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38,743 results for “efficacy”
Table 1 in Molecular characterization and protective efficacy of a new conserved hypothetical protein of Eimeria tenella
<p><b>Table 1.</b> Protective effect of r <i>Et</i> CHP protein on <i>E. tenella</i> infection.</p><table><tbody><tr><th>Group</th><th>Average body</th><th>Mean lesion scores</th><th>Oocyst shedding</th><th>Percentage reduction</th></tr></tbody><tbody><tr><th></th><td>weight gains (g)</td><td></td><td>per bird (<i>×</i> 10 7)</td><td>of oocyst excretion (%)</td></tr><tr><th>Unchallenged control</th><td>258.62 ± 70.26c</td><td>0.00 ± 0.00a</td><td>0.00 ± 0.00a</td><td>100d</td></tr><tr><th>Challenged control</th><td>180.87 ± 45.38a</td><td>3.20 ± 0.83c</td><td>4.43 ± 0.99c</td><td>0.00a</td></tr><tr><th>r <i>Et</i> CHP-50 <b>μ</b> g</th><td>226.25 ± 24.47b</td><td>1.75 ± 0.95b</td><td>2.10 ± 0.88b</td><td>54.07 ± 11.76c</td></tr><tr><th>r <i>Et</i> CHP-100 <b>μ</b> g</th><td>235.25 ± 23.44bc</td><td>1.20 ± 0.44b</td><td>3.26 ± 2.47bc</td><td>31.99 ± 29.35b</td></tr></tbody></table><p><sup>a–d</sup> Values with different letters in the same column are significantly different (<i>P</i> <0.05) according to the ANOVA Duncan test.</p>
The impact of social complexity on the efficacy of natural selection in termites
<p>This repository contains the dataset and markdown files necessary to reproduce the analysis conducted for the article entitled <em>Social evolution in termites reduces natural selection efficacy</em> (NEW TITLE: <em>The impact of social complexity on the efficacy of natural selection in termites</em>). It includes both raw and processed data, as well as all scripts used in the analysis, organized by the order of execution. Instructions for setting up the environment and running the scripts are provided to facilitate replication of the results.</p> <p>Here, we look at the distribution of dN/dS within Blattodea and Isoptera in order to test for a positive relationship with eusociality.</p> <p>The file <strong>analysis.html</strong> is a R-markdown file describing step by step the analysis of the submitted manuscript. To reproduce the analysis, all files have to be downloaded within the same directory.</p> <p>For any further information or questions, please contact camille.roux@univ-lille.fr or jonathan.romiguier@umontpellier.fr.</p> <p>Please cite this repository if you use these materials in your research.</p>
The efficacy of hemoglobin spray in wound management: a systematic review and network meta-analysis of comparative studies
<p>Dataset</p>
Efficacy and in vitro pharmacological assessment of novel N-hydroxypyridinediones as hepatitis B virus ribonuclease H inhibitors
<p>The data here is summarized in Efficacy and in vitro pharmacological assessment of novel N-hydroxypyridinediones as hepatitis B virus ribonuclease H inhibitors by Woodson, et al. </p>
Dataset for Examining the Antimicrobial Efficacy of Granulated Tetraacetylethylenediamine (TAED) Derived Peracetic Acid and Commercial Peracetic Acid in Urban Wastewaters
<p>The dataset used to generate figures in the manuscript, <em>Examining the Antimicrobial Efficacy of Granulated Tetraacetylethylenediamine (TAED) Derived Peracetic Acid and Commercial Peracetic Acid in Urban Wastewaters,</em><strong> </strong>submitted to Water Environment Research for publication. </p>
Adaptive, randomized, non-inferiority trial to evaluate the efficacy of monoclonal antibodies in outpatients with mild or moderate COVID-19
<p><span>The dataset is based on the results of a trial called MANTICO (Clinical trial number NCT05205759). The study is a non-inferiority randomised controlled trial comparing the clinical efficacy of bamlanivimab/etesevimab, casirivimab/imdevimab, and sotrovimab in outpatients aged 50 or older with early COVID-19. The primary outcome was COVID-19 progression (hospitalisation, need of supplemental oxygen therapy, or death through day 14). </span></p>
Dataset of Prediction of Self-efficacy in Recognizing Deepfake based on Personality Traits
<p>Dataset of <em>Prediction of Self-efficacy in Recognizing Deepfake based on HEXACO Personality Traits</em> </p>
Dataset for comparison of the efficacy of different drug combinations for the treatment of patients with triple negative breast cancer.
