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Text-fig. 6. Metacheiromys marshi, AMNH 131777, left petrosal isosurface from CT scans in endocranial view. a – shaded drawing; b – line drawing with labels. Abbreviations: app – apex partis petrosae, cc – cochlear canaliculus, crp – crista petrosa, cs – cerebral surface, iam – internal acoustic meatus, lji – lateral jugular incisure, me – mastoid exposure, mji – medial jugular incisure, saf – subarcuate fossa, sips – sulcus for inferior petrosal sinus, soev – sulcus for occipital emissary vein, sss – sulcus for sigmoid sinus, tc – transverse crest, to ptc – to posttemporal canal, va – vestibular aqueduct. in Skeletal Anatomy Of The Basicranium And Auditory Region In The Metacheiromyid Palaeanodont Metacheiromys (Mammalia, Pholidotamorpha) Based On High-Resolution Ct Scans
Text-fig. 6. Metacheiromys marshi, AMNH 131777, left petrosal isosurface from CT scans in endocranial view. a – shaded drawing; b – line drawing with labels. Abbreviations: app – apex partis petrosae, cc – cochlear canaliculus, crp – crista petrosa, cs – cerebral surface, iam – internal acoustic meatus, lji – lateral jugular incisure, me – mastoid exposure, mji – medial jugular incisure, saf – subarcuate fossa, sips – sulcus for inferior petrosal sinus, soev – sulcus for occipital emissary vein, sss – sulcus for sigmoid sinus, tc – transverse crest, to ptc – to posttemporal canal, va – vestibular aqueduct.
Text-fig. 2. Metacheiromys marshii, AMNH 131777, drawing of basicranium in ventral view with isosurface from CT scans of left petrosal inserted (compare with Simpson 1931: fig. 7). Much of the mastoid exposure on the specimen's left side is damaged. Numbers 1 to 4 indicate depressions that based on the right side include a thin layer of entotympanic; 1 to 3 are between petrosal and basioccipital and 4 is petrosal only. The white arrow in the lower left passes through a canal between the petrosal and exoccipital for the auricular branch of the vagus nerve. Abbreviations: abX – grooves and foramina for auricular branch of vagus nerve, as – alisphenoid, astp – alisphenoid tympanic process, bo – basioccipital, bs – basisphenoid, eam – roof of external acoustic meatus, ec – ectotympanic, en – entotympanic, eo – exoccipital, es – epitympanic sinus of squamosal, fm – foramen magnum, fo – foramen ovale, gf – glenoid fossa, hf – hypoglossal foramen, ips – foramen for inferior petrosal sinus, ljf – lateral jugular foramen, me – mastoid exposure of petrosal, mjf – medial jugular foramen, mt – muscular tubercle, mtc – musculotubal canal, oc – occipital condyle, pa – porus acousticus (hidden), pas – parasphenoid, pgp – postglenoid process, pr – promontorium of petrosal, ps – presphenoid, smf – stylomastoid foramen, sof – superior orbital fissure, sq – squamosal, tca – tympanic canaliculus, th – tympanohyal, tm – tubular external acoustic meatus. in Skeletal Anatomy Of The Basicranium And Auditory Region In The Metacheiromyid Palaeanodont Metacheiromys (Mammalia, Pholidotamorpha) Based On High-Resolution Ct Scans
Text-fig. 2. Metacheiromys marshii, AMNH 131777, drawing of basicranium in ventral view with isosurface from CT scans of left petrosal inserted (compare with Simpson 1931: fig. 7). Much of the mastoid exposure on the specimen's left side is damaged. Numbers 1 to 4 indicate depressions that based on the right side include a thin layer of entotympanic; 1 to 3 are between petrosal and basioccipital and 4 is petrosal only. The white arrow in the lower left passes through a canal between the petrosal and exoccipital for the auricular branch of the vagus nerve. Abbreviations: abX – grooves and foramina for auricular branch of vagus nerve, as – alisphenoid, astp – alisphenoid tympanic process, bo – basioccipital, bs – basisphenoid, eam – roof of external acoustic meatus, ec – ectotympanic, en – entotympanic, eo – exoccipital, es – epitympanic sinus of squamosal, fm – foramen magnum, fo – foramen ovale, gf – glenoid fossa, hf – hypoglossal foramen, ips – foramen for inferior petrosal sinus, ljf – lateral jugular foramen, me – mastoid exposure of petrosal, mjf – medial jugular foramen, mt – muscular tubercle, mtc – musculotubal canal, oc – occipital condyle, pa – porus acousticus (hidden), pas – parasphenoid, pgp – postglenoid process, pr – promontorium of petrosal, ps – presphenoid, smf – stylomastoid foramen, sof – superior orbital fissure, sq – squamosal, tca – tympanic canaliculus, th – tympanohyal, tm – tubular external acoustic meatus.
