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68 results for “experimental manipulation”
Data from: Experimental manipulation of avian social structure reveals segregation is carried over across contexts
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Data from: Experimental manipulation reveals a trade-off between weapons and testes
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Data from: Sexual conflict over mating in red-sided garter snakes (Thamnophis sirtalis) as indicated by experimental manipulation of genitalia
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Non-native species outperform natives in coastal marine ecosystems subjected to warming and freshening events - A meta-analysis of coastal marine native and non-native species responses to experimentally manipulated climatic events
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Data from: Experimental manipulation suggests effect of polyandry but not mate familiarity on within-pair aggression in the social skink, Liopholis whitii
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The experimental manipulation of atmospheric drought: Teasing out the role of microclimate in biodiversity experiments
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Data from: What drives selection on flowering time? An experimental manipulation of the inherent correlation between genotype and environment
The optimal timing of the seasonal switch from somatic growth to reproduction can depend on an individual's condition at reproduction, the quality of the environment in which it will reproduce, or both. In annual plants, vegetative size (a function of age at flowering) affects resources available for seed production, while exposure to mutualists, antagonists, and abiotic stresses in the environment (functions of Julian date of flowering), influences success in converting resources into offspring. The inherent tight correlation between age, size, and environment obscures their independent fitness contributions. We isolated the fitness effects of these factors by experimentally manipulating the correlation between age at flowering and date of flowering in Brassica rapa. We staggered the planting dates of families with differing ages at flowering to produce experimental populations in which age at flowering and date of flowering were positively-, negatively-, or uncorrelated. In all populations, plants with an early date of flowering produced more seed than those flowering late, regardless of age or size at flowering onset. The temporal environment was thus the principal driver of selection on flowering time, but its importance relative to that of age and size varied with the presence/absence of herbivores and seed predators.
Data from: Pre- and post-natal effects of experimentally manipulated maternal corticosterone on growth, stress reactivity, and survival of nestling house wrens
1. Corticosterone plays a central role in maintaining homeostasis, promoting energy acquisition, and regulating the stress response in birds. Exposure to elevated levels of corticosterone during development can profoundly alter offspring behaviour and physiology, but the effects of elevated maternal corticosterone on offspring development remain poorly understood. 2. We tested two competing hypotheses concerning the effect of maternally derived corticosterone on growth and development of free-living house wrens: i) elevated maternal corticosterone causes damaging effects on nestling phenotype and fitness (collateral damage hypothesis) and (ii) increased maternal corticosterone enhances offspring fitness by preparing nestlings for the environment experienced by their mother (environmental/maternal-matching hypothesis). 3. We used a non-invasive means to increase maternal corticosterone by providing females with corticosterone-injected mealworms prior to and during egg production in the absence of any overt pre-natal maternal stress. To disentangle pre- and post-natal effects of this elevation in maternal corticosterone, we cross-fostered young in two experiments: i) nestlings of control and experimental females were reared by unmanipulated, natural females in a uniform maternal environment; ii) a split-brood design that enabled us to assess the interaction between the mother's corticosterone treatment and that of the nestlings. 4. There were significant pre-natal effects of increased maternal corticosterone on nestling growth and survival. Offspring of females experiencing experimentally increased corticosterone were heavier and larger than offspring of control females. There also was a significant interaction between maternal corticosterone treatment and the corticosterone treatment to which young were exposed within the egg in their effect on nestling survival while in the nest; experimental young exhibited greater survival than control young, but only when reared by control mothers. There was also a significant effect of maternal corticosterone treatment on nestling stress reactivity and, in both experiments, on the eventual recruitment of offspring as breeding adults in the local population. 5. These patterns are broadly consistent with the environmental/maternal-matching hypothesis, and highlight the importance of disentangling pre- and post-natal effects of manipulations of maternal hormone levels on offspring phenotype.
