Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
67
datasets available to search
ShareScore release 0.9.0
Dataset results
67 results for “Chemical identification”
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
GEO Series GSE70249. Mus musculus. 405 samples. Type: Expression profiling by high throughput sequencing.
Development of Chemical Categories for Per- and Polyfluoroalkyl Substances (PFAS) and the Proof-of-Concept Approach to the Identification of Potential Candidates for Tiered Toxicological Testing and Human Health Assessment
<p>Supplementary information for the manuscript and raw data files underpinning the analysis are available here as compressed tar files. </p> <p>Please cite: Patlewicz G., Judson R., Williams A. J., Butler T., Barone Jr. S ., Carstens K. E., Cowden J., Dawson J. L., Degitz S. , Fay K., Henry T. R., Lowit A., Padilla S., Paul Friedman K., Phillips M. B., Turk D., Wambaugh J., Wetmore B., Thomas R.S. Development of Chemical Categories for Per- and Polyfluoroalkyl Substances (PFAS) and the Proof-of-Concept Approach to the Identification of Potential Candidates for Tiered Toxicological Testing and Human Health Assessment. <em>Computational Toxicology</em> <strong>2024</strong> <a href="https://doi.org/10.1016/j.comtox.2024.100327" rel="nofollow">https://doi.org/10.1016/j.comtox.2024.100327</a></p>
Identification of biomarkers that distinguish chemical contaminants using a gradient feature selection method
GEO Series GSE19662. Rattus norvegicus. 531 samples. Type: Expression profiling by array.
Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
GEO Series GSE262419. Homo sapiens. 4558 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide profiling and identification of disordered transcription factors through chemical precipitation mapping [RNA-Seq]
GEO Series GSE190962. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Identification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease
GEO Series GSE67849. Mus musculus; Homo sapiens. 46 samples. Type: Expression profiling by array.
Rapid Electrochemical Detection and Identification of Microbiological and Chemical Contaminants for Manned Spaceflight Project
<p>A great deal of effort has gone into the development of point-of-use methods to meet the challenge of rapid bacterial identification for both environmental monitoring and clinical applications.&nbsp; Unfortunately, most of the methods developed rely on Preliminary Chain Reaction (PCR) and face inherent limitations because of the requirement for enzymatic components and thermal control.&nbsp; Other methods based on surface plasmon resonance, quartz crystal microbalance, and fluorescence has been reported with good detection limits, but, these methods are immunological and cannot provide genetic-level information.&nbsp; Further, they require labeled markers, complicated fluid handling systems, and sensitive optics that drive up cost and complexity and preclude them from outside the laboratory.&nbsp; Recent work by a group at the University of Toronto has focused on developing an electrochemical platform that combines ultrasensitive detection, straightforward sample processing, and inexpensive components to create a cost-effective, user-friendly device for detection and identification of microorganisms.&nbsp; The platform combines an electrical cell lysis chamber, and electrochemical reporter system, and nanostructured microelectrodes (NMEs) to detect specific nucleic acid sequences.&nbsp; The nucleic acid sequences are unique to a given type of microorganism and can be used to identify the microorganisms present in a sample.</p><p>From the perspective of the anticipated prototype device &nbsp;(Lam, et al. 2012. <em>Polymerase Chain Reaction-Free, Sample-to-Answer Bacterial Detection in 30 Minutes with Integrated Cell Lysis</em>. Anal. Chem. <strong>84(1)</strong>: 21-5), detection of microbial contaminants will begin with a lysis chamber designed to release DNA and RNA from microorganisms present in the sample using ultrasonic or electrochemical technology.&nbsp; The DNA and RNA mixture is then passed into an analysis chamber containing an array of nanostructured microelectrodes (NMEs).&nbsp; The surface of the NMEs will be functionalized with probe molecules for DNA or RNA sequences specific to the bacteria being targeted.&nbsp; Binding of the DNA or RNA to the appropriate detection probe on the NME surface in the presence of an electrochemical reporter system will change the electrochemical properties of the NMEs.&nbsp; A potentiostat is used to measure the current at each individual electrode before and after addition of the DNA and RNA mixture.&nbsp; The difference in current before and after addition of the mixture to the NMEs is compared against a pre-determined threshold to check for the presence of target bacteria in the sample.&nbsp; The process for detection of chemical contaminants is very similar.&nbsp; The lysis chamber would be bypassed and the sample would flow directly into the analysis chamber.&nbsp; The NMEs will be functionalized with molecules to selectively bind the desired targets (analytes) and the change in the electrochemical response of each NME can again be used to detect and quantify the contaminants.&nbsp; Depending on the analyte of interest, it may be possible to directly measure analyte binding on the surface of the NMEs without the use of an electrochemical reporter system. The overall project will focus on optimization of the individual aspects of the detection platform in preparation for construction of a prototype for a flight experiment.&nbsp; The scope of the work in this proposal is limited to characterization and optimization of the lysis step/sample preparation, probe selection, and NME structure.&nbsp; Lysis conditions will be optimized by evaluating parameters associated with the oscillation frequency and lysis time for ultrasonic techniques and applied voltage for the electrochemical techniques.&nbsp; Cell viability, as determined by fluorescent detection of DNA or R
Genome-wide profiling and identification of disordered transcription factors through chemical precipitation mapping
GEO Series GSE190963. Homo sapiens. 84 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Genome-wide profiling and identification of disordered transcription factors through chemical precipitation mapping [DisP-Seq]
GEO Series GSE190961. Homo sapiens. 46 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide profiling and identification of disordered transcription factors through chemical precipitation mapping [ATAC-seq]
GEO Series GSE190959. Homo sapiens. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of a New Chemical Class of Antimalarials, ACT-213615
GEO Series GSE39485. Plasmodium falciparum. 10 samples. Type: Expression profiling by array.