Text-fig. 5. Metacheiromys marshi, AMNH 131777, left petrosal isosurface from CT scans in tympanic view; the posttympanic process of the squamosal and some possible entotympanic are also included. a – isosurface; b – line drawing with labels. Numbers 1 to 4 indicate depressions on medial flange. Abbreviations: ams – anteromedial septum, aptt – anteroventral process of tegmen tympani, cct – canal for chorda tympani nerve, ci – crista interfenestralis, cof – cochlear fossula, cp – crista parotica, ctp – caudal tympanic process, en? – possible entotympanic, epc – epitympanic crest, ew – epitympanic wing, fc – facial canal, fv – fenestra in Skeletal Anatomy Of The Basicranium And Auditory Region In The Metacheiromyid Palaeanodont Metacheiromys (Mammalia, Pholidotamorpha) Based On High-Resolution Ct Scans
Text-fig. 5. Metacheiromys marshi, AMNH 131777, left petrosal isosurface from CT scans in tympanic view; the posttympanic process of the squamosal and some possible entotympanic are also included. a – isosurface; b – line drawing with labels. Numbers 1 to 4 indicate depressions on medial flange. Abbreviations: ams – anteromedial septum, aptt – anteroventral process of tegmen tympani, cct – canal for chorda tympani nerve, ci – crista interfenestralis, cof – cochlear fossula, cp – crista parotica, ctp – caudal tympanic process, en? – possible entotympanic, epc – epitympanic crest, ew – epitympanic wing, fc – facial canal, fv – fenestra
Text-fig. 4. Metacheiromys marshii, AMNH 131777, basicranial isosurface from CT scans in oblique posteroventral view: left petrosal in blue and small piece of left entotympanic in red. The white arrow on the left petrosal passes through a canal traversed by the tympanic nerve. Abbreviations: abX – foramen for auricular branch of vagus nerve, aptt – anteroventral process of tegmen tympani, as – alisphenoid, bo – basioccipital, bs – basisphenoid, ctp – caudal tympanic process, eam – squamosal roof of external acoustic meatus, ec – ectotympanic, en – entotympanic, eo – exoccipital, hf – hypoglossal foramen, ips – foramen for inferior petrosal sinus, ljf – lateral jugular foramen, me – mastoid exposure of petrosal, mjf – medial jugular foramen, mt – muscular tubercle, oc – occipital condyle, pcf – posterior carotid foramen, pp – paroccipital process of petrosal, pr – promontorium of petrosal, ptp – posttympanic process of squamosal, smf – stylomastoid foramen, sq – squamosal, stf – stapedial artery foramen, tca – tympanic canaliculus, th – tympanohyal. in Skeletal Anatomy Of The Basicranium And Auditory Region In The Metacheiromyid Palaeanodont Metacheiromys (Mammalia, Pholidotamorpha) Based On High-Resolution Ct Scans
Text-fig. 4. Metacheiromys marshii, AMNH 131777, basicranial isosurface from CT scans in oblique posteroventral view: left petrosal in blue and small piece of left entotympanic in red. The white arrow on the left petrosal passes through a canal traversed by the tympanic nerve. Abbreviations: abX – foramen for auricular branch of vagus nerve, aptt – anteroventral process of tegmen tympani, as – alisphenoid, bo – basioccipital, bs – basisphenoid, ctp – caudal tympanic process, eam – squamosal roof of external acoustic meatus, ec – ectotympanic, en – entotympanic, eo – exoccipital, hf – hypoglossal foramen, ips – foramen for inferior petrosal sinus, ljf – lateral jugular foramen, me – mastoid exposure of petrosal, mjf – medial jugular foramen, mt – muscular tubercle, oc – occipital condyle, pcf – posterior carotid foramen, pp – paroccipital process of petrosal, pr – promontorium of petrosal, ptp – posttympanic process of squamosal, smf – stylomastoid foramen, sq – squamosal, stf – stapedial artery foramen, tca – tympanic canaliculus, th – tympanohyal.
