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1,326 results for “neutrophil”
Data from: Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment
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Flow cytometric analysis of neutrophil populations present in orthotopic KCKO cancers
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Data from: Analyses Xenopus laevis mast cells, neutrophils, and mast cell-enriched, chytrid infected skin
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Data from: Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst
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Acinetobacter lwoffii exposure promotes PD-L1+ neutrophils and dampens viral-induced type 2 immunity
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DNA microarray of long-lived neutrophils versus control
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Photoreceptor loss does not recruit neutrophils despite strong microglial activation
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Data from: Neutrophils actively swell to potentiate rapid migration
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Dataset related to article "Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors"
<p>Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. Neutrophils were essential for the activation of an interferon-γ-dependent pathway of immune resistance, associated with polarization of a subset of CD4<sup>-</sup> CD8<sup>-</sup> unconventional αβ T cells (UTC<sub>αβ</sub>). Bulk and single-cell RNA sequencing (scRNA-seq) analyses unveiled the innate-like features and diversity of UTC<sub>αβ</sub> associated with neutrophil-dependent anti-sarcoma immunity. In selected human tumors, including undifferentiated pleomorphic sarcoma, CSF3R expression, a neutrophil signature and neutrophil infiltration were associated with a type 1 immune response and better clinical outcome. Thus, neutrophils driving UTC<sub>αβ</sub> polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.</p>
Neutrophil extracellular traps are present in the airways of ENaC-overexpressing mice with cystic fibrosis-like lung disease
<p>Background: Neutrophils are key components of the exacerbated inflammation and tissue damage in cystic fibrosis (CF) airways. Neutrophil extracellular traps (NETs) trap and kill extracellular pathogens. While NETs are abundant in the airways of CF patients and have been hypothesized to contribute to lung damage in CF, the in vivo role of NETs remains controversial, partially due to lack of appropriate animal models. The goal of this study was to detect NETs and to further characterize neutrophilmediated inflammation in the airways of mice overexpressing the epithelial sodium channel (βENaC-Tg mice on C57BL/6 background) in their lung with CF-like airway disease, in the absence of any apparent bacterial infections.</p> <p>Methods: Histology scoring of lung tissues, flow cytometry, multiplex ELISA, immunohistochemistry and immunofluorescence were used to characterize NETs and the airway environment in uninfected, βENaC-Tg mice at 6 and 8 weeks of age, the most chronic time points so far studied in this model.</p> <p>Results: Excessive neutrophilic infiltration characterized the lungs of uninfected, βENaC-Tg mice at 6 and 8 weeks of age. The bronchoalveolar lavage fluid (BALF) of βENaC-Tg mice contains increased levels of CF-associated cytokines and chemokines: KC, MIP-1α/β, MCP-1, G-CSF, IL-5, and IL-6. The BALF of βENaC-Tg mice contain MPO-DNA complexes, indicative of the presence of NETs. Immunofluorescence and flow cytometry of BALF neutrophils and lung tissues demonstrated increased histone citrullination, a NET-specific marker, in βENaC-Tg mice.</p> <p>Conclusions: NETs are detected in the airways of βENaC-Tg mice, in the absence of bacterial infections. These data demonstrate the usefulness of the βENaC-Tg mouse to serve as a model for studying the role of NETs in chronic CF airway inflammation.</p> <p>Keywords Cystic fibrosis; neutrophil extracellular traps; NET; ENaC, neutrophil.</p>
Dataset for the publication "Neutrophilic Bioleaching of Synthetic Covellite – A Model System Combining Experimental Data and Geochemical Modeling"
<p>This dataset contains data, which were used in preparation of the publication "Neutrophilic Bioleaching of Synthetic Covellite – A Model System Combining Experimental Data and Geochemical Modeling"</p>
Dataset BD "Inflammation Biomarkers in Blood as Mortality Predictors in Community-Acquired Pneumonia Admitted Patients: Importance of comparison with Neutrophil Count Percentage or Neutrophil-Lymphocyte Ratio."
