reflux, 12 h; (g) diethylamine or dimethylamine, DMSO, RT, 4 h; (h) 1-iodopentane, Cs2CO3, acetone, reflux, 12 h, then diethylamine, DMSO, RT, 4 h.
Fig. 14 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 14. Synthesis of icaritin derivatives (393–402). Reagents and conditions: (a) ethyl iodoacetate, K2CO3, acetone, reflux, 12 h; (b) LiOH, THF, H2O, RT, 1.5 h; (c) corresponding basic amino acid, DIC, HOBt, anhydrous DMF, RT, overnight, His = histidine, Arg = arginine, Lys = lysine; (d) corresponding basic amino acid, HATU, DIPEA, anhydrous DMF, RT, overnight; (e) piperidine, DMF, RT, 20 min.
Fig. 23 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 23. Synthetic route of C-8 prenylated flavonoids. Reagents and conditions: (a) CH3OCH2Cl, K2CO3, acetone, room temp., 83–90%; (b) 4-MOMO-benzaldehyde, KOH, EtOH, reflux, 85%; (c) I2, DMSO, reflux, 8 h, 70%; (d) oxone, acetone, CH2Cl2/NaHCO3/ Na2CO3, RT; then p-toluenesulfonic acid, RT, 76%; (e) dilute HCl (aq.), EtOH, RT, 89%; (f) prenyl bromide, K2CO3, acetone, reflux, 95%; (g) microwave, PhNEt2, reflux, 82%. (h) H2SO4 (20% aq.), CH3OH, reflux, 86%; (j) DDQ, 1,4-dioxane, reflux, 76%.
Fig. 10 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 10. Synthesis of isolaxifolin (369). Reagents and conditions: (a) 3-methyl-2-butenal, Ca(OH), MeOH, 18 ◦ C, 72 h; (b) Ac O, CH Cl, 18 ◦ C, 6 h; (c) 3-methyl-2- 2 2 2 2 buten-1-ol, DEAD, PPh, THF, 0–18 ◦ C, 6 h; (d) Eu(fod), CHCl, 60 ◦ C, 6 h; (e) K CO, MeOH, 0 ◦ C, 1 h.
Fig. 24 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 24. Regioselective synthesis of C-6/C-8 prenylated flavonoids. Reagents and conditions: (a) TEA, TBDMS-Cl, H2SO4, dichloromethane, room temp., 83%; (b) Prenyl alcohol, TPP, DIAD, dichloromethane, ice bath, 56%; (c) Eu(fod), toluene, 140 ◦ C, 81%; (d) NaH, pivaloyl vanilloyl chloride (aq.), tetrahydrofuran, reflux, 3 85%; (e) CuCl, TMS-Cl, dry acetonitrile, RT, 60%; (f) i TBAF (aq.) dry tetrahydrofuran ii Pyrrolidine, H SO, 60%; (g) Pivaloyl chloride, DMAP, dry pyridine, 40 ◦ C, 2 2 4 15 min, H SO dilution; (h) TFA, dichloromethane, water, 30 ◦ C, 72%.
Fig. 7 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 7. Synthesis of icaritin derivatives (237–272). Reagents and conditions: i. bromo-carboxylic acid ethyl esters (2.5–4.0 equiv.), acetone, K2CO3, reflux, 6 h; ii. bromo-carboxylic acid ethyl esters (1.0–1.5 equiv.), acetone, K2CO3, reflux, 6 h; iii. NaOH, MeOH/H2O (2:1), rt, 4 h; iv. glutaric anhydride, DMAP, TEA, DCM, rt, 8 h.
Fig. 4 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 4. Synthesis of antiproliferative prenyl flavonoid derivatives (197–207). Reagents and conditions: (a) CH CN, ZnCl, Et O, HCl g, 0–5 ◦ C; (b) H O, reflux, 2 h; 3 2 2 2 (c) Me SO, K CO, acetone, rt, 0.5 h; (d) benzaldehyde or p-anisaldehyde, KOH, EtOH, H O, rt, 3 h; (e) CH –CHCH Br, K CO, acetone, reflux, 12 h; (f) heat, 2 4 2 3 2 2– 2 2 3 210 ◦ C, 4 h; (g) CH COONa, C H OH, reflux, 24 h; (h) I, pyridine, 90 ◦ C, 16 h; (i) KMnO, HIO, i-PrOH, H O, rt; (j) R R CHP + Ph3Br, n-BuLi, THF, rt, 24 h; (k) 1 3 2 5 2 4 4 2 2 3 equiv BBr3, ClCH2CH2Cl, rt, 2 h; (l) 8 equiv BBr3, ClCH2CH2Cl, reflux, 4 h.
Fig. 6 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 6. Synthesis of potential MDR reversal icariin derivatives (231–236). Reagents and conditions: (a) H2SO4 (2–5 equiv), 90% EtOH, reflux; 1.5 h; (b) 20% H2SO4, MeOH, reflux, 2 h; (c) 20% H SO, MeOH, 25 ◦ C, 4 h; (d) ClSO CH, Et N, 4 h, then HCl; (e) ClSO CH, pyridine, 0 ◦ C, 3 h; then HCl; (f) ClSO NH, DMA, CH Cl, 2 4 2 3 3 2 3 2 2 2 2 0 ◦ C, 3 h; (g) ClSO H, Et N, 0 ◦ C, 3 h; then HCl.