Data for: Mobility of the human foot's medial arch helps enables upright bipedal locomotion
<p class="MsoNormal"><span>Developing the ability to habitually walk and run upright on two feet is one of the most significant transformations to have occurred in human evolution. Many musculoskeletal adaptations enabled bipedal locomotion, including dramatic structural changes to the foot and, in particular, the evolution of an elevated medial arch. The foot's arched structure has previously been assumed to play a central role in directly propelling the center of mass forward and upward through leverage about the toes and a spring-like energy recoil. However, it is unclear whether or how the plantarflexion mobility and height of the medial arch support its propulsive lever function. Here we show, using high-speed biplanar x-ray, that regardless of intraspecific differences in medial arch height, arch recoil enables a longer contact time and favorable propulsive conditions at the ankle for walking upright on an extended leg. This mechanism may have helped drive the evolution of the longitudinal arch after our last common ancestor with chimpanzees, who lack this plantarflexion mobility during push-off. We discovered that the generally overlooked navicular-medial cuneiform joint is primarily responsible for arch recoil in human arches, suggesting that future morphological investigations of this joint will provide new interpretations of the fossil record. Our work further suggests that enabling longitudinal arch recoil in footwear and surgical interventions may be critical for maintaining the ankle's natural propulsive ability.</span></p>
Рис. 2. Основные части теΛа и эΛементы окраски Mesobuthus eupeus: I – просома; II – мезосома; III – метасома; a – меΑиаΛьная поΛоса; b – парамеΑиаΛьная поΛоса; с – маргинаΛьная поΛоса; d – поперечная поΛоса; e – пятна. Fig. 2. Main body parts and colour pattern elements of Mesobuthus eupeus: I – prosoma; II – mesosome; III – metasoma; a – medial stripe; b – paramedical stripe; с – marginal stripe; d – transverse stripe; e – spots. in Materials on the colour pattern variability of Mesobuthus eupeus (C.L. Koch, 1839) (Arachnida: Scorpiones) in southeastern Shirvan and Gobustan (Eastern Azerbaijan)
Рис. 2. Основные части теΛа и эΛементы окраски Mesobuthus eupeus: I – просома; II – мезосома; III – метасома; a – меΑиаΛьная поΛоса; b – парамеΑиаΛьная поΛоса; с – маргинаΛьная поΛоса; d – поперечная поΛоса; e – пятна. Fig. 2. Main body parts and colour pattern elements of Mesobuthus eupeus: I – prosoma; II – mesosome; III – metasoma; a – medial stripe; b – paramedical stripe; с – marginal stripe; d – transverse stripe; e – spots.
