Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
168
datasets available to search
ShareScore release 0.9.0
Dataset results
168 results for “Toxicology”
Fig. 7 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 7. Schematic representation of the possible mechanism of neuroprotective and anti-depression activities of polyacetylenes. (5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, 5-hydroxytyrptamine; AC, adenylate cyclase; cAMP, cyclic adenosine monophosphate; CREB, cAMP-response element binding protein; COMT, catechol-Omethyltransferase; DA, dopamine; DAT, dopamine transporter; EAAT, excitatory amino acid transporter; EpAC1, the exchange protein directly activated by cAMP1; ERK, extracellular signal-regulated kinase; GS, stimulating adenylate cyclase g protein; HVA, homovanillic acid; MAO-A, monoamine oxidase-A; mGluR, metabotropic glutamate receptor; MEK, mitogen extracellular kinase; NMDAR, N-methyl-D-asparticacidreceptor; PSD95, postsynaptic density-95 kDa; Rap1, RASrelated protein 1; RSK, ribosomal S6 kinase; SERT, serotonin transporter).
Fig. 6 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 6. Schematic representation of the possible mechanism of immunoregulation activity of polyacetylenes. (COX-2, cyclo-oxygenase-2; GATA-3, GATA binding protein 3; GM-CSF, granulocyte macrophage-colony stimulating factor; IFN-γ, interferon-γ; IL-1/4/5/6/10, interleukin-1/4/5/6/10; NF-κB, nuclear factor κB; STAT3/6, signal transducer and activator of transcription 3/6; TGF-β, transforming growth factor-β; TNF-α, tumor necrosis factor-α; Th1/2/17 lymphocyte, helper T type 1/2/17; Treg cell, regulatory T cell).
Fig. 21 in Euphorbia ebracteolata Hayata (Euphorbiaceae): A systematic review of its traditional uses, botany, phytochemistry, pharmacology, toxicology, and quality control
Fig. 21. Schematic of the proposed role of water extract from E. ebracteolata on anticancer (↑: increase, ↓: decrease).
Fig. 1 in Euphorbia ebracteolata Hayata (Euphorbiaceae): A systematic review of its traditional uses, botany, phytochemistry, pharmacology, toxicology, and quality control
Fig. 1. Whole plant (A), the fresh root (B) (Cited from Flora Republicae Populairs Sinicae at http://ppbc.iplant.cn), the dry root (C) and preparation (Youfuning Capsule) (D) (Cited from http://www.nj-tongrentang.com/product/1trt/89.html) of E. ebracteolata.
Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure
ClinicalTrials.gov study NCT03310697. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Toxicological Analysis in Chemical Submission
ClinicalTrials.gov study NCT05442255. IPD Sharing: NO. Countries: 1. Publications: 1.
Preoperative Toxicological Screening on Perioperative Anesthetic Management
ClinicalTrials.gov study NCT07100314. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM).
Open the record for dataset details and reuse information.
Data from: A systems toxicology approach for the prediction of kidney toxicity and its mechanisms in vitro
The failure to predict kidney toxicity of new chemical entities early in the development process before they reach humans remains a critical issue. Here, we used primary human kidney cells and applied a systems biology approach that combines multidimensional datasets and machine learning to identify biomarkers that not only predict nephrotoxic compounds but also provide hints towards their mechanism of toxicity. Gene expression and high content imaging phenotypical data from 46 diverse kidney toxicants were analyzed using Random Forest machine learning. Imaging features capturing changes in cell morphology and nucleus texture along with mRNA levels of HMOX1 and SQSTM1 were identified as the most powerful predictors of toxicity. These biomarkers were validated by their ability to accurately predict kidney toxicity of 4 out of 6 candidate therapeutics that exhibited toxicity only in in late stage preclinical/clinical studies. Network analysis of similarities in toxic phenotypes was performed based on live-cell high-content image analysis at seven time points. Using compounds with known mechanism as reference, we could infer potential mechanisms of toxicity of candidate therapeutics. In summary, we report an approach to generate a multidimensional biomarker panel for mechanistic de-risking and prediction of kidney toxicity in vitro for new therapeutic candidates and chemical entities.