<p>Dataset of the article tittled: <strong>Inflammation Biomarkers in Blood as Mortality Predictors in Community-Acquired Pneumonia Admitted Patients: Importance of comparison with Neutrophil Count Percentage or Neutrophil-Lymphocyte Ratio.</strong></p> <p> </p>
CCR. Low-dose ionizing-radiation elicits the extrusion of neutrophil extracellular traps
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Pre-Treatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Occult Cervical Metastasis in Clinically Negative Neck Supraglottic and Glottic Cancer
<p>I uploaded the dataset of the patient enrolled in the manuscript: Salzano, Giovanni, Francesco Perri, Fabio Maglitto, Giulia Togo, Gianluca R. De Fazio, Michela Apolito, Federica Calabria, Claudia Laface, Luigi A. Vaira, Umberto Committeri, Mario Balia, Ettore Pavone, Corrado Aversa, Francesco A. Salzano, Vincenzo Abbate, Alessandro Ottaiano, Marco Cascella, Mariachiara Santorsola, Roberta Fusco, Luigi Califano, and Franco Ionna. 2021. "Pre-Treatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Occult Cervical Metastasis in Clinically Negative Neck Supraglottic and Glottic Cancer" <em>Journal of Personalized Medicine</em> 11, no. 12: 1252. https://doi.org/10.3390/jpm11121252</p>
Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality
<p>This work reports that COVID-19-induced oxidative stress inflicts structural damages to human serum albumin (HSA) and is linked with mortality outcome in critically ill patients. Analyzing blood samples from patients and healthy individuals, the paper provides evidence that neutrophils are major sources of oxidative stress in blood and that hydrogen peroxide is highly accumulated in plasmas of non-survivors. The electron paramagnetic resonance spectra of spin-labeled fatty acids (SLFAs) bound with HSA in whole blood of control, survivor, and non-survivor subjects (n=10–11) were analyzed to probe structural damages to the protein. Non-survivors' HSA showed dramatically altered biophysical parameters that reflect remarkably fluid protein microenvironments. Following loading/unloading of 16-DSA, the results show that the transport function of HSA may be impaired in severe patients. Stratified at the means, Kaplan–Meier survival analysis indicated that lower values of S/W ratio and accumulated H<sub>2</sub>O<sub>2</sub> in plasma significantly predicted in-hospital mortality.</p>
DeepCAD-RT dataset: mouse brain neutrophils
<p>DeepCAD-RT dataset: mouse brain neutrophils</p>
DeepCAD-RT dataset: mouse brain neutrophils (3D)
<p>DeepCAD-RT dataset: mouse brain neutrophils (3D)</p>
NanoString dataset for study: Dynamic changes in the NK-, Neutrophil-, and B-cell immunophenotypes relevant in high metastatic risk post neoadjuvant chemotherapy–resistant early breast cancers
<p>Pre-processed DSP and mRNA abundance datasets used in this study.</p>
FIG. 7 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 7. Hellbender neutrophil: lymphocyte ratio across 2017 and 2018 at Little River (LR; n ¼ 8), Tumbling Creek (TC; n ¼ 12), Hiwassee River (HR; n ¼ 11), Elk River (ER; n ¼ 3), North Fork Triplett Creek (NFTC; n ¼ 4), Little Buffalo River (LBR; n ¼ 4), Doe River (DR; n ¼ 1), and South Fork New River (SFNR; n ¼ 5). Letters indicate among-site differences, where sites that are significantly different have different letters, and error bars represent two standard deviations from the mean.
FIG. 5 in Neutrophil: Lymphocyte Ratios as a Measure of Chronic Stress in Populations of the Hellbender (Cryptobranchus alleganiensis) across a Habitat Quality Gradient
FIG. 5. Scatterplot showing regression between Hellbender neutrophil: lymphocyte ratio and water pH observed in 2018.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.