Рис. 21–25. Частота изменчивости основных эΛементов рисунка (меΑиаΛьной, парамеΑиаΛьных и маргинаΛьных поΛос) ΑорсаΛьной поверхности мезосомы Mesobuthus eupeus в посеΛениях кажΑой из выборок. 21 – Северо-ЗапаΑный Гобустан (n = 57); 22 – Северо-Восточный Гобустан (n = 40); 23 – ЦентраΛьный Гобустан (n = 81); 24 – Юго-Восточный Гобустан (n = 103); 25 – Юго-Восточный Ширван (n = 86). По оси абсцисс указаны посеΛения, по оси орΑинат – частота изменчивости. Figs 21–25. Frequency of variability of the main elements of pattern (medial, paramedical and marginal stripes) of dorsal surface of mesosome of Mesobuthus eupeus in conglomerations of each sample. 21 – northwestern Gobustan (n = 57); 22 – northeastern Gobustan (n = 40); 23 – central Gobustan (n = 81); 24 – southeastern Gobustan (n = 103); 25 – southeastern Shirvan (n = 86). Abscissas show conglomerations, ordinates – the frequency of variability. in Materials on the colour pattern variability of Mesobuthus eupeus (C.L. Koch, 1839) (Arachnida: Scorpiones) in southeastern Shirvan and Gobustan (Eastern Azerbaijan)
Рис. 21–25. Частота изменчивости основных эΛементов рисунка (меΑиаΛьной, парамеΑиаΛьных и маргинаΛьных поΛос) ΑорсаΛьной поверхности мезосомы Mesobuthus eupeus в посеΛениях кажΑой из выборок. 21 – Северо-ЗапаΑный Гобустан (n = 57); 22 – Северо-Восточный Гобустан (n = 40); 23 – ЦентраΛьный Гобустан (n = 81); 24 – Юго-Восточный Гобустан (n = 103); 25 – Юго-Восточный Ширван (n = 86). По оси абсцисс указаны посеΛения, по оси орΑинат – частота изменчивости. Figs 21–25. Frequency of variability of the main elements of pattern (medial, paramedical and marginal stripes) of dorsal surface of mesosome of Mesobuthus eupeus in conglomerations of each sample. 21 – northwestern Gobustan (n = 57); 22 – northeastern Gobustan (n = 40); 23 – central Gobustan (n = 81); 24 – southeastern Gobustan (n = 103); 25 – southeastern Shirvan (n = 86). Abscissas show conglomerations, ordinates – the frequency of variability.
Data for: Mobility of the human foot's medial arch helps enables upright bipedal locomotion
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Spatial coding dysfunction and network instability in the aging medial entorhinal cortex
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Medial amygdala ERα expression influences monogamous behavior of male prairie voles in the field
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Action potential evoked dendritic calcium signals in the medial superior olive (MSO) during development
<p>Dataset underlying the analysis of dendritic calcium signals evoked by somatic action potentials in MSO neurons during development (postnatal day 10 - 60). The data includes recordings from Mongolian gerbils (<em>Meriones unguiculatus</em>) raised in a normal acoustic environment and in omnidirectional white noise.</p> <p><strong>Linked paper:</strong> Franzen DL, Gleiss SA, Kellner CJ, Kladisios N, Felmy F. Activity-Dependent Calcium Signaling in Neurons of the Medial Superior Olive during Late Postnatal Development. J Neurosci. 2020 Feb 19;40(8):1689–700. <a href="https://doi.org/10.1523/JNEUROSCI.1545-19.2020">https://doi.org/10.1523/JNEUROSCI.1545-19.2020</a>.</p> <p><strong>Files included:</strong></p> <ul> <li> <p>A folder entitiled <em>data</em> containing:</p> <ul> <li>The imaging files (<code>.nix</code>) (1 file per imaged neuron). NIX files contain the kymograph data extracted from a ROI in the raw images along with the metadata. The imaging kymographs and associated <code>.nix</code> files were created with the <a href="https://zenodo.org/record/2575542#.XiYdAS2ZNo4">CaManager: ImageJ Plugin For Ca²⁺ Imaging</a>.</li> <li>An <code>excludes.csv</code> file that contains cells/trials to be excluded (e.g. recording error, movement, difficulty in tracing)</li> <li>A <code>Megatable_C.csv</code> file containing the electrophysiological data corresponding to imaged cells</li> </ul> </li> <li> <p>A <code>.nix</code> intermediate analysis file for <em>default parameters</em></p> </li> <li> <p>A <code>.csv</code> file with the combined electrophysiological and imaging data for <em>default parameters</em></p> </li> <li> <p>Several <code>.xlsx</code> files with the single cell data in Figures 2C, 2D, 2F.</p> </li> </ul> <p><strong>Jupyter notebook:</strong></p> <p>The <a href="https://github.com/delwen/CaJupyter">CaJupyter</a> GitHub repository contains a Jupyter notebook with a step-by-step guide of the analysis. It also allows for further exploration of the data.</p> <p><strong>See also:</strong></p> <ul> <li> <p>The original analysis code (without adaptations for the Jupyter notebook and Python 3) can be found at <a href="https://zenodo.org/record/2575675#.Xi%E2%80%A6">CaAnalysis: Analysis Toolbox for Ca²⁺ Imaging</a>.</p> </li> <li> <p>More information on NIX can be found at this <a href="https://g-node.github.io/nix/">link</a>.</p> </li> </ul>