Papers 2022 . Research Group Pharmacology and Toxicology. University of Antioquia
<p>Papers 2022 . Research Group Pharmacology and Toxicology. University of Antioquia</p>
Fig. 3 in Morphological, ecological and toxicological aspects of Raphidiopsis raciborskii (Cyanobacteria) in a eutrophic urban subtropical lake in southern Brazil
Fig. 3. Bar graphs indicating the specific densities (ind. ml-1) of Raphidiopsis raciborskii and other phytoplankton organisms (Cyanobacteria, Chlorophyta, Heterokontophyta, Euglenophyta and unidentified) sampled from the lake inflow (a) and outflow (b), every month from November 2009 to November 2010.
Fig. 5a, b in Morphological, ecological and toxicological aspects of Raphidiopsis raciborskii (Cyanobacteria) in a eutrophic urban subtropical lake in southern Brazil
Fig. 5a, b. Bar graphs showing the percentage of Raphidiopsis raciborskii trichomes that are vegetative cells only, with akinetes, with heterocytes, or with both heterocytes and akinetes. Data represent samples taken from the lake inflow (a) and outflow (b), every month from November 2009 to November 2010.
Data from: Formulation and toxicology evaluation of the intrathecal AYX1 DNA-decoy in Sprague Dawley rats
The longevity of pain after surgery is debilitating and limits the recovery of patients. AYX1 is a double-stranded, unprotected, 23 base-pair oligonucleotide designed to reduce acute post-surgical pain and prevent its chronification with a single intrathecal perioperative dose. AYX1 mimics the DNA sequence normally bound by EGR1 on chromosomes, a transcription factor transiently induced in the dorsal root ganglia—spinal cord network following a noxious input. AYX1 binds to EGR1 and prevents it from launching waves of gene regulation that are necessary to maintain pain over time. A formulation suitable for an intrathecal injection of AYX1 was developed, including a specific ratio of AYX1 and calcium so the ionic homeostasis of the cerebrospinal fluid is maintained and no impact on neuromuscular control is produced upon injection. A GLP toxicology study in naïve Sprague Dawley rats was conducted using 3 dose levels up to the maximum feasible dose. Clinical observations, neurobehavioral observations, clinical pathology and histopathology of the nervous system and peripheral tissues were conducted. An additional nonGLP study was conducted in the spared nerve injury model of chronic neuropathic pain in which EGR1 is induced in the dorsal root ganglia and spinal cord. Similar testing was performed, including a modified Irwin test to assess a potential impact of AYX1 on autonomic nervous system responses, locomotion, activity, arousal, sensorimotor, and neuromuscular function. No AYX1-related adverse events were observed in any of the studies and the no-observed-adverse-effect-level was judged to be the maximum feasible dose.
Fig. 2 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 2. Polyacetylenes from plants of the family of Araliaceae.
Fig. 4 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 4. Polyacetylenes from plants of other families.
Fig. 3 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 3. (continued).
Fig. 3 in Polyacetylenes in herbal medicine: A comprehensive review of its occurrence, pharmacology, toxicology, and pharmacokinetics (2014-2021)
Fig. 3. Polyacetylenes from plants of the family of Asteraceae.
Fig. 22 in Euphorbia ebracteolata Hayata (Euphorbiaceae): A systematic review of its traditional uses, botany, phytochemistry, pharmacology, toxicology, and quality control
Fig. 22. The SAR studies of abietane diterpenoids 10–11, 14–20 and 32.
Fig. 19. Essential oil isolated from E in Euphorbia ebracteolata Hayata (Euphorbiaceae): A systematic review of its traditional uses, botany, phytochemistry, pharmacology, toxicology, and quality control
Fig. 19. Essential oil isolated from E. ebracteolata.
Fig. 18. Steroids isolated from E in Euphorbia ebracteolata Hayata (Euphorbiaceae): A systematic review of its traditional uses, botany, phytochemistry, pharmacology, toxicology, and quality control
Fig. 18. Steroids isolated from E. ebracteolata.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.