Supplemental data. Experimentally manipulated food availability affects offspring quality but not quantity in zebra finch meso-populations
<p>Data used for the publication: " Experimentally manipulated food availability affects offspring quality but not quantity in zebra finch meso-populations "</p>
Dataset related to article "Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes"
<p><em>The files contain raw data related to the article "Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes", available from <a href="https://www.nature.com/articles/s41598-020-65423-0">https://www.nature.com/articles/s41598-020-65423-0</a>.</em></p> <p><strong>Abstract of the manuscript</strong>: More effective treatments for diabetic nephropathy remain a major unmet clinical need. Increased oxidative stress is one of the most important pathological mechanisms that lead to kidney damage and functional impairment induced by diabetes. Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase and critically regulates cellular reactive oxygen species (ROS) production and detoxification. Honokiol is a natural biphenolic compound that, by activating mitochondrial SIRT3, can carry out anti-oxidant, anti-inflammatory and anti-fibrotic activities. Here, we sought to investigate the renoprotective effects of honokiol in BTBR <em>ob/ob</em> mice with type 2 diabetes. Diabetic mice were treated with vehicle or honokiol between the ages of 8 and 14 weeks. Wild-type mice served as controls. Renal <em>Sirt3</em> expression was significantly reduced in BTBR <em>ob/ob</em> mice, and this was associated with a reduction in its activity and increased ROS levels. Selective activation of SIRT3 through honokiol administration translated into the attenuation of albuminuria, amelioration of glomerular damage, and a reduction in podocyte injury. SIRT3 activation preserved mitochondrial wellness through the activation of SOD2 and the restoration of PGC-1α expression in glomerular cells. Additionally, the protective role of SIRT3 in glomerular changes was associated with enhanced tubular <em>Sirt3</em> expression and upregulated renal <em>Nampt</em> levels, indicating a possible tubule-glomerulus retrograde interplay, which resulted in improved glomerular SIRT3 activity. Our results demonstrate the hitherto unknown renoprotective effect of SIRT3 against diabetic glomerular disease and suggest that the pharmacological modulation of SIRT3 activity is a possible novel approach to treating diabetic nephropathy.</p>
The effect of temporal changes in stamen position on reproductive success in flowers with many stamens: experimental manipulations of stamen position
<p class="MsoNormal"><span><strong>Premise of the study</strong>: </span><span>Male and female reproductive success is enhanced (increased outcrossing and seed production) by stamen movement</span><span> in species that have few stamens per flower.</span><span> Does such enhancement also occur in species that have many stamens per flower?</span></p> <p class="MsoNormal"><span><strong>Methods</strong>: </span><span>We examined the effects of stamen movement on male and female reproductive success in <em>Anemone flaccida</em>, which has </span><span>many stamens</span><span> per flower. We measured stamen movement, including temporal changes in anther-stigma and anther-anther distances. We controlled stamen movement experimentally.</span></p> <p class="MsoNormal"><span><strong>Key results</strong>: </span><span>The anthers moved horizontally away from the stigmas with increasing flower age, resulting in reduction in female-male interference. The dehisced anthers tended to move further away from the stigmas while the undehisced or dehiscing anthers remained nearer to them. The number of anthers touched per flower visit was higher in flowers whose stamens were fixed in the pre-movement position than in flowers whose stamens were fixed in the post-movement position or in flowers that were not manipulated. Thus, this position may promote male reproductive success. Seed production was lower for the untreated flowers than for the post-movement position flowers, suggesting that the post-movement stamen position is advantageous and stamen movement is suboptimal for female reproductive success.</span></p> <p class="MsoNormal"><span><strong>Conclusions</strong>: </span><span>Stamen movement promotes male reproductive success in the early flowering stage and female reproductive success in the late flowering stage. In species having many stamens per flower, female-male interference can be reduced, but not eliminated, by stamen movement due to the conflict between female and male reproductive successes.</span></p>
Dual clumped isotope analyses and model calculations constrain equilibrium, experimentally-manipulated kinetic isotope effects, and mixing effects in calcite
<p>Replicate data for standards and samples; XRD data. </p>
Cigarette and E-cigarette Flavors Manipulations in the Experimental Tobacco Marketplace
ClinicalTrials.gov study NCT05110872. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Pre- and post-natal effects of experimentally manipulated maternal corticosterone on growth, stress reactivity, and survival of nestling house wrens
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Data from: Experimental manipulation of population-level MHC diversity controls pathogen virulence evolution in Mus musculus
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Data from: Experimental evolution of bet hedging under manipulated environmental uncertainty in Neurospora crassa
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Data from: Behaviour out of control: experimental evolution of resistance to host manipulation
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Data from: Experimental manipulation of food availability leads to short-term intra-clutch adjustment in egg mass but not in yolk androgen or thyroid hormones
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Data from: What drives selection on flowering time? An experimental manipulation of the inherent correlation between genotype and environment
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Data from: Experimental evolution of parasitic host manipulation
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.