Data from: Evaluation of the horizontal approach to the medial malleolar facet in sagittal talar fractures through dorsiflexion and plantarflexion positions
<p><strong>Background</strong></p> <p>Talar fractures often require osteotomy during surgery to achieve reduction and screw fixation of the fractured fragments due to limited visualization and operating space of the talar articular surface. The objective of this study was to evaluate the horizontal approach to the medial malleolus facet by maximizing exposure through dorsiflexion and plantarflexion positions.</p> <p><strong>Methods</strong><strong> </strong></p> <p>In the positions of foot dorsiflexion, plantarflexion, and functional, we respectively obtained the anterior and posterior edge lines of the projection of the medial malleolus on the medial malleolar facet. The talar model from Mimics was imported into Geomagic software for image refinement. Then Solidworks software was used to segment the medial surface of the talus and extend the edge lines from the three positions to project them onto the "semicircular" base for 2D projection. The exposed area in different positions, the percentage of total area it represents, and the anatomic location of the insertion point at the groove between the anteroposternal protrusions of the medial malleolus were calculated.</p> <p><strong>Results</strong><strong> </strong></p> <p>The mean total area of the "semicircular" region on the medial malleolus surface of the talus was 542.10 ± 80.05 mm<sup>2</sup>. In the functional position, the exposed mean area of the medial malleolar facet around the medial malleolus both anteriorly and posteriorly was 141.22 ± 24.34 mm<sup>2</sup>, 167.58 ± 22.36mm<sup>2</sup>, respectively. In dorsiflexion, the mean area of the posterior aspect of the medial malleolar facet was 366.28 ± 48.12 mm<sup>2</sup>.<sup> </sup>In plantarflexion, the mean of the anterior aspect of the medial malleolar facet was 222.70 ± 35.32 mm<sup>2</sup>.<sup> </sup>The mean overlap area of unexposed area in both dorsiflexion and plantarflexion was 23.32 ± 5.94 mm<sup>2</sup>.<sup> </sup>The mean percentage of the increased exposure area in dorsiflexion (36.71 ± 3.25 %) and plantarflexion were 36.71 ± 3.25 % and 15.13 ± 2.83 %. The mean distance from the insertion point to the top of the talar dome was 10.69 ± 1.24 mm, to the medial malleolus facet border of the talar trochlea was 5.61 ± 0.96 mm, and to the tuberosity of the posterior tibiotalar portion of the deltoid ligament complex was 4.53 ± 0.64 mm.</p> <p><strong>Conclusions</strong><strong> </strong></p> <p>Within the 3D model, we measured the exposed area of the medial malleolus facet in different positions and the anatomic location of the insertion point at the medial malleolus groove. When the foot is in plantarflexion or dorsiflexion, a sufficiently large area and operating space can be exposed during surgery. The data regarding the exposed visualization area and virtual screws need to be combined with clinical experience for safer reduction and fixation of fracture fragments. Further validation of its intraoperative feasibility will require additional clinical research.</p>
Medial prefrontal cortex and anteromedial thalamus interaction regulates motivation related behavior and dopaminergic neuron activity: Animal Behavior
<p>The excel Source DATA file contains the data described in Figures 2c, 2d, 2f, and 3b and Supplementary Figure 3b and 3c. The fiber photometry data described in Supplementary Figure 9 are found in the CSV files. The CSV file names reflect animal IDs. </p>
Georgian: V-final or V-medial