caArray_stegm-00394: Broad: Identification of AML1-ETO modulators by chemical genomics
GEO Series GSE91002. Homo sapiens. 30 samples. Type: Expression profiling by array.
Systematic identification of changes in the yeast protein interaction network in response to environmental, chemical, and genetic perturbation [interactome data]
GEO Series GSE72336. Saccharomyces cerevisiae. 80 samples. Type: Other.
Substrate Identification Using a Chemical Genetics Approach Reveals a Role for PARP-7-Mediated MARylation in Controlling Microtubule Stability in Ovarian Cancer Cells
GEO Series GSE153395. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Systematic identification of changes in the yeast protein interaction network in response to environmental, chemical, and genetic perturbation [transcriptome data]
GEO Series GSE72423. Saccharomyces cerevisiae; Schizosaccharomyces pombe. 10 samples. Type: Expression profiling by array.
Systematic identification of changes in the yeast protein interaction network in response to environmental, chemical, and genetic perturbation
GEO Series GSE72425. Schizosaccharomyces pombe; Saccharomyces cerevisiae. 90 samples. Type: Other; Expression profiling by array.
Fig. 5 in Chemical identification of 18-hydroxycarlactonoic acid as an LjMAX1 product and in planta conversion of its methyl ester to canonical and noncanonical strigolactones in Lotus japonicus
Fig. 5. Conversion of [13C]-CL to [13C]-5DS in the feeding experiment using L. japonicus roots. A) 13C-incorporation rates of (11R)- and (11S)-[1-13CH]-CL 3 into [8-13CH]-5DS. 13C-incorporation rates were cal3 culated from the formula: (peak area of m/z 332.15/ 97.00–peak area of m/z 331.15/97.00*0.20)/((peak area of 332.15/97.00–peak area of m/z 331.15/ 97.00*0.20)+peak area of m/z 331.15/97.00), where 0.20 is the ratio of peak area of 332.15/97.00 to peak area of m/z 331.15/97.00 of natural 5DS. Peak areas were measured using the MRM transition for 5DS (331.15/97.00 and 332.15/97.00 m/z in positive mode) in LC-MS/MS analysis. n = 3. B) Determination of the stereochemistry of 5DS converted from (11R)- [1-13CH]-CL. Chiral LC-MS/MS analysis of stereo3 isomers of 5DS in root exudates after feeding of (11R)- [1-13CH]-CL. MRM of synthetic standards of 5DS and 3 4DO stereoisomers and [8–13C]-(+)-5DS from L. japonicus root exudates after feeding (11R)-[1-13CH]-CL.
Fig. 4 in Chemical identification of 18-hydroxycarlactonoic acid as an LjMAX1 product and in planta conversion of its methyl ester to canonical and noncanonical strigolactones in Lotus japonicus
Fig. 4. Identification of 18-OH-CLA as a MAX1 product. The CL metabolite by Os900 was methyl esterified with diazomethane and analyzed by LC-MS/MS. The product ions and retention time of the compound were identical to those of the authentic chemically synthesized 18-OH-MeCLA. 18-OH-MeCLA was detected in the MRM transition 345.15[M + H-H O]+/97.00, m/z in positive mode.
Fig. 18 in Glucosinolate structural diversity, identification, chemical synthesis and metabolism in plants
Fig. 18. Some proposed glucosinolates (GSLs) in need of more evidence. (A) Two GSLs suggested from MS to be isomers of [3], but without general NMR evidence or published MS/MS evidence for the position of the acetyl groups at the rhamnose residue, as opposed to the glucose residue or another isomer. (B) 2-Hydroxy-8-(methylsulfinyl)octyl GSL suggested from MS/MS evidence but without NMR evidence.
Fig. 13 in Glucosinolate structural diversity, identification, chemical synthesis and metabolism in plants
Fig. 13. The usefulness of the COSY spectrum for establishing connectivity, and an example of NMR of an intact glucosinolate (GSL). (A) The 1H NMR spectrum of 3-(hydroxymethyl)methylpentyl GSL (141) in D2O. A major impurity of acetate from the ion exchange isolation is seen. (B) The corresponding COSY spectrum. Signals along the diagonal correspond to the 1D spectrum. Whenever protons are found at the same or neighboring carbons, a "cross peak" can be seen with the x-coordinate of the one signal and the y-coordinate of the other. Original data by the authors (CEO and NA, Sections 6.1 and 6.2).
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.