<p>Dataset for comparison of the efficacy of different drug combinations for the treatment of patients with triple negative breast cancer.</p>
Dataset for: Efficacy of prescribed fire as a fuel reduction treatment in the Colorado Front Range
<p>Prescribed fires are an important management tool for reducing fuels and returning fire to the landscape. However, rarely are changes in fuels fully quantified using pre- to post-prescribed fire measurements, and those studies that do exist show variable results. In the southern Rockies, little literature exists on the impacts of prescribed fires, thus we examined multiple prescribed fires in northern Colorado to understand fire effects and changes in fuel complexes. Most prominently, prescribed fires influenced litter, duff, and rotten coarse woody debris but did not influence other surface fuels. Crown base height increased and tree density decreased, while basal area was relatively unimpacted. Season of burning impacted fire effects as substrate burn severity, bole char, and crown volume scorched were highest in summer and fall. Continued monitoring of prescribed fires is critical to understand the influence of prescribed fire on wildfires and ultimately improving prescribed fire outcomes.</p>
Efficacy of low temperature plasma in eliminating fungi and aflatoxins - data set
<p>Set of data generated during the experimental runs</p>
Supplementary data for "Testing the efficacy of different molecular tools for parasite conservation genetics: a case study using horsehair worms (Phylum Nematomorpha)"
<p>Supplementary data for "Testing the efficacy of different molecular tools for parasite conservation genetics: a case study using horsehair worms (Phylum Nematomorpha)"</p> <p>alignments: alignments used for BEAST ("bayes") and PopArt ("popart"). The "popart" folder also has a traits file per each species.</p> <p>bayesian_plots: TSVs ("tsv") and PDF files ("ogs") generated by BEAST. The "tsv" folder also has the scripts for plotting the results in R.</p> <p>easysfs: scripts, population file and results from the VCF to SFS conversione done by easySFS.</p> <p>fineRADstructure: fineRADstructure input files and output PDF plots ("plots") for <em>C. formosanus</em> ipyrad and Stacks ("stacks") data. </p> <p>logs: logs for ipyrad, ModelTest, PGDspider, PopArt ("popart") and Stacks ("stacks"). The "popart" folder also have the generated networks in a TXT file. The "stacks" folder also has ODS files for calculating the amount of loci per each M/n fixed value.</p> <p>snapclust: STR files used with R for snapclust. Scripts included.</p> <p>stairway_plot: input (blueprint files) and outputs for Stairway Plot 2 analyses. The <em>C. formosanus</em> folder ("chordodes") also has scripts for R plotting.</p> <p>vcfs: VCF and HDF5 files used in this study. Also scripts for filtering/converting data and plotting the PCA with ipyrad (activate python first!) for <em>C. formosanus</em>.</p> <p>"acutogordius" = <em>A. taiwanensis</em><br> "chordodes" = <em>C. formosanus</em><br> "gordius" = <em>G. chiashanus</em></p>
Data for: Implications of climate change for biocontrol efficacy across the northern range of the invasive plant Linaria dalmatica
<p>The effect of insect biological control agents on invasive plant populations can vary spatially, and spatial variation in climate may drive regional variation in herbivory, and thus biocontrol efficacy. Within host plant populations, local plant abundance can also be affected by the spatial distribution of herbivores, but whether local patterns persist at larger scales is less well understood. We examined how infestation and damage of the stem-mining weevil <em>Mecinus janthiniformis</em>, a specialist biocontrol agent of the invasive plant <em>Linaria dalmatica</em>, varied with and among populations across the northern edge of the range in North America. We quantified weevil and invasive plant densities, as well as plant fecundity, stem diameter and height across sites spanning an area of ~39,000 km<sup>2</sup> in British Columbia, Canada. We found that specialist weevils did not respond to host plant density within sites across the study region. Instead, weevil attack and load were most sensitive to among-site variability in climate, with stems at warmer sites have four times as many weevils compared to stems at cooler sites. Weevils also reduced plant fecundity more at warmer sites, when controlled for plant size (stem diameter) with larger effects of weevils in thicker stems, indicating that <span><em>L. dalmatica</em> </span><span>suppression is highest in warmer locations where weevils are more abundant and environmental conditions more favorable</span>. Our results suggest that, with climate change, the efficacy of biocontrol for <em>L. dalmatica</em> will improve across the northern edge of the range. We recommend that at cooler sites, where biocontrols are less prevalent and effects on plant fecundity are weaker, alternative management strategies are necessary at this time. Across invasive plant species more generally, future studies that establish the role of climate in variability in biocontrol efficacy long after introduction can improve management of invasive plants under climate change.</p>
Data from: Components of local adaptation and divergence in pollination efficacy in a coevolving species interaction