<p>Lecture on Georgian word order, OV/VO, evidence for verb-final, including exercises.</p> <p> </p> <p>This lecture is part of the lecture series:</p> <p><em>Glottothèque: Languages of the Anatolia, Caucasus, Iran, Mesopotamia; grammatical snippets online </em>(electronic resource). Bamberg, Cambridge, Göttingen, Moskow, Nicosia, Paris: LACIM network, at https://spw.uni-goettingen.de/projects/lacim/, edited by Christiane Bulut, Anaïd Donabédian-Demopoulos, Geoffrey Haig, Geoffrey Khan, Pollet Samvelian, Stavros Skopeteas, Nina Sumbatova.</p>
Theta dominates cross-frequency coupling in hippocampal-medial entorhinal circuit during awake-behavior in rats
<p>Hippocampal theta and gamma rhythms are hypothesized to play a role in the physiology of higher cognition. Prior research has reported that an offset in theta cycles between the entorhinal cortex, CA3, and CA1 regions promotes independence of population activity across the hippocampus. In line with this idea, it has recently been observed that CA1 pyramidal cells can establish and maintain coordinated place cell activity intrinsically, with minimal reliance on afferent input. Counter to these observations is the contemporary hypothesis that CA1 neuron activity is driven by a gamma oscillation arising from the medial entorhinal cortex (MEC) that relays information by providing precisely timed synchrony between MEC and CA1. Reinvestigating this in rats during appetitive track running, we found that theta is the dominant frequency of cross-frequency coupling between the MEC and hippocampus, with hippocampal gamma largely independent of entorhinal gamma.</p>
Data - Medial gastrocnemius muscle remodeling correlates with reduced plantar flexor kinetics fourteen weeks following Achilles tendon rupture
<p>ultrasound images and biodex data published used in analysis.</p> <p>study timeline:</p> <p>s1 - week 0</p> <p>s2 - week 2</p> <p>s3 - week 4</p> <p>s4 - week 6</p> <p>s5 - week 10</p> <p>s6 - week 14</p>
The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses
<p><span>The perforant path provides the primary cortical excitatory input to the hippocampus. Due to its important role in information processing and coding, entorhinal projections to the dentate gyrus have been studied in considerable detail. Nevertheless, synaptic transmission between individual connected pairs of entorhinal </span><span>stellate cells and dentate granule cells</span><span> remains to be characterized. Here, we have used mouse organotypic entorhino-hippocampal tissue cultures of either sex, in which the entorhino-dentate (EC-GC) projection is present and EC-GC pairs can be studied using whole-cell patch clamp recordings. By using cultures of wildtype mice, the properties of EC-GC synapses formed by afferents from the lateral and medial entorhinal cortex were compared and differences in short-term plasticity were identified. Since the perforant path is severely affected in Alzheimer´s disease, we used tissue cultures of amyloid-precursor protein (APP)-deficient mice to examine the role of APP at this synapse. APP deficiency altered excitatory neurotransmission at medial perforant path synapses, which was accompanied by transcriptomic and ultrastructural changes. Moreover, presynaptic but not postsynaptic APP deletion through the local injection of Cre-expressing adeno-associated viruses in conditional APP<sup>flox/flox</sup> tissue cultures increased the neurotransmission efficacy at perforant path synapses. In summary, these data suggest a physiological role for presynaptic APP at medial perforant path synapses that may be adversely affected under altered APP processing conditions.</span></p>
Augmented Medial Rectus Muscle Recession Versus Posterior Scleral Fixation in Partially Accommodative Esotropia
ClinicalTrials.gov study NCT02413463. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Clinical Trial Evaluating Acutrak Headless Compression Screw Fixation of Medial Malleolus Fractures
ClinicalTrials.gov study NCT03061279. IPD Sharing: NO. Countries: 1. Publications: 8.
A Prospective Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves Versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome
ClinicalTrials.gov study NCT03614793. IPD Sharing: YES. Countries: 1. Publications: 1.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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