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249 results for “human selection”
Data from: What does the fox select? Spatial ecology of Rocky Mountain red fox during peaks and troughs of human recreation
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Patterns of recent natural selection on genetic loci associated with sexually differentiated human body size and shape phenotypes
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Natural selection and language genes in humans
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Resource selection by New York City deer reveals the effective interface between wildlife, zoonotic hazards, and humans
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Data and code from: The shared selection landscape of dog and human cancers
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Archived data for: Balancing selection, genetic drift, and human mediated-introgression interplay to shape MHC (functional) diversity in Mediterranean brown trout
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Central place foraging in a human-dominated landscape - how do common cranes select feeding sites?
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Selected survey data for the outcome assessment of a human–carnivore conflict mitigation project (ELC) in Europe
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Dataset related to article "Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors"
<p>Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. Neutrophils were essential for the activation of an interferon-γ-dependent pathway of immune resistance, associated with polarization of a subset of CD4<sup>-</sup> CD8<sup>-</sup> unconventional αβ T cells (UTC<sub>αβ</sub>). Bulk and single-cell RNA sequencing (scRNA-seq) analyses unveiled the innate-like features and diversity of UTC<sub>αβ</sub> associated with neutrophil-dependent anti-sarcoma immunity. In selected human tumors, including undifferentiated pleomorphic sarcoma, CSF3R expression, a neutrophil signature and neutrophil infiltration were associated with a type 1 immune response and better clinical outcome. Thus, neutrophils driving UTC<sub>αβ</sub> polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.</p>
Data from: Patterns of MHC-dependent mate selection in humans and non-human primates: a meta-analysis
Genes of the major histocompatibility complex (MHC) in vertebrates are integral for effective adaptive immune response and are associated with sexual selection. Evidence from a range of vertebrates supports MHC-based preference for diverse and dissimilar mating partners, but evidence from human mate choice studies has been disparate and controversial. Methodologies and sampling peculiarities specific to human studies make it difficult to know whether wide discrepancies in results among human populations are real or artefact. To better understand what processes may affect MHC-mediated mate choice across humans and nonhuman primates, we performed phylogenetically controlled meta-analyses using 58 effect sizes from 30 studies across seven primate species. Primates showed a general trend favouring more MHC-diverse mates, which was statistically significant for humans. In contrast, there was no tendency for MHC-dissimilar mate choice, and for humans, we observed effect sizes indicating selection of both MHC-dissimilar and MHC-similar mates. Focusing on MHC-similar effect sizes only, we found evidence that preference for MHC similarity was an artefact of population ethnic heterogeneity in observational studies but not among experimental studies with more control over sociocultural biases. This suggests that human assortative mating biases may be responsible for some patterns of MHC-based mate choice. Additionally, the overall effect sizes of primate MHC-based mating preferences are relatively weak (Fisher's Z correlation coefficient for dissimilarity Zr = 0.044, diversity Zr = 0.153), calling for careful sampling design in future studies. Overall, our results indicate that preference for more MHC-diverse mates is significant for humans and likely conserved across primates.
Movement-integrated habitat selection reveals wolves balance ease of travel with human avoidance in a risk-reward trade-off
<p>We captured and collared 46 wolves across 12 packs in eastern Manitoba between 2014-2019. Each wolf was fit with a GPS telemetry collar programmed to collect a GPS relocation every two hours across all seasons.</p> <p>To produce the dataset, GPS locations were used to generate steps (linear connection between consecutive locations) using the integrated Step Selection Function (iSSA) framework. For a given used step, we randomly generated ten steps based on observed distributions of individual-level movement behaviour. We then extracted habitat covariates for each start and end point of a step, including proportion of forest, distance to linear features, and time of day. </p>
Green-up selection by red deer in heterogeneous, human-dominated landscapes of Central Europe
The forage maturation hypothesis [FMH] assumes that herbivores cope with the trade-off between digestibility and biomass in forage by selecting vegetation at intermediate growth. The green wave hypothesis [GWH] extends the FMH to suggest how spatiotemporal heterogeneity in plant quality shapes migratory movements of herbivores. Growing empirical support for these hypotheses mainly comes from studies in vast landscapes with large-scale habitat heterogeneity. It is unclear, however, to what extent ungulates surf green waves in human-altered landscapes with small-scale heterogeneity in terms of land use and topography. We used plant phenological proxies derived from Sentinel 2 satellite data to analyse the habitat selection of 93 collared red deer [Cervus elaphus] in montane and alpine habitats. Using a step selection analysis, we investigated how plant phenology, i.e. the instantaneous rate of green-up [IRG] and normalised difference vegetation index [NDVI], and a set of variables describing topography and human presence influenced red deer resource selection in open habitats. We learned that red deer selected areas with high biomass at green-up and avoided habitats with possible exposure to human activity. Additionally, landscape structure and topography strongly influenced spatial behaviour of red deer. We further compared cumulative access to high-quality forage across migrant strategies and found migrants gained better access than residents. Many migratory individuals surfed the green wave, their surfing behaviour, however, became less pronounced with decreasing distance to settlements. Within the constraints of topography and human land use, red deer track spring green-up on a fine spatiotemporal scale and follow the green wave across landscapes in migration movements. Thus, they benefit from high quality forage even in human-dominated landscapes with small-scale heterogeneity and vegetation emerging in a heterogenic, dynamic mosaic. --
Data from "A population of neurons selective for human voice in the monkey brain"
<p>Preprocessed datasets associated to the research article "A population of neurons selective for human voice in the monkey brain", PNAS.</p>
Dataset of the study on field evidence for manipulation of mosquito host selection by the human malaria parasite
<p>This repository contains the dataset from host preferences assays to determine odour-mediated mosquito host preference as well as mosquito host selection determination through identification of the blood meal origin from indoor-resting blood-fed mosquito females in Burkina Faso.</p>
cellsig: a Bayesian sparse random-effect model and large-scale human bulk transcriptional catalogue support cell-type marker selection
<p><strong>Human Bulk Cell-type Catalogue (HBCC): This database harmonises 1,435 samples of 67 cell types from 58 datasets which can be utilised in the cellsig method for estimating cell-type transcriptional profiles.</strong></p>
Major De-escalation to 30 Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma
ClinicalTrials.gov study NCT03323463. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Sex Selection of Human Spermatozoa
ClinicalTrials.gov study NCT05500573. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Sperm Selection Techniques on Human Neonatal Gender Ratio in Patients Undergoing ICSI
ClinicalTrials.gov study NCT03922568. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
REFOCUS: A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With ICC and Other Advanced Solid Tumors
ClinicalTrials.gov study NCT04526106. IPD Sharing: NO. Countries: 13. Publications: 0.
Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans
ClinicalTrials.gov study NCT01280006. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.