Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,017
datasets available to search
ShareScore release 0.9.0
Dataset results
1,017 results for “antimicrobial”
Fig. 2 in The antimicrobial potential from insect microbiomes of Streptomyces
Fig. 2 Distinct lineages of Streptomyces associate with insect hosts. a A genomic phylogeny constructed from 93 single-copy core bacterial genes is shown to the left with the major clades, Clade I (C–I) and Clade II (C-II), labeled (B = Basal, S = Streptomyces). 16S sequences were mapped to the genomic phylogeny and the distribution of free-living (tan) and insectassociated (blue) strains is shown as both pie and bar charts to the right. Number of total strains is shown to left of pies. b–f A more detailed mapping of 16S sequences onto the genomic tree is shown for clades S01 (b), S06 (c), S07 (d), S08 (e), and S13 (f). g–j 16S phylogenies from sequences mapped to clade S06 (g), S07 (h), S08 (i), and S13 (j)
Antimicrobial Resistance Genes in Milk: a 10-year-systematic review and critical comment
Open the record for dataset details and reuse information.
Antimicrobial Resistance Genes in MIlk: a 10-year-systematic review and critical comment
Open the record for dataset details and reuse information.
Fig. 1 in Antimicrobial and antioxidant efficacy of Citrus limon L. peel extracts used for skin diseases by Xhosa tribe of Amathole District, Eastern Cape, South Africa
Fig. 1. DPPH scavenging activity of Citrus limon extracts. Results are means of 3 replicates.
Fig. 3 in Antimicrobial and antioxidant efficacy of Citrus limon L. peel extracts used for skin diseases by Xhosa tribe of Amathole District, Eastern Cape, South Africa
Fig. 3. Reducing power of C. limon extracts. Results are means of 3 replicates.
Data from: A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP
Antimicrobial peptides (AMPs) are one of the most important defense mechanisms against bacterial infections in insects, plants, non-mammalian vertebrates, and mammals. In the present study, a class of synthetic AMPs was evaluated for anti-inflammatory activity. One cationic AMP, GW-A2, demonstrated the ability to inhibit the expression levels of nitric oxide (NO), inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-activated macrophages. GW-A2 reduced LPS-induced increases in the phosphorylation of mitogen-activated protein kinase and protein kinase C-α/δ and the activation of NF-κB. GW-A2 also inhibited NLRP3 inflammasome activation induced by LPS and ATP. Furthermore, in the mice injected with LPS, GW-A2 reduced (1) the concentration of IL-1β, IL-6 and TNF-α in the serum; (2) the concentration of TNF-α in the peritoneal lavage; (3) the expression levels of iNOS, COX-2 and NLRP3 in the liver and lung; (4) the infiltration of polymorphonuclear neutrophils in the liver and lung. The underlying mechanisms for the anti-inflammatory activity of GW-A2 were found to be partially due to LPS and ATP neutralization. These results provide insights into how GW-A2 inhibits inflammation and the NLRP3 inflammasome and provide a foundation for the design of rational therapeutics for inflammation-related diseases.
Data from: Evidence for adaptation from standing genetic variation on an antimicrobial peptide gene in the mussel Mytilus edulis
Genome scans of population differentiation identify candidate loci for adaptation but provide little information on how selection has influenced the genetic structure of these loci. Following a genome scan, we investigated the nature of the selection responsible for the outlying differentiation observed between populations of the marine mussel Mytilus edulis at a leucine/arginine polymorphism (L31R) in the antimicrobial peptide MGD2. We analysed DNA sequence polymorphisms, allele frequencies and population differentiation of polymorphisms closely linked to L31R, and pairwise and third-order linkage disequilibria. An outlying level of population differentiation was observed at L31R only, while no departure from panmixia was observed at linked loci surrounding L31R, as in most of the genome. Selection therefore seems to affect L31R directly. Three hypotheses can explain the lack of differentiation in the chromosomal region close to L31R: (i) hitchhiking has occurred but migration and recombination subsequently erased the signal, (ii) selection was weak enough and recombination strong enough to limit the hitchhiking effect to a very small chromosomal region or (iii) selection acted on a pre-existing polymorphism (i.e. standing variation) at linkage equilibrium with its background. Linkage equilibrium was observed between L31R and linked polymorphisms in every population analysed, as expected under the three hypotheses. However, linkage disequilibrium was observed in some populations between pairs of loci located upstream and downstream to L31R, generating a complex pattern of third-order linkage disequilibria which is best explained by the hypothesis of selection on a pre-existing polymorphism. We hypothesise that selection could be either balanced, maintaining alleles at different frequencies depending on the pathogen community encountered locally by mussels, or intermittent, resulting in sporadic fluctuations in allele frequency.