<p>Selection leading to adaptation to interactions may generate rapid evolutionary feedbacks and drive diversification of species interactions. The challenge is to understand how the many traits of interacting species combine to shape local adaptation in ways directly or indirectly resulting in diversification. We used the well-studied interactions between <em>Lithophragma</em> plants (Saxifragaceae) and <em>Greya</em> moths (Prodoxidae) to evaluate how plants and moths together contribute to local divergence in pollination efficacy. Specifically, we studied <em>L. bolanderi</em> and its two specialized <em>Greya</em> moth pollinators in two contrasting environments in the Sierra Nevada, California. Both moths pollinate <em>L. bolanderi</em> during nectaring, and one of them – <em>G. politella</em> – also while ovipositing through the floral corolla into the ovary. Firstly, field surveys of floral visitors and the presence of <em>G. politella</em> eggs and larvae in developing capsules showed that one population is visited only by <em>G. politella</em> and few other pollinators, whereas the other is visited by both <em>Greya</em> species and other pollinators. Secondly, <em>L. bolanderi</em> in these two natural populations differed in several floral traits putatively important for pollination efficacy. Thirdly, laboratory experiments with greenhouse-grown plants and field-collected moths showed that <em>L. bolanderi</em> is more efficiently pollinated by local compared to non-local nectaring moths of both species. Pollination efficacy of ovipositing <em>G. politella</em> was also higher for local moths for the <em>L. bolanderi</em> population that relies more heavily on this species in nature. Finally, time-lapse photography in the laboratory showed that <em>G. politella</em> from different populations differ in oviposition behavior, suggesting the potential for local adaptation also among <em>Greya</em> populations. Collectively, our results are a rare example of components of local adaptation contributing to divergence in pollination efficiency in a coevolving interaction and, thus, provide insights into how geographic mosaics of coevolution may lead to coevolutionary diversification in species interactions.</p>
Workplace bullying, emotional regulation self-efficacy and well-being.
<p>Workplace bullying is one of the most relevant social stressors at work. Although previous research has shown its negative consequences on health and well-being, scarce evidence is available about the emotional mechanisms of this relationship. Thus, we conducted a longitudinal study. The final sample comprised 139 participants over 4 waves</p>
The efficacy and safety of meal replacement in patients with type 2 diabetes: a systematic review and meta-analysis
<p>There are supplemental materials for a systematic review and meta-analysis, which studied the efficacy and safety of meal replacement in patients with type 2 diabetes, with a focus on subgroup analysis of variable participant characteristics and MR prescription.</p>
Pharmacokinetic dataset of a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19
<p>Abstract</p> <p>Background</p> <p>The coronavirus disease 2019 (COVID-19) pandemic has led to a disruptive increase in the number of intensive care unit (ICU) admissions with acute respiratory distress syndrome (ARDS). ARDS is a severe, life-threatening medical condition characterized by widespread inflammation and vascular leak in the lungs. Although there is no proven therapy to reduce pulmonary vascular leak in ARDS, recent studies demonstrated that the tyrosine kinase inhibitor imatinib reinforces the endothelial barrier and prevents vascular leak in inflammatory conditions, while leaving the immune response intact.</p> <p>Methods</p> <p>This is a randomized, double-blind, parallel-group, placebo-controlled, multicenter clinical trial of intravenous (IV) imatinib mesylate in 90 mechanically ventilated subjects with COVID-19-induced ARDS. Subjects are 18 years or older, admitted to the ICU for mechanical ventilation, meeting the Berlin criteria for moderate-severe ARDS with a positive polymerase chain reaction test for SARS-CoV2. Participants will be randomized in a 1:1 ratio to either imatinib (as mesylate) 200 mg bis in die (b.i.d.) or placebo IV infusion for 7 days, or until ICU discharge or death. The primary study outcome is the change in Extravascular Lung Water Index (EVLWi) between day 1 and day 4. Secondary outcome parameters include changes in oxygenation and ventilation parameters, duration of invasive mechanical ventilation, number of ventilator-free days during the 28-day study period, length of ICU stay, and mortality during 28 days after randomization. Additional secondary parameters include safety, tolerability, and pharmacokinetics.</p> <p>Discussion</p> <p>The current study aims to investigate the efficacy and safety of IV imatinib in mechanically ventilated subjects with COVID-19-related ARDS. We hypothesize that imatinib decreases pulmonary edema, as measured by extravascular lung water using a PiCCO catheter. The reduction in pulmonary edema may reverse hypoxemic respiratory failure and hasten recovery. As pulmonary edema is an important contributor to ARDS, we further hypothesize that imatinib reduces disease severity, reflected by a reduction in 28-day mortality, duration of mechanical ventilation, and ICU length of stay.</p>
Individual and collective school-students' self-efficacy on climate change. Raw data set.