Fig. 5 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 5. Synthesis of 4′-methoxy licoflavanone derivatives (208–230). Reagents and conditions: (a) RX, K CO, dry acetone, room temperature, 1–4 h, 75–86%; (b) 2 3 Propargyl bromide, K2CO3, dry acetone, room temperature, 2 h, 89% (c) TfN3, CuSO4 (aq.), Et3N, CH2Cl2/MeOH, 2–4 h, 90–96% (d) Sodium ascorbate, R–N3, CuSO4⋅5H2O, t-BuOH/water (1:1), 85–93%.
Fig. 5 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 5. Feline calicivirus (FCV)-inactivating activities of Dracocephalum spp.-derived compounds. Compounds isolated from D. fruticulosum (A and B), D. nutans (C and D), and D. foetidum (E and F) were incubated with FCV suspensions for 48 h (A, C, and E) and 6 h (B, D, and F), respectively. Viral titer data are presented as the mean ± standard deviation (n = 3–7 per group). *p <0.05; **p <0.01 vs. the dimethyl sulfoxide (DMSO) control group (Student's t-test). TCID50, 50% tissue culture infectious dose.
Fig. 4 in Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Fig. 4. Key heteronuclear multiple bonds (HMBC) and nuclear Overhauser effect (NOE) correlations of compounds 19–21.
Fig. 27 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 27. Synthesis of C-3-prenylated flavonoids. Reagents and conditions: (a) CH OCH Cl, K CO, acetone 0 ◦ C, RT; (b) 3-methylbut-2-enyl bromide (2 equiv), fresh 3 2 2 3 LDA (2.5 equiv), THF, 75 ◦ C–4 ◦ C, 20 h, 50%; (c) ArCHO (2 equiv), NaHMDS (3 equiv), THF, 75 ◦ C to reflux, 30 h, 13–46%; (d) 4 N HCl, MeOH, reflux, 8–15 h, 22–63%.
Fig. 3 in Mechanisms of action for the anti-obesogenic activities of phytochemicals
Fig. 3. Differentiation of white, brown, and beige adipocytes. Plant products (Extracts and specific phytochemicals) inhibit white adipogenesis and activate brown adipogenesis. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2 in Mechanisms of action for the anti-obesogenic activities of phytochemicals
Fig. 2. Absorption of lipids in the body and physiological role of Pancreatic Lipase (PL). Plants products inhibit the activity of PL, thus preventing the hydrolysis of triglycerides (TGs) into monoglycerides (MGs) and free fatty acids (FFAs). Arrows indicate activation or further processing while bar indicates inhibition.
Correlation between LDH/PDH activities ratio and tissue pH in the perfused mouse heart – a potential non-invasive indicator of cardiac pH provided by hyperpolarized magnetic resonance
<p>Primary data for DOI: 10.1002/nbm.4444</p> <p>NMR in Biomedicine. 2021;34:e4444.</p> <p>Title: Correlation between LDH/PDH activities ratio and tissue pH in the perfused mouse heart – a potential non-invasive indicator of cardiac pH provided by hyperpolarized magnetic resonance</p> <p>Authors: David Shaul, Assad Azar, Gal Sapir, Sivaranjan Uppala, Atara Nardi-Schreiber, Ayelet Gamliel, Jacob Sosna, J. Moshe Gomori, and Rachel Katz-Brull</p> <p> </p> <p>These primary datasets contain data presented in the above publication and consist of:</p> <p>1. <sup>31</sup>P-NMR spectra</p> <p>2. Hyperpolarized <sup>13</sup>C-NMR spectra</p> <p>Please consult the Archive Guide.</p>
Valar: Streamlining Alarm Ranking in Static Analysis with Value-Flow Assisted Active Learning
<p>static analysis alarm data</p>
Valar: Streamlining Alarm Ranking in Static Analysis with Value-Flow Assisted Active Learning
<p>static analysis alarm dataset</p>
Active Brownian particles in external force fields: field-theoretical models, generalized barometric law, and programmable density patterns
<p>Supplementary data for the following manuscript: Jens Bickmann, Stephan Bröker, Michael te Vrugt, Raphael Wittkowski, "Active Brownian particles in external force fields: field-theoretical models, generalized barometric law, and programmable density patterns".</p>
Physicochemical characteristics and antioxidant activities of polysaccharides from red seaweeds
<p>Figure S1: <sup>1</sup>H NMR spectra of <em>Chondrus crispus </em>(CC), <em>Palmaria palmate </em>(PP)<em>, Ahnfeltiopsis devoniensis </em>(AD), <em>Sarcodiotheca gaudichaudii </em>(SG). <sup>1</sup>H-NMR spectroscopy showed the full spectrum: 0.0 to 9.0 ppm</p> <p>Figure S2: Spectroscopic analysis of <em>Chondrus crispus </em>extracts 2D HC-HSQC spectra A) CC1A, B) CC2B, C) AD3A, D) SG1A, E) PP2B;</p> <p>Figure S3:<em> </em>2D spectra (CC2A, CC2B) based on HSQCs with k- and i-standards carrageenans samples</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.