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226 results for “Active compounds”
Enhanced accumulation of biologically active compounds in lichens with potential functional food applications
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Bioactive compounds, antioxidant activity, and sensory profile of sorghum tisane
<p>This dataset provides the result of bioactive compounds, antioxidant activity, sensory acceptance, and sensory profile measurements towards sorghum tisane with different pericarp colors.</p>
Fig. 5 in In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds
Fig. 5. Anti-proliferative effect of isolated compounds and standard adriamycin at different concentrations. Growth between 0% and 50% indicated a cytostatic effect, while growth <0% indicated a cytocidal effect. (a) Percent control growth for MCF-7 cell line and (b) percent control growth for MDA-MB-468.
Fig. 2 in In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds
Fig. 2. Percentage scavenging activities of different fractions of P. dulcis at different concentrations. (a) DPPH radical scavenging activity, (b) Scavenging of hydrogen peroxide, (c) Percentage iron chelation, (d) Superoxide radical scavenging activity and (e) Reducing power of different fractions of P. dulcis (in %) at different concentrations. Each value represents as mean ± SD (n = 3). HF, hexane fraction; EF, ethyl acetate fraction; BF, butanol fraction; AqF, aqueous fraction. SD, standard deviation.
Fig. 1 in In-vitro antioxidative potential of different fractions from Prunus dulcis seeds: Vis a vis antiproliferative and antibacterial activities of active compounds
Fig. 1. Flow diagram of extraction of P. dulcis seeds and isolation of components from ethyl acetate fraction through different chromatography.
Screening of 165,988 compounds reflecting biological and chemical diversity in the Janssen Library for anti-SARS-CoV-2 activity
<p>This report describes the most relevant results of screening a diversity set of the Janssen Pharmaceutica compound collection for potential activity against SARS-CoV-2 in a stable eGFP-expressing VeroE6 cell line infected with SARS-CoV-2.</p>
Fig. 8. Compound 14 activated Nrf2 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii
Fig. 8. Compound 14 activated Nrf2/HO-1 signaling pathway. (A–C) The expressions of Nrf2 and HO-1 were determined by Western blot analysis and the quantification of protein expression was performed by Image J. (D) The inhibitory effect of 14 (16 μM) on the nuclear translocation of Nrf2 induced by LPS via confocal laser scanning microscopy. RAW264.7 cells stained for Nrf2 (red) and nuclei (DAPI, blue) (scale bar: 10 μm). The values are presented as mean ± SD of three independent experiments, n 3. ###p <0.001, vs. the control group; **p <0.01, ***p <0.001, vs. LPS-treated group. (For interpretation of the references to color in = this figure legend, the reader is referred to the Web version of this article.)
Fig. 7. Compound 14 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii
Fig. 7. Compound 14 reduced LPS-induced inflammatory factors production and inhibited NF-κB nuclear translocation. (A–C) The expressions of iNOS and COX-2 were determined by Western blot analysis. (D–F) The expressions of NF-κB, p-IκBα, and IκBα were determined by Western blot analysis. The quantification of protein expression was performed by Image J. (G) The inhibitory effect of compound 14 (16 μM) on the nuclear translocation of NF-κB p65 induced by LPS via confocal laser scanning microscopy. RAW264.7 cells stained for NF-κB (green) and nuclei (DAPI, blue) (scale bar: 10 μm). The values were presented as mean ± SD of three independent experiments, n 3. ###p <0.001, vs. the control group; **p <0.01, ***p <0.001, vs. LPS-treated group. (For interpretation of the references to color in = this figure legend, the reader is referred to the Web version of this article.)
Fig. 6. Compound 14 in Diterpenoids with anti-inflammatory activity from Euphorbia wallichii
Fig. 6. Compound 14 reduced LPS-induced pro-inflammatory cytokines release. (A) The NO inhibition curve of compound 14, with an IC50 of 3.84 ± 0.25 μM. (B) Cell viability rate of RAW264.7 cells treated with compound 14 (0, 3.125, 6.25, 12.5, 25, 50, 100 μM) for 24 h. (C–D) Effects of compound 14 on production of inflammatory cytokines (IL-6 and TNF-α) in LPS-induced RAW264.7 cells. ###, p <0.001 vs. control group. *, p <0.1, **, p <0.01 and ***, p <0.001 vs. LPStreated group.
Fig. 9. Compounds 4 and 5 in Eremophilane-type and xanthanolide-type sesquiterpenes from the aerial parts of Xanthium sibiricum and their anti-inflammatory activities
Fig. 9. Compounds 4 and 5 inhibited the activation of the PI3K/AKT/mTOR signaling pathway in LPS induced RAW264.7 cells. Compound 4 (A) influenced the expression of relative proteins related to the PI3K/AKT/mTOR signaling pathway and the relative levels of P-mTOR/mTOR (B) and P-AKT/AKT (C) were quantified. Compound 5 (D) influenced the expression of relative proteins related to the PI3K/AKT/mTOR signaling pathway and the relative levels of P-mTOR/mTOR (E) and PAKT/AKT (F) were quantified. Data are presented as the mean ± SD (n = 3). ##p <0.01 and ###p <0.001, compared with the group untreated with LPS; *p <0.05, **p <0.01, and ***p <0.001 compared with the group treated with LPS.