<p>The dataset comprises 12 items on the topic of "self-efficacy on climate change" and additionally some items on person-related information. The items were developed with individual self-efficacy (8 items, iSE1 to iSE8) and collective self-efficacy (4 items, coSE1 to coSE4) in mind. The instruction was: "How do you think about yourself? Please tick to what extent the following statements apply to you" [translated from German]. A six-point Likert-type scale was used as response scale, headed with numbers from 1 to 6, only the ends of the response scale were verbally labelled (1 = "strongly disagree" to 6 = "strongly agree" [translated from German]). The items were used in German. The English translations were added to the dataset in square brackets. Data collection took place at German "Gymnasien" (equivalent to grammar schools) in 2022. The data set includes N = 163 school-students.</p>
Individual and collective university students' self-efficacy on climate change. Raw data set.
<p>The dataset comprises 12 items on the topic of "self-efficacy on climate change" and additionally some items on person-related information. The items were developed with individual self-efficacy (8 items, iSE1 to iSE8) and collective self-efficacy (4 items, coSE1 to coSE4) in mind. The instruction was: "How do you think about yourself? Please tick to what extent the following statements apply to you" [translated from German]. A six-point Likert-type scale was used as response scale, headed with numbers from 1 to 6, only the ends of the response scale were verbally labelled (1 = "strongly disagree" to 6 = "strongly agree" [translated from German]). The items were used in German. The English translations were added to the dataset in square brackets. Data collection took place at a German university in 2022. The data set includes N = 145 university students studying to become geography teachers.</p>
Data from: Efficacy of multiple defences of mimics from the golden mimicry complex against two predators
<p>Many prey species employ multiple defences during interactions with predators. Multiple defences can provide a selective advantage against a single predator at different stages of the interaction or attack, as well as against multiple predator types. However, the efficacy of multiple defences both during different sequences of an attack and against multiple predator types, remains poorly understood. We measured and classified defensive traits used by five mimics (Müllerian and Batesian) of the myrmecomorphic golden mimicry complex and one non-mimetic species. We then performed predatory trials using two different predators that differed markedly in their body size, trophic specialisation, and how they handle prey – one being an ant specialist (spider) and the other a generalist which avoided ants (skink). We identified 12 defensive traits and classified them into four groups (primary, chemical, mechanical, behavioural), which were strongly correlated. Skinks were much less likely to attack and capture mimics than the ant-eating spider predators. Our results show that multiple defences (five or six) were used against each predator. The defensive behaviours and features that were most effective against skinks included appendage waving and large body size, whereas the golden 'shine' warning signal, large body size, cuticle thickness, and defensive gland size were most effective against spiders. Most defences appeared to be predator-specific. We conclude that potential prey in the golden mimicry complex have been selected for multiple defences because of their vulnerability to different predator types and consequently, the efficacy of some of these defences likely represents a trade-off.</p>
Evaluating the efficacy of using GPS satellite transmitters to assess movement of bigheaded carp in a riverine system
<p>We have evaluated the feasibility of using GPS satellite transmitters on invasive bigheaded carp species, silver carp, and bighead carp, that could determine patterns of movement, identify potential feeding and spawning areas, and inform a comprehensive monitoring and commercial removal program in the Illinois River Waterway system in the United States. Despite a wealth of information on bigheaded carp movement from acoustic and radio telemetry, a finer-scale approach to understanding habitat use and daily surfacing trends in movement would strengthen management efforts.</p> <p>Custom Fastloc™-GPS data-logging transmitters (with radio telemetry capability) manufactured by Sirtrack™ were tethered to adult bigheaded carp in field experiments. </p> <p>Sixteen field-deployed transmitters were recovered and yielded 490 individual GPS waypoints when transmitters were attached to fish. We observed movement rates within the Dresden Island Reach of the Illinois River Waterway of approximately 16 river km, and movement in and out of backwater habitats, and the warm-water discharge of a nuclear generating station.</p> <p>We have demonstrated the use of this technology to monitor bigheaded carp and will use the information gained from this study to inform future work with remotely accessed, real-time, Argos satellite-linked prototypes. Fine-scale accuracies, fast acquisition speeds, and the ability to gather real-time data make this a promising tool and is one of the first uses of GPS technology to track fish movement in a riverine system. Continued exploration to improve tag retention efficiency will enhance its utility for continued invasive carp management. </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.