Figure 5 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 5 Results of quantification and identification of flavonoids in ethanol extract of Osage Orange.
Figure 4 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 4 Results of quantification and identification of flavonoids in aqueous extract of Osage Orange.
Figure 10 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 10 Evaluation of the antimicrobial activity of Osage Orange extracts on strains of Bacillus subtilis 1820, E. Coli 5002, Serratia marcescens 5251 and Staphylococcus aureus ATCC-6538.
Figure 6 from: Dadayan AS, Stepanyan LA, Sargsyan TH, Hovhannisyan AM, Dadayan SA (2021) Quantitative analysis of biologically active substances and the investigation of antioxidant and antimicrobial activities of some extracts of Osage orange fruits. Pharmacia 68(4): 731-739. https://doi.org/10.3897/pharmacia.68.e70180
Figure 6 Results of quantification and identification of flavonoids in ethyl acetate extract of Osage Orange.
Assessment of animal diseases caused by bacteria resistant to antimicrobials: Swine - Appendix B: Excel file with all data extracted
<p>Information on all the full-text studies that were assessed, including the reason for exclusion for those that were excluded at the full-text screening and the data extracted from the included studies, can be consulted here. </p> <p>The extensive literature review was carried out by the University of Copenhagen under the contract OC/EFSA/ALPHA/2020/02 – LOT 1 (https://ted.europa.eu/udl?uri=TED:NOTICE:457654-2020:TEXT:EN:HTML)</p>
Assessment of animal diseases caused by bacteria resistant to antimicrobials: Poultry- Appendix B: Excel file with all data extracted
<p>Information on all the full-text studies that were assessed, including the reason for exclusion for those that were excluded at the full-text screening and the data extracted from the included studies, can be consulted here. </p> <p>The extensive literature review was carried out by the University of Copenhagen under the contract OC/EFSA/ALPHA/2020/02 – LOT 1 (https://ted.europa.eu/udl?uri=TED:NOTICE:457654-2020:TEXT:EN:HTML)</p>
Figure 2 from: Karpun Ye, Parchenko V, Fotina T, Demianenko D, Fotin A, Nahornyi V, Nahorna N (2021) The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones. Pharmacia 68(4): 797-804. https://doi.org/10.3897/pharmacia.68.e65761
Figure 2 (A) Scheme of synthesizing the S-derivatives of bis-1,2,4-triazoles; (B) Scheme of synthesizing the S-amides of bis-1,2,4-triazoles.
Supplementary material 1 from: Al Tall Y, Al-Nassar B, Abualhaijaa A, Sabi SH, Almaaytah A (2023) The design and functional characterization of a novel hybrid antimicrobial peptide from Esculentin-1a and melittin. Pharmacia 70(1): 161-170. https://doi.org/10.3897/pharmacia.70.e97116
RP-HPLC analysis Chromatogram of BKR1 peptide
Antimicrobial resistance monitoring results complementing the European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2020/2021 – Greece
<p>This dataset contains AMR monitoring results in animals and food at the isolate level pursuant to Article 9 of Directive 2003/99/EC and to Annex, part B, of Commission implementing Decision (EU) 2020/1729. In addition, the dataset includes any other results from isolates than the ones mentioned in the Commission implementing Decision (EU) 2020/172. The quantitative minimum inhibitory concentration (MIC) data from dilution methods are included.</p> <p>Reporting authorities contributing to 2021 AMR data collection: Ministry of Rural Development and Food</p>
Antimicrobial resistance monitoring results complementing the European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2020/2021 – Czechia
<p>This dataset contains AMR monitoring results in animals and food at the isolate level pursuant to Article 9 of Directive 2003/99/EC and to Annex, part B, of Commission implementing Decision (EU) 2020/1729. In addition, the dataset includes any other results from isolates than the ones mentioned in the Commission implementing Decision (EU) 2020/172. The quantitative minimum inhibitory concentration (MIC) data from dilution methods, as well as the voluntary reporting of and Whole Genome Sequencing (WGS) data are included.</p> <p>Reporting authorities contributing to 2021 AMR data collection: State Veterinary Administration</p>
Candidate antimicrobial peptide sequences mined from the UniProtKB/Swiss-Prot database using AMPlify
<p>Here we provide the datasets used in the study of AMP mining from the UniProtKB/Swiss-Prot database (2022_02 release), as well as the predicted AMP sequences by AMPlify v2.0.0. </p>
Fig. 4 in Chemical constituents of Rumex dentatus L. and their antimicrobial and anti-inflammatory activities
Fig. 4. Experimental ECD spectra of compounds 1–2 in MeOH.
Fig. 3 in Chemical constituents of Rumex dentatus L. and their antimicrobial and anti-inflammatory activities
Fig. 3. Selected NOESY correlations of compounds 1 and 2.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.