Fig. 6 in Diverse undescribed compounds from the rhizome of Zingiber officinale Rosc. And their anti-inflammatory activity
Fig. 6. Effects of compounds 1–7 on cell viability. The concentrations of these compounds ranged from 10 to 100 μM. Experiments were performed in triplicate, and the data are presented as the mean ± SD. Statistical analyses were performed by one-way ANOVA and Dunnett's test. #p <0.001 vs. the control group; *p <0.05, **p <0.01, ***p <0.001 vs. the LPS-stimulated group.
Fig. 7 in Hyperforin: A natural lead compound with multiple pharmacological activities
Fig. 7. The mechanisms of anti-ischemic stroke activity, anti-diabetes activity, effect on cutaneous wound healing and treating hypertrophic scars and anti-obesity activity of hyperforin.
Fig. 2. a in Hyperforin: A natural lead compound with multiple pharmacological activities
Fig. 2. a: Cross-section of leaf with translucent gland; b: Paradermal section of leaf with translucent gland; c: The translucent and dark glands on leaf under dissecting microscope. Scale bars = 1 cm.
Fig. 2. 1H–1H in Antitumoral activity of 1,2,4-oxadiazoles compounds isolated from the Neowerdermannia vorwerkii in liver and colon human cancer cells
Fig. 2. 1H–1H COSY and HMBC key correlations of 3-(pyridin-3-yl)-5-(tiophen-3-yl)-1,2,4-oxadiazole (1), 5-(3-methoxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (2) and 5-(3-hydroxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (3).
Fig. 1. 3 in Antitumoral activity of 1,2,4-oxadiazoles compounds isolated from the Neowerdermannia vorwerkii in liver and colon human cancer cells
Fig. 1. 3-(pyridin-3-yl)-5-(tiophen-3-yl)-1,2,4-oxadiazole (1), 5-(3-methoxyphenyl)-3-(pyridin-3-yl)-1,2,4-oxadiazole (2) and 5-(3-hydroxyphenyl)-3-(pyridin-3-yl)- 1,2,4-oxadiazole (3).
Fig. 10. Compounds 1–8 in Bisabolane-type sesquiterpenes from Vernonia amygdalina: Absolute configuration and anti-inflammatory activity
Fig. 10. Compounds 1–8 inhibited the activation of PI3K/AKT signaling pathways in LPS-induced RAW 264.7 cells. A: The expression of relative proteins related to the PI3K/AKT signaling pathways involved inflammation, including PI3K, NF-κB (p65), and AKT RAW 264.7 cells. B–D: The relative levels of p-PI3K/PI3K, p-AKT/ AKT, and p-p65/p65 were quantified (mean ± SD. ###p <0.001, compared with the group untreated with LPS; *p <0.05, **p <0.01 and ***p <0.001 compared with the group treated with LPS.).
Fig. 3 in Chemical constituents of Antidesma bunius aerial parts and the anti-AGEs activity of selected compounds
Fig. 3. Experimental CD spectra of 1 and 2; (B–F) Calculated and experimental ECD spectra of 2, 3, 4, 5, and 8.
Fig. 9. Compound 4 in Four undescribed ergostane-type steroids from Lasiodiplodia pseudotheobromae and their neuroprotective activity
Fig. 9. Compound 4 preserves mitochondrial function in glutamate-treated SH-SY5Y cell lines. Cell lines were measured using JC-1 staining by flow cytometry. Cell lines were assessed using H2DCF-DA staining and flow cytometry. Data are presented as the means ± S.D. (n = 3). ###p <0.001 vs. the control group (the no glutamate or compound 4-treated group); *p <0.05 and **p <0.001 vs. the glutamate-treated group.
Fig. 8. Compound 4 in Four undescribed ergostane-type steroids from Lasiodiplodia pseudotheobromae and their neuroprotective activity
Fig. 8. Compound 4 decreased glutamate-induced cellular apoptosis in SH-SY5Y cell lines. (A) Cellular morphological changes were observed by phase contrast microscopy. (B) Flow cytometry was applied to determine the apoptotic ratio after Annexin V-FITC/PI staining. The percentage of apoptotic cells was calculated in the bar chart. Data are presented as the means S.D. (n 3). ###p <0.001 vs. the control group (the no glutamate or compound 4-treated group); *p <0.05 and ± = ***p <0.001 vs. the glutamate-treated group.
Fig. 18 in Review of lignans from 2019 to 2021: Newly reported compounds, diverse activities, structure-activity relationships and clinical applications
Fig. 18. The "source-category-activities" network of lignans. (The green nodes represent the source (families), the red nodes indicate the category, and the purple nodes emblem the activities). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.