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6,782 results for “project”
Database of NGS results of MSTN gene of intensive fattening lambs of sheep breeds raised in Latvia in 2022 within the framework of project of the Latvian Council of Science LZP-2021/1-0489 project
<p>Project of The Latvian Council of Science (LCS) - LZP-2021/1-0489 project: “<strong>Development of an innovative approach to identify biological determinants involved in the between-animal variation in feed efficiency in sheep farming</strong>.”</p> <p><strong>The aim of the project</strong> is to determine whether the feed efficiency status of Latvian meat sheep breeds could be predicted using a panel of genetic and molecular markers previously found to be associated with divergent Feed efficiency status in a training population of lambs when fed the same diet.</p> <p><strong>Novelty</strong>: to determine the parameters predicting the most productive result of lamb rearing, we set out to develop the cheapest and most effective method for determining markers of feed efficiency - based on molecular and genetic markers obtained from the blood of live lambs.</p> <p><strong>About the project:</strong></p> <p>The costs associated with lambing (buying or keeping sheep) and preparing or purchasing feed are the two largest components of variable costs in sheep raising. Feed costs are high due to poor grain growing conditions in major producing countries, the use of feed grains in ethanol production, and increased competition for land in crop production compared to urban development. Feed efficiency in growing lambs (i.e., the animal’s ability to reach a market or adult body weight (BW) with the least amount of feed intake) is a key factor in the sheep industry. Improving Feed efficiency reduces production costs. Improving Feed efficiency by 5% can bring economic benefits that are up to four times higher than a 5% increase in average daily gain (ADG).</p> <p>Traditionally, meat breeding programs have focused on outputs due mainly to the routine availability of phenotypic data on outputs or correlated traits. Currently, no marker has successfully explained enough of the variability in feed efficiency that they were used as part of a routine improvement program, as well as, according to our data, no genetic parameters for performance and feed efficiency traits are available for sheep. The physiological determinants of feed efficiency or putative biomarkers used to analyze animal-to-animal variation in live lambs could be used as a cost-effective and rapid tool for genetic selection or management decisions.</p> <p>As with other complex traits (also referred to as quantitative or polygenic traits), Feed efficiency is controlled by many genes which are involved in several molecular mechanisms and pathways causing animal-to-animal genetic variation in different biological functions. GWAS results suggested genes impacting lipid and energy metabolism as markers of Feed efficiency. Detection of many variants in these genes is necessary to predict or identify efficient animals accurately.</p> <p>Myostatin (MSTN), a highly conserved member of the transforming growth factor-beta (TGF-b) superfamily, also known as growth/differentiation factor 8 (GDF8), the major regulator of myogenesis, functions as a negative regulator of muscle growth and development in mammals. Myostatin is a transforming growth factor (TGF)-β superfamily member and cannot be classified into the existing TGF-β subfamilies, such as inhibins or bone morphogenic proteins. Mutations of <em>MSTN</em> produce a “double-muscle” phenotype, making it commercially invaluable for improving livestock meat production and providing high-quality human protein. However, mutations at different loci of the <em>MSTN</em> often produce a variety of different phenotypes.</p> <p><strong>About the data of the project:</strong></p> <p>LZP-2021/1-0489 project data on lamb samples of the year 2022, or the A22 group, which consists of 76 intensively fattened lambs from six breeds.</p> <p>Full MSTN gene were sequenced using Illumina NGS technology (AmpliSeq). The MSTN gene has been fully sequenced in lambs of Latvia (in sheep research in Latvia) for the first time.</p> <p>Information about 23 loci were found comparing with the last reference sequences ARS_UI_Ramb_v2.0. Nine (9) loci form three groups with complete linkage disequilibrium between polymorphisms. One new SNP (without ID number) were found.</p> <p>The database contains information on each locus for each lamb and the distribution of alleles and genotypes for each locus across all 76 samples. The data will be used in (1) analysis of Latvian sheep and (2) analysis of association with feed efficiency.</p> <p> </p> <p>The data is the<strong> joint property</strong> of the participants of the LCS project: the University of Latvia and the Latvian University of Life Sciences and Technologies.</p>
Database of NGS results of CAST gene of intensive fattening lambs of sheep breeds in Latvia within the framework of project of the Latvian Council of Science LZP-2021/1-0489 project
<p>Project of The Latvian Council of Science (LCS) - LZP-2021/1-0489 project: “<strong>Development of an innovative approach to identify biological determinants involved in the between-animal variation in feed efficiency in sheep farming</strong>.”</p> <p><strong>The aim of the project</strong> is to determine whether the feed efficiency status of Latvian meat sheep breeds could be predicted using a panel of genetic and molecular markers previously found to be associated with divergent feed efficiency status in a training population of lambs when fed the same diet.</p> <p><strong>Novelty</strong>: to determine the parameters predicting the most productive result of lamb rearing, we set out to develop the cheapest and most effective method for determining markers of feed efficiency - based on molecular and genetic markers obtained from the blood of live lambs.</p> <p><strong>About the project:</strong></p> <p>The costs associated with lambing (buying or keeping sheep) and preparing or purchasing feed are the two largest components of variable costs in sheep raising. Feed costs are high due to poor grain growing conditions in major producing countries, the use of feed grains in ethanol production, and increased competition for land in crop production compared to urban development. Feed efficiency in growing lambs (i.e., the animal's ability to reach a market or adult body weight (BW) with the least amount of feed intake) is a key factor in the sheep industry. Improving feed efficiency reduces production costs. Improving Feed efficiency by 5% can bring economic benefits that are up to four times higher than a 5% increase in average daily gain (ADG).</p> <p>Traditionally, meat breeding programs have focused on outputs due mainly to the routine availability of phenotypic data on outputs or correlated traits. Currently, no marker has successfully explained enough of the variability in feed efficiency that they were used as part of a routine improvement program, as well as according to our data, no genetic parameters for performance and feed efficiency traits are available for sheep. The physiological determinants of feed efficiency or putative biomarkers used to analyze animal-to-animal variation in live lambs could be used as a cost-effective and rapid tool for genetic selection or management decisions.</p> <p>As with other complex traits (also referred to as quantitative or polygenic traits), Feed efficiency is controlled by many genes which are involved in several molecular mechanisms and pathways causing animal-to-animal genetic variation in different biological functions. GWAS results suggested genes impacting lipid and energy metabolism as markers of Feed efficiency. Detection of many variants in these genes is necessary to predict or identify efficient animals accurately.</p> <p>Calpastatin (CAST) plays a key role in skeletal muscle development and is involved in myoblast migration, protein metabolism, apoptosis, muscle growth and development, and fat deposition.</p> <p><strong>About the data of the project:</strong></p> <p>LZP-2021/1-0489 project data on lamb samples of the year 2022, or the A22 group, which consists of 76 intensively fattened lambs from six breeds.</p> <p>Exons (29) of the CAST gene and their flanking intron regions were sequenced using Illumina NGS technology (AmpliSeq). The CAST gene has been sequenced in lambs of Latvia (in sheep research in Latvia) for the first time.</p> <p>Information about 89 loci were found, from which eight were monozygotic or were found only for the rear allele compering with the last reference sequences ARS_UI_Ramb_v2.0. Forty (40) loci form five groups with complete linkage disequilibrium between polymorphisms. Four new SNP (without ID number) were found, and three SNPs were determined to be a single polymorphism.</p> <p>The database contains information on each locus for each lamb and the distribution of alleles and genotypes for each locus across all 76 samples. The data will be used in (1) an analysis of Latvian sheep and (2) an analysis of the association with feed efficiency.</p> <p> </p> <p>The data is the<strong> joint property</strong> of the participants of the LCS project: the University of Latvia and the Latvian University of Life Sciences and Technologies.</p>
Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548)
<p>Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548).</p> <p><strong>Aim 1:</strong></p> <p>Understanding whether LRRK2 mediates neuroinflammation triggered by PD and AD misfolded proteins using in vitro and in vivo models.</p> <p><strong>Aim 2:</strong></p> <p>Exploring whether and how LRRK2-related neuroinflammation affects hiPSC-derived neuronal function.</p> <p><strong>Aim 3:</strong></p> <p>Exploring whether hiPSC-derived neurons carrying LRRK2 mutation/variant are more vulnerable to neuroinflammation.</p> <p> </p> <p>The present dataset contains the following folders:</p> <p><strong>1- Aim 1</strong></p> <p>- In vitro</p> <p> - Attivazione infiammazione</p> <p> - Generazione proteina amiloide</p> <p> - LRRK2 infiammazione</p> <p>- In vivo</p> <p> - Generazione proteina amiloidi</p> <p> - Infiammazione abeta</p> <p> - Infiammazione asyn</p> <p> - Microglia-Astrociti abeta</p> <p> - Microglia-Astrociti asyn </p> <p> </p> <p><strong>2- Aim 2</strong></p> <p>- hiPSC Col RNASeq</p> <p>- hiPSC DA RNASEq</p> <p>- Neuroni colinergici</p> <p>- Neuroni dopaminergici</p> <p> </p> <p><strong>3- Aim 3</strong></p> <p>- Gentotyping human cells</p>
caArray_landi-00077: EAGLE Project
GEO Series GSE75324. Homo sapiens. 132 samples. Type: Expression profiling by array.
Expression Level Polymorphism Project (ELP) - Kin-0
GEO Series GSE5757. Arabidopsis thaliana. 18 samples. Type: Expression profiling by array.
Expression Level Polymorphism Project (ELP) - Tsu-1
GEO Series GSE5755. Arabidopsis thaliana. 18 samples. Type: Expression profiling by array.
Auratus: Goldfish genome project
GEO Series GSE5768. Carassius auratus; Cyprinus carpio. 3 samples. Type: Expression profiling by array.
Academy of Program/Project & Engineering Leadership: NASA's Path to Project Management Excellence
NASA's Path to Project Management Excellence eBook. Leadership plays a critical role in the success of today’s programs and projects. In an increasingly global and dynamic project environment, the ability to for organizations to foster and develop project leaders who can lead in and deliver unique, innovative products and missions on time and budget has never been more important.
Academy of Program/Project & Engineering Leadership: APPEL Case Studies
Case studies illustrate the kinds of decisions and dilemmas managers face every day, and as such provide an effective learning tool for project management. Due to the dynamic and complex environment of projects, a great deal of project management knowledge is tacit and hard to formalize. A case study captures the complex nature of a project and identifies key decision points, allowing the reader an inside look at the project from a practitioner’s point of view.
Academy of Program/Project & Engineering Leadership: NASA's Path to Project Management Excellence
NASA's Path to Project Management Excellence eBook. Leadership plays a critical role in the success of today’s programs and projects. In an increasingly global and dynamic project environment, the ability to for organizations to foster and develop project leaders who can lead in and deliver unique, innovative products and missions on time and budget has never been more important.
Academy of Program/Project & Engineering Leadership: NASA's Path to Project Management Excellence
NASA's Path to Project Management Excellence eBook. Leadership plays a critical role in the success of today’s programs and projects. In an increasingly global and dynamic project environment, the ability to for organizations to foster and develop project leaders who can lead in and deliver unique, innovative products and missions on time and budget has never been more important.
3-COLOR MESSENGER MDIS MAP PROJECTED MULTISPECTRAL RDR V1.0
Abstract ======== The Mercury Dual Imaging System (MDIS) consists of two cameras, a Wide Angle Camera (WAC) and a Narrow Angle Camera (NAC), mounted on a common pivot platform. This dataset includes 3-Color Multispectral Reduced Data Records for the WAC. The 3-Color Map Projected Multispectral RDR (MD3) data set consists of a 3-color map of northern and equatorial latitudes acquired during MESSENGER's Extended Mission, and includes I/F in the 3 filters used for this map. This product has higher spatial resolution than, and complements, an 8-color multispectral map acquired during the primary mission. This product is photometrically normalized to a solar incidence angle (i) = 30 degrees, emission angle (e) = 0 degrees, and phase angle (g) = 30 degrees at a spatial sampling of 128 pixels per degree. The map is divided into 'tiles', each representing the NW, NE, SW, or SE quadrant of one of the 13 non-polar or one of the 2 polar quadrangles or 'Mercury charts' already defined by the USGS. Each tile is composed of 3 bands corresponding to 3 of the 11 WAC filters. Each tile also contains backplanes describing ancillary information. The subset of 3 of 11 available multispectral filters samples both albedo and spectral slope over MDIS's wavelength range. The fewer colors than in the Primary Mission 8-color product is to balance the higher spatial resolution to manage data volume during acquisition.
Academy of Program/Project & Engineering Leadership: APPEL Case Studies
Case studies illustrate the kinds of decisions and dilemmas managers face every day, and as such provide an effective learning tool for project management. Due to the dynamic and complex environment of projects, a great deal of project management knowledge is tacit and hard to formalize. A case study captures the complex nature of a project and identifies key decision points, allowing the reader an inside look at the project from a practitioner’s point of view.
Academy of Program/Project & Engineering Leadership Annual Publications
Academy of Program/Project & Engineering Leadership's Annual Report highlights the Academy's efforts to serve the NASA workforce's needs in adapting to the challenges of today and the future.
IT Policies and Standards - NASA Information Technology and Institutional Infrastructure Program and Project Management Requirements
The documents contained in this dataset reflect NASA's comprehensive IT policy in compliance with Federal Government laws and regulations.
Academy of Program/Project & Engineering Leadership: Shared Voyage: Learning and Unlearning from Remarkable Projects
Shared Voyage is about four remarkable projects:the Advanced Composition Explorer (NASA), the Joint Air-to-Surface Standoff Missile (U.S. Air Force), the Pathfinder Solar-Powered Airplane (NASA), and the Advanced Medium Range Air-to-Air Missile (U.S. Air Force).
Academy of Program/Project & Engineering Leadership Annual Publications
Academy of Program/Project & Engineering Leadership's Annual Report highlights the Academy's efforts to serve the NASA workforce's needs in adapting to the challenges of today and the future.
Academy of Program/Project & Engineering Leadership: APPEL Case Studies
Case studies illustrate the kinds of decisions and dilemmas managers face every day, and as such provide an effective learning tool for project management. Due to the dynamic and complex environment of projects, a great deal of project management knowledge is tacit and hard to formalize. A case study captures the complex nature of a project and identifies key decision points, allowing the reader an inside look at the project from a practitioner’s point of view.
Academy of Program/Project & Engineering Leadership: Interactive Case Studies
Case studies illustrate the kinds of decisions and dilemmas managers face every day, and as such provide an effective learning tool for project management. Due to the dynamic and complex environment of projects, a great deal of project management knowledge is tacit and hard to formalize. A case study captures the complex nature of a project and identifies key decision points, allowing the reader an inside look at the project from a practitioner’s point of view.
Academy of Program/Project & Engineering Leadership Annual Publications
Academy of Program/Project & Engineering Leadership's Annual Report highlights the Academy's efforts to serve the NASA workforce's needs in adapting to the challenges of today and the future.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.