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519 results for “hydrogels”
3D printing of functional hydrogel devices for screenings of membrane permeability and selectivity
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Data from: Sustained neurotrophin-3 delivery from hyaluronic acid hydrogels for neural tissue regeneration
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Printability, durability, contractility and vascular network formation in 3D bioprinted cardiac endothelial cells using alginate-gelatin hydrogels
<p>TBC</p>
Data from: Amphotericin B-conjugated polypeptide hydrogels as a novel innovative strategy for fungal infections
The present work is focused on design and development of novel Amphotericin B-conjugated biocompatible and biodegradable poly-peptide hydrogels to improve the antifungal activity. Using three kinds of promoting self-assembly groups (2-naphthalene acetic acid, Naproxen and Dexamethasone) and poly-peptide sequence (Phe-Phe-Asp-Lys-Tyr, FFDKY), we successfully synthesized the Nap-FFDK (AmB) Y gels, Npx-FFDK (AmB) Y gels and Dex-FFDK (AmB) Y gels. The Amphotericin B-conjugated hydrogelators are highly soluble in different aqueous solutions. The Cryo-transmission electron microscopy (TEM) and scanning electron microscopy (SEM) micrographs of hydrogels afford nanofibers with width of 20~50 nm. Powder X-ray diffraction (PXRD) analyses demonstrate that the crystalline structure of the AmB and Dex are changed into amorphous structure after formation of hydrogels. Circular dichroism (CD) spectra of the solution of blank carriers and the corresponding drug deliveries further help elucidate the molecular arrangement in gel phase, indicating the existence of turn features. The in vitro drug releases suggest that the Amphotericin B-conjugated hydrogels are suitable as drug-controlled release vehicles for hydrophobic drug. The antifungal effect of AmB-conjugated hydrogels significantly exhibits the antifungal activity against Candida albicans. The results of present study indicated that the Amphotericin B-conjugated hydrogels are suitable carriers for poorly water soluble drugs and for enhancement of therapeutic efficacy of antifungal drugs.
Data from: Cation identity in clay-polyelectrolyte self-assembled hydrogels: Rheological and NMR study of the polyitaconate-counterion interactions
<p>The upload contains data associated with the publication, including raw data in the original file format whenever possible. Dataset content: NMR and rheology.</p> <p>This work was financially supported by the Lead Agency bilateral a Czech-Polish project provided by the Czech Science Foundation (21-07004K) and National Science Center Poland (CEUS-UNISONO project grant no. 2020/02/Y/ST5/00021).</p>
Data from: Insight into the aqueous Laponite nanodispersions for self-assembled poly(itaconic acid) nanocomposite hydrogels: The effect of multivalent phosphate dispersants
<p>The upload contains data associated with the publication, including raw data in the original file format whenever possible. Dataset content: SAXS, NMR reology, zeta potential.</p> <p>This work was financially supported by the Lead Agency bilateral a Czech-Polish project provided by the Czech Science Foundation (21-07004K) and National Science Center Poland (CEUS-UNISONO project grant no. 2020/02/Y/ST5/00021).</p>
Schiff Base Crosslinked Hyaluronic Acid Hydrogels with Tunable and Cell Instructive Time-Dependent Mechanical Properties
<p>This folder contains raw data for the paper titled "<strong>Schiff Base Crosslinked Hyaluronic Acid Hydrogels</strong><strong> with Tunable and Cell Instructive Time-Dependent Mechanical Properties</strong>" authored by Taha Behroozi Kohlan, Yanru Wen, Carina Milena Mini, and Anna Finne-Wistrand, published in <em>Carbohydrate Polymers</em> journal. The raw data presented here contains NMR, FTIR, SEC, swelling and stability, and rheology data used to create figures.</p> <p><strong>Abstract:</strong></p> <p>The dynamic interplay between cells and their native extracellular matrix (ECM) influences cellular behavior, imposing a challenge in biomaterial design. Dynamic covalent hydrogels are viscoelastic and show self-healing ability, making them a potential scaffold for recapitulating native ECM properties. We aimed to implement kinetically and thermodynamically distinct crosslinkers to prepare self-healing dynamic hydrogels to explore the arising properties and their effects on cellular behavior. To do so, aldehyde-substituted hyaluronic acid (HA) was synthesized to generate imine, hydrazone, and oxime crosslinked dynamic covalent hydrogels. Differences in equilibrium constants of these bonds yielded distinct properties including stiffness, stress relaxation, and self-healing ability. The effects of degree of substitution (DS), polymer concentration, crosslinker to aldehyde ratio, and crosslinker functionality on hydrogel properties were evaluated. The self-healing ability of hydrogels was investigated on samples of the same and different crosslinkers and DS to obtain hydrogels with gradient properties. Subsequently, human dermal fibroblasts were cultured in 2D and 3D to assess the cellular response considering the dynamic properties of the hydrogels. Moreover, assessing cell spreading and morphology on hydrogels having similar modulus but different stress relaxation rates showed the effects of matrix viscoelasticity with higher cell spreading in slower relaxing hydrogels.</p>
Mechanoreceptive soft robotic molluscoids made of granular hydrogel-based organoelectronics
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Data supporting: Assessment of the performance of nonfouling polymer hydrogels utilizing citizen scientists
<p>This dataset contains all data collected by citizen scientists in support of the publication: "Hansen N, Bryant A, McCormack R, Johnson H, Lindsay T, Stelck K, et al. (2021) Assessment of the performance of nonfouling polymer hydrogels utilizing citizen scientists. PLoS ONE 16(12): e0261817. https://doi.org/10.1371/journal.pone.0261817".</p> <p>This study evaluates the performance of several commercially available nonfouling polymers using citizen science, to identify the best performing chemistry for future applications as bacteria resistant coatings.<b> </b>The specific polymer chemistries tested were zwitterionic sulfobetaine methacrylate (SBMA), and polyampholytes composed of [2-(acryloyloxy)ethyl] trimethylammonium chloride and 2-carboxyethyl acrylate (TMA:CAA) or TMA and 3-sulfopropyl methacrylate (TMA:SA). Each polymer chemistry is known to exhibit bacteria resistance, and this study utilizes a citizen science approach to compare the performance of these chemistries.</p>
Raw data for: Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform
<p>Raw data for the article "Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform." to be published in Nature communications.</p>
Spectra related to the study about the Permselectivity of Silk Fibroin Hydrogels for Advanced Drug Delivery Neurotherapies
<p>This material is associated with the study about the Permselectivity of Silk Fibroin Hydrogels for Advanced Drug Delivery Neurotherapies. Herein are enclosed the FTIR spectra of silk fibroin solutions and hydrogels, and representative spectra from mass spectrometry technique for the quantification of cholesteronitrone F2 released from silk fibroin hydrogels.</p> <ul> <li>FTIR spectra prior to sonication are named as SF_2%_pre-sonication_0X and SF_6%_pre-sonication_0X, being 2 and 6% the concentration of silk fibroin in the solution and X the number of replicate.</li> <li>FTIR spectra 24 hours after sonication are named as SF_2%_post-sonication_0X and SF_6%_post-sonication_0X, being 2 and 6% the concentration of silk fibroin in the hydrogel and X the number of replicate.</li> <li>The files with file format .mzXML and named as spectrum are representative spectra from mass spectrometry technique from the calibration curve (Spectrum_matrix; Spectrum_IS_10uM; Spectrum_F2_10uM; Spectrum_IS+F2_10uM) and the quatification of F2 released from SF hydrogels (Spectrum_2%_X; Spectrum_6%_X; being X the time point of release).</li> </ul> <p> </p>
Dataset for Osmosis-driven stiffening of structured hydrogels
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Lysozyme-sensitive plasmonic hydrogel nanocomposite for colorimetric dry-eye inflammation biosensing_[Biosensing]
<p>Biosensing of a lysozyme-sensitive plasmonic hydrogel</p>
Lysozyme-sensitive plasmonic hydrogel nanocomposite for colorimetric dry-eye inflammation biosensing_[Photoresponsivity]
<p>Photoresponsivity of a lysozyme-sensitive plasmonic hydrogel</p>
Lysozyme-sensitive plasmonic hydrogel nanocomposite for colorimetric dry-eye inflammation biosensing_[Colorimetric Tests]
<p>Colorimetric tests for a lysozyme-sensitive plasmonic hydrogel.</p>
A pH-responsive amphiphilic hydrogel based on pseudo-peptides and poly(ethylene glycol) for oral drug delivery
<p>The original data for the paper titled "A pH-responsive amphiphilic hydrogel based on pseudo-peptides and poly(ethylene glycol) for oral drug delivery"</p>
Evaluation data for publication 'Swelling of kappa carrageenan hydrogels in a simulated body fluid'
<p>Original excel files, python script and rheometry data for the evaluation of the publication data.</p>
Dataset_ 3D Printable κ-Carrageenan-Based Granular Hydrogels
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Dataset for: Multivascular networks and functional intravascular topologies within biocompatible hydrogels
<p>Dataset for:</p> <p>Multivascular networks and functional intravascular topologies within biocompatible hydrogels</p> <p>Bagrat Grigoryan1,∗, Samantha J. Paulsen1,∗, Daniel C. Corbett2,∗, Daniel W. Sazer1, Chelsea L. Fortin2, Alexander J. Zaita1, Paul T. Greenfield1, Nicholas J. Calafat1, John P. Gounley3, Anderson H. Ta1, Fredrik Johansson2, Amanda Randles3, Jessica E. Rosenkrantz4, Jesse D. Louis-Rosenberg4, Peter A. Galie5, Kelly R. Stevens2,†, Jordan S. Miller1,†</p> <p>1Department of Bioengineering, Rice University, Houston, TX 77005, USA 2Department of Bioengineering, University of Washington, Seattle, WA 98195, USA 3Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA 4Nervous System, Somerville, MA 02143, USA 5Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, USA</p> <p>∗Equal contribution. †Corresponding authors. Email: ksteve@uw.edu (K.R.S.) and jmil@rice.edu (J.S.M.).</p> <p>Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex 3D transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels produced in minutes comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deployed structured biodegradable hydrogel carriers in a rodent model of hepatic disease to highlight the potential translational utility of this materials innovation.</p>
Load-bearing hydrogels ionically reinforced through competitive ligand exchanges
<p>Fast advances in soft robotics and tissue engineering demand for new soft materials whose mechanical properties can be interchangeably and locally varied, thereby enabling, for example, the design of soft joints within an integral material. Inspired by nature, we introduce a competitive ligand-mediated approach to selectively and interchangeably reinforce metal-coordinated hydrogels. This is achieved by reinforcing carboxylate-containing hydrogels with Fe<sup>3+</sup> ions. Key to achieving a homogeneous, predictable reinforcement of the hydrogels is the presence of weak complexation agents that delay the formation of metal-complexes within the hydrogels, thereby allowing a homogeneous distribution of the metal ions. The resulting metal-reinforced hydrogels show a compressive modulus of up to 2.5 MPa, while being able to withstand pressures as high as 0.6 MPa without appreciable damage. Competitive ligand exchanges offer an additional advantage: they enable non-linear compositional changes that, for example, allow the formation of joints within these hydrogels. These features open up new possibilities to extend the field of use of metal reinforced hydrogels to load-bearing applications that are omnipresent for example in soft robots and actuators.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.