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12,683
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ShareScore release 0.9.0
Dataset results
12,683 results for “tolerability”
CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors [docetaxelRNAseq]
GEO Series GSE261193. Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Chromasome accessibility profiles at single cell level of Drug-tolerant persister cells induced by targeted therapy in lung adenocarcinoma.
GEO Series GSE275305. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The barley stripe mosaic virus expression system reveals the wheat C2H2 zinc finger protein TaZFP1B as a key regulator of drought tolerance
GEO Series GSE136683. Triticum aestivum. 16 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional control of central T cell tolerance by NR4A family transcription factors
GEO Series GSE235101. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Excessive miR-27 expression impairs regulatory T cell-mediated immunological tolerance [CD4cre miR-23 clusterTg Tr]
GEO Series GSE89546. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
A single malaria episode induces mechanisms that minimise inflammation and promote tolerance in spleen inflammatory monocytes.
GEO Series GSE150047. Mus musculus. 53 samples. Type: Expression profiling by high throughput sequencing.
Exposure of Anopheles gambiae larvae to a sub-lethal dose of an agrochemical mixture induces tolerance to Fludora® Fusion and to its neonicotinoid component in adults
GEO Series GSE189345. Anopheles gambiae. 16 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA sequencing reveals peripheral blood mononuclear immune cell landscape associated with operational tolerance in a kidney transplant recipient
GEO Series GSE230651. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
RNA sequencing data of whole blood cells of normal glucose tolerant (NGT) and gestational diabetes (GDM) pregnant women
GEO Series GSE92772. Homo sapiens. 32 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK targeted therapy in TNBC
GEO Series GSE206748. Homo sapiens. 3 samples. Type: Other.
Genome-wide analyses of direct target genes of four rice NAC-domain transcription factors involved in drought tolerance [RNA-seq]
GEO Series GSE102919. Oryza sativa. 10 samples. Type: Expression profiling by high throughput sequencing.
A type 1 immune-stromal cell network mediates disease tolerance and barrier protection against intestinal infection
GEO Series GSE292516. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Comparison between syngeneic kidney transplant and a model of allogeneic kidney transplant tolerance induced by anti-classII regimen in the rat
GEO Series GSE28474. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Identification of two mutations increasing the methanol tolerance of Corynebacterium glutamicum
GEO Series GSE71590. Corynebacterium glutamicum; Corynebacterium glutamicum ATCC 13032. 7 samples. Type: Expression profiling by array.
Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer
GEO Series GSE281129. Homo sapiens. 794 samples. Type: Other; Expression profiling by high throughput sequencing.
Suberized exodermis is required for tomato drought tolerance
GEO Series GSE212405. Solanum lycopersicum. 8 samples. Type: Expression profiling by high throughput sequencing.
Raman data for "A coralline alga gains tolerance to ocean acidification over multiple generations of exposure"
<p>This file contains the Raman data and code for "A coralline alga gains tolerance to ocean acidification over multiple generations of exposure" by Cornwall et al. in Nature Climate Change. Run the file, "run.R" in R to reproduce the analysis.</p> <p>Please see the published paper for methods and details (doi will be provided here when it becomes available).</p>
Exosomes mediate intercellular transfer of non-autonomous tolerance to proteasome inhibitors in mixed-lineage leukemia
<p><strong>Supplementary Materials</strong></p> <p>Figure S1. PI resistance is reversible in MLL cells.</p> <p>Figure S2. PI-treated cell-derived exosomes induce cell cycle arrest and PI resistance in SEM cells.</p> <p>Figure S3. Unsupervised hierarchical clustering heatmap of differentially expressed proteins in RS4;11-Nexo- or RS4;11-Rexo-treated RS4;11 cells.</p> <p>Figure S4. Integrated network nodes and edges related to “upstream” exosomal proteins.</p> <p>Figure S5. Integrated network nodes and edges related to “downstream” genes in the transcriptome profile of recipient cells.</p> <p>Figure S6. Potential therapeutic targets related to exosomal regulatory proteins.</p> <p>Figure S7. TieDIE integration network nodes and edges related to the cell cycle pathway.</p> <p>Figure S8. TieDIE integration network nodes and edges related to the stemness pathway.</p> <p>Figure S9. The original western blot images in this manuscript.</p> <p>Table S1. Differentially expressed proteins in exosomes.</p> <p>Table S2. Nodes of the TieDIE integrated network.</p> <p>Table S3. The exosomal regulatory proteins and the corresponding drugs or compounds.</p>
The contribution of stress-tolerant endosymbiotic dinoflagellate Durusdinium to Pocillopora acuta survival in a highly urbanized reef system
<p><strong>Online Resource 1</strong> BLAST results for <em>cp23S </em>Symbiodineaceae sequences.</p> <p>Online Resource 2 BLAST results for <em>ITS2 </em>Symbiodineaceae sequences.</p> <p><strong>Online Resource 3 </strong>Summary of EDGE analysis showing DETs across genotypes and treatment comparisons with corresponding fold change values, FDR and protein matches.</p> <p><strong>Online Resource 4 </strong>Summary of DEGs across genotypes and treatment comparisons with corresponding fold change values.</p>
Data from: The effect of diet and time after bacterial infection on fecundity, resistance, and tolerance in Drosophila melanogaster
Mounting and maintaining an effective immune response in the face of infection can be costly. The outcome of infection depends on two host immune strategies: resistance and tolerance. Resistance limits pathogen load, while tolerance reduces the fitness impact of an infection. While resistance strategies are well studied, tolerance has received less attention, but is now considered to play a vital role in host–pathogen interactions in animals. A major challenge in ecoimmunology is to understand how some hosts maintain their fitness when infected while others succumb to infection, as well as how extrinsic, environmental factors, such as diet, affect defense. We tested whether dietary restriction through yeast (protein) limitation affects resistance, tolerance, and fecundity in Drosophila melanogaster. We predicted that protein restriction would reveal costs of infection. Because infectious diseases are not always lethal, we tested resistance and tolerance using two bacteria with low lethality: Escherichia coli and Lactococcus lactis. We then assayed fecundity and characterized bacterial infection pathology in individual flies at two acute phase time points after infection. As expected, our four fecundity measures all showed a negative effect of a low-protein diet, but contrary to predictions, diet did not affect resistance to either bacteria species. We found evidence for diet-induced and time-dependent variation in host tolerance to E. coli, but not to L. lactis. Furthermore, the two bacteria species exhibited remarkably different infection profiles, and persisted within the flies for at least 7 days postinfection. Our results show that acute phase infections do not necessarily lead to fecundity costs despite high bacterial loads. The influence of intrinsic variables such as genotype are the prevailing factors that have been studied in relation to variation in host tolerance, but here we show that extrinsic factors should also be considered for their role in influencing tolerance